嗜酸性粒细胞性食管炎的结局:目前的认识和未来的方向。

IF 3 4区 医学 Q2 ALLERGY
Sara Urbani, Giulio Dinardo, Maria Cristina Artesani, Alessandro Fiocchi
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引用次数: 0

摘要

回顾目的:嗜酸性粒细胞性食管炎(EoE)是一种慢性免疫介导的疾病,由于其可能发展为纤维化和食管狭窄,需要终身治疗。这篇综述综合了评估EoE结果的当前策略,并强调了旨在调和临床症状和组织学发现之间经常不一致的关系的新兴方法。更新的综合对指导不断发展的临床实践至关重要。最近的发现:最近的文献强调了EoE的多面性,揭示了传统结果测量方法的局限性。患者报告结果(PROs)、组织学评分系统和内窥镜评估的进展丰富了我们对疾病活动的理解。此外,通过高分辨率测压仪和EndoFLIP等模式整合功能评估,以及数字数据整合,已经改进了疾病监测,并提供了对治疗反应和长期进展的细致见解。此外,新出现的证据表明,整合新的生物标志物可能进一步完善疾病分层和结果。总结:结合临床、组织学、内窥镜和功能数据的多维方法对于EoE的个性化管理至关重要。这些见解为改进治疗决策铺平了道路,并强调了在临床实践和未来研究中对标准化、综合工具的需求。这些额外的发现提倡向精确医学转变,强调多学科和以患者为中心的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Outcomes in eosinophilic esophagitis: current understanding and future directions.

Purpose of review: Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disorder that demands lifelong management due to its potential to progress to fibrosis and esophageal strictures. This review synthesizes current strategies for evaluating EoE outcomes and highlights emerging approaches aimed at reconciling the often discordant relationship between clinical symptoms and histologic findings. An updated synthesis is crucial to guide evolving clinical practices.

Recent findings: Recent literature emphasizes the multifaceted nature of EoE, revealing limitations in traditional outcome measures. Advances in patient-reported outcomes (PROs), histologic scoring systems, and endoscopic assessments have enriched our understanding of disease activity. Furthermore, the integration of functional assessments through modalities such as high-resolution manometry and EndoFLIP, along with digital data integration, has refined disease monitoring and provided nuanced insights into treatment responses and long-term progression. Additionally, emerging evidence suggests that integrating novel biomarkers may further refine disease stratification and outcomes.

Summary: A multidimensional approach that combines clinical, histologic, endoscopic, and functional data is crucial for personalized management of EoE. These insights pave the way for improved therapeutic decision-making and highlight the need for standardized, comprehensive tools in both clinical practice and future research. These additional findings advocate for a shift towards precision medicine, emphasizing multidisciplinary and patient-centric approaches.

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来源期刊
CiteScore
5.90
自引率
3.60%
发文量
109
审稿时长
6-12 weeks
期刊介绍: This reader-friendly, bimonthly resource provides a powerful, broad-based perspective on the most important advances from throughout the world literature. Featuring renowned guest editors and focusing exclusively on one to three topics, every issue of Current Opinion in Allergy and Clinical Immunology delivers unvarnished, expert assessments of developments from the previous year. Insightful editorials and on-the-mark invited reviews cover key subjects such as upper airway disease; mechanisms of allergy and adult asthma; paediatric asthma and development of atopy; food and drug allergies; and immunotherapy.
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