Current Health Sciences Journal最新文献

{"title":"Calcium and Phosphorus Deficiencies in Patients with Liver Cirrhosis.","authors":"Claudiu Marinel Ionele,&nbsp;Mihaela Simona Subtirelu,&nbsp;Bogdan Silviu Ungureanu,&nbsp;Mircea-Sebastian Serbanescu,&nbsp;Ion Rogoveanu","doi":"10.12865/CHSJ.48.03.09","DOIUrl":"10.12865/CHSJ.48.03.09","url":null,"abstract":"<p><p>Patients with cirrhosis often develop malnutrition and micronutrient deficiencies, leading to a worse prognosis and increased mortality. Our purpose was to assess the prevalence of micronutrient deficiencies especially calcium and phosphorus in patients with decompensated liver cirrhosis (LC). This was a retrospective study including 143 consecutive patients hospitalized for acute decompensation of cirrhosis, most of them with alcoholic etiology along with viral B or viral C and autoimmune induced cirrhosis. A blood test including minerals was performed on admission. Lower serum calcium levels were found in patients with a more severe forms of LC and also the ones diagnosed with viral and alcoholic LC rather than autoimmune induced LC. Peritoneal ascitic fluid was observed in 51 patients with hypocalcemia and only 24 patients with normal calcium levels had fluid accumulation. Low levels of phosphorus were noted in patients with a more severe form of LC (chi-square: 20.2504; p-value 0.000446). Ascitic fluid was found in patients with low values of phosphorus as well as in those with hypocalcemia (chi-square 5.235; p-value 0.022137). In conclusion, this study confirmed that patients with advanced liver disease had lower values of calcium and phosphorus and a more severe form of LC can be associated with hypocalcemia and hypophosphatemia.</p>","PeriodicalId":10938,"journal":{"name":"Current Health Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b6/25/CHSJ-48-03-311.PMC9940930.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10761887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Cytotoxicity of Dental Restorative Materials on Gingival Stromal Mesenchymal Cells-an In Vitro Study.","authors":"Diana Oneț,&nbsp;Alexandra Roman,&nbsp;Andrada Soancă,&nbsp;Andreea Ciurea,&nbsp;Iulia Cristina Micu,&nbsp;Ștefan Cristian Vesa,&nbsp;Dora-Maria Popescu,&nbsp;Ana-Maria Rîcă","doi":"10.12865/CHSJ.48.03.12","DOIUrl":"10.12865/CHSJ.48.03.12","url":null,"abstract":"<p><strong>Background: </strong>Due to their minimally invasive high-quality adhesive, aesthetic and mechanical qualities, composite resins are the most frequently used materials in modern restorative dentistry. However, polymerization shrinkage and cytotoxicity are still unresolved drawbacks associated with these biomaterials.</p><p><strong>Purpose: </strong>The present study aimed to assess the cytotoxicity of some restorative resin-based materials on gingival mesenchymal stromal cells (gMSCs), assuming that no differences in their behavior will be highlighted.</p><p><strong>Material and methods: </strong>The cytotoxicity of the tested materials was evaluated by comparing the behavior of gMSCs cultured in normal conditions and in association with disc-shaped material samples indirectly through functionality tests (colony-forming unit-fibroblast assay, migratory potential) and directly through the MTT assay. The results were statistically analyzed with the ANOVA test and Tukey's Honest Significant Difference test.</p><p><strong>Results: </strong>According to the MTT assay, there are no statistically significant differences regarding the viability of gMSCs cultured in normal conditions or in the presence of resin-based material samples. On the other hand, the present study identified a significantly reduced number of colonies formed by the gMSCs cultured in association with BF and B discs, compared to that of gMSCs cultured in normal conditions. Also, the migratory potential was significantly lower for control gMSCs when compared to ZE-gMSCs and significantly higher for ZE-gMSCs when compared to BF-gMSCs or BFL-gMSCs.</p><p><strong>Conclusions: </strong>The results of the present study highlight a possible risk of cytotoxicity when using resin based-materials in dental practice, but they cannot be directly extrapolated to in vivo situations.</p>","PeriodicalId":10938,"journal":{"name":"Current Health Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9a/b7/CHSJ-48-03-331.PMC9940923.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10761888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classification and Grading Systems in Gastric Adenocarcinomas.","authors":"Oana Iulia Crețu,&nbsp;Alex Emilian Stepan,&nbsp;Cristiana Eugenia Simionescu,&nbsp;Daniela Marinescu,&nbsp;Mioara Desdemona Stepan","doi":"10.12865/CHSJ.48.03.06","DOIUrl":"10.12865/CHSJ.48.03.06","url":null,"abstract":"<p><p>Gastric adenocarcinomas are lesions that raise important issues in clinical practice, due to their incidence and biological behavior. Over time, various systems have been used for classifying and grading of gastric adenocarcinomas, in the hope of increasing the diagnostic accuracy. In this study we statistically analyzed 112 cases of gastric adenocarcinomas in relation to different classification and grading systems, in order to identify their efficacy and concordance in the histopathological diagnosis. The results indicated a significant association of the Lauren and World Health Organization 2019 classifications and also between these and the three-tier and two-tier grading systems, which supports their practical utility in establishing the diagnosis and assessment of the tumor aggressiveness, for the differentiated therapy.</p>","PeriodicalId":10938,"journal":{"name":"Current Health Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bd/f2/CHSJ-48-03-284.PMC9940934.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10771112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subtle Immunoreactivity Differences in the Fractal Patterns of Membrane E-Cadherin in Gastric Adenocarcinoma.","authors":"Ilona Mihaela Liliac,&nbsp;Mihai Victor Sacerdoțianu,&nbsp;Bogdan Silviu Ungureanu,&nbsp;Laurențiu Mogoantă,&nbsp;Claudiu Mărgăritescu,&nbsp;Daniel Pirici,&nbsp;Adrian Săftoiu,&nbsp;Anda Elena Crisan","doi":"10.12865/CHSJ.48.03.08","DOIUrl":"10.12865/CHSJ.48.03.08","url":null,"abstract":"<p><p>Gastric cancer continues to be a significant malignancy worldwide, accounting for approximately one million new cases in 2020. Scientists are focusing on the cancerous cells' plasma membrane (PM) as a potential therapeutic target in cancer because it functions as the cell's interface with its environment through a variety of mechanisms. The capacity of membrane shape and its structures to influence biological processes frequently occurs through the regulation of enzymes or preferential protein binding to membranes via membrane shape changes. We aimed here to assess the morphological irregularities of the cellular membranes in gastric adenocarcinoma tumors, and to find any putative differences from normal gastric mucosae epithelial cells. We analyzed the pattern of E-cadherin at the level of the cell membrane using the fractal dimension (FD) analysis on fluorescence immunohistochemistry samples labeled with E-cadherin in gastric well/moderate and solid gastric adenocarcinoma from patients without any associated chemotherapeutic treatment or radiotherapy. Images were binarized based on a fixed threshold of the E-cadherin fluorescence channel, and then the FD of the binarized image outlines has been calculated in order to assess the ruggedness of the cellular membranes. Overall assessment of the FD revealed that the subtle membrane variations were evident enough to deem a statistically significant difference and the complexity of the membrane roughness was clearly higher for adenocarcinoma cases. We intended to evaluate if separating adenocarcinoma cases as low grade (G1 and G2) and high grade (G3 and solid), FD analysis could still differentiate membrane patterns and check if the available clinical parameters like age, gender, tumor location, lymph ganglia involved might correlate with FD values for adenocarcinoma patients. Altogether, the morphological analysis of a simple marker for the cell membrane can identify and distinguish tumor cells. Although there was a limited correlation between this analysis and the main clinical and pathological indicators of the disease, it will be very useful in the future for automatic computer-assisted diagnosis on slides, as well as for evaluating cellular adhesion and inter-cellular trafficking in cancer cells.</p>","PeriodicalId":10938,"journal":{"name":"Current Health Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bc/fa/CHSJ-48-03-303.PMC9940928.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10761890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Study of Moderate Sedation with Propofol Versus Propofol Combined with Midazolam for Ambulatory Care Digestive Endoscopic Procedures.","authors":"Denisa-Ancuța Popa-Ion,&nbsp;Dan-Ionuț Gheonea,&nbsp;Mădălina Maria Denicu,&nbsp;Luminița Cristina Chiuțu","doi":"10.12865/CHSJ.48.03.07","DOIUrl":"10.12865/CHSJ.48.03.07","url":null,"abstract":"<p><p>Anesthesia is essential during colonoscopy because it provides patients with necessary sedation to perform the investigation safely and nonetheless to obtain the highest quality of the results. We aimed here to evaluate and establish which of the combinations of anesthetic drugs most frequently used for sedation purposes for gastrointestinal endoscopic procedures performed in the ambulatory best covers the needs of the patient and the gastroenterologist. This is a prospective, randomized, double-blind study carried out on a total of 100 patients, aged between 18 and 80 years, who meet the conditions for inclusion in the study. Patients were randomly allocated into either group A (Propofol) or group B (Midazolam plus Propofol). Evaluation of the dose of Propofol used in the 2 groups, awakening time, anesthetic induction, as well as the occurrence of episodes of bradycardia and hypotension represented the parameters followed in the study. In group A, 50 patients received on average 218.6mg of Propofol in bolus of 10-20mg. In group B, 50 patients received 0.1mg/kg Midazolam and an average of up to 129.2mg of Propofol in bolus of 10-20mg. Awakening time was shorter in group A-3.18 minutes, than in group B-15.7 minutes. Bradycardia and hypotension were met in a larger number in group B than in group A. The quality of the endoscopic evaluation was similar in both groups. The conclusion of our study was that the group to which only Propofol was administered had the best results from all aspects (rapid anesthetic induction, stability of vital functions, lower cost, awakening time much faster) compared to the combination of Propofol with Midazolam.</p>","PeriodicalId":10938,"journal":{"name":"Current Health Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b2/44/CHSJ-48-03-292.PMC9940920.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10761889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postmortem Evaluation of First Trimester Fetal Heart.","authors":"Dan Ruican,&nbsp;Ana-Maria Petrescu,&nbsp;Anca-Maria Istrate-Ofiţeru,&nbsp;Dominic Gabriel Iliescu","doi":"10.12865/CHSJ.48.03.01","DOIUrl":"10.12865/CHSJ.48.03.01","url":null,"abstract":"<p><p>Due to rapid technology advancement and increasing diagnostic expertise, fetal medicine is rapidly improving. Prenatal diagnostic advancements made it possible to identify structural abnormalities in fetuses as early as the first trimester of pregnancy. However, to validate the echocardiographic diagnosis that led to the pregnancy termination, the termination of pregnancy owing to severe fetal deformities should be audited in accordance with a correct anatomic diagnosis. Following the PRISMA declaration, a systematic literature search was done to find articles on post-mortem first trimester human fetal heart evaluation. Thirteen suitable studies were found using the search method. It is theoretically possible to examine the human fetal heart after death in early pregnancy however these methods are not widely available due the costs associated with the procedure and the equipment, the effects of tissue coloration and distortion brought on by the fixation and contrasting processes (for micro-CT), the current requirement for a skilled operator to acquire, reconstruct, and process the images, and data storage requirements greater than those of conventional clinical scans.</p>","PeriodicalId":10938,"journal":{"name":"Current Health Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2f/30/CHSJ-48-03-247.PMC9940927.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10754679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Alterations in Acute Cerebral Ischemia.","authors":"Alexandra Maria Poenaru,&nbsp;Mihaela Ionescu,&nbsp;Carmen-Valeria Albu,&nbsp;Ion Rogoveanu,&nbsp;Tudor-Adrian Bălşeanu","doi":"10.12865/CHSJ.48.03.02","DOIUrl":"10.12865/CHSJ.48.03.02","url":null,"abstract":"Cerebral ischemia is a major health problem worldwide, that affects millions of people, leaving a major percentage of them with major disabilities, therefore becoming one of the most resource consuming pathology. Beside the blockage of blood supply of the brain that leads to loss of cellular function and neuronal necrosis, metabolic processes are modified in the whole body through mechanisms that are not fully explained yet. The results in the analysis of the 2 groups, one with 70 patients with stroke and another with 68 patients with no cerebral infarction, revealed that brain ischemia is more often found in patients with atrial fibrillation and higher blood pressure values. The metabolic changes, found in the stroke group, are represented by increased values of blood glucose, serum urea and lower levels of creatinine levels. Also, the value of leucocytes count and the erythrocyte sedimentation rate were shown to be increased in stroke patients, indicating that inflammation is highly present in cerebral infarction. In the regard of these findings, cerebral ischemia is associated with major systemic disruptions that could be significant pathogenic factors and also effects of the complex processes that take place in the affected brain region, but further investigation should be done in order to explain all the mechanisms involved and also the possible impact in prophylaxis and acute management of stroke.","PeriodicalId":10938,"journal":{"name":"Current Health Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e5/94/CHSJ-48-03-255.PMC9940935.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10771110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HUBUNGAN PERILAKU PERAWATAN KAKI DENGAN KUALITAS HIDUP PASIEN DIABETES MELITUS DI RSU MUHAMMADIYAH DAN KLINIK RULIA MEDIKA PONOROGO","authors":"Nelly Adelian Nur Safitri, L. Purwanti, Sri Andayani","doi":"10.24269/hsj.v6i1.1159","DOIUrl":"https://doi.org/10.24269/hsj.v6i1.1159","url":null,"abstract":"Foot care behavior is a part of primary prevention efforts in diabetic foot management. Foot care aims to prevent the occurence of chronic complications in the form of diabetic neuropathy or the death of nerves of the feet so that it can cause diabetic foot ulcers. This research aims to analyze the relationship between foot care behavior and the quality of life of Diabetes Mellitus patients at RSU Muhammadiyah and Klinik Rulia Medika Ponorogo. The research design used is a correlation study. The population in this study were Diabetes Mellitus patients at RSU Muhammadiyah and Klinik Rulia Medika Ponorogo, totalling 41 patients. The sampling technique was purposive sampling with a sample size of 41 patients. The data were collected with foot care behavior questionnaire and quality of life questionaire (WHOQoL-BREF). Data were analyzed using Chi-Square test using application SPSS. The results showed that the majority of patients had positive foot care behavior as many as 27 patients (65,9%), and 22 patients (53,7%) high quality of life and 19 patients (46,3%) medium quality of life. From this research, it was found that a significant value was 0,020 (α 0,05) so that there was a relationship between foot care behavior and the quality of life in Diabetes Melitus patients at RSU Muhammadiyah and Klinik Rulia Medika Ponorogo. Positive behavior is needed in foot care so that the risk of complications can be minimized, especially the risk of diabetic foot ulcers which will also have an impact on the quality of life in patients with Diabetes Mellitus.","PeriodicalId":10938,"journal":{"name":"Current Health Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80318866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Influencing the Length of Hospital Stay in a Safety Measures Psychiatric Hospital in Romania.","authors":"Monica-Elena Parfene Banu","doi":"10.12865/CHSJ.48.02.06","DOIUrl":"10.12865/CHSJ.48.02.06","url":null,"abstract":"<p><strong>Introduction: </strong>A growth in the number of patients admitted to forensic psychiatric services has been reported worldwide. At the same time, an increase in the length of hospital stay of these patients was observed.</p><p><strong>Objectives: </strong>To identify the factors that influence the length of hospital stay in a Romanian forensic psychiatric sample, as well as to compare the socio-demographic, clinical and criminological features of the \"long stay\" and \"shorter stay\" patients.</p><p><strong>Methods: </strong>This was a retrospective, cross-sectional study that included all patients admitted to Săpoca Psychiatry and Safety Measures Hospital according to article 110 of the Penal code (n=650) over a period of 11 years (2008-2018). Long stay was considered as a period of hospitalization greater than 5 years.</p><p><strong>Results: </strong>The average length of hospital stay in the sample was 3.20 years. Approximately one quarter (n=154) of the patients were classified as \"long stay\". The variables that were significantly associated with length of stay included the main psychiatric diagnosis, social support, the severity of the offence and the perpetration of violence.</p><p><strong>Conclusions: </strong>Overall, our findings are in line with observations made by researchers from other countries. Our study highlights the need for further, more detailed research on the patients admitted to forensic psychiatric units in Romania.</p>","PeriodicalId":10938,"journal":{"name":"Current Health Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40448775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Mesenchymal Hamartoma of Liver: A Case Report with Histomorphological Differential Diagnosis and Review of Literature.","authors":"Sudhamani Rao,&nbsp;Divya Shetty,&nbsp;Anita Sharan,&nbsp;Snigdha Mukharji","doi":"10.12865/CHSJ.48.02.14","DOIUrl":"https://doi.org/10.12865/CHSJ.48.02.14","url":null,"abstract":"<p><p>Mesenchymal hamartoma of liver (MHL) is a benign liver tumour that occurs mainly in children, especially those under 2 years old. The pathogenesis of this tumor is still unknown. It is believed that MHL is derived from the Ito cells and either a developmental malformation of primitive hepatic mesenchyme; result of toxic or ischemic insult; or a true neoplasm. It is amenable to treatment and has a good prognosis but presents with varied clinical, imaging and histological findings. However, it can be confused with other hepatic tumors and can mimic malignancy. Therefore, it is important to recognize this rare entity to avoid unnecessary over management. We present a case of MHL in a 3-year-old boy with abdominal distension. Based on the clinical presentation, laboratory and radiological findings a diagnosis of complex cyst of liver was made. A final diagnosis of MHL was given after histopathological examination.</p>","PeriodicalId":10938,"journal":{"name":"Current Health Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40448776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}