Current Health Sciences Journal最新文献_第10页

The Influence of the Inflammatory Bowel Diseases on the Perceived Stress and Quality of Life in a Sample of the South-Western Romanian Population. 炎症性肠病对罗马尼亚西南部人群感知压力和生活质量的影响

Current Health Sciences Journal Pub Date : 2022-01-01 Epub Date: 2022-03-31 DOI: 10.12865/CHSJ.48.01.01

Denisa-Elena Popa, Mihail-Cristian Pîrlog, Dragoş-Ovidiu Alexandru, Dan-Ionuţ Gheonea

{"title":"The Influence of the Inflammatory Bowel Diseases on the Perceived Stress and Quality of Life in a Sample of the South-Western Romanian Population.","authors":"Denisa-Elena Popa, Mihail-Cristian Pîrlog, Dragoş-Ovidiu Alexandru, Dan-Ionuţ Gheonea","doi":"10.12865/CHSJ.48.01.01","DOIUrl":"https://doi.org/10.12865/CHSJ.48.01.01","url":null,"abstract":"Background: Inflammatory bowel diseases (IBD) represent a category of chronic diseases of gastrointestinal tract with a long-term evolution which includes flares and periods of remission. The aim of the study is to identify and quantify the relationship between IBD status, perceived stress, coping mechanisms, and patients QOL.Methods: Cross-sectional study on two samples consisting of 70 IBD patients monitored in the Gastroenterology Department of the Emergency Clinical County Hospital Craiova, Romania, respectively 70 healthy volunteers. Collected data include socio-demographic details, personal and familial medical history, clinical status, presumed risk factors, perceived stress (Perceived Stress Scale-PSS), coping strategies (COPE questionnaire) and Health-Related Quality of Life (HRQOL-SF-36 scale).Results: Perceived stress was considerably higher on IBD subjects (p<0.0001). The assessment of HRQOL has shown that patients had the best perception over their physical and emotional domains of SF-36 (p<0.0001), while the most often coping mechanisms used are those from the problem-focused category.Conclusions: There is a significant relationship between increased activity of IBD and higher level of stress, that led to the development of problem-focused coping strategies. We did not find a strong correlation between lower HRQOL levels and the items considered as potential risk factors.","PeriodicalId":10938,"journal":{"name":"Current Health Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40573900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aspects of Humoral Immunity after Vaccination with Bnt162b2: A Small Study. 接种Bnt162b2后体液免疫方面:一项小型研究

Current Health Sciences Journal Pub Date : 2022-01-01 Epub Date: 2022-03-31 DOI: 10.12865/CHSJ.48.01.03

Lucian-Ion Giubelan, Florentina Dumitrescu, Livia Dragonu, Andreea Cristina Stoian, Cristina Ilie, Ilona Stanciu

{"title":"Aspects of Humoral Immunity after Vaccination with Bnt162b2: A Small Study.","authors":"Lucian-Ion Giubelan, Florentina Dumitrescu, Livia Dragonu, Andreea Cristina Stoian, Cristina Ilie, Ilona Stanciu","doi":"10.12865/CHSJ.48.01.03","DOIUrl":"https://doi.org/10.12865/CHSJ.48.01.03","url":null,"abstract":"Starting from December 2020, vaccination against COVID-19 became available in Romania. There are a lot of uncertainties regarding the kinetics of immunity and its persistance over time. This is a small prospective study developed between January-September 2021 in the Infectious Diseases Clinic from Craiova and comprising 61 subjects immunised with BNT162b2 (Comirnaty). We have found that after two doses of vaccine there is a strong humoral response, but the immunity lowers six months later. Subjects with a diagnosis of COVID-19, previously or in between the two doses, have had the most significant immunological response, but, also, the sharpest decline in antibody titer. The immune response seems to be the same, regardless the gender of the subjects. There are a variety of responses at the individual level, but overall vaccine effectiveness is 96.72% two weeks following immunisation and 88.52% after six months; however for those who have been in contact with the virus, they all had an antibody titer well above the laboratory limit.","PeriodicalId":10938,"journal":{"name":"Current Health Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40590915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accuracy of Endoscopic Ultrasonography for Gastric Cancer Staging. 内镜超声检查对胃癌分期的准确性。

Current Health Sciences Journal Pub Date : 2022-01-01 Epub Date: 2022-03-31 DOI: 10.12865/CHSJ.48.01.13

Victor Mihai Sacerdotianu, Bogdan Silviu Ungureanu, Sevastita Iordache, Maria Monalisa Filip, Daniel Pirici, Ilona Mihaela Liliac, Adrian Saftoiu

{"title":"Accuracy of Endoscopic Ultrasonography for Gastric Cancer Staging.","authors":"Victor Mihai Sacerdotianu, Bogdan Silviu Ungureanu, Sevastita Iordache, Maria Monalisa Filip, Daniel Pirici, Ilona Mihaela Liliac, Adrian Saftoiu","doi":"10.12865/CHSJ.48.01.13","DOIUrl":"https://doi.org/10.12865/CHSJ.48.01.13","url":null,"abstract":"Gastric cancer remains a health problem, with treatment indications varying with the TNM stage. We aimed in this study to highlight the role of EUS in GC patients and also to calculate the accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of EUS for T and N staging in our group of patients with this disease. In this study, we included 41 GC patients, and individual values for every T stage accuracy, sensitivity, specificity, PPV, NPV, correct staging, understaging, and overstaging were calculated. EUS overall accuracy for T staging was 58.53%, with the highest sensitivity reached for the T4 stage, 95.83%. For N+vs. N-staging, EUS accuracy was 68.29%, with a sensitivity of 75% and a specificity of 44.44%. The positive and negative predicted values for the presence or absence of nodal disease were 82.75%, respectively 33.33%. In conclusion, this study confirmed the importance of EUS for the assessment of GC T and N stage and highlighted the role of this tool in the detection of liver micrometastasis unrevealed by other imaging techniques like abdominal ultrasound or MSCT.","PeriodicalId":10938,"journal":{"name":"Current Health Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40574951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Colorectal Cancer in County Durham-England a Clinical and Statistical Study. 英国达勒姆郡结直肠癌的临床与统计研究。

Current Health Sciences Journal Pub Date : 2021-07-01 Epub Date: 2021-09-30 DOI: 10.12865/CHSJ.47.03.02

Daniel Sorin Ilie, Mircea-Sebastian Şerbanescu, Nina Ionovici, Cristina Jana Busuioc, Laurenţiu Mogoantă

{"title":"Colorectal Cancer in County Durham-England a Clinical and Statistical Study.","authors":"Daniel Sorin Ilie, Mircea-Sebastian Şerbanescu, Nina Ionovici, Cristina Jana Busuioc, Laurenţiu Mogoantă","doi":"10.12865/CHSJ.47.03.02","DOIUrl":"https://doi.org/10.12865/CHSJ.47.03.02","url":null,"abstract":"Colorectal cancer is one of the most frequently occurring malignancies which associates increasing mortality and morbidity rates. According to data provided by the World Health Organization, colorectal cancer deaths account for approximately 13% of all cancer fatalities. The carcinogenesis of this type of malignancy is a very complex process characterized by various molecular changes which in turn are influenced by factors likes sex, diet, intestinal microbiota, exposure to environmental factors, hosts' immune response and also genetic factors. Our study looked at a total number of 1024 patients, which were all diagnosed with colorectal cancer in a hospital in the north of England, a country that is known for both a high prevalence of this type of cancer but also its robust screening programmers. In our analyses, we concluded that this type of malignancies affected mostly males, aged between 60 and 80. The most commonly affected regions were the rectum, the sigmoid colon and also the cecum. The majority of colorectal cancers (51%) were diagnosed by GPs (general practitioners) or other medical specialties; 43.55% of all cases presented as surgical emergencies and 5.47% were diagnosed through national screening programs. Majority of tumors were diagnosed in late stages, mainly T3 and T4 whilst in was observed that rectal cancers were mainly diagnosed in T2 and T3 stages.","PeriodicalId":10938,"journal":{"name":"Current Health Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39677494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hip Joint Abnormalities During Midstance in Osteoarthritic Patients. 骨关节炎患者站立时髋关节异常。

Current Health Sciences Journal Pub Date : 2021-07-01 Epub Date: 2021-09-30 DOI: 10.12865/CHSJ.47.03.05

Carmen Stătescu, Bogdan-Ion Gavrilă, Andrei Deaconu, Rodica-Magdalena Trăistaru, Tudor-Adrian Bălşeanu

{"title":"Hip Joint Abnormalities During Midstance in Osteoarthritic Patients.","authors":"Carmen Stătescu, Bogdan-Ion Gavrilă, Andrei Deaconu, Rodica-Magdalena Trăistaru, Tudor-Adrian Bălşeanu","doi":"10.12865/CHSJ.47.03.05","DOIUrl":"https://doi.org/10.12865/CHSJ.47.03.05","url":null,"abstract":"Osteoarthritis is one of the most debilitating diseases in Europe affecting the lower limb joints, especially the hip and knee, having a bad influence on gait in the long run as well. Rehabilitation physicians use gait in order for the whole body to be seen in ensemble, and through midstance as moment of gait to also take predilection to falls into consideration. Goniometry is the quantifiable measure of a rehabilitation treatment by measuring the range of motion of each treated joint and studied during time. The patients that volunteered to be part of this study have been divided into four groups, depending on the level of osteoarthritis present at the lower limb joints: hip, knee, both hip and knee osteoarthritis or control group with no osteoarthritis, have been asked to walk for a few times and the video recordings were uploaded into the Angles App where we measured the lower limb joint angles during midstance. Patients with knee osteoarthritis present a more extended hip on both dominant and non-dominant sides compared to the ones with hip osteoarthritis, hip and knee osteoarthritis or control group. The results can be explained through the body's kinematic chains that link the knee and hip, hip and pelvis during the midstance phase in the sagittal plane. A physician can use a video goniometry app in order for him to thoroughly evaluate an osteoarthritic patient as well as follow him or her during the entire course of treatment.","PeriodicalId":10938,"journal":{"name":"Current Health Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39677496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Metabolic Impact of Diabetes Mellitus Type 2 in Hepatitis C Virus Infected Patients. 2型糖尿病对丙型肝炎病毒感染患者代谢的影响

Current Health Sciences Journal Pub Date : 2021-07-01 Epub Date: 2021-09-30 DOI: 10.12865/CHSJ.47.03.11

Marian-Sorin Popescu, Dan-Mihai Firu, Radu Mitruţ, Dragoş Nicolae Mărgăritescu, Adina-Maria Kamal, Vlad Pădureanu, Paul Mitruţ

{"title":"Metabolic Impact of Diabetes Mellitus Type 2 in Hepatitis C Virus Infected Patients.","authors":"Marian-Sorin Popescu, Dan-Mihai Firu, Radu Mitruţ, Dragoş Nicolae Mărgăritescu, Adina-Maria Kamal, Vlad Pădureanu, Paul Mitruţ","doi":"10.12865/CHSJ.47.03.11","DOIUrl":"https://doi.org/10.12865/CHSJ.47.03.11","url":null,"abstract":"Objective: Patients with chronic hepatitis C are subjected to a greater risk of cardiovascular disease and difficult to control diabetes mellitus type 2 (T2DM) comparatively to people that have never contracted Hepatitis C Virus (HCV). We aimed to investigate the impact of T2DM on HCV patients with the help of Fibromax test results compared to nonT2DM patients, and the metabolic differences between the 2 study groups. Our long term goals are to observe the long term impact of achieving systemic virusologic response (SVR) by means of Direct-Acting antivirals (DAA) between the 2 cohorts.Research design and methods: We selected a lot of 200 patients with HCV that will undergo interferon-free DAA-based antiviral treatment for HCV and we used the results of the Fibromax Test to compare the biological parameters of T2DM and nonT2DM patients. RESULTS Among patients with T2DM compared to NonT2DM there is a significant correlation on Steatotest, NashTest, GGT, Glycemia, body weight, height and BMI. Test also showed that 15,5% of the test group had elevated glycemia, indicating the probability of developing diabetes in the future.Conclusions: Our results suggest that HCV patients that also have T2DM are subjected to a combined higher risk of accelerated steatosis development, steatohepatitis, added difficulty in controlling glycemic levels. All these previous elements combined with a prevalence for patients to be overweight have a negative metabolic impact. Eradication of HCV with the help of DAA is important in order to help improving the metabolic impact of diabetes on steatosis, steatohepatitis. An added benefit is better management of glycemic control by decreasing insulin use and eliminating one risk factor of T2DM.","PeriodicalId":10938,"journal":{"name":"Current Health Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39914180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Potential of Helianthin Loaded Into Magnetic Nanoparticles to Induce Cytotoxicity in Glioblastoma Cells. 向日葵素负载磁性纳米颗粒诱导胶质母细胞瘤细胞毒性的潜力。

Current Health Sciences Journal Pub Date : 2021-07-01 Epub Date: 2021-09-30 DOI: 10.12865/CHSJ.47.03.12

Alexandra Costachi, Cătălina Elena Cioc, Sandra Alice Buteică, Daniela Elise Tache, Ştefan-Alexandru Artene, Ani-Simona Sevastre, Oana Alexandru, Ligia Gabriela Tătăranu, Ştefana Oana Popescu, Anica Dricu

{"title":"The Potential of Helianthin Loaded Into Magnetic Nanoparticles to Induce Cytotoxicity in Glioblastoma Cells.","authors":"Alexandra Costachi, Cătălina Elena Cioc, Sandra Alice Buteică, Daniela Elise Tache, Ştefan-Alexandru Artene, Ani-Simona Sevastre, Oana Alexandru, Ligia Gabriela Tătăranu, Ştefana Oana Popescu, Anica Dricu","doi":"10.12865/CHSJ.47.03.12","DOIUrl":"https://doi.org/10.12865/CHSJ.47.03.12","url":null,"abstract":"The central nervous system tumors are the most common solid tumors in adults.. Unlike other types of cancers, brain cancer is much difficult to treat because of the blood-brain barrier (BBB) that prevents drug substances from crossing it and accessing the brain. Different types of methods to overcome BBB have been used in vivo and in vitro, of which the use of nanoparticle-mediated delivery of therapeutic drugs is particularly promising. In the present study, we used iron oxide magnetic nanoparticles (NPs) as carrier system for helianthin (He/NPs) to treat cancer cells derived from glioblastoma. An early passage cell cultures (GB1B), established in our laboratory from tissue obtained from a patient diagnosed with glioblastoma, was used. The cells were treated with different concentrations of NPs or HeNPs and then cell proliferation was measured at 24, 48 and 72 hours. Our results showed that the treatment with NPs was well tolerated by glioblastoma cells, the viability of the cells increased very slightly after the treatment. Furthermore, we demonstrated that helianthin loaded Fe3O4 magnetic nanoparticles induced cytotoxicity in human glioblastoma cells. The treatment with HeNPs induced dose and time dependent.","PeriodicalId":10938,"journal":{"name":"Current Health Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39914181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Conservative Management of a Jejuno-Jejunal Intussusception in a Patient with Severe Haemophilia A. 1例严重血友病a患者空肠-空肠肠套叠的保守治疗。

Current Health Sciences Journal Pub Date : 2021-07-01 Epub Date: 2021-09-30 DOI: 10.12865/CHSJ.47.03.20

Fares Salma, Wakrim Soukaina

引用次数: 1

Hepatitis C Virus Infection and the New Therapeutical Approach. 丙型肝炎病毒感染和新的治疗方法。

Current Health Sciences Journal Pub Date : 2021-07-01 Epub Date: 2021-09-30 DOI: 10.12865/CHSJ.47.03.04

Claudia Monica Danilescu, Mihail Cristian Pîrlog, Ion Rogoveanu

引用次数: 0

Macroscopic Changes in Oral Mucosa and Hygiene Indicators in Smokers. 吸烟者口腔黏膜及卫生指标的宏观变化。

Current Health Sciences Journal Pub Date : 2021-07-01 Epub Date: 2021-09-30 DOI: 10.12865/CHSJ.47.03.08

Gabriel Valeriu Popa, Laurenţiu Mogoantă, Oana Badea

{"title":"Macroscopic Changes in Oral Mucosa and Hygiene Indicators in Smokers.","authors":"Gabriel Valeriu Popa, Laurenţiu Mogoantă, Oana Badea","doi":"10.12865/CHSJ.47.03.08","DOIUrl":"https://doi.org/10.12865/CHSJ.47.03.08","url":null,"abstract":"Smoking is the most important factor affecting the oral cavity by components born in the tobacco combustion process and acting directly on the oral mucous membranes, dental arch and indirectly on the teeth support. Recent studies show the tobacco action on the oral cavity, manifestations in the form of gingivitis, bacterial plaque, dental plaque, papillary bleeding at drilling, periodontitis.Purpose of the study: In this study, we have set out to assess the macroscopic modifications of oral cavity on smokers.Materials and methods: The participants in the study were divided into two groups, the first group of smokers with a smoking period over 5 years and the control group of nonsmokers. The patients in the two groups underwent a physical examination and an objective clinical examination, the resulting data being compared with the control group.Results: For the bacterial plaque indicatorin the smoker group there was obtained a mean value of 35.68±12.45, compared to a mean value of 16.32±6.61 for the nonsmoker group, the dental plaque indicatorfor the smoker group had a mean value of 2.24±1.02, higher than the one in the nonsmoker group, namely 0.94±0.68, and for the drilling bleeding indicator we obtained a mean value of 19.54±7.89 in the nonsmoker group, which is lower than that in the smoker group, namely 42.86±14.93.Conclusions: Smoking is a cause that maintains and aggravates the periodontal disease, including the risk of periodontitis, allowing the aggravation of gingivitis, considered a reversible surface inflammation of the gum mucosa which, by accumulation of dental plaque, the dental plaque accompanied by incorrect oral hygiene, favors the progression to periodontitis.","PeriodicalId":10938,"journal":{"name":"Current Health Sciences Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8679161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39914178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0