Current Health Sciences Journal最新文献_第5页

Snail Immunoexpression in Endometrioid Endometrial Carcinomas. 蜗牛在子宫内膜样子宫内膜癌中的免疫表达。

Current Health Sciences Journal Pub Date : 2022-10-01 Epub Date: 2022-12-31 DOI: 10.12865/CHSJ.48.04.05

Mirela Marinela Florescu, Oana Iulia Crețu, Andrei Muraru, Dan Nicolae Florescu, Cristiana Eugenia Simionescu

引用次数: 0

Oncocytic Papillary Cystadenoma, an Unusual Variant Presenting as a Laryngeal Ventricular Cyst. 癌细胞乳头状囊腺瘤，一种表现为喉室性囊肿的异常变体。

Current Health Sciences Journal Pub Date : 2022-07-01 Epub Date: 2022-09-30 DOI: 10.12865/CHSJ.48.03.15

Sravan K Kavuri, Asad Ullah, Ehiremen Iyoha, Kalyani Ballur, Lauren Gilstrap, Samantha N Mattox

{"title":"Oncocytic Papillary Cystadenoma, an Unusual Variant Presenting as a Laryngeal Ventricular Cyst.","authors":"Sravan K Kavuri, Asad Ullah, Ehiremen Iyoha, Kalyani Ballur, Lauren Gilstrap, Samantha N Mattox","doi":"10.12865/CHSJ.48.03.15","DOIUrl":"10.12865/CHSJ.48.03.15","url":null,"abstract":"Cystadenoma arising from the larynx is a rare benign minor salivary gland tumor that can show mucinous or papillary morphology. The epithelial lining of the salivary gland tumor can present with oncocytic features, which is attributed to an increased number of mitochondria. We present a rare case of oncocytic papillary cystadenoma (OPC) of the larynx which has a combination of these features. The WHO defines OPC tumors as entities which closely resemble Warthin tumor, but lack its classic lymphoid component. The immunohistochemical profile and molecular genetic features are largely unknown. We present an 84-year-old female, former smoker, who presented with progressive dysphonia, dysphagia, and shortness of breath. Laryngoscopy revealed a large, smooth mass originating from the ventricle of the right vocal fold. Subsequent biopsy demonstrated cyst wall fragments lined by a bilayer of large columnar to cuboidal oncocytic cells that had granular eosinophilic cytoplasm, round to oval nuclei with finely dispersed chromatin, and small but distinct nucleoli. The surrounding stroma was slightly fibrotic with scant lymphoid elements. No nuclear pleomorphism, increased mitosis, or necrosis was identified. In the larynx, benign salivary gland tumors are rare and less frequent than malignant neoplasms. Awareness of rare benign entities like OPC help ensure proper management and aid in avoiding unnecessary therapy.","PeriodicalId":10938,"journal":{"name":"Current Health Sciences Journal","volume":"48 3","pages":"353-355"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8f/ed/CHSJ-48-03-353.PMC9940932.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10754678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Combined Effects of Doxorubicin and Temozolomide in Cultured Glioblastoma Cells. 阿霉素和替莫唑胺对培养的胶质母细胞瘤细胞的联合作用。

Current Health Sciences Journal Pub Date : 2022-07-01 Epub Date: 2022-09-30 DOI: 10.12865/CHSJ.48.03.03

Carina Baloi, Alexandru Oprita, Liliana Eleonora Semenescu, Daniela Elise Tache, Oana Stefana Popescu, Georgiana Adeline Staicu, Anica Dricu

引用次数: 0

Anticipatory Grief in the Families of Patients with Palliative Requiring Metastatic Cancer. 需要缓解的转移性癌症患者家属的预期性悲伤。

Current Health Sciences Journal Pub Date : 2022-07-01 Epub Date: 2022-09-30 DOI: 10.12865/CHSJ.48.03.10

Liliana Semenescu, Amelia Drăcea, Daniel Zimţa, Anda Crişan

{"title":"Anticipatory Grief in the Families of Patients with Palliative Requiring Metastatic Cancer.","authors":"Liliana Semenescu, Amelia Drăcea, Daniel Zimţa, Anda Crişan","doi":"10.12865/CHSJ.48.03.10","DOIUrl":"10.12865/CHSJ.48.03.10","url":null,"abstract":"Background/aim: When dealing with metastatic cancer patients, family distortions, such as anticipatory mourning, psychiatric and psychosocial disorders may occur. In the case of anticipatory mourning, there exists the risk of the patient being \"given up\" as if he is already gone, which will only make the patient feel lonely, with numerous problems occurring in the subsequent period of familial mourning. Currently, the importance of identifying the type of mourning affecting families of cancer patients has become more and more clear, as this allows not only for greater therapeutic success, but also avoids a high number of risks and complications that appear during the critical care period. Our paper aims to identify and assess these risk factors in order to contribute to the optimization and success of palliative therapy.Material and method: We performed this study on a group of 78 subjects with metastatic cancer. We developed a questionnaire in order to assess the patient-family relationship, family profile and the patient's unique psychological traits, in order to identify potential risk factors. Data processing was performed using Microsoft Excel; the XLSTAT package was used to perform complex statistical tests (χ2 test, Spearman correlation coefficient).Results and conclusions: Women are more prone to fears related to developing cancer themselves. No risk factors leading to the development of significant pathological mourning were identified in our study group. However, the clinician who deals with the treatment of the terminally ill cancer patient will have to include the following objectives related to the relatives in the therapeutic plan: to motivate their involvement, but with the maintenance of a separation in order to maintain the individuality; to keep their realism and to distinguish between normal/pathological mourning.","PeriodicalId":10938,"journal":{"name":"Current Health Sciences Journal","volume":"48 3","pages":"317-323"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/13/e1/CHSJ-48-03-317.PMC9940926.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10765177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

QRS and QT Interval Modifications in Patients with Type 2 Diabetes Mellitus. 2型糖尿病患者QRS和QT间期的改变。

Current Health Sciences Journal Pub Date : 2022-07-01 Epub Date: 2022-09-30 DOI: 10.12865/CHSJ.48.03.04

Elibet Chávez-González, Yuliet María Echavarría Calero, Suruj Harrichand, Edward Bediako Mensah

{"title":"QRS and QT Interval Modifications in Patients with Type 2 Diabetes Mellitus.","authors":"Elibet Chávez-González, Yuliet María Echavarría Calero, Suruj Harrichand, Edward Bediako Mensah","doi":"10.12865/CHSJ.48.03.04","DOIUrl":"10.12865/CHSJ.48.03.04","url":null,"abstract":"Introduction: Diabetes Mellitus imbricates inflammatory processes on their pathophysiology, it could affect cardiac electrophysiology. Cardiac inflammatory process leads electrocardiogram changes. Nevertheless, there are discrepancies about whether it prolongs or decreases waves and intervals such as QRS and QT. Furthermore, QRS dispersion has not been studied.Objective: To identify QRS complex and QT interval modifications in type 2 diabetic patients.Methods: A descriptive cross-sectional study was carried out in 59 type 2 diabetic patients selected by non-probabilistic sampling. Electrocardiogram was performed, QRS and QT interval were measured manually by two observers. Dispersion of both variables was calculated to compare with normal values.Results: Two variables showed differences for sex, QRS dispersion was higher in females (45.84), p=0.0001 vs. reference value; QT dispersion (63.12) showed significance difference (p=0.0246) vs. reference value for males. Greater than five years of illness was related to higher QRS values (124.11 vs. 137.28), p=0.005 and corrected QT dispersion (61.81 vs. 78.79), p=0.022.Conclusions: The electrocardiographic differences between sexes may suggest a gender influence. The longer duration of diabetes diseases could increase cardiovascular risk of arrhythmias due to greater QRS duration and corrected QT interval prolongation.","PeriodicalId":10938,"journal":{"name":"Current Health Sciences Journal","volume":"48 3","pages":"270-276"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fc/b7/CHSJ-48-03-270.PMC9940933.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10771113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Neglected Giant Basal Cell Carcinoma in a Nurse-Case Report and Literature Review. 一例罕见的被忽视的巨大基底细胞癌护士病例报告和文献复习。

Current Health Sciences Journal Pub Date : 2022-07-01 Epub Date: 2022-09-30 DOI: 10.12865/CHSJ.48.03.13

Anca Cojocaru, Olguța-Anca Orzan, Carrol Bîrjovanu, Nicolae Cătălina Andreea, Diana Petrache, Elena-Alexandra Marinescu, Marius-Eugen Ciurea

{"title":"A Rare Case of Neglected Giant Basal Cell Carcinoma in a Nurse-Case Report and Literature Review.","authors":"Anca Cojocaru, Olguța-Anca Orzan, Carrol Bîrjovanu, Nicolae Cătălina Andreea, Diana Petrache, Elena-Alexandra Marinescu, Marius-Eugen Ciurea","doi":"10.12865/CHSJ.48.03.13","DOIUrl":"10.12865/CHSJ.48.03.13","url":null,"abstract":"Basal cell carcinoma (BCC) is the most common skin cancer in the fair-skinned adult population over 50 years of age and the incidence is rising. Generally, BCC has an indolent course, low mortality and a good prognosis due to low rates of metastasis. Giant basal cell carcinoma is a rare reported oncological entity which accounts for 0.5% to 1% of all cases of BCC and has a diameter larger than 5cm. Basosquamous carcinoma is a rare high-risk type of BCC with clinical and histopathological features of both BCC and squamous cell carcinoma. A 61-year-old female presented to our clinic for a giant bleeding tumor located under her left breast. She initially noted the tumor almost 15 years ago. Although the patient was a nurse, she was afraid to seek medical advice until an episode of significant bleeding. At presentation the tumor was a 15/7cm in size, was invading the underlying structures and had a central ulceration. The margins of the tumoral plaque had several nodules and pearly structures suggesting the possible clinical diagnosis of BCC.","PeriodicalId":10938,"journal":{"name":"Current Health Sciences Journal","volume":"48 3","pages":"340-344"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b1/c6/CHSJ-48-03-340.PMC9940922.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10761892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Ability of Doppler Uterine Artery Ultrasound to Predict Premature Birth. 子宫动脉多普勒超声预测早产的能力。

Current Health Sciences Journal Pub Date : 2022-07-01 Epub Date: 2022-09-30 DOI: 10.12865/CHSJ.48.03.05

Ioana-Victoria Camen, Maria Magdalena Manolea, Sidonia Catalina Vrabie, Maria-Sidonia Sandulescu, Mircea-Sebastian Serbanescu, Mihail Virgil Boldeanu, Simona-Daniela Neamtu, Anca-Maria Istrate-Ofiteru, Anda Lorena Dijmarescu, Marius Bogdan Novac

{"title":"The Ability of Doppler Uterine Artery Ultrasound to Predict Premature Birth.","authors":"Ioana-Victoria Camen, Maria Magdalena Manolea, Sidonia Catalina Vrabie, Maria-Sidonia Sandulescu, Mircea-Sebastian Serbanescu, Mihail Virgil Boldeanu, Simona-Daniela Neamtu, Anca-Maria Istrate-Ofiteru, Anda Lorena Dijmarescu, Marius Bogdan Novac","doi":"10.12865/CHSJ.48.03.05","DOIUrl":"10.12865/CHSJ.48.03.05","url":null,"abstract":"Objective: Demonstration of the predictive capacity of Doppler Uterine Artery (UtA) on preterm birth (PB) by serial measurement at various ages of pregnancy.Methods: The prospective study included a group of 116 pregnant women, of whom 85 gave birth prematurely and 31 pregnant women gave birth at term, constituting the control group. UtA Doppler measurement was performed by the abdominal approach. Quantitative wave evaluations were performed by the pulsatility index (PI), the systole/diastole ratio (S/D), as well as the qualitative analysis of the flow rate waveform (notch). UtA Doppler evaluation was performed in 3 pregnancy periods: 18.0-22.6 weeks, 28.0-31.6 weeks, and 32.0-35.6 weeks.Results: Only at the third examination, at 32.0-35.5 weeks of gestation, was there a statistically significant difference between the S/D-UtA ratio and PI-UtA correlated with the risk of premature birth (p<0.05). Although there was an association between UtA Doppler and late preterm birth, the predictive ability was low. Also, UtA Doppler was not statistically significant for preterm birth before 32 weeks of gestation.Conclusions: Although we did not find a statistical association between second-trimester UtA Doppler and preterm birth, we do suggest a closer look at women with abnormal UtA Doppler in the second trimester. We believe that, according to the results obtained, UtA Doppler can predict especially iatrogenic premature birth depending on the prediction of the most severe complications, severe preeclampsia, and SGA.","PeriodicalId":10938,"journal":{"name":"Current Health Sciences Journal","volume":"48 3","pages":"277-283"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/05/1d/CHSJ-48-03-277.PMC9940921.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10754680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Isolated Lichen Planus of the Lower Lip: Report of a Rare Case with an Updated Literature Review. 孤立性下嘴唇扁平苔藓：一例罕见病例的报告及最新文献综述。

Current Health Sciences Journal Pub Date : 2022-07-01 Epub Date: 2022-09-30 DOI: 10.12865/CHSJ.48.03.14

Shamimul Hasan, Shahnaz Mansoori, Keya Sircar, Deepika Bablani Popli

{"title":"Isolated Lichen Planus of the Lower Lip: Report of a Rare Case with an Updated Literature Review.","authors":"Shamimul Hasan, Shahnaz Mansoori, Keya Sircar, Deepika Bablani Popli","doi":"10.12865/CHSJ.48.03.14","DOIUrl":"10.12865/CHSJ.48.03.14","url":null,"abstract":"Lichen planus (LP) is a chronic inflammatory, autoimmune entity typically affecting the skin, oral and genital mucosa, and skin appendages, with an underlying malignant potential. Oral lichen planus (OLP) represents the mucosal counterpart of the cutaneous LP and exhibits episodes of exacerbation and remissions. OLP typically manifests as bilateral symmetrical lesions on the buccal mucosa, followed by tongue, and gingiva. However, the occurrence of LP lesions solely on the lip is rarely reported in the literature. The altered clinical appearance of the lip lesions poses a diagnostic threat and raises the possibility of a misdiagnosis. Our aim was to report an unusual case of isolated lower lip LP, and also to carry out a literature review about isolated lip LP lesions, thus, emphasizing the demographic, clinicopathologic attributes, and therapeutic regimen. We report an uncommon occurrence of an isolated lichen planus on the lower lip in a 53-year-old male patient. Clinical evaluation revealed a diffuse erosive crusted lesion bordered by peripheral lacy radiating streaks on the lower lip. After a confirmed OLP histopathology, the patient was treated with low potency topical steroids and Vaseline therapy, with almost completely resolved lesions after 2 months of therapy. We report a rare case of isolated lip LP, and our detailed review revealed 44 reported cases of lip LP till date. The majority of the cases were seen on the lower lip and exhibited an age and gender affinity (mostly in middle-aged males). Significant healing was observed after topical steroid therapy.","PeriodicalId":10938,"journal":{"name":"Current Health Sciences Journal","volume":"48 3","pages":"345-352"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4f/7a/CHSJ-48-03-345.PMC9940924.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10771109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

An Unusual Presentation of Bilateral Split Hand-Foot Malformation (SHFM) in Family: A Tale of Two Generations. 家族性双侧手足裂畸形的罕见表现：两代人的故事。

Current Health Sciences Journal Pub Date : 2022-07-01 Epub Date: 2022-09-30 DOI: 10.12865/CHSJ.48.03.16

Surya Vijay Singh, Gyanendra Puri, Anisha Elizabeth Gemmy

引用次数: 0

Educational Potential of Three-Dimensional Volumes Based on Seriate Histological Slices of First Trimester Fetal Hearts. 基于胎儿早期心脏丝氨酸组织切片的三维体积的教育潜力。

Current Health Sciences Journal Pub Date : 2022-07-01 Epub Date: 2022-09-30 DOI: 10.12865/CHSJ.48.03.11

Dan Ruican, Ana-Maria Petrescu, Niculina Raluca Ciurea, Dominic Gabriel Iliescu

{"title":"Educational Potential of Three-Dimensional Volumes Based on Seriate Histological Slices of First Trimester Fetal Hearts.","authors":"Dan Ruican, Ana-Maria Petrescu, Niculina Raluca Ciurea, Dominic Gabriel Iliescu","doi":"10.12865/CHSJ.48.03.11","DOIUrl":"10.12865/CHSJ.48.03.11","url":null,"abstract":"The advantages of earlier diagnosis give the family more time to adjust to the fetal cardiac and related extracardiac diagnoses and to make informed pregnancy decisions. If a severe fetal CHD is detected in the first trimester and pregnancy termination is selected, the intervention may have a lower risk for the mother's physical and mental health. Training medical staff is a crucial part of implementing obstetric ultrasonography services well, since effective patient care depends on their ability to use the equipment skillfully and interpret results properly. In many low-and middle-income nations, there is a scarcity of healthcare professionals trained to offer ultrasound services and one of the reasons for this issue is the lack of available lectures, simulations and instruments to explain how ultrasound sections are acquired. We propose an alternative method of visualizing the ultrasound planes of interest using three-dimensional volumes of fetal hearts reconstructed from seriate histological slices. This method may aid trainees in understanding echocardiography.","PeriodicalId":10938,"journal":{"name":"Current Health Sciences Journal","volume":"48 3","pages":"324-330"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/82/af/CHSJ-48-03-324.PMC9940931.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10771116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0