Current Organic Chemistry最新文献_第2页

Synthesis of N-[trisubstitutedphenyl]-4-methyl Aniline Derivatives as Novel Anti-Breast Cancer Agents 作为新型抗乳腺癌药物的 N-[三取代苯基]-4-甲基苯胺衍生物的合成

IF 2.6 3区化学

Current Organic Chemistry Pub Date : 2024-08-28 DOI: 10.2174/0113852728321140240811170956

Fayez Althobaiti

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Synthesis of Pregna-1,4,16-triene-3,20-dione from a Mixture of Soybean Phytosterols using a Combination of Chemical and Microbiological Methods 采用化学和微生物方法从大豆植物甾醇混合物中合成 Pregna-1,4,16-三烯-3,20-二酮

IF 2.6 3区化学

Current Organic Chemistry Pub Date : 2024-08-28 DOI: 10.2174/0113852728317835240812102433

Luu D. Huy, Tatiana S. Savinova, Alexey V. Kazantsev, Victoria V. Fokina, Marina V. Donova

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Proline-based Organocatalyst for the Synthesis of Arylidene Benzofuranone Intermediates Enabling the Construction of Aurone-derived Azadienes 基于脯氨酸的有机催化剂用于合成芳基苯并呋喃酮中间体，从而构建由橙黄酮衍生的偶氮染料

IF 2.6 3区化学

Current Organic Chemistry Pub Date : 2024-08-26 DOI: 10.2174/0113852728316945240807114705

Azhaar T. Alsaggaf, Mostafa Sayed, Ahmed I.A. Soliman, Mostafa Ahmed

{"title":"Proline-based Organocatalyst for the Synthesis of Arylidene Benzofuranone Intermediates Enabling the Construction of Aurone-derived Azadienes","authors":"Azhaar T. Alsaggaf, Mostafa Sayed, Ahmed I.A. Soliman, Mostafa Ahmed","doi":"10.2174/0113852728316945240807114705","DOIUrl":"https://doi.org/10.2174/0113852728316945240807114705","url":null,"abstract":"Organocatalysis has been recognized as a part of chemical research for a long time, and it gained significant attention in catalysis in recent decades. Amine catalyst is a substantial type of organocatalysis, and it is successively employed for the activation of carbonyl compounds. This manuscript delves into the exploration of a proline-based organocatalyst for the synthesis of arylidene benzofuranone intermediates, a critical step that facilitates the subsequent construction of aurone-derived azadienes. In this work, we successfully reported the synthesis of arylidene benzofuranone intermediates through Aldol condensation of benzofuranone with different aldehydes enabled by proline-derived organic catalysts. To achieve this strategy, six examples of amine organocatalysts (A1-A6) were evaluated to showcase the optimal catalyst for this transformation. Moreover, the arylidene benzofuranone intermediates were further employed for the synthesis of interesting aurone-derived azadiene substrates through its reaction with TsNH2. Notably, the using of organocatalyst A6 resulted in the delivery of the product with the best yield (94% isolated yield). Under the optimized conditions, different aromatic and heterocyclic containing aldehydes were effectively tolerated to generate the corresponding arylidene benzofuranone intermediates, which further converted to the azadiene products in high to excellent yield. The claimed structures were confirmed by the spectral analysis.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142214518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Comparison of Microwave-assisted Synthesis and Steglich Thioesterification for the Modification of Nanotubes 比较微波辅助合成法和 Steglich 硫代酯化法对纳米管的改性作用

IF 2.6 3区化学

Current Organic Chemistry Pub Date : 2024-08-15 DOI: 10.2174/0113852728319332240806053131

Mehmet Aslan, Ümit Çalışır, Baki Çiçek

{"title":"Comparison of Microwave-assisted Synthesis and Steglich Thioesterification for the Modification of Nanotubes","authors":"Mehmet Aslan, Ümit Çalışır, Baki Çiçek","doi":"10.2174/0113852728319332240806053131","DOIUrl":"https://doi.org/10.2174/0113852728319332240806053131","url":null,"abstract":"Organo-modified carbon nanotubes have recently gained the interest of many research groups. The potential for applying a new generation of organo-modified carbon nanotubes in many technological fields reveals the importance of covalent modifications on nanotubes. In this study, using the microwave synthesis method, multi-walled carbon nanotube (MWCNT) thiophenol derivatives were obtained with a thioesterification reaction. For this purpose, MWCNT-COOH was obtained from MWCNT by oxidation, and MWCNTCOCl was synthesized from MWCNT-COOH. The MWCNT-CO-S-(ortho/meta/para-methyl/methoxyphenyl) (MA1-MA6) compounds were synthesized through both microwave synthesis methods starting with MWCNT-COCl and Steglich ester reaction of MWCNT-COOH. Products were characterized using Fourier Transform-Infrared Spectroscopy (FTIR), Nuclear Magnetic Resonance (NMR), Thermogravimetric Analysis (TGA), and Transmission Electron Spectroscopy (TEM) methods. Furthermore, step numbers, reaction times, and temperatures of obtained molecules, MA1–MA6, were compared. Steglich esterification was found to be the most effective technique for creating these compounds. The photoluminescent characteristics of MWCNT, MWCNT-COOH, and MA1-MA6 compounds were examined. The intensity of the photoluminescence (PL) was found to vary with the location of the functional group. It was detected that the MA2 compound had the highest photoluminescence intensity (6.9x102 a.u.), while the MA1 compound had the second-highest photoluminescence intensity (6.9x102 a.u.). MA1 and MA2 were radiated at low wavelengths of 475–490 nm with high PL values. Possible transitions were nàπ* transitions, with high PL values obtained because of the oxygen atom in the methoxy group. It is expected that these materials will find use in imaging devices operating at high temperatures, particularly because structures containing methoxy groups exhibit favourable photoluminescence properties.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142214517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advancements in Glycosylation Reactions: An Access to Privileged C- and S-Glycosides 糖基化反应的最新进展：获得特级 C-和 S-糖苷的途径

IF 2.6 3区化学

Current Organic Chemistry Pub Date : 2024-08-07 DOI: 10.2174/0113852728322447240718054734

Ram Pratap Pandey, Bindu Tiwari, Anand Kumar Pandey, Nazar Hussain

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A New Perspective on the Molecular Targets, Mechanisms of Action, and Clinical Significance of Ursolic Acid’s Multifaceted Anti-Cancer Effects 熊果酸多方面抗癌作用的分子靶点、作用机制和临床意义的新视角

IF 2.6 3区化学

Current Organic Chemistry Pub Date : 2024-08-07 DOI: 10.2174/0113852728320575240719052529

Md. Rezaul Islam, Abdur Rauf, Shopnil Akash, Md Naeem Hossain Fakir, Md. Ibrahim Khalil Al – Imran, Gazi Kaifeara Thufa, Sadiya Islam Trisha, Umme Habiba, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Marcello Iriti

{"title":"A New Perspective on the Molecular Targets, Mechanisms of Action, and Clinical Significance of Ursolic Acid’s Multifaceted Anti-Cancer Effects","authors":"Md. Rezaul Islam, Abdur Rauf, Shopnil Akash, Md Naeem Hossain Fakir, Md. Ibrahim Khalil Al – Imran, Gazi Kaifeara Thufa, Sadiya Islam Trisha, Umme Habiba, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Marcello Iriti","doi":"10.2174/0113852728320575240719052529","DOIUrl":"https://doi.org/10.2174/0113852728320575240719052529","url":null,"abstract":": A pentacyclic triterpenoid produced from medicinal herbs, fruits, and vegetables, Ursolic acid [UA] has pharmacological activity. This review provides a comprehensive overview of the interactions of UA with molecular targets, its various mechanisms of action, and its clinical implications in cancer therapy. Numerous studies have been conducted on the pharmacological effects of UA, and its biological benefits, such as its antiinflammatory, antioxidant, and anti-cancer activities, have been demonstrated. The study showed how signaling pathways, such as PI3K/Akt, MAPK, and NF-κB, work together to control cell death, proliferation, and inflammation. UA effectively treats cancer by interacting with molecular targets in cell signaling pathways, making it a potent treatment option. UA inhibits tumor cell transformation, limits their reproduction ability, and triggers apoptosis. UA has been found to inhibit various pro-inflammatory transcription factors and cell cycle proteins, such as kinases, cytokines, chemokines, adhesion molecules, and inflammatory enzymes. The targets may aid in UA's chemopreventive and therapeutic benefits by preventing cancer initiation, growth, and metastasis. UA inhibits cancer cell proliferation by arresting and triggering apoptosis through the cell cycle. UA is a promising anti-cancer agent with various mechanisms of action. UA can target multiple signaling pathways and influence the tumor microenvironment, suggesting its potential as a complementary therapy in cancer treatment. Further clinical investigations are needed to entirely understand the therapeutic potential of UA and optimize its application in cancer. This review explores the molecular targets of UA and provides insights into its potential anticancer activities.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141944340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Carbohydrate Derived α,β-Unsaturated Enals (Perlin’s Aldehyde) as Chiral Synthon for the Synthesis of Privileged Scaffolds 碳水化合物衍生的 α、β-不饱和烯醛（佩林醛）作为手性合成物合成特级支架

IF 2.6 3区化学

Current Organic Chemistry Pub Date : 2024-07-31 DOI: 10.2174/0113852728320618240711104927

Yogesh Yadav, Rajdeep Tyagi, Ram Sagar

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Synthesis and Characterization of Pyridine-Pyrrole-Modified Carbon Nanotube Derivatives via Ylides 通过酰化物合成吡啶-吡咯修饰碳纳米管衍生物并确定其特性

IF 2.6 3区化学

Current Organic Chemistry Pub Date : 2024-07-30 DOI: 10.2174/0113852728319336240711055314

Ümit Çalışır

{"title":"Synthesis and Characterization of Pyridine-Pyrrole-Modified Carbon Nanotube Derivatives via Ylides","authors":"Ümit Çalışır","doi":"10.2174/0113852728319336240711055314","DOIUrl":"https://doi.org/10.2174/0113852728319336240711055314","url":null,"abstract":": The high dipolarophile structure of MWCNT compounds enables them to be used as a reactive 2π member in 1,3-dipolar cycloaddition reactions. N-substituted glycine ester compounds and employed 1,3- dipolar cycloaddition reactions involving azomethine-ylides for the synthesis of multiwalled carbon nanotube compounds that underwent covalent modification. Initially, N-substituted glycine esters (3a) and N-substituted glycine compounds were synthesized. N-substituted glycine (4a) and substituted aromatic aldehyde derivatives were reacted with the dipolarophilic MWCNTs, which have regioselectivity only on (6,6)-bonds, via azomethine ylide intermediates over a 1,3-dipolar cycloaddition reaction to obtain the target pyridine-pyrrolemodified carbon nanotube derivatives (6a-g). The compounds' structural characterizations were achieved using FTIR, Raman, NMR, TEM, UV-VIS, and TGA methods. The dispersibility of the compounds was evaluated in various solvents. The activity of each compound's antimicrobial properties against Escherichia coli was assessed. Based on the obtained results, it was concluded that the compounds, by the method employed, adsorbed Escherichia coli bacteria and decreased the bacterial concentration in their film form. According to the results, the compounds can be used in bacterial adsorption-based purification systems (the eradication of water and environmental pollutants) based on the results obtained.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141867999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Cesium Carbonate (Cs2CO3) in Organic Synthesis: A Sexennial Update (2018 to Date) 有机合成中的碳酸铯（Cs2CO3）：六年更新一次（2018 年至今）

IF 2.6 3区化学

Current Organic Chemistry Pub Date : 2024-07-30 DOI: 10.2174/0113852728325969240711105055

Ravi Varala, Kamsali Murali Mohan Achari, Mohammed Hussein, Mohammed Mujahid Alam, Seella Ramanaiah

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“Green” Synthesis of Substituted Tetraketones with Prominent Bactericide Effect "绿色 "合成具有显著杀菌效果的取代四酮类化合物

IF 2.6 3区化学

Current Organic Chemistry Pub Date : 2024-07-30 DOI: 10.2174/0113852728310688240711064139

Roosenilson Muniz, Mateus J. Matos, Alex de N. de Oliveira, André L.M. Porto, Alexander Pokutsa, Francisco F. Oliveira, David E. Q. Jimenez, Irlon M. Ferreira

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