"绿色 "合成具有显著杀菌效果的取代四酮类化合物

IF 1.7 3区 化学 Q3 CHEMISTRY, ORGANIC
Roosenilson Muniz, Mateus J. Matos, Alex de N. de Oliveira, André L.M. Porto, Alexander Pokutsa, Francisco F. Oliveira, David E. Q. Jimenez, Irlon M. Ferreira
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引用次数: 0

摘要

:详细阐述了四酮衍生物的有效和 "绿色 "合成。最后的化合物对金黄色葡萄球菌(ATCC-6538P)具有显著的杀菌活性。这种方法的新颖之处在于将 Al(OH)3 催化剂用于芳香醛和 1,3-环二酮在水中的 Knoevenagel-Michael 级联反应。该过程具有化学选择性,并能在良性条件下获得高产率的四酮类化合物。催化剂在四个周期内保持了 80% 的初始活性。所提出的方法可以替代现有的使用均相催化剂和昂贵的异相催化剂合成具有生物活性的四酮类化合物的方法:该反应具有化学选择性,在温和的条件下可获得高产率的四酮类化合物。催化剂的产率一直保持在 80%,直到第三个重复使用周期。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
“Green” Synthesis of Substituted Tetraketones with Prominent Bactericide Effect
: Effective and “green” synthesis of tetraketone derivatives was elaborated. The last compounds developed prominent bactericide activity against both MIC and MBC S. aureus (ATCC-6538P) bacteria. The novelty of this approach is concluded in the application of Al(OH)3 catalyst for the Knoevenagel-Michael cascade reaction of aromatic aldehydes and 1,3-cyclic diketones in water. The process is chemoselective and affords high yield of tetraketones under benign conditions. The catalyst maintained 80% of initial activity within four cycles. The proposed method can be regarded as an alternative to the existing syntheses of biologically active tetraketones that utilize homogeneous and expensive heterogeneous catalysts. result: The reaction is chemoselective and gives high yields of tetraketones under mild conditions. The catalyst maintained 80% yield until the third reuse cycle.
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来源期刊
Current Organic Chemistry
Current Organic Chemistry 化学-有机化学
CiteScore
3.70
自引率
7.70%
发文量
76
审稿时长
1 months
期刊介绍: Current Organic Chemistry aims to provide in-depth/mini reviews on the current progress in various fields related to organic chemistry including bioorganic chemistry, organo-metallic chemistry, asymmetric synthesis, heterocyclic chemistry, natural product chemistry, catalytic and green chemistry, suitable aspects of medicinal chemistry and polymer chemistry, as well as analytical methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by chosen experts who are internationally known for their eminent research contributions. The Journal also accepts high quality research papers focusing on hot topics, highlights and letters besides thematic issues in these fields. Current Organic Chemistry should prove to be of great interest to organic chemists in academia and industry, who wish to keep abreast with recent developments in key fields of organic chemistry.
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