Current Organic Chemistry最新文献_第3页

Recent Advances in N-Arylation of Heterocycles in the Past Decade 过去十年杂环 N-芳基化的最新进展

IF 2.6 3区化学

Current Organic Chemistry Pub Date : 2024-07-25 DOI: 10.2174/0113852728320325240710053300

Xun Yang, Haiyan Li, Quan Jiang, Zhiguo Lei, Yuxuan Xiao, Jialing Liu, Wengui Duan, Lin Yu

{"title":"Recent Advances in N-Arylation of Heterocycles in the Past Decade","authors":"Xun Yang, Haiyan Li, Quan Jiang, Zhiguo Lei, Yuxuan Xiao, Jialing Liu, Wengui Duan, Lin Yu","doi":"10.2174/0113852728320325240710053300","DOIUrl":"https://doi.org/10.2174/0113852728320325240710053300","url":null,"abstract":"N-arylated heterocycles are a significant class of core scaffolds in medicinal chemistry, materials science, and agrochemistry, highlighting their importance in various fields. The development of innovative methodologies for synthesizing these fundamental structures has been a central focus in organic synthesis. Over the past few decades, numerous approaches have been established to synthesize N-aryl heterocycles efficiently. Among these methods, the direct N-arylation of N-H heterocycles stands out as one of the most straightforward and robust strategies for accessing N-arylated heterocycles. This review provides a comprehensive review of the recent advances in the synthesis of N-arylated heterocycles, encompassing the relevant literature from the past decade. The review summarizes the N-arylation of N-H heterocycles using various catalytic systems, including palladium, nickel, copper, visible light-induced metal-catalyzed, and metal-free catalyzed methodologies. These advances highlighted the continuous evolution and optimization of synthetic strategies to create diverse and complex N-arylated heterocycles, which are pivotal for furthering research and development in multiple scientific domains.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141775621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Status and Applications of Gamma Radiation-induced Graft Copolymerized Chitosan 伽马辐射诱导接枝共聚壳聚糖的现状与应用

IF 2.6 3区化学

Current Organic Chemistry Pub Date : 2024-07-23 DOI: 10.2174/0113852728317918240710112955

Maykel González Torres

引用次数: 0

Design, Synthesis, Cytotoxicity Profiling, Molecular Docking and ADMET Studies of Novel Functionalized Coumarin-Pyrazole-Thiazole Hybrids: Cyclization of Chromonyl Thiazolyl Pyrazolyl Thiosemicarbazone with α-Halocarbonyl Reagents 新型功能化香豆素-吡唑-噻唑杂化物的设计、合成、细胞毒性分析、分子对接和 ADMET 研究：铬酰基噻唑基吡唑基硫代氨基甲酸唑酮与α-卤代羰基试剂的环化反应

IF 2.6 3区化学

Current Organic Chemistry Pub Date : 2024-07-22 DOI: 10.2174/0113852728316450240702075812

Tarik E. Ali, Ayat K. Alsolimani, Mohammed A. Assiri, Ali A. Shati, Mohammad Y. Alfaifi, Serag E. I. Elbehairi

{"title":"Design, Synthesis, Cytotoxicity Profiling, Molecular Docking and ADMET Studies of Novel Functionalized Coumarin-Pyrazole-Thiazole Hybrids: Cyclization of Chromonyl Thiazolyl Pyrazolyl Thiosemicarbazone with α-Halocarbonyl Reagents","authors":"Tarik E. Ali, Ayat K. Alsolimani, Mohammed A. Assiri, Ali A. Shati, Mohammad Y. Alfaifi, Serag E. I. Elbehairi","doi":"10.2174/0113852728316450240702075812","DOIUrl":"https://doi.org/10.2174/0113852728316450240702075812","url":null,"abstract":": A simple synthetic method was performed to design a novel series of polycyclic systems consisting of a coumarin-pyrazole-thiazole skeleton linked with a completed thiazole ring via hydrazone linkage. The methodology depended on the cyclization of the active precursor 2-[(3-(2-oxo-2H-chromen-3-yl)-1-(4- phenylthiazol-2-yl)-1H-pyrazol-4-yl)methy-lene]hydrazine-1-carbothioamide (2) by its reaction with a series of α-halocarbonyl reagents under Hantzsch reaction conditions. The spectral and analytical data confirmed the structures of all the synthesized compounds. The target compounds were screened for their in vitro anticancer activity. The cytotoxic effects of obtained compound were screened against cancer cell lines (MCF-7, HepG2, and HCT116) using the standard SRB method. Furthermore, products 4, 5, and 7b were the most active against all cancer cell lines, compared with Doxorubicin. These bioactive products effectively suppress the growth of cancer cells by activating the cell death program through late apoptosis. In addition, products 4 and 5 arrested the cell cycle at the S and G2 phases, while product 7b has the ability to arrest the cell cycle at the G2 phase against all three cancer cells. The molecular docking of the products 4, 5, and 7b showed good binding affinities with Cyclin-dependent kinase 8 (CDK-8), while the ADMET prediction supported that these bioactive products can be promising anticancer agents.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141754130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Heteroaromatization of Coumarin Part III: One-Pot Synthesis, Antitumor Activity, DFT Studies, and Molecular Docking of Coumarin Derivatives 香豆素的异芳香化第三部分：香豆素衍生物的单锅合成、抗肿瘤活性、DFT 研究和分子对接

IF 2.6 3区化学

Current Organic Chemistry Pub Date : 2024-07-22 DOI: 10.2174/0113852728320798240711052115

Abdullah A. Alamri, Rita M. A. Borik, Ashraf H. F. Abd El-Wahab, Al-Anood M. Al-Dies, Hany M. Mohamed, Diaa A. Ibrahim

引用次数: 0

Recent Insights into the Synthesis of Oligosaccharides from Escherichia coli: Review 大肠杆菌合成低聚糖的最新见解：综述

IF 2.6 3区化学

Current Organic Chemistry Pub Date : 2024-07-22 DOI: 10.2174/0113852728322510240711045944

Anjali Sharma, Padmashri Rabha, Rajib Panchadhayee

引用次数: 0

Synthetic Development in Inulin Modification and its Applications 菊粉改性及其应用的合成发展

IF 2.6 3区化学

Current Organic Chemistry Pub Date : 2024-07-12 DOI: 10.2174/0113852728318805240627112106

Mahendra Singh, Himanshu Rani, Harish Kumar Chopra

{"title":"Synthetic Development in Inulin Modification and its Applications","authors":"Mahendra Singh, Himanshu Rani, Harish Kumar Chopra","doi":"10.2174/0113852728318805240627112106","DOIUrl":"https://doi.org/10.2174/0113852728318805240627112106","url":null,"abstract":"Inulin is a naturally occurring polydisperse and flexible polysaccharide. It is a non-toxic, biocompatible, water-soluble, biodegradable, and affordable polymer. Furthermore, because of its unique properties, inulin has piqued the interest of many researchers. Studies have revealed that inulin demonstrates a broad range of biological activities such as antioxidant, antifungal, antibacterial, anticancer, antidiabetic, and immunological modulating properties in the pharmaceutical industry. Inulin has been demonstrated to function as a sweetener, fat replacer, water-holding agent, thickener, texture modifier, and browning agent in dairy and bakery food items. Inulin has produced EMF, a biofuel that is one of the most desirable gasoline substitutes. Today, inulin is widely used in the chemical, food, and pharmaceutical industries. Chemical modification of inulin is an important methodology for expanding its applications in a variety of fields. This article discusses the numerous synthesis methods used to modify the inulin structure, including conventional and non-conventional methods such as microwave and ultrasonication, as well as the diverse applications of inulin and its derivatives in several industries. This review article seeks to explore the current state of research on synthetic modifications of inulin and its wide array of applications.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141612238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microwave-assisted Synthesis of Pyrroles, Pyridines, Chromenes, Coumarins, andBetti Bases via Alcohol Dehydrogenation with Chroman-4-one Amino Ligands 通过酒精脱氢与色满-4-酮氨基配体微波辅助合成吡咯、吡啶、色满、香豆素和贝蒂碱

IF 1.7 3区化学

Current Organic Chemistry Pub Date : 2024-07-11 DOI: 10.2174/0113852728304957240628180342

Danish Khan, Beauty kumari, Abdullah Yahya Abdullah Alzahrani, Neha Dua, Shaily, Nirma Maurya

{"title":"Microwave-assisted Synthesis of Pyrroles, Pyridines, Chromenes, Coumarins, and\u0000Betti Bases via Alcohol Dehydrogenation with Chroman-4-one Amino Ligands","authors":"Danish Khan, Beauty kumari, Abdullah Yahya Abdullah Alzahrani, Neha Dua, Shaily, Nirma Maurya","doi":"10.2174/0113852728304957240628180342","DOIUrl":"https://doi.org/10.2174/0113852728304957240628180342","url":null,"abstract":"\u0000\u0000This study outlines the development of a novel approach utilizing microwave assistance for the alcohol dehydrogenative reaction. The process is catalyzed by manganese (II) and cobalt (II) in conjunction with\u0000chroman-4-one amino ligands. This research introduces a unique catalytic system capable of synthesizing various heterocyclic compounds, including pyrroles, pyridines, Betti bases, chromenes, and coumarins via alcohol\u0000dehydrogenation. The synthesis involved the preparation and characterization of a series of chroman-4-one\u0000amino ligands (C1-C6) using standard analytical techniques. These ligands, in combination with MnCl2‧4H2O\u0000and CoCl2, demonstrated remarkable catalytic activity, effectively driving alcohol dehydrogenation. The catalytic cycle was initiated by the in-situ formation of metal complexes with the ligands during the reaction. Characterization using ESI-MS confirmed the presence of metal complexes (Int-1) and other intermediates (Int-II\u0000and Int-III) throughout the catalytic cycle. Additionally, the controlled experiment corroborated the efficacy of\u0000the catalytic system, evidenced by the evolution of H2 gas.\u0000","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141655768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and Biological Evaluation of 1,2,3-Triazole Appended Benzothiazinone Derivatives via Click Chemistry 通过点击化学合成 1,2,3-三唑附属苯并噻嗪酮衍生物并进行生物学评估

IF 2.6 3区化学

Current Organic Chemistry Pub Date : 2024-07-10 DOI: 10.2174/0113852728316869240626060258

Satish V. Akolkar, Mubarak H. Shaikh, Amol A. Nagargoje, Jaiprakash N. Sangshetti, Manoj G. Damale, Bapurao B. Shingate

{"title":"Synthesis and Biological Evaluation of 1,2,3-Triazole Appended Benzothiazinone Derivatives via Click Chemistry","authors":"Satish V. Akolkar, Mubarak H. Shaikh, Amol A. Nagargoje, Jaiprakash N. Sangshetti, Manoj G. Damale, Bapurao B. Shingate","doi":"10.2174/0113852728316869240626060258","DOIUrl":"https://doi.org/10.2174/0113852728316869240626060258","url":null,"abstract":": We have created novel 1,2,3-triazole-based benzothiazinone derivatives in the current work. The produced compounds' in vitro antioxidant, antifungal, and antitubercular properties were assessed. Moreover, a simulated molecular docking analysis was conducted on the cytochrome P450 lanosterol 14α-demethylase active site to elucidate the enzyme's binding affinity and interactions with synthesised benzothiazinone derivatives. A notable correlation between these compounds' antifungal activity and binding score was indicated by molecular docking data. The synthetic 1,2,3-triazole-based benzothiazinone derivatives may satisfy the structural criteria for creating novel antifungal drugs, according to the results of the in vitro and in silico investigations. result: The synthesized derivatives were evaluated for in vitro antifungal, Antitubercular and antioxidant activity. Furthermore, an in silico molecular docking study was performed against the active site of cytochrome P450 lanosterol 14α-demethylase to explicate the binding affinity and binding interactions of enzyme and synthesized benzothiazinone derivatives. Molecular docking data suggested a significant relationship between the binding score and antifungal activity for these molecules. The findings of the in vitro and in silico studies indicate that the synthesized 1,2,3-triazole-based benzothiazinone derivatives may meet the structural requirements for developing new antifungal agents.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141587912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modified Microwave-assisted Solid-liquid Halex Reaction using Phosphonium Salt as Efficient and Robust Phase Transfer Catalyst 利用鏻盐作为高效稳健的相转移催化剂进行改良微波辅助固液哈莱克斯反应

IF 2.6 3区化学

Current Organic Chemistry Pub Date : 2024-07-10 DOI: 10.2174/0113852728311593240626091836

Dhanaji M. Mohite, Pandurang M. Chavhan, Arghya Basu

引用次数: 0

Unraveling of Potential Targets for Andrographolide, Neoandrographolide and 5-hydroxy, 7-methoxy Flavone in the Treatment of Rheumatoid Arthritis using Network Pharmacology and Molecular docking 利用网络药理学和分子对接揭示穿心莲内酯、新穿心莲内酯和 5-羟基 7-甲氧基黄酮治疗类风湿关节炎的潜在靶点

IF 2.6 3区化学

Current Organic Chemistry Pub Date : 2024-07-04 DOI: 10.2174/0113852728301440240620093751

Neha Rana, Parul Grover, Hridayanand Singh, Sameer Rastogi, Pooja A. Chawla

{"title":"Unraveling of Potential Targets for Andrographolide, Neoandrographolide and 5-hydroxy, 7-methoxy Flavone in the Treatment of Rheumatoid Arthritis using Network Pharmacology and Molecular docking","authors":"Neha Rana, Parul Grover, Hridayanand Singh, Sameer Rastogi, Pooja A. Chawla","doi":"10.2174/0113852728301440240620093751","DOIUrl":"https://doi.org/10.2174/0113852728301440240620093751","url":null,"abstract":": Joint degeneration is a possible outcome of rheumatoid arthritis, an inflammatory disorder that is chronic, systemic, and progressive. Andrographis paniculata is known to contain many phytoconstituents that have demonstrated therapeutic effects in terms of inflammation. However, the therapeutic actions of Andrographis paniculata are still not fully understood. The present study aims to better understand rheumatoid arthritis and its possible treatments through the identification of relevant targets and mechanisms. A total of 47 common targets were identified for andrographolide, while 38 common targets were found for neoandrographolide. Additionally, 53 common targets were discovered for 5-hydroxy-7-methoxy flavone. Furthermore, a screening process was carried out to identify 9 primary hubb targets for andrographolide, neoandrographolide, and 5-hydroxy-7-methoxy flavone. Twenty useful gene ontology (GO) terms and twenty important Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathways were found through the study of gene ontology and pathways. Molecular-docking analysis revealed that andrographolide had the highest binding efficacy (- 7.8) towards the Serine/threonine-protein kinase 2 (PIM2) target. On the other hand, neoandrographolide displayed the highest binding efficacy towards mitogen-activated protein kinase (MAPK1) and Interlukine-6 (IL6), with docking scores of (-9.0) and (-7.2), respectively. Furthermore, 5-hydroxy-7-methoxy flavone showed the highest docking score (-6.6) with Arachidonate 12-lipoxygenase (ALOX-12). The identification of numerous targets linked with various pathways in the treatment of Rheumatoid arthritis proves to be a helpful resource for future investigation into the mechanism and clinical applications of AP, NP, and 5H-flavone.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141547094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0