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Recent Advances in Self-healing Polymer Materials: Routes and Strategies 自愈合聚合物材料的最新进展：途径与策略
IF 2.6 3区 化学
Current Organic Chemistry Pub Date : 2024-02-22 DOI: 10.2174/0113852728277993240126114403
Zhonglin Cao, Jinbao Xu
{"title":"Recent Advances in Self-healing Polymer Materials: Routes and Strategies","authors":"Zhonglin Cao, Jinbao Xu","doi":"10.2174/0113852728277993240126114403","DOIUrl":"https://doi.org/10.2174/0113852728277993240126114403","url":null,"abstract":":: The most intriguing area of scientific study and engineering applications is to synthetize materials that can autonomously heal damage similar to biological tissues. Since the concept of self-healing materials was established, several variations of self-healing polymer materials have been developed based on distinct healing techniques. This review outlines the most recent breakthroughs in self-healing polymers and utilizes the opportunity to categories the descriptions of self-healing technologies in the literatures according to extrinsic and intrinsic routes (noncovalent bonds, physical interaction, and covalent bonds). The major focus is on the routes and strategies used to generate self-healing polymer materials. In addition, the strengths and weaknesses of polymer materials with different self-healing routes and strategies in terms of mechanical and self-healing properties were summarized. Furthermore, we also reviewed the progress of the development from a single selfhealing mechanism to multiple self-healing mechanisms to achieve balanced comprehensive performance. Finally, the future trajectory of self-healing polymers is envisioned.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":"5 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139951397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nano-biocomposites: A Versatile Combination of Nanocomposites and Biopolymers for the Synthesis of Heterocycles via Multicomponent Reactions 纳米生物复合材料：纳米复合材料与生物聚合物的多功能组合：通过多组分反应合成杂环化合物
IF 2.6 3区 化学
Current Organic Chemistry Pub Date : 2024-02-02 DOI: 10.2174/0113852728268779240102101311
Archana Rajmane, Arjun Kumbhar
{"title":"Nano-biocomposites: A Versatile Combination of Nanocomposites and Biopolymers for the Synthesis of Heterocycles via Multicomponent Reactions","authors":"Archana Rajmane, Arjun Kumbhar","doi":"10.2174/0113852728268779240102101311","DOIUrl":"https://doi.org/10.2174/0113852728268779240102101311","url":null,"abstract":": Organic natural materials like chitosan, cellulose, starch, agarose, and alginate possess unique structures that are useful in creating advanced nanostructured materials. These materials are highly sought after in catalysis because of their numerous functional groups and catalytic properties. They can also be combined with inorganic materials to create \"nano-Biocomposites\" with specialized properties that can be utilized as catalysts in multi-component reactions. This review provides an overview of the use of nano-Biocomposites in multicomponent reactions (MCRs).","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":"38 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139668124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Green Methodologies for Tetrazole Synthesis from Different Starting Materials: A Recent Update 从不同起始材料合成四氮唑的绿色方法：最新进展
IF 2.6 3区 化学
Current Organic Chemistry Pub Date : 2024-02-02 DOI: 10.2174/0113852728283721240109092312
Shivangi Jaiswal, Jaya Dwivedi, Dharma Kishore, Swapnil Sharma
{"title":"Green Methodologies for Tetrazole Synthesis from Different Starting Materials: A Recent Update","authors":"Shivangi Jaiswal, Jaya Dwivedi, Dharma Kishore, Swapnil Sharma","doi":"10.2174/0113852728283721240109092312","DOIUrl":"https://doi.org/10.2174/0113852728283721240109092312","url":null,"abstract":": Tetrazole is a most versatile pharmacophore of which more than twenty FDA-approved drugs have been marketed globally for the management of various diseases. In spite of many remarkable and consistent efforts having been made by the chemists towards the development of greener and sustainable strategies for the synthesis of tetrazole derivatives, this approach still needs more attention. The present review focuses on the green synthetic approach for the preparation of tetrazole derivatives from different starting materials such as nitrile, isonitrile, carbonyl, amine, amide, oxime and terminal alkyne functions. The mechanism of tetrazole synthesis from different substrates is discussed. In addition to this, a four component Ugi-azide reaction to the tetrazole synthesis is also described. Of note, the present articles exploited several water-mediated and solventfree methodologies for tetrazole synthesis. The important key features of tetrazole synthesis were pinpointing in each synthetic scheme which provides excellent guide to those searching for selective procedure to achieve the desired transformation. This review seeks to present a timely account (2011-2023) on the splendid array of ecofriendly procedures of synthesis known today for the preparation of tetrazole derivatives from different starting materials. The rational of this review is to enlighten recent advancements in the synthesis of tetrazole derivatives from different substrates.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":"3 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139668130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Advances in Synthetic Routes for Biologically Active Tetrahydroquinoxalines and Derivatives: A Comprehensive Review 生物活性四氢喹喔啉及其衍生物合成路线的最新进展：全面综述
IF 2.6 3区 化学
Current Organic Chemistry Pub Date : 2024-02-02 DOI: 10.2174/0113852728285439240109071659
Ashis Kumar Sahoo, Aditya Bhattacharyya
{"title":"Recent Advances in Synthetic Routes for Biologically Active Tetrahydroquinoxalines and Derivatives: A Comprehensive Review","authors":"Ashis Kumar Sahoo, Aditya Bhattacharyya","doi":"10.2174/0113852728285439240109071659","DOIUrl":"https://doi.org/10.2174/0113852728285439240109071659","url":null,"abstract":": Tetrahydroquinoxalines are found in many biologically and pharmacologically active small molecules. In the past two decades, significant progress has been made in the development of novel synthetic routes for the preparation of biologically active tetrahydroquinoxalines and their derivatives. This synthetic review aims to provide a comprehensive overview of the advancements in the field of various synthetic strategies and methodologies employed for the synthesis of tetrahydroquinoxaline scaffolds during this period. The review emphasizes the diverse synthetic approaches employed, including cycloaddition reactions, condensation reactions, intramolecular cyclization reactions, ring expansion reactions, hydrogenation reactions, and other miscellaneous methods.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":"62 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139668230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, Characterization, Molecular Docking Studies and Biological Evaluation of Some Novel 3,5-disubstituted-1-phenyl-4,5-dihydro-1H-pyrazole Derivatives 一些新型 3,5-二取代-1-苯基-4,5-二氢-1H-吡唑衍生物的合成、表征、分子对接研究和生物学评价
IF 2.6 3区 化学
Current Organic Chemistry Pub Date : 2024-01-29 DOI: 10.2174/0113852728287379231229102847
Fatih Tok, İlayda Rumeysa Bayrak, Elif Karakaraman, İrem Soysal, Cansel Çakır, Kübra Tuna, Serap Yılmaz Özgüven, Yusuf Sıcak, Mehmet Öztürk, Bedia Koçyiğit-Kaymakçıoğlu
{"title":"Synthesis, Characterization, Molecular Docking Studies and Biological Evaluation of Some Novel 3,5-disubstituted-1-phenyl-4,5-dihydro-1H-pyrazole Derivatives","authors":"Fatih Tok, İlayda Rumeysa Bayrak, Elif Karakaraman, İrem Soysal, Cansel Çakır, Kübra Tuna, Serap Yılmaz Özgüven, Yusuf Sıcak, Mehmet Öztürk, Bedia Koçyiğit-Kaymakçıoğlu","doi":"10.2174/0113852728287379231229102847","DOIUrl":"https://doi.org/10.2174/0113852728287379231229102847","url":null,"abstract":": In this study, some new pyrazoline derivatives bearing cyano or nitro groups were synthesized. The structures of the compounds were characterized by IR, 1H-NMR, 13C-NMR and elemental analysis data. The ABTS·+, DPPH·, CUPRAC and β-Carotene/linoleic acid assays were carried out to determine the antioxidant activity of the synthesized pyrazolines. Compound P14 showed higher antioxidant activity than the standard substance BHA with IC50 values of 1.71±0.31 μM and 0.29±0.04 μM in ABTS+ and β-carotene/linoleic acid assays, respectively. Compound P12 also exhibited higher antioxidant activities than BHA with an IC50 value of 0.36±0.14 μM in β-carotene/linoleic acid analysis. In activity studies of pyrazolines against cholinesterase (AChE and BChE), tyrosinase, α-amylase and α- glucosidase, compound P1 (IC50 = 39.51±3.80 μM) showed higher activity against α-amylase and compounds P5 and P12 displayed higher activity against α-glucosidase than acarbose with IC50 values of 14.09±0.62 and 83.26±2.57 μM, respectively. The drug-like properties such as Lipinski and Veber, bioavailability and toxicity risks of the synthesized compounds were also evaluated. The compounds were predicted to be compatible with Lipinski and Veber rules, have high bioavailability and low toxicity profiles. Moreover, molecular docking studies were performed to better understand the high activity of the compounds against a-amylase and a-glucosidase enzymes.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":"146 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139589114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organic Synthesis via Renewable Heterogeneous Nanocatalysts Based on Montmorillonite Clay 通过基于蒙脱石粘土的可再生异质纳米催化剂进行有机合成
IF 2.6 3区 化学
Current Organic Chemistry Pub Date : 2024-01-29 DOI: 10.2174/0113852728294884240105073842
Mustafa M.H. Al-Abayechi, Abbas Al-Nayili, Asim A. Balakit, Gamal A. El-Hiti
{"title":"Organic Synthesis via Renewable Heterogeneous Nanocatalysts Based on Montmorillonite Clay","authors":"Mustafa M.H. Al-Abayechi, Abbas Al-Nayili, Asim A. Balakit, Gamal A. El-Hiti","doi":"10.2174/0113852728294884240105073842","DOIUrl":"https://doi.org/10.2174/0113852728294884240105073842","url":null,"abstract":": Synthetic organic molecules are vital for human life, serving as medications, pesticides, dyes, and food additives. Organic synthesis provides routes for the production of these molecules. The traditional methods of organic synthesis require energy, solvents, time, and certain conditions based on the nature of the reactions. To address the issues associated with conventional processes, various environmentally friendly (green) methodologies have been developed. Catalysts are crucial in many chemical methods. Chemists aim to develop catalysts that are cost-effective, easy to recover, and can be synthesized with high catalytic activity and renewability. Natural montmorillonite clay is an ideal material for efficient catalysts since it satisfies all these requirements. This review focuses on the recent advances in the development of renewable nanocatalysts made from montmorillonite to be used for the synthesis of various organic compounds.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":"25 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139589297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two-step Continuous-Flow Synthesis of 1,2-dimethyl-3-methylsulfanylbenzene via Diazotization and Methanethiolation 通过重氮化和甲硫醇化两步连续流合成 1,2-二甲基-3-甲硫基苯
IF 2.6 3区 化学
Current Organic Chemistry Pub Date : 2024-01-29 DOI: 10.2174/0113852728277310240103111746
lixia Li, Qi Zhang, Ce Bian, Wei Wei, Wenxuan Sun, Lu Ji, Hande Wang, Chuan Zhou, Ke Wang, Dangsheng Gong, Dongmao Yan
{"title":"Two-step Continuous-Flow Synthesis of 1,2-dimethyl-3-methylsulfanylbenzene via Diazotization and Methanethiolation","authors":"lixia Li, Qi Zhang, Ce Bian, Wei Wei, Wenxuan Sun, Lu Ji, Hande Wang, Chuan Zhou, Ke Wang, Dangsheng Gong, Dongmao Yan","doi":"10.2174/0113852728277310240103111746","DOIUrl":"https://doi.org/10.2174/0113852728277310240103111746","url":null,"abstract":": 1,2-Dimethyl-3-methylsulfanylbenzene is the key intermediate of topramezone. This work designed a two-step continuous-flow device to synthesize 1,2-dimethyl-3-methylsulfanylbenzene via diazotization and methanethiolation. The results showed that compared with the batch process, the continuous-flow method greatly shortened the residence time to 1 minute, avoided the accumulation of large amounts of diazonium salts to reduce decomposition and increased the product yield to 91.7%. At the same time, the continuous-flow process improved the safety and efficiency of the reactions, saved reaction time and had good prospects for industrial application.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":"20 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139589291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Part 2, Studies on the Synthesis of Quinolone Derivatives with their Biological Activity 第 2 部分，具有生物活性的喹诺酮衍生物的合成研究
IF 2.6 3区 化学
Current Organic Chemistry Pub Date : 2024-01-29 DOI: 10.2174/0113852728271272231124042138
Nishtha Saxena, Swapnil Shankhdhar, Anil Kumar, Nivedita Srivastava
{"title":"Part 2, Studies on the Synthesis of Quinolone Derivatives with their Biological Activity","authors":"Nishtha Saxena, Swapnil Shankhdhar, Anil Kumar, Nivedita Srivastava","doi":"10.2174/0113852728271272231124042138","DOIUrl":"https://doi.org/10.2174/0113852728271272231124042138","url":null,"abstract":": Quinolones are among the class of antibiotics that are used most frequently worldwide and are used for treating a variety of bacterial diseases in humans. Recent research has shown that new, improved analogues of quinolones are being used as anticancer, antifungal, antiviral and other antimicrobial agents. In an earlier review (Part 1) [8], we discussed the synthesis and antibacterial activity of quinolones in detail. This review focuses on the detailed study of newly synthesized quinolone compounds and their biological activity in different dimensions.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":"8 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139589290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovations in Treating Sporotrichosis: Drug Repurposing and Lead Compound Synthesis 治疗孢子丝菌病的创新：药物再利用和先导化合物合成
IF 2.6 3区 化学
Current Organic Chemistry Pub Date : 2024-01-29 DOI: 10.2174/0113852728283383240111055602
Alcione S. de Carvalho, Gabriel R.M. de Freitas, Caroline D. Nicoletti, Fernando de C. da Silva, Débora O. Futuro, Vitor F. Ferreira, Patricia G. Ferreira
{"title":"Innovations in Treating Sporotrichosis: Drug Repurposing and Lead Compound Synthesis","authors":"Alcione S. de Carvalho, Gabriel R.M. de Freitas, Caroline D. Nicoletti, Fernando de C. da Silva, Débora O. Futuro, Vitor F. Ferreira, Patricia G. Ferreira","doi":"10.2174/0113852728283383240111055602","DOIUrl":"https://doi.org/10.2174/0113852728283383240111055602","url":null,"abstract":": Sporotrichosis, recognized by the World Health Organization (WHO) as a neglected tropical disease and classified among significant fungal health concerns, remains both underestimated and underreported. There is a profound impact of sporotrichosis on public health, affecting both humans and domestic animals. The causative agents are fungi within the Sporothrix genus, primarily transmitted through traumatic exposure to contaminated soil, plants, decomposing materials, or through scratches from infected animals, notably cats. While sporotrichosis is a global concern, its prevalence is particularly noteworthy in tropical and subtropical regions. The limited treatment options for sporotrichosis, with itraconazole as the preferred choice, underscore the challenges posed by fungal infections. Issues such as toxicity and drug resistance further complicate effective management. Consequently, this review aims to elucidate key objectives: identification of novel synthetic compounds revealed in the literature, highlighting ongoing efforts to develop new treatments against sporotrichosis, examining promising anti-sporothrix natural products, and providing an overview of endeavors to repurpose approved drugs. The key findings from the study underscore the urgent need for diversified and effective drugs for the treatment of Sporotrichosis.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":"693 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139589299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Progress in the Synthetic Methods of Pyrazoloquinoline Derivatives (Part I) 吡唑喹啉衍生物合成方法的最新进展（第一部分）
IF 2.6 3区 化学
Current Organic Chemistry Pub Date : 2024-01-24 DOI: 10.2174/0113852728285959240108060645
Rita M. Borik, Mohamed S. Mostafa, Mohamed S. Behalo, Rizk E. khidre
{"title":"Recent Progress in the Synthetic Methods of Pyrazoloquinoline Derivatives (Part I)","authors":"Rita M. Borik, Mohamed S. Mostafa, Mohamed S. Behalo, Rizk E. khidre","doi":"10.2174/0113852728285959240108060645","DOIUrl":"https://doi.org/10.2174/0113852728285959240108060645","url":null,"abstract":"The focus of this review is on the synthetic routes available for different types of pyrazoloquinoline derivatives. There are three types of synthetic methods: i) from pyrazole derivatives; ii) from quinoline derivatives; and iii) miscellaneous methods. The position of the linkage between pyrazole and quinoline rings determines the seven isomers of pyrazoloquinolines. The purpose of this review is to provide a guide for both synthetic and medicinal chemists to discover and design new pyrazoloquinolines for medical purposes.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":"4 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139559797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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