{"title":"Synthesis of Aromatic Azides using Different Methodologies","authors":"Elisa Leyva, Silvia E. Loredo-Carrillo","doi":"10.2174/0113852728301737240307111549","DOIUrl":"https://doi.org/10.2174/0113852728301737240307111549","url":null,"abstract":":: For several decades, aromatic azides have been applied in diverse areas of research like synthesis of organic compounds, novel materials and photoaffinity labeling of biomolecules. The discovery of click chemistry and bioorthogonal chemistry expanded their applications. Currently, they are extensively used in biology, biochemistry and medicine. For many years, aromatic azides were usually prepared using nucleophilic substitution. In this classical procedure, commercially available anilines are first converted into aryl diazonium salts which in turn are transformed into aromatic azides by nucleophilic substitution with sodium azide. However, this procedure is rather inconvenient experimentally since it requires the use of strong acids and low temperatures. In recent years, several alternative procedures have been developed. In the present review, we present the synthesis of aromatic azides by means of different experimental methodologies.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140581028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashlesha P. Kawale, Nishant Shekhar, Arti Srivastava, Subhash Banerjee
{"title":"A Review on the Development of Polymer Supported Heterogeneous Palladium Materials for Organic Synthesis and Electrochemical Applications","authors":"Ashlesha P. Kawale, Nishant Shekhar, Arti Srivastava, Subhash Banerjee","doi":"10.2174/0113852728299173240302041524","DOIUrl":"https://doi.org/10.2174/0113852728299173240302041524","url":null,"abstract":":: This comprehensive review explores the advancements in catalytic transformation, focusing on the use of heterogeneous catalytic systems with a particular emphasis on polymeric-supported palladium (Pd) complexes. This study explores the limitations associated with conventional homogeneous reagents, emphasizes the transition to eco-friendly catalytic systems, and emphasizes the importance of Pd nanoparticles. These nanoparticles are particularly noteworthy for their distinctive properties, including elevated catalytic activity, making them promising for various applications in organic synthesis. The review thoroughly examines the design and synthesis of heterogeneous catalysts, emphasizing the crucial selection of safe and recyclable supports to augment the longevity and reusability of metallic catalysts. Diverse polymer varieties, including polystyrene (PS), polyethylene (PE), polyacrylate derivatives, polyethylene glycol (PEG), and grafted polymers, are investigated as viable supports for Pd complexes. The authors intricately describe the synthesis techniques for these polymer-supported Pd catalysts and furnish illustrative examples showcasing their effectiveness in organic transformation. This comprehensive review additionally highlights the synthesis of polymer-supported palladium (Pd) materials and discusses their applications in electrochemistry. The focus extends to the electrocatalytic properties of Pdbased polymeric nanomaterials, showcasing their effectiveness in glucose sensing, hydrogen peroxide detection, and the sensing of other biological analytes. Furthermore, the catalytic capabilities of Pd nanoparticles in various electrochemical applications, including wastewater treatment and electrochemical capacitors, are explored. Integrating polymer-supported Pd materials into these electrochemical processes underscores their versatility and potential contributions to advancements in catalysis and electrochemical sensing. Catalytic applications featuring polymer-supported palladium complexes with polymeric ligands in organic synthesis processes use the Sonogashira reaction, Suzuki-Miyaura coupling, Heck reaction, Catalytic asymmetric transformations, etc. The subsequent section of the paper focuses on the creation of polymeric palladium complexes, achieved by the complexation of polymeric ligands with palladium precursors. It delves into noteworthy examples of catalytic processes employing polymer-supported palladium complexes featuring polymeric ligands, emphasizing distinct polymers, such as PS, PE, polyacrylate derivatives, PEG, and grafting polymers. The review concludes by exploring catalytic asymmetric transformations using chiral palladium complexes immobilized on polymer supports and discusses various chiral ligands and their immobilization on polymer supports, emphasizing their application in asymmetric allylic alkylation. The review furnishes a comprehensive summary of recent advancements, challenges, and prospective avenues in","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140581244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis, Characterization, Antimicrobial Activity, and Molecular Docking Study of Newer Chalcone-based Triazolo Pyrimidine Compounds","authors":"Monik Gohil, Siva Prasad Das, Jeena Jyoti Boruah","doi":"10.2174/0113852728298472240305110906","DOIUrl":"https://doi.org/10.2174/0113852728298472240305110906","url":null,"abstract":":: In this work, we present the synthesis of a newer series of 15 chalcone-based pyrimidine compounds 4a-o. All the compounds were characterized by elemental analysis, melting point determination, mass, FTIR, and NMR analysis. We have evaluated the antimicrobial activity of these compounds. The compounds showed good inhibition activity towards different bacterial and fungal species such as S. aureus, S. pneumonia, E. coli, P. aeruginosa, Candida albicans, Aspergillus niger, and Alternaria alternata. Compounds 4c, 4h, 4k, and 4g showed comparable activities to those of commercially available drugs. Molecular docking study showed good interaction between each of the compounds and DNA gyrase enzyme. The docking score of the compounds ranges between -8.0 to -8.9 kcal/mol. Further, the ADMET analysis indicated the potential of the compounds as a drug candidate.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140581370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chirality Sensing in Coordination-driven Supramolecular Assemblies","authors":"Abhik Paul, Subhadip Roy","doi":"10.2174/0113852728292501240301062823","DOIUrl":"https://doi.org/10.2174/0113852728292501240301062823","url":null,"abstract":": Chirality is a widespread structural characteristic found in nature and plays a vital role in the structure and functioning of almost all biological systems. Nevertheless, the translation of chirality into synthetic systems is highly intricate yet captivating, as it not only applies fundamental understanding but also has the potential to tackle significant difficulties in biochemistry and medicine. Structurally, the process of coordination- driven self-assembly involves the organization of basic molecular components into well-defined porous homochiral metal-organic cages (MOCs). This allows for a systematic investigation of the enantioselective processes occurring within the nanocavities, which have limited space and specific chiral microenvironments. This article aims to provide a comprehensive summary of the recent advancements in supramolecular chirality generated in the fascinating class of porous MOCs. It will cover the synthesis and characterization of these materials, as well as the implications of their stereochemical information in terms of chiral recognition and enantio- separation. Subsequently, a subjective viewpoint will be presented regarding the potential, possibilities, and significant challenges in the future advancement of this domain, aiming to expand the progress in creating novel chiral functional materials in the realm of chemistry and beyond.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140323401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multicomponent 3D-printed Collagen-based Scaffolds for Cartilage Regeneration: Recent Progress, Developments, and Emerging Technologies","authors":"Babak Mikaeeli Kangarshahi, Seyed Morteza Naghib","doi":"10.2174/0113852728293437240227065230","DOIUrl":"https://doi.org/10.2174/0113852728293437240227065230","url":null,"abstract":": Cartilage tissue presents challenges in terms of repair and regeneration due to its inherent limitations in self-healing and the scarcity of available donors. Cartilage damage can result in the development of joint problems characterized by symptoms, such as pain, swelling, and osteoarthritis. Collagen scaffolds are extensively used as biomimetic substances for cartilage engineering due to their ability to offer structural, biochemical, and mechanical signals for chondrocytes. Nevertheless, traditional techniques for producing collagen scaffolds frequently yield inadequate pore architecture, diminished mechanical robustness, and restricted form accuracy. Hence, 3D printing is a developing method that can surpass these restrictions by allowing accurate manipulation of the shape, porousness, and makeup of the scaffold. 3D printing has the capability to include various materials and cells in the scaffolds, resulting in the production of intricate and personalized tissue structures. This research examines the latest progress in utilizing 3D printing to create collagen scaffolds for the purpose of regenerating cartilage. This text discusses the different sources of collagen, methods of cross-linking, techniques for printing, and strategies for post-processing that are employed to improve the performance of scaffolds. Furthermore, it discusses the difficulties and potential future paths of utilizing 3D printing to create collagen scaffolds for the purpose of regenerating cartilage.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140300813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mostafa Badreldin, Pedro Salas-Ambrosio, Marcela Ayala, Simon Harrisson, Colin Bonduelle
{"title":"Synthesis of Polypeptides by Ring-opening Polymerization: A Concise Review","authors":"Mostafa Badreldin, Pedro Salas-Ambrosio, Marcela Ayala, Simon Harrisson, Colin Bonduelle","doi":"10.2174/0113852728274519240228105518","DOIUrl":"https://doi.org/10.2174/0113852728274519240228105518","url":null,"abstract":": The most economical and efficient route to prepare polypeptides from synthetic chemistry is through the Ring-Opening Polymerization (ROP) of amino acids using N-carboxyanhydride (NCA) monomers. Peptide polymers, in contrast to proteins, consist of repeated amino acid units and are comparatively simpler macromolecules. Despite their simplicity, these polypeptides offer a unique combination of beneficial traits found in both synthetic polymers (such as solubility, processability, and rubber elasticity) and natural proteins (including secondary structure, functionality, and biocompatibility). Nevertheless, NCA polymerization faces significant challenges, including intricate monomer purification and the necessity for processing toxic solvents. In this context, this review presents the fundamental principles of this polymer chemistry, the synthesis of NCA monomers, and the different methodologies to access polypeptides by ROP. It also explores the most recent advances in this field of research, with a focus on how new methods enable the use of more reactive initiators and the development of original processes, including the use of aqueous solvents.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140300928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hany M. Abd El-Lateef, Thomas Nady A. Eskander, Mohammad Saleh Hussein Alzubi, Mai M. Khalaf, Mahmoud Abd El Aleem Ali El-Remaily
{"title":"Cobalt (III)–porphyrin Complex as an Efficient and Recyclable Homogeneous Catalyst for the Synthesis of Tetrahydro-2-oxa-4-thia-diazapentalen-5-one Derivatives in Aqueous Medium","authors":"Hany M. Abd El-Lateef, Thomas Nady A. Eskander, Mohammad Saleh Hussein Alzubi, Mai M. Khalaf, Mahmoud Abd El Aleem Ali El-Remaily","doi":"10.2174/0113852728295698240220081550","DOIUrl":"https://doi.org/10.2174/0113852728295698240220081550","url":null,"abstract":": In this study, we successfully synthesized the CoPHrn complex as an efficient and recyclable catalyst for the one-pot, three-component reaction of aromatic aldehydes, 2,4-thiazolidenedione, and hydroxylamine hydrochloride, leading to the synthesis of tetrahydro-2-oxa-4-thia-diazapentalen-5-one derivatives under environmentally friendly conditions. The structures of the newly formed compounds were determined through elemental and spectral analyses. This methodology offers significant advantages, including its eco-friendliness, cost-effectiveness, operational simplicity, extensive reusability, and applicability, as well as the easy recovery of the catalyst using straightforward methods. Additionally, a series of tetrahydro-2-oxa-4-thia-diazapentalen-5- one derivatives were successfully synthesized. Notably, this novel procedure demonstrates remarkable benefits in terms of safety, simplicity, stability, mild reaction conditions, short reaction times, excellent yields, and high purity, all achieved without the use of hazardous solvents.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140166975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bubun Banerjee, Manmeet Kaur, Anu Priya, Aditi Sharma, Arvind Singh
{"title":"Ionic Liquid-promoted the Synthesis of Structurally Diverse Pyrans, Pyranannulated Heterocycles, and Spiropyrans","authors":"Bubun Banerjee, Manmeet Kaur, Anu Priya, Aditi Sharma, Arvind Singh","doi":"10.2174/0113852728300880240223063813","DOIUrl":"https://doi.org/10.2174/0113852728300880240223063813","url":null,"abstract":": During the last two decades, non-conventional solvents, especially various ionic liquids, have been utilized as efficient reaction media as they can play a dual role as solvents and promoters. The use of ionic liquids as a medium increases the efficiency of the reactions due to their inherent features like high thermal stability, ability to act as a catalyst, non-volatility, high polarity, reusability, ability to dissolve a large number of organic and inorganic compounds, etc. Under this direction, various structurally diverse ionic liquids have been employed as efficient reaction media for various organic transformations. On the other hand, among many other important synthetic scaffolds, during the last two decades, the synthesis of pyrans, pyran-annulated heterocyclic scaffolds, and spiropyrans have gained huge attention as they possess a wide range of significant biological efficacies, which include antibacterial, anticancer, antimycobacterial, antioxidant, xanthine oxidase inhibitory, etc. activities. Almost every day, many new methods are being added to the literature related to synthesizing pyrans, pyran-annulated heterocyclic scaffolds, and spiropyrans. Among many other alternatives, various ionic liquids have also played an efficient role as promoters for synthesizing structurally diverse pyrans, pyranannulated heterocyclic scaffolds, and spiropyrans. In this review, we have summarized a large number of literature reported during the last two decades related to the ionic liquid-promoted synthesis of pyrans, pyranannulated heterocyclic scaffolds, and spiropyran derivatives.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140166981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seyed Morteza Naghib, Morteza Zarrineh, M. R. Mozafari
{"title":"3D Printing Chitosan-based Nanobiomaterials for Biomedicine and Drug Delivery: Recent Advances on the Promising Bioactive Agents and Technologies","authors":"Seyed Morteza Naghib, Morteza Zarrineh, M. R. Mozafari","doi":"10.2174/0113852728298168240222114449","DOIUrl":"https://doi.org/10.2174/0113852728298168240222114449","url":null,"abstract":": 3D bioprinting is a novel technology that has gained significant attention recently due to its potential applications in developing simultaneously controlled drug delivery systems (DDSs) for administering several active substances, such as growth factors, proteins, and drug molecules. This technology provides high reproducibility and precise control over the fabricated constructs in an automated way. Chitosan is a naturalderived polysaccharide from chitin, found in the exoskeletons of crustaceans such as shrimp and crabs. Chitosan- based implants can be prepared using 3D bioprinting technology by depositing successive layers of chitosan- based bioink containing living cells and other biomaterials. The resulting implants can be designed to release drugs at a controlled rate over an extended period. The use of chitosan-based implants for drug delivery has several advantages over conventional drug delivery systems. Chitosan is biodegradable and biocompatible, so it can be safely used in vivo without causing any adverse effects. It is also non-immunogenic, meaning it does not elicit an immune response when implanted in vivo. Chitosan-based implants are also costeffective and can be prepared using simple techniques. 3D bioprinting is an emerging technology that has revolutionized the field of tissue engineering by enabling the fabrication of complex 3D structures with high precision and accuracy. It involves using computer-aided design (CAD) software to create a digital model of the desired structure, which is then translated into a physical object using a 3D printer. The printer deposits successive layers of bioink, which contains living cells and other biomaterials, to create a 3D structure that mimics the native tissue. One of the most promising applications of 3D bioprinting is developing drug delivery systems (DDSs) to administer several active substances, such as growth factors, proteins, and drug molecules. DDSs are designed to release drugs at a controlled rate over an extended period, which can improve therapeutic efficacy and reduce side effects. Chitosan-based implants have emerged as a promising candidate for DDSs due to their attractive properties, such as biodegradability, biocompatibility, low cost, and nonimmunogenicity. 3D bioprinting technology has emerged as a powerful tool for developing simultaneously controlled DDSs for administering several active substances. The rationale behind integrating 3D printing technology with chitosan-based scaffolds for drug delivery lies in the ability to produce customized, biocompatible, and precisely designed systems that enable targeted and controlled drug release. This novel methodology shows potential for advancing individualized healthcare, regenerative treatments, and the creation of cutting- edge drug delivery systems. This review highlights the potential applications of 3D bioprinting technology for preparing chitosan-based implants for drug delivery.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140166880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis, Molecular Docking, Anti-cholinesterase Activity, Theoretical Investigation, and Catalytic Effect of New Encumbered N-benzyladamantyl Substituted Imidazolidin-2-ylidene Carbene Pd-PEPPSI Complexes","authors":"Sofiane ikhlef, Sarra Lasmari, Saber Mustapha Zendaoui, El Hassen Mokrani, Dahmane Tebbani, Nevin Gürbüz, Chawki Bensouici, Raouf Boulcina, Bachir Zouchoune, Ismail Özdemir","doi":"10.2174/0113852728289791240222054306","DOIUrl":"https://doi.org/10.2174/0113852728289791240222054306","url":null,"abstract":": This study aimed to describe the preparation of novel PEPPSI type Pd(II)-NHC complexes bearing N-benzyladamantyl substituted imidazolidin-2-ylidene group. All synthesized compounds were characterized by using 1 H-NMR and 13C-NMR spectroscopies, FTIR, and elemental analysis techniques. One of the objectives of this study was the synthesis of Pd-NHC complexes with AChE/BChE inhibition activities. Among all the tested compounds, complexes 4b and 4c were found to have the most high potential AChE and BChE inhibitory activities with IC50 values of 21.57 ± 0.23 Mm and 15.78 ± 0.39 Mm, respectively. Conducting molecular docking studies helped us in gathering crucial information about the main binding interactions of inhibitors and enzymes, and the results were in agreement with the biological evaluation. The synthesized Pd-NHC complexes were employed for catalyzing the direct C2- and C5-arylation reaction between aryl (hetero) halide and a variety of heterocyclic systems. In both cases (C2 and C5-arylation), Pd-NHC complexes catalysts provided access to the arylated heterocycles in good to high yields in the presence of 1 mol% catalyst loading at 150 °C. The DFT theoretical investigation showed that the Pd-NHC complexes were of ML2X2 type, where the the Pd(II) cation had a square planar geometry. The interaction energies obtained by energy decomposition analysis (EDA) demonstrated that the 4d and 4e complexes were more stable in the presence of more methyl substituents. The chemical indicators demonstrated that the less stable 4c complex was more reactive in regard to the chemical hardness, chemical potential, and electrophilicity values.","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140166876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}