Modified Microwave-assisted Solid-liquid Halex Reaction using Phosphonium Salt as Efficient and Robust Phase Transfer Catalyst

IF 1.7 3区 化学 Q3 CHEMISTRY, ORGANIC
Dhanaji M. Mohite, Pandurang M. Chavhan, Arghya Basu
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引用次数: 0

Abstract

A modified solid-liquid halex reaction was developed in the presence of a robust phase transfer catalyst under microwave conditions. A fast, mild, and practical microwave-assisted synthesis of 2,3-difluoro-5- chloropyridine 3 starting from 2,3,5-trichlorpyridine 1 and spray-dried KF in polar aprotic solvent was developed. The addition of Tetrakis (piperidino) phosphonium chloride as phase transfer catalyst A was studied under microwave irritation (450W) and increased the yield and significantly reduced the reaction time in contrast to the conventional heating procedure. The highest reaction rate was observed at 5 wt% phase transfer phosphonium salt catalyst to 2,3,5-trichloropyridine 1.
利用鏻盐作为高效稳健的相转移催化剂进行改良微波辅助固液哈莱克斯反应
在微波条件下,在一种强力相转移催化剂的存在下,开发了一种改良的固液哈来克斯反应。以 2,3,5-三氯吡啶 1 和喷雾干燥的 KF 为原料,在极性非沸腾溶剂中,开发了一种快速、温和、实用的 2,3-二氟-5-氯吡啶 3 的微波辅助合成方法。在微波刺激(450W)下,研究了添加四(哌啶基)氯化鏻作为相转移催化剂 A 的情况,与传统加热程序相比,该催化剂提高了产率并显著缩短了反应时间。在 5 wt%相转移鏻盐催化剂作用下,2,3,5-三氯吡啶 1 的反应速率最高。
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来源期刊
Current Organic Chemistry
Current Organic Chemistry 化学-有机化学
CiteScore
3.70
自引率
7.70%
发文量
76
审稿时长
1 months
期刊介绍: Current Organic Chemistry aims to provide in-depth/mini reviews on the current progress in various fields related to organic chemistry including bioorganic chemistry, organo-metallic chemistry, asymmetric synthesis, heterocyclic chemistry, natural product chemistry, catalytic and green chemistry, suitable aspects of medicinal chemistry and polymer chemistry, as well as analytical methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by chosen experts who are internationally known for their eminent research contributions. The Journal also accepts high quality research papers focusing on hot topics, highlights and letters besides thematic issues in these fields. Current Organic Chemistry should prove to be of great interest to organic chemists in academia and industry, who wish to keep abreast with recent developments in key fields of organic chemistry.
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