糖基化反应的最新进展：获得特级 C-和 S-糖苷的途径

IF 1.7 3区化学 Q3 CHEMISTRY, ORGANIC

Current Organic Chemistry Pub Date : 2024-08-07 DOI:10.2174/0113852728322447240718054734

Ram Pratap Pandey, Bindu Tiwari, Anand Kumar Pandey, Nazar Hussain

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引用次数: 0

摘要

糖基化反应是碳水化合物化学的核心，因为它们在药物开发和生物探针中有着广泛的应用。尽管糖基化反应面临着巨大的挑战，而且往往需要大量的促进剂，但这些反应产生的增值产品却具有巨大的生物学意义。在糖基化反应中加入过渡金属催化作用具有反应条件温和、选择性更强等优点。目前，合成化学家对 C-糖苷和 S-糖苷特别感兴趣，因为与更脆弱的糖苷相比，它们的糖苷键具有更高的代谢稳定性。本综述旨在探讨各种结构多样、具有生物相关性的 C-和 S-糖苷合成的最新进展，涵盖 2019 年至 2024 年的文献。

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Recent Advancements in Glycosylation Reactions: An Access to Privileged C- and S-Glycosides

Glycosylation reactions are central to carbohydrate chemistry due to their broad applications in drug development and biological probes. Despite presenting significant challenges and often requiring substantial amounts of promoters, these reactions yield value-added products of immense biological importance. The incorporation of transition metal catalysis in glycosylation reactions offers advantages, such as mild reaction conditions and enhanced selectivity. Currently, synthetic chemists are particularly interested in C- and S-glycosides because their glycosidic linkages exhibit greater metabolic stability compared to the more vulnerable Oglycosides. This review aims to explore recent advances in the synthesis of various structurally diverse and biologically relevant C- and S-glycosides, covering literature from 2019 to 2024.

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来源期刊

Current Organic Chemistry 化学-有机化学

CiteScore

3.70

自引率

7.70%

发文量

审稿时长

1 months

期刊介绍： Current Organic Chemistry aims to provide in-depth/mini reviews on the current progress in various fields related to organic chemistry including bioorganic chemistry, organo-metallic chemistry, asymmetric synthesis, heterocyclic chemistry, natural product chemistry, catalytic and green chemistry, suitable aspects of medicinal chemistry and polymer chemistry, as well as analytical methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by chosen experts who are internationally known for their eminent research contributions. The Journal also accepts high quality research papers focusing on hot topics, highlights and letters besides thematic issues in these fields. Current Organic Chemistry should prove to be of great interest to organic chemists in academia and industry, who wish to keep abreast with recent developments in key fields of organic chemistry.