Cumhuriyet Science Journal最新文献_第6页

Melatonin as a Potential Therapeutic Tool in Allergic Rhinitis Induced by House-Dust Mite 褪黑素治疗屋尘螨致变应性鼻炎的研究进展

Cumhuriyet Science Journal Pub Date : 2023-09-29 DOI: 10.17776/csj.1202272

ŞAFAK, Ayşe Sezim , TAŞLI, Pakize Neslihan , AVŞAR ABDİK, Ezgi , ABDİK, Hüseyin , ŞAHİN, Fikrettin

{"title":"Melatonin as a Potential Therapeutic Tool in Allergic Rhinitis Induced by House-Dust Mite","authors":"ŞAFAK, Ayşe Sezim\u0000 , TAŞLI, Pakize Neslihan\u0000 , AVŞAR ABDİK, Ezgi\u0000 , ABDİK, Hüseyin\u0000 , ŞAHİN, Fikrettin\u0000 ","doi":"10.17776/csj.1202272","DOIUrl":"https://doi.org/10.17776/csj.1202272","url":null,"abstract":"Melatonin is known as an important regulator of circadian rhythm in humans. In the literature, there are no studies evaluating the efficacy of melatonin in the management of allergic rhinitis (AR) or nasal polyps (Np). Np tissue was taken from nasal cavity and mucosal tissue (Mu) was taken from the nasal septal area. Melatonin (25-200nM) and Mite Allergen (2.5-12.5%) were prepared in complete media. Cell viability, apoptosis, intracellular reactive oxygen species production and gene expression levels were determined. Our results showed that there is no toxic effect of Melatonin, Mite and their combination which was given to Np-MSCs and Mu-MSCs. Melatonin significantly reduced reactive oxygen species levels in both mite-treated Np-MSCs and Mu-MSCs. Indoleamine 2,3-dioxygenase level was significantly decreased in melatonin-treated cells. Cyclooxygenase-1 level was significantly decreased in melatonin-treated healthy and allergic Np-MSCs while there was no significant difference in 100 and 150nM Melatonin-treated Mu-MSCs. Interestingly, 50nM Melatonin significantly increased Cyclooxygenase-1 level in Mu-MSCs. 50, 100 and 150nm Melatonin significantly decreased Interleukin-6 level in Mite-treated Np-MSCs. In addition, 100 and 150nM Melatonin significantly decreased Interleukin-6 level in Mite-treated Mu-MSCs. Melatonin has well-established anti-oxidant and anti-neoplastic activity, could be a promising therapeutic agent in the treatment of AR and nasal polyposis.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"131 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135133127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant Capacity of Essential Oils Obtained from Myrtus communis L. and Citrus sinensis (L.) Osbeck Plants Widely Consumed in Adana Region 桃金娘和柑桔精油抗氧化能力的研究奥斯贝克植物在阿达纳地区广泛使用

Cumhuriyet Science Journal Pub Date : 2023-09-29 DOI: 10.17776/csj.1195938

NENNİ, Merve , KARAHÜSEYİN, Seçil

{"title":"Antioxidant Capacity of Essential Oils Obtained from Myrtus communis L. and Citrus sinensis (L.) Osbeck Plants Widely Consumed in Adana Region","authors":"NENNİ, Merve\u0000 , KARAHÜSEYİN, Seçil\u0000 ","doi":"10.17776/csj.1195938","DOIUrl":"https://doi.org/10.17776/csj.1195938","url":null,"abstract":"Vitamin C, an antioxidant, is abundant in oranges (Citrus sinensis (L.) Osbeck), which are consumed worldwide. It has treated constipation, diarrhea, upper respiratory illnesses, obesity, menstruation issues, hypertension, and stress. Traditional medicine worldwide uses myrtle (Myrtus communis L.). Clinical and experimental studies show that the plant has a wide range of pharmacological and therapeutic activities, including antioxidant, anticancer, antidiabetic, antibacterial, antifungal, antiviral, pulmonary and skin diseases, dysentery, vomiting, rheumatism, sinusitis, leucorrhoea, and hair loss control. These plants contain flavonoids, terpenes, steroids, fatty acids, carbohydrates, volatile chemicals, carotenoids, and nutritional components. Plant antioxidants have gained popularity due to their health benefits. Many studies focused on medicinal organic antioxidants. The main goal of this research was to investigate the volatile components and antioxidant capacities of the essential oils of myrtle and orange, both of which are commonly utilized for medicinal purposes in the Adana region. Myrtle and orange extracts demonstrated substantial antioxidant properties when tested with the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, a test based on the scavenging of the DPPH radical. It has been revealed that myrtle essential oil has a higher capacity in terms of antioxidant activity than orange essential oil.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"220 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135133259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effects of Heavy Metals and Molasses on Enzyme Activity of Candida Yeast 重金属和糖蜜对念珠菌酵母菌酶活性的影响

Cumhuriyet Science Journal Pub Date : 2023-09-29 DOI: 10.17776/csj.1127921

BAŞKAN, Gülşah , AÇIKEL, Unsal

{"title":"The Effects of Heavy Metals and Molasses on Enzyme Activity of Candida Yeast","authors":"BAŞKAN, Gülşah\u0000 , AÇIKEL, Unsal\u0000 ","doi":"10.17776/csj.1127921","DOIUrl":"https://doi.org/10.17776/csj.1127921","url":null,"abstract":"Lipases are mainly applied in the food, abluent and medicine industries. Through the high production costs of lipase enzymes for industrial applications, cheap and eco-friendly enzyme production has gained great importance in recent years. Yeasts can produce lipase enzyme and grow in acidic media. In the present study, the act of Cu2+, Ni2+ and molasses concentrations on the enzyme activity of Candida yeasts were investigated in a batch system. The maximum enzyme activities of microorganisms were determined at pH:4. Lipase enzyme activity was investigated changing metal ion and molasses sucrose concentrations by 25-250 mg/L and 1-20 g/L respectively. When molasses sucrose concentration was increased, the enzyme activity of all yeasts increased to 10 g/L, and the lipase enzyme activity decreased at the higher molasses concentrations. Enzyme activity of yeasts decreased with increasing both metal ion concentrations at constant molasses sucrose concentrations. Ni2+ cations were more inhibited to enzyme activity of all yeasts than Cu2+. Among the yeasts, Candida membranefeciens (936.96 U/L) showed the highest enzyme activity in media containing a constant molasses concentration of 10 g/L.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135133261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of Adsorption Isotherm Models for Interaction of P(AAm-ClAETA) and Carminic Acid, and Theoretical Approaches P(AAm-ClAETA)与Carminic酸相互作用的吸附等温线模型及理论方法研究

Cumhuriyet Science Journal Pub Date : 2023-09-29 DOI: 10.17776/csj.1268752

IŞIKVER, Yasemin , IŞIKVER, Ali

{"title":"Investigation of Adsorption Isotherm Models for Interaction of P(AAm-ClAETA) and Carminic Acid, and Theoretical Approaches","authors":"IŞIKVER, Yasemin\u0000 , IŞIKVER, Ali\u0000 ","doi":"10.17776/csj.1268752","DOIUrl":"https://doi.org/10.17776/csj.1268752","url":null,"abstract":"In this study, the adsorption isotherm models for the sorption of carminic acid on P(AAm-ClAETA) hydrogels are explained by experimental and theoretical studies. The crosslinked hydrogels with ethylene glycol dimethacrylate were prepared by radical addition reaction of acrylamide (AAm) and 2-(acryloyloxy)ethyl trimethylammonium chloride (ClAETA) monomers in an aqueous solution. The spectral and morphological analyses of P(AAm-ClAETA) hydrogels were performed by FTIR/ATR and SEM, respectively. The adsorbed amounts of carminic acid on P(AAm-ClAETA) hydrogels were evaluated by Giles, Langmuir, and Freundlich adsorption isotherm models. Langmuir parameters were calculated for the adsorption of the dye on the hydrogels according to the L-type Giles isotherm. In addition, it was determined that its adsorption was appropriate from the RL values calculated for 500 mg L-1 carminic acid concentration. In addition, molecular electrostatic potential (MEP) mapping was performed to predict the reactive sites of P(AAm-ClAETA) hydrogels and carminic acid. The results showed that the theoretical and experimental data of the hydrogels were in agreement with each other. As a result, it can be said that P(AAm-ClAETA) hydrogels are suitable for the removal of anionic dyes such as carminic acid from aqueous solutions.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135133267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Analytical Approach to Contaminant Transport with Spatially and Temporally Dependent Dispersion in a Heterogeneous Porous Medium 非均质多孔介质中具有时空依赖色散的污染物输运分析方法

Cumhuriyet Science Journal Pub Date : 2023-09-29 DOI: 10.17776/csj.1258286

KUSHWAHA, Sujata , YADAV, Raja Ram , KUMAR, Lav Kush , ROY, Joy

引用次数: 0

Investigation of Antimicrobial and Antioxidant Activities of some Lichens 几种地衣的抗菌和抗氧化活性研究

Cumhuriyet Science Journal Pub Date : 2023-09-29 DOI: 10.17776/csj.1317923

US, Dilek , KARA, Ayşe , ÜNAL, Elif , AKINCIOĞLU, Hülya , ASLAN, Ali , TAŞKIN, Mesut

{"title":"Investigation of Antimicrobial and Antioxidant Activities of some Lichens","authors":"US, Dilek\u0000 , KARA, Ayşe\u0000 , ÜNAL, Elif\u0000 , AKINCIOĞLU, Hülya\u0000 , ASLAN, Ali\u0000 , TAŞKIN, Mesut\u0000 ","doi":"10.17776/csj.1317923","DOIUrl":"https://doi.org/10.17776/csj.1317923","url":null,"abstract":"This study investigated the antimicrobial and antioxidant properties of methanol extracts from five lichen species: Polycauliona candelaria (Syn. Xanthoria candelaria), Nephromopsis chlorophylla (Syn. Cetraria chlorophylla), Circinaria calcarea (Syn. Aspicilia calcarea), Bryoria capillaris (Syn. Alectoria cana), and Peltigera canina (Syn. Dermatodea canina). Antimicrobial activities were determined using the agar disc diffusion method, while minimal inhibitory concentration (MIC) values were determined using the micro-well dilution method. Among the lichen species, methanol extract of Circinaria calcarea exhibited the highest antimicrobial activity, with a 15 mm zone of inhibition against Escherichia coli and Bacillus cereus. It also demonstrated the lowest MIC value (31.25 μg/mL) against Bacillus cereus, Bacillus subtilis, Clostridium perfringens and Escherichia coli were the most sensitive microorganisms to lichens. Various antioxidant determination methods were employed to assess the antioxidant activities of the lichens, including ferric ion (Fe+3) reduction capacity, cupric ion (Cu+2) reduction capacity, ferric ion reducing antioxidant power (FRAP), DPPH radical scavenging activity, DMPD radical scavenging activity and metal chelating activity using the bipyridyl reagent. All lichens exhibited excellent antioxidant activity, particularly in metal chelating activity using the bipyridyl reagent. Peltigera canina demonstrated the highest antioxidant activity among the studied lichen species across most of the applied method.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135133133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relations Among Minimal Elements of a Family of Sets with Respect to Various Set Order Relations 集合族最小元素间关于各种集序关系的关系

Cumhuriyet Science Journal Pub Date : 2023-09-29 DOI: 10.17776/csj.1262453

ATASEVER GÜVENÇ, İlknur

引用次数: 0

A Density Functional Theory (DFT) based Analysis on the Inhibition Performances of Some Triazole Derivatives for Iron Corrosion 基于密度泛函理论(DFT)的三唑类化合物对铁的缓蚀性能分析

Cumhuriyet Science Journal Pub Date : 2023-09-29 DOI: 10.17776/csj.1330590

KARAKUŞ, Nihat , KAYA, Savaş

{"title":"A Density Functional Theory (DFT) based Analysis on the Inhibition Performances of Some Triazole Derivatives for Iron Corrosion","authors":"KARAKUŞ, Nihat\u0000 , KAYA, Savaş\u0000 ","doi":"10.17776/csj.1330590","DOIUrl":"https://doi.org/10.17776/csj.1330590","url":null,"abstract":"Iron is one of the widely used metals in industry. For that reason, the prevention of the corrosion of such metals via new designed inhibitor systems is among the interest of corrosion scientists. In the present paper, we investigated the corrosion inhibition performance of 2-((1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl) methoxy) benzaldehyde (A), 4-((1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl) methoxy) benzaldehyde (B), 4-((4-nitrophenoxy) methyl)-1-(4-nitrophenyl)-1H-1,2,3-triazole (C), 4-methyl-7-((1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl) methoxy)-2H-chromen-2-one (D) against iron corrosion. For the mentioned inhibitor systems, important reactivity descriptors like frontier orbital energies, chemical potential, electronegativity, hardness, softness, polarizability, dipole moment, back-donation energy, electrophilicity, electroaccepting power and electrodonating power were calculated and discussed. Calculations were repeated using various methods and basis sets in different phases. The chemical reactivities of the inhibitors were predicted in the light of well-known electronic structure rules like Maximum Hardness and Minimum Polarizability Principles. The obtained data showed that the best corrosion inhibitor among them is molecule D while the most stable molecule is molecule C. The theoretical data support the experimental observations.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135133140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D Stabilized FEM Solution of the MHD Equations in an External Medium and Around a Solid 外介质和固体周围MHD方程的三维稳定有限元解

Cumhuriyet Science Journal Pub Date : 2023-09-29 DOI: 10.17776/csj.1293551

AYDIN, Selçuk Han , ERDOĞAN, Mahir Ceylan

引用次数: 0

Exploration of Seasonal Metal Pollution in Karacaören II Dam Lake Sediment Samples using X-ray Fluorescence Method 利用x射线荧光法探测Karacaören II大坝湖泊沉积物样品中的季节性金属污染

Cumhuriyet Science Journal Pub Date : 2023-09-29 DOI: 10.17776/csj.1269391

APAYDIN, Gökhan , KÖKSAL, Oğuz Kağan , CENGİZ, Erhan , ŞİRİN, Murat , BALTAS, Hasan , TIRAŞOĞLU, Engin

{"title":"Exploration of Seasonal Metal Pollution in Karacaören II Dam Lake Sediment Samples using X-ray Fluorescence Method","authors":"APAYDIN, Gökhan\u0000 , KÖKSAL, Oğuz Kağan\u0000 , CENGİZ, Erhan\u0000 , ŞİRİN, Murat\u0000 , BALTAS, Hasan\u0000 , TIRAŞOĞLU, Engin\u0000 ","doi":"10.17776/csj.1269391","DOIUrl":"https://doi.org/10.17776/csj.1269391","url":null,"abstract":"In this study, the seasonal metal pollution of sediment samples taken from twelve distinct notes of the Karacaören II Dam Lake was examined. The quantity of metal in soil samples was determined using energy dispersive X-ray fluorescence spectroscopy. The geoaccumulation index and enrichment factor expressions were created using the metal concentrations found in the sediments. Seasonal values at the local, state, and international levels were compared to the findings. The ratios of the elements copper, zinc, lead, arsenic, nickel, chromium, and mercury, measured in parts per million (ppm), were found to be 42-96, 53-78, 11-14, 4-7, 233-244, and 611-711, respectively. There is also discussion of the sediments' elemental composition and degree of pollution. In contrast, it was found that the Urbach energy increased from 0.246 eV to 0.630 eV with increasing levels of V2O5. These synthetic glasses' densities and molar volumes were also investigated and discussed.","PeriodicalId":10906,"journal":{"name":"Cumhuriyet Science Journal","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135133134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0