Critical Reviews in Toxicology最新文献_第4页

Consideration of the variability in control tumor incidence data at the Ramazzini Institute in evaluating treatment-related effects following chemical exposure. 在评估接触化学品后与治疗相关的影响时，考虑拉马齐尼研究所对照肿瘤发病率数据的可变性。

IF 5.9 2区医学

Critical Reviews in Toxicology Pub Date : 2024-03-01 Epub Date: 2024-03-12 DOI: 10.1080/10408444.2024.2314056

Robinan Gentry, Tracy Greene, Holly Bartow, Cynthia Van Landingham, Joseph Rodricks, Harvey Clewell

{"title":"Consideration of the variability in control tumor incidence data at the Ramazzini Institute in evaluating treatment-related effects following chemical exposure.","authors":"Robinan Gentry, Tracy Greene, Holly Bartow, Cynthia Van Landingham, Joseph Rodricks, Harvey Clewell","doi":"10.1080/10408444.2024.2314056","DOIUrl":"10.1080/10408444.2024.2314056","url":null,"abstract":"The Ramazzini Institute (RI) has been conducting animal carcinogenicity studies for decades, many of which have been considered by authoritative bodies to determine potential carcinogenicity in humans. Unlike other laboratories, such as the U.S. National Toxicology Program (NTP), the RI does not provide a report or record of historical control data. Transparently documenting historical control data is critical in the interpretation of individual study results within the same laboratory. Historical control data allow an assessment of significant trends, either increasing or decreasing, resulting from changes in laboratory methods or genetic drift. In this investigation: (1) we compiled a dataset of the tumors reported in control groups of Sprague-Dawley rats and Swiss mice based on data included in published RI studies on specific substances, and (2) conducted case studies to compare data from this RI control dataset to the findings from multiple RI studies on sweeteners and corresponding breakdown products. We found considerable variability in the tumor incidence across multiple tumor types when comparing across control groups from RI studies. When compared to the tumor incidence in treated groups from multiple studies, the incidence of some tumors considered to be treatment-related fell within the variability of background incidence from the RI control dataset.","PeriodicalId":10869,"journal":{"name":"Critical Reviews in Toxicology","volume":" ","pages":"153-173"},"PeriodicalIF":5.9,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140101209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-acute exposure of neonicotinoids, health risk assessment, and evidence integration: a systematic review. 新烟碱类药物的非急性接触、健康风险评估和证据整合：系统综述。

IF 5.7 2区医学

Critical Reviews in Toxicology Pub Date : 2024-03-01 Epub Date: 2024-03-12 DOI: 10.1080/10408444.2024.2310593

Imen Benchikh, Kaddour Ziani, Antonio Gonzalez Mateos, Boumediène Méghit Khaled

{"title":"Non-acute exposure of neonicotinoids, health risk assessment, and evidence integration: a systematic review.","authors":"Imen Benchikh, Kaddour Ziani, Antonio Gonzalez Mateos, Boumediène Méghit Khaled","doi":"10.1080/10408444.2024.2310593","DOIUrl":"10.1080/10408444.2024.2310593","url":null,"abstract":"Neonicotinoid pesticides are utilized against an extensive range of insects. A growing body of evidence supports that these neuro-active insecticides are classified as toxicants in invertebrates. However, there is limited published data regarding their toxicity in vertebrates and mammals. the current systematic review is focused on the up-to-date knowledge available for several neonicotinoid pesticides and their non-acute toxicity on rodents and human physiology. Oral lethal dose 50 (LD50) of seven neonicotinoids (i.e. imidacloprid, acetamiprid, clothianidin, dinotefuran, thiamethoxam, thiacloprid, and nitenpyram) was initially identified. Subsequently, a screening of the literature was conducted to collect information about non-acute exposure to these insecticides. 99 studies were included and assessed for their risk of bias and level of evidence according to the Office of Health and Translation (OHAT) framework. All the 99 included papers indicate evidence of reproductive toxicity, hepatotoxicity, nephrotoxicity, neurotoxicity, immunotoxicity, and oxidative stress induction with a high level of evidence in the health effect of rodents and a moderate level of evidence for human health. The most studied type of these insecticides among 99 papers was imidacloprid (55 papers), followed by acetamiprid (22 papers), clothianidin (21 papers), and thiacloprid (11 papers). While 10 of 99 papers assessed the relationship between clothianidin, thiamethoxam, dinotefuran, and nitenpyram, showing evidence of liver injury, dysfunctions of oxidative stress markers in the reproductive system, and intestinal toxicity. This systematic review provides a comprehensive overview of the potential risks caused by neonicotinoid insecticides to humans and rodents with salient health effects. However, further research is needed to better emphasize and understand the patho-physiological mechanisms of these insecticides, taking into account various factors that can influence their toxicity.","PeriodicalId":10869,"journal":{"name":"Critical Reviews in Toxicology","volume":" ","pages":"194-213"},"PeriodicalIF":5.7,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140101235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The skin sensitization adverse outcome pathway: exploring the role of mechanistic understanding for higher tier risk assessment 皮肤过敏不良后果途径：探索机理认识对更高层次风险评估的作用

IF 5.9 2区医学

Critical Reviews in Toxicology Pub Date : 2024-02-22 DOI: 10.1080/10408444.2024.2308816

Maja Aleksic, Ramya Rajagopal, Renato de-Ávila, Sandrine Spriggs, Nicola Gilmour

引用次数: 0

Thank you to authors and reviewers of papers in Critical Reviews in Toxicology (CRT) volume 53, 2023 感谢《毒理学关键评论》（CRT）第 53 卷第 2023 期的论文作者和审稿人

IF 5.9 2区医学

Critical Reviews in Toxicology Pub Date : 2024-02-15 DOI: 10.1080/10408444.2024.2310971

Roger O. McClellan

引用次数: 0

Complex roles for sulfation in the toxicities of polychlorinated biphenyls. 硫化作用在多氯联苯毒性中的复杂作用。

IF 5.9 2区医学

Critical Reviews in Toxicology Pub Date : 2024-02-01 Epub Date: 2024-02-16 DOI: 10.1080/10408444.2024.2311270

Michael W Duffel, Hans-Joachim Lehmler

{"title":"Complex roles for sulfation in the toxicities of polychlorinated biphenyls.","authors":"Michael W Duffel, Hans-Joachim Lehmler","doi":"10.1080/10408444.2024.2311270","DOIUrl":"10.1080/10408444.2024.2311270","url":null,"abstract":"Polychlorinated biphenyls (PCBs) are persistent organic toxicants derived from legacy pollution sources and their formation as inadvertent byproducts of some current manufacturing processes. Metabolism of PCBs is often a critical component in their toxicity, and relevant metabolic pathways usually include their initial oxidation to form hydroxylated polychlorinated biphenyls (OH-PCBs). Subsequent sulfation of OH-PCBs was originally thought to be primarily a means of detoxication; however, there is strong evidence that it may also contribute to toxicities associated with PCBs and OH-PCBs. These contributions include either the direct interaction of PCB sulfates with receptors or their serving as a localized precursor for OH-PCBs. The formation of PCB sulfates is catalyzed by cytosolic sulfotransferases, and, when transported into the serum, these metabolites may be retained, taken up by other tissues, and subjected to hydrolysis catalyzed by intracellular sulfatase(s) to regenerate OH-PCBs. Dynamic cycling between PCB sulfates and OH-PCBs may lead to further metabolic activation of the resulting OH-PCBs. Ultimate toxic endpoints of such processes may include endocrine disruption, neurotoxicities, and many others that are associated with exposures to PCBs and OH-PCBs. This review highlights the current understanding of the complex roles that PCB sulfates can have in the toxicities of PCBs and OH-PCBs and research on the varied mechanisms that control these roles.","PeriodicalId":10869,"journal":{"name":"Critical Reviews in Toxicology","volume":" ","pages":"92-122"},"PeriodicalIF":5.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11067068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Procedural application of mode-of-action and human relevance analysis: styrene-induced lung tumors in mice. 作用模式和人体相关性分析的程序应用：苯乙烯诱导的小鼠肺肿瘤。

IF 5.9 2区医学

Critical Reviews in Toxicology Pub Date : 2024-02-01 Epub Date: 2024-03-05 DOI: 10.1080/10408444.2024.2310600

Evan A Frank, M E Bette Meek

{"title":"Procedural application of mode-of-action and human relevance analysis: styrene-induced lung tumors in mice.","authors":"Evan A Frank, M E Bette Meek","doi":"10.1080/10408444.2024.2310600","DOIUrl":"10.1080/10408444.2024.2310600","url":null,"abstract":"Risk assessment of human health hazards has traditionally relied on experiments that use animal models. Although exposure studies in rats and mice are a major basis for determining risk in many cases, observations made in animals do not always reflect health hazards in humans due to differences in biology. In this critical review, we use the mode-of-action (MOA) human relevance framework to assess the likelihood that bronchiolar lung tumors observed in mice chronically exposed to styrene represent a plausible tumor risk in humans. Using available datasets, we analyze the weight-of-evidence 1) that styrene-induced tumors in mice occur through a MOA based on metabolism of styrene by Cyp2F2; and 2) whether the hypothesized key event relationships are likely to occur in humans. This assessment describes how the five modified Hill causality considerations support that a Cyp2F2-dependent MOA causing lung tumors is active in mice, but only results in tumorigenicity in susceptible strains. Comparison of the key event relationships assessed in the mouse was compared to an analogous MOA hypothesis staged in the human lung. While some biological concordance was recognized between key events in mice and humans, the MOA as hypothesized in the mouse appears unlikely in humans due to quantitative differences in the metabolic capacity of the airways and qualitative uncertainties in the toxicological and prognostic concordance of pre-neoplastic and neoplastic lesions arising in either species. This analysis serves as a rigorous demonstration of the framework's utility in increasing transparency and consistency in evidence-based assessment of MOA hypotheses in toxicological models and determining relevance to human health.","PeriodicalId":10869,"journal":{"name":"Critical Reviews in Toxicology","volume":" ","pages":"134-151"},"PeriodicalIF":5.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140027612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis, toxicological mechanism, and detoxification for hepatotoxicity induced by pyrrolizidine alkaloids from herbal medicines or other plants. 中药或其他植物中的吡咯烷生物碱引起的肝中毒的诊断、毒理机制和解毒方法。

IF 5.9 2区医学

Critical Reviews in Toxicology Pub Date : 2024-02-01 Epub Date: 2024-02-27 DOI: 10.1080/10408444.2024.2310597

Zhenlin Huang, Zeqi Wu, Xinnan Gu, Lili Ji

{"title":"Diagnosis, toxicological mechanism, and detoxification for hepatotoxicity induced by pyrrolizidine alkaloids from herbal medicines or other plants.","authors":"Zhenlin Huang, Zeqi Wu, Xinnan Gu, Lili Ji","doi":"10.1080/10408444.2024.2310597","DOIUrl":"10.1080/10408444.2024.2310597","url":null,"abstract":"Pyrrolizidine alkaloids (PAs) are one type of phytotoxins distributed in various plants, including many medicinal herbs. Many organs might suffer injuries from the intake of PAs, and the liver is the most susceptible one. The diagnosis, toxicological mechanism, and detoxification of PAs-induced hepatotoxicity have been studied for several decades, which is of great significance for its prevention, diagnosis, and therapy. When the liver was exposed to PAs, liver sinusoidal endothelial cells (LSECs) loss, hemorrhage, liver parenchymal cells death, nodular regeneration, Kupffer cells activation, and fibrogenesis occurred. These pathological changes classified the PAs-induced liver injury as acute, sub-acute, and chronic type. PAs metabolic activation, mitochondria injury, glutathione (GSH) depletion, inflammation, and LSECs damage-induced activation of the coagulation system were well recognized to play critical roles in the pathological process of PAs-induced hepatotoxicity. A lot of natural compounds like glycyrrhizic acid, (-)-epicatechin, quercetin, baicalein, chlorogenic acid, and so on were demonstrated to be effective in alleviating PAs-induced liver injury, which rendered them huge potential to be developed into therapeutic drugs for PAs poisoning in clinics. This review presents updated information about the diagnosis, toxicological mechanism, and detoxification studies on PAs-induced hepatotoxicity.","PeriodicalId":10869,"journal":{"name":"Critical Reviews in Toxicology","volume":" ","pages":"123-133"},"PeriodicalIF":5.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fungicides as a risk factor for the development of neurological diseases and disorders in humans: a systematic review. 杀真菌剂是导致人类神经系统疾病和失调的风险因素：系统综述。

IF 5.7 2区医学

Critical Reviews in Toxicology Pub Date : 2024-01-01 Epub Date: 2024-01-30 DOI: 10.1080/10408444.2024.2303481

Renata Sano Lini, Deborah Thais Palma Scanferla, Nadya Garcia de Oliveira, Raul Gomes Aguera, Thais da Silva Santos, Jorge Juarez Vieira Teixeira, Alice Maria de Souza Kaneshima, Simone Aparecida Galerani Mossini

{"title":"Fungicides as a risk factor for the development of neurological diseases and disorders in humans: a systematic review.","authors":"Renata Sano Lini, Deborah Thais Palma Scanferla, Nadya Garcia de Oliveira, Raul Gomes Aguera, Thais da Silva Santos, Jorge Juarez Vieira Teixeira, Alice Maria de Souza Kaneshima, Simone Aparecida Galerani Mossini","doi":"10.1080/10408444.2024.2303481","DOIUrl":"10.1080/10408444.2024.2303481","url":null,"abstract":"Although studies show that pesticides, especially insecticides, may be toxic to humans, publications on the neurological effects of fungicides are scarce. As fungicides are used widely in Brazil, it is necessary to gather evidence to support actions aimed at safely using of these chemicals. We investigated through a systematic review of publications on the use of fungicides and consequences of exposure related to nervous system diseases or neurological disorders in humans. The protocol review was registered on PROSPERO and followed the guidelines of the PRISMA-Statement. As far as it is known, there is no apparent systematic review in the literature on this topic. The search was comprised of the following databases: PubMed; Web of Science; Scopus and EMBASE, using groups of Mesh terms and strategies specific to each database. Thirteen articles were selected for this review. Regarding the substances analyzed in the studies, some reported the use of fungicides in general, without separating them by type, while others summarized the categories of all pesticides by their function (insecticides, herbicides, fungicides, etc.) or chemical class (dithiocarbamate, dicarboximide, inorganic, etc.). However, most of the articles referred to fungicides that contain the metal manganese (Mn) in their composition. As for neurological disorders, articles addressed Parkinson's disease (PD), neurodevelopmental outcomes, extrapyramidal syndrome resembling PD, cognitive disorders, depression, neural tube defects, motor neurone disease, and amyotrophic lateral sclerosis. Most investigations pointed to exposure to fungicides, mainly maneb and mancozeb, leading to the development of at least one neurological disease, which suggests the need for further multicentric clinical trials and prospective studies for greater clarity of the research problem.","PeriodicalId":10869,"journal":{"name":"Critical Reviews in Toxicology","volume":" ","pages":"35-54"},"PeriodicalIF":5.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139575539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 更正。

IF 5.9 2区医学

Critical Reviews in Toxicology Pub Date : 2024-01-01 Epub Date: 2023-07-27 DOI: 10.1080/10408444.2023.2229209

引用次数: 0

Grouping approaches based on structure alone are insufficient to conclude about toxicological properties-the example of monoamine-based chelates. 仅根据结构进行分组不足以得出毒理学特性的结论--以单胺螯合物为例。

IF 5.9 2区医学

Critical Reviews in Toxicology Pub Date : 2024-01-01 Epub Date: 2024-01-25 DOI: 10.1080/10408444.2024.2303487

Josje H E Arts, Sina Bader, Steffen Bade

{"title":"Grouping approaches based on structure alone are insufficient to conclude about toxicological properties-the example of monoamine-based chelates.","authors":"Josje H E Arts, Sina Bader, Steffen Bade","doi":"10.1080/10408444.2024.2303487","DOIUrl":"10.1080/10408444.2024.2303487","url":null,"abstract":"Aminocarboxylic acid (monoamine-based) chelating agents such as GLDA, MGDA, NTA, and EDG are widely used in a variety of products and processes. In the European Union, based on the Green Deal and the Chemicals Strategy for Sustainability (CSS), there is an increasing tendency to speed up chemical hazard evaluation and to regulate chemicals by grouping substances based on molecular structure similarity. Recently, it was proposed to group polycarboxylic acid monoamines, hydroxy derivatives and their salts with monovalent cations, and to consider all group members as potential carcinogens based on the official CLP classification of one group member, viz. NTA, which is classified as suspected carcinogen Cat. 2. In this review, we show that a grouping approach for harmonized classification and labeling based on molecular structure alone, disregarding existing animal test data as well as current scientific and regulatory knowledge, would result in incorrect classification. Using such a simplistic, although considered pragmatic approach, classification of all group members upfront would not improve protection of human health. Instead, it could not only lead to unnecessary additional vertebrate animal testing but also to onerous and disproportionate restrictions being placed on the use of these valuable substances; some of these even being considered as green chemicals.","PeriodicalId":10869,"journal":{"name":"Critical Reviews in Toxicology","volume":" ","pages":"55-67"},"PeriodicalIF":5.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139545627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0