Current protein & peptide science最新文献_第2页

Phytoconstituents as Potential Therapeutics against Enzymatic Targets for Neurodegenerative Diseases. 植物成分作为抗神经退行性疾病酶靶点的潜在疗法。

IF 1.9 4区生物学

Current protein & peptide science Pub Date : 2025-05-27 DOI: 10.2174/0113892037350938250514110643

Harshita Singh, Veda Prakash Pandey

{"title":"Phytoconstituents as Potential Therapeutics against Enzymatic Targets for Neurodegenerative Diseases.","authors":"Harshita Singh, Veda Prakash Pandey","doi":"10.2174/0113892037350938250514110643","DOIUrl":"https://doi.org/10.2174/0113892037350938250514110643","url":null,"abstract":"Neurodegenerative diseases are brought on by the loss of function of nerve cells in the brain or peripheral nervous system and afflict millions of people worldwide. Parkinson's disease and Alzheimer's disease are the two most common neurodegenerative diseases. These neurodegenerative diseases are multi-factorial, progressive, age-related, and influenced by two factors: genetic and environmental. Successful treatment of neurodegenerative diseases is yet a challenging task due to lack of selectivity, toxicity, and the growth of multi-drug-resistant cells to the currently available drugs. Plant-derived, natural secondary metabolites have a significant impact on the research and development of novel medications against neurodegenerative disease. Plant-derived natural products are frequently regarded as safe and relatively safer substitutes for synthetic drugs. The present review deals with the elucidation of plant-derived secondary metabolites, namely alkaloids, flavonoids, and terpenoids, as anti-neurological therapeutics with special reference to various enzymatic targets, such as β-secretase, γ-secretase, α-Secretase, acetylcholinesterase, monoamine oxidase, and phosphodiesterase-4.","PeriodicalId":10859,"journal":{"name":"Current protein & peptide science","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aquatic BPI/LBPs: A Promising Antimicrobial Peptide Resource for Disease Control in Aquaculture. 水生BPI/ lbp：一种有前途的水产疾病控制抗菌肽资源。

IF 1.9 4区生物学

Current protein & peptide science Pub Date : 2025-05-27 DOI: 10.2174/0113892037364423250516032256

Jingxian Sun, Huiqi Deng, Bingyu Ning, Yaoyao Zhan, Yaqing Chang

{"title":"Aquatic BPI/LBPs: A Promising Antimicrobial Peptide Resource for Disease Control in Aquaculture.","authors":"Jingxian Sun, Huiqi Deng, Bingyu Ning, Yaoyao Zhan, Yaqing Chang","doi":"10.2174/0113892037364423250516032256","DOIUrl":"https://doi.org/10.2174/0113892037364423250516032256","url":null,"abstract":"Aquaculture is currently the fastest-growing food supply industry worldwide. Disease control has always been a core concern in the sector of aquaculture. In recent years, the frequency of aquaculture disease outbreaks has increased dramatically due to the continuously increased antibiotic resistance of pathogens. Therefore, it is imperative to find effective antibiotic alternatives for disease control in aquaculture. Bactericidal permeability increasing/lipopolysaccharide binding proteins (BPI/LBPs) are endogenous peptides ubiquitously expressed in aquatic animals that exhibit antimicrobial effects similar to antibiotics. This review presents an overview of current research on BPI/LBPs derived from aquatic animals, the predicted antimicrobial mechanisms of aquatic BPI/LBPs, and the application potential and prospects of aquatic BPI/LBPs as an antimicrobial peptide (AMP) resource. To sum up, the systematic research on aquatic BPI/LBPs may not only enrich AMP resources but also provide new clues for the development of eco-friendly disease control strategies in aquaculture.","PeriodicalId":10859,"journal":{"name":"Current protein & peptide science","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential of Circular RNAs (circRNAs) Neoantigen Vaccines in Tumor Immunotherapy. 环状rna （circRNAs）新抗原疫苗在肿瘤免疫治疗中的潜力

IF 1.9 4区生物学

Current protein & peptide science Pub Date : 2025-05-26 DOI: 10.2174/0113892037389566250515094946

Md Sadique Hussain, Vikas Jakhmola, Ayesha Sultana, Ajay Singh Bisht, Gyas Khan

{"title":"Potential of Circular RNAs (circRNAs) Neoantigen Vaccines in Tumor Immunotherapy.","authors":"Md Sadique Hussain, Vikas Jakhmola, Ayesha Sultana, Ajay Singh Bisht, Gyas Khan","doi":"10.2174/0113892037389566250515094946","DOIUrl":"https://doi.org/10.2174/0113892037389566250515094946","url":null,"abstract":"Circular RNAs (circRNAs) have emerged as promising candidates for neoantigen vaccine development due to their unique structural stability, enhanced translational efficiency, and immunostimulatory properties. Unlike linear RNAs, circRNAs exhibit exonuclease resistance, prolonged antigen expression, and increased activation of innate immune receptors such as RIG-I and MDA5, thereby enhancing anti-tumor immune responses. Preclinical studies have demonstrated that circRNA-based vaccines encoding tumor-specific neoantigens effectively stimulate Antigen- Presenting Cells (APCs), particularly Dendritic Cells (DCs), leading to robust CD8+ Cytotoxic T Lymphocyte (CTL) activation. This results in increased cytokine production, T-cell proliferation, and durable anti-tumor immunity. Compared to conventional neoantigen vaccine platforms, circRNA vaccines offer distinct advantages, including higher immunogenicity, improved cytosolic delivery, and minimal risk of genomic integration. CircRNA vaccines have demonstrated efficacy in preclinical tumor models, with studies highlighting their ability to induce long-term memory T-- cell responses and enhance the efficacy of immune checkpoint blockade therapies. However, challenges remain in optimizing circRNA delivery, mitigating unintended immune activation, and scaling up manufacturing processes. The translational potential of circRNA vaccines in tumor immunotherapy is significant, offering a novel and scalable approach to personalized cancer treatment. Further research and clinical validation are needed to optimize their design, improve manufacturing efficiency, and assess their efficacy in human trials. CircRNA vaccines represent a next-- generation platform with the potential to revolutionize cancer immunotherapy by harnessing durable and targeted anti-tumor immune responses.","PeriodicalId":10859,"journal":{"name":"Current protein & peptide science","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How Do Mitochondria Manage Competing Biochemical Metabolic Processes Under Stress? 线粒体如何在压力下管理竞争的生化代谢过程？

IF 1.9 4区生物学

Current protein & peptide science Pub Date : 2025-05-16 DOI: 10.2174/0113892037381885250506091434

Drew Hindrer, Tyler Stark, Selman Aydogdu, Cade Ward, Mohamed Eldeeb

引用次数: 0

Coupling of SARS-CoV-2 to Amyloid Fibrils and Liquid-Liquid Phase Separation. SARS-CoV-2与淀粉样蛋白原纤维的偶联及液-液相分离

IF 1.9 4区生物学

Current protein & peptide science Pub Date : 2025-05-08 DOI: 10.2174/0113892037354482250414045355

Hoang Linh Nguyen, Mai Suan Li

{"title":"Coupling of SARS-CoV-2 to Amyloid Fibrils and Liquid-Liquid Phase Separation.","authors":"Hoang Linh Nguyen, Mai Suan Li","doi":"10.2174/0113892037354482250414045355","DOIUrl":"https://doi.org/10.2174/0113892037354482250414045355","url":null,"abstract":"COVID-19 is a respiratory disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), but because the receptor protein of this virus can appear not only in the lungs and throat but also in various parts of the host's body, it causes different diseases. Recent observations have suggested that SARS-CoV-2 damages the central nervous system of patients in a manner similar to amyloid-associated neurodegenerative diseases such as Alzheimer's and Parkinson's. Neurodegenerative diseases are believed to be associated with the self-assembly of amyloid proteins and peptides. On the other hand, whole proteins or parts of them encoded by SARS-CoV-2 can form amyloid fibrils, which may play an important role in amyloid-related diseases. Motivated by this evidence, this mini-review discusses experimental and computational studies of SARS-CoV-2 proteins that can form amyloid aggregates. Liquid-Liquid Phase Separation (LLPS) is a dynamic and reversible process leading to the creation of membrane-less organelles within the cytoplasm, which is not bound by a membrane that concentrates specific types of biomolecules. These organelles play pivotal roles in cellular signaling, stress response, and the regulation of biomolecular condensates. Recently, LLPS of the Nucleocapsid (N) protein and SARS-CoV-2 RNA has been disclosed, but many questions about the phase separation mechanism and the formation of the virion core are still unclear. We summarize the results of this phenomenon and suggest potentially intriguing issues for future research.","PeriodicalId":10859,"journal":{"name":"Current protein & peptide science","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What Can Proteomics Tell us About COVID-19 Infections? Mass Spectrometry as a Tool to Find New Proteins as Biomarkers. 关于COVID-19感染，蛋白质组学能告诉我们什么？质谱法作为寻找新蛋白质作为生物标志物的工具。

IF 1.9 4区生物学

Current protein & peptide science Pub Date : 2025-05-08 DOI: 10.2174/0113892037364237250402151440

Laís L Brasil-Oliveira, Pedro F N Souza, Carlos R K Paier, Maria G L Bandeira, Lina C B Motta, Raquel C Montenegro, Maria E A de Moraes

{"title":"What Can Proteomics Tell us About COVID-19 Infections? Mass Spectrometry as a Tool to Find New Proteins as Biomarkers.","authors":"Laís L Brasil-Oliveira, Pedro F N Souza, Carlos R K Paier, Maria G L Bandeira, Lina C B Motta, Raquel C Montenegro, Maria E A de Moraes","doi":"10.2174/0113892037364237250402151440","DOIUrl":"https://doi.org/10.2174/0113892037364237250402151440","url":null,"abstract":"The COVID-19 outbreak, caused by the SARS-CoV-2 coronavirus, has threatened and taken many lives since the end of 2019. Given the importance of COVID-19 worldwide, since its spread, many research groups have been seeking blood markers that could help to understand the disease establishment and prognosis. Usually, those markers are proteins with a differential accumulation only during infection. Based on that, proteomic studies have played a crucial role in elucidating diseases. Mass spectrometry (MS) is a promising technique in COVID-19 studies, allowing the identification and quantification of proteins present in the plasma or serum of affected patients. It helps us to understand pathological mechanisms, predict clinical outcomes, and develop specific therapies. MS proteomics revealed biomarkers associated with infection, disease severity, and immune response. Plasma or blood serum is easy to collect and store; however, its composition and the higher concentration of proteins (e.g., albumins) shadow the identification of less abundant proteins, which usually are essential markers. So, clean-up approaches such as depletion strategies and fractionating are often required to analyze blood samples, allowing the identification of low-abundant proteins. This review will discuss many proteomic approaches to discovering new plasma biomarkers of COVID-19 employed in recently published studies. The challenges inherent to blood samples will also be discussed, such as sample preparation, data processing, and identifying reliable biomarkers.","PeriodicalId":10859,"journal":{"name":"Current protein & peptide science","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Bugs to Benefits: Edible Insects as Exceptional Protein Sources. 从虫子到好处：食用昆虫作为特殊的蛋白质来源。

IF 1.9 4区生物学

Current protein & peptide science Pub Date : 2025-05-06 DOI: 10.2174/0113892037379345250407143848

Ravi Kumar Mittal, Gaurav Krishna, Sohini Chowdhury, Sorabh Lakhanpal, Muhammed Shabil, Rajeev Sharma, Sahil Suri

引用次数: 0

Herbs and their Active Constituents for Gastric Cancer and Related Problems - Preclinical and Clinical Studies. 胃癌及相关问题的草药及其有效成分-临床前和临床研究。

IF 1.9 4区生物学

Current protein & peptide science Pub Date : 2025-05-06 DOI: 10.2174/0113892037353177250409095158

Pragya Singh, Neelam Singh, Dheeraj Nagpal, Puneet Gupta

{"title":"Herbs and their Active Constituents for Gastric Cancer and Related Problems - Preclinical and Clinical Studies.","authors":"Pragya Singh, Neelam Singh, Dheeraj Nagpal, Puneet Gupta","doi":"10.2174/0113892037353177250409095158","DOIUrl":"https://doi.org/10.2174/0113892037353177250409095158","url":null,"abstract":"Gastric cancer remains one of the leading cancer-related deaths worldwide. Despite the research advances, many challenges persist because the diseases are usually diagnosed at an advanced stage and have a complex treatment protocol. Conventional treatments such as chemotherapy, radiation, and surgery pose several side effects and low efficiency. The growing worldwide interest in herbal products, particularly, their bioactive ingredients, presents a promising prospect for auxiliary or alternative therapies for gastric cancer.. In vivo experiments show that the given compounds increase the effectiveness and decrease the cumulative harmful impact of conventional anticancer treatments, which may have additive effects. Furthermore, clinical trials have revealed that phytoconstituents have possible anti-gastric cancer properties in humans. Nonetheless, these encouraging preclinical observations have not progressed into clinical practice all that much due to the absence of adequately powered Phase III trials for GC. Therefore, this review stresses the need for well-controlled human interventions to confirm the effectiveness and safety of herb- based therapies. In the long run, the incorporation of these herbal products could present a new approach to constructing the gastric cancer prevention and treatment outlook while minimizing the side effects of conventional treatments and opening up arenas of functional foods and pharmaceuticals.","PeriodicalId":10859,"journal":{"name":"Current protein & peptide science","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A2 Milk: The Impact of Genetic Variation in Milk Protein on Human Health. A2牛奶：牛奶蛋白遗传变异对人体健康的影响。

IF 1.9 4区生物学

Current protein & peptide science Pub Date : 2025-04-24 DOI: 10.2174/0113892037366987250401183000

Leila Ben Farhat, Hiba Selmi, Violetta Toth, Amanda Hoarau, Agnes Suli, Kata Sara Labas, Abidi Ferid, Edit Mikó

{"title":"A2 Milk: The Impact of Genetic Variation in Milk Protein on Human Health.","authors":"Leila Ben Farhat, Hiba Selmi, Violetta Toth, Amanda Hoarau, Agnes Suli, Kata Sara Labas, Abidi Ferid, Edit Mikó","doi":"10.2174/0113892037366987250401183000","DOIUrl":"https://doi.org/10.2174/0113892037366987250401183000","url":null,"abstract":"Recently, a new type of cow's milk has been commercialized in the markets, called A2 milk. It is derived from a specific allelic composition on chromosome 6. The only difference between A1 and A2 milk results from the polymorphism at the 67 amino acid chain. In this position, A2 milk has a proline amino acid, while A1 milk has a histidine amino acid. Proteins are one of the most important components of milk, especially casein, and have received significant attention as they are the source of bioactive opioid peptides called beta-casomorphin-7. Peptides are released through enzymatic digestion of casein and whey proteins. More precisely, this bioactive peptide is produced by sequential gastrointestinal digestion of bovine A1 variants proteins, while this phenomenon is not present in variant A2. Studies have reported that A1 milk can be harmful to health not only for adults but also for infants and that β-casein A2 becomes a safer choice following the relationship between disease risk and consumption of the beta-casomorphin-7 peptide. Indeed, epidemiological studies suggest that the released beta-casomorphin-7 peptide is a risk factor for the development of diseases in humans, but this has not yet been validated by other studies. In contrast, A2 milk has been suggested as an appropriate substitute for A1 milk since populations consuming milk containing high levels of the A2 beta-casein variant have lower rates of diseases, such as diabetes, coronary heart disease, autism, and schizophrenia.","PeriodicalId":10859,"journal":{"name":"Current protein & peptide science","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Messenger RNA Nanomedicine: Innovations and Future Directions. 信使RNA纳米医学：创新与未来方向。

IF 1.9 4区生物学

Current protein & peptide science Pub Date : 2025-04-23 DOI: 10.2174/0113892037357900250401020207

Jyotsana Dwivedi, Pranay Wal, Subbulakshmi Ganesan, Ashish Sharma, Pawan Sharma, Syeda Wajida Kazmi, Reena Gupta

{"title":"Messenger RNA Nanomedicine: Innovations and Future Directions.","authors":"Jyotsana Dwivedi, Pranay Wal, Subbulakshmi Ganesan, Ashish Sharma, Pawan Sharma, Syeda Wajida Kazmi, Reena Gupta","doi":"10.2174/0113892037357900250401020207","DOIUrl":"https://doi.org/10.2174/0113892037357900250401020207","url":null,"abstract":"With its high potential, mRNA nanomedicine has become one of the transformative frontiers of modern therapeutic strategies for treating and preventing a wide array of diseases. This review article covers recent developments in mRNA nanomedicine and its prospects in terms of innovations in drug delivery systems, stability improvements, and targeted therapeutic applications. The versatility of mRNA means that almost any protein can potentially be encoded into it, making it a powerhouse for vaccines, gene editing, and protein replacement therapies. Recent breakthroughs in nanoparticle technology have significantly enhanced mRNA molecules' delivery efficiency and stability, surmounting previous barriers concerning rapid degradation and immune system activation. It has been developed Innovations such as LNPs, polymer-based carriers, and hybrid nanocarriers have been central to the success of targeted delivery and the sustained release of mRNA. This review further underlines the potential of mRNA nanomedicine for oncological, infectious, and genetic diseases by highlighting ongoing clinical trials, emerging therapeutic paradigms, and future directions that lay much emphasis on delivery platform optimization, mRNA stability, and broadening the scope of mRNA nanomedicine therapy. With the power of emerging technologies and solving present challenges, mRNA nanomedicine has a vast potential to revolutionize the future landscape of personalized medicine and targeted therapies.","PeriodicalId":10859,"journal":{"name":"Current protein & peptide science","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0