Fatima Akram, Zoha Naeem Rana, Ifrah Shabbir, Taseer Fatima, Ikram Ul Haq
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引用次数: 0
Abstract
Circular RNAs, or circRNAs, play a key role in breast cancer biology, directly impacting the diagnosis, prognosis, and treatment of the disease. This review explores the mechanisms, regulatory roles, and functional significance of circRNAs in breast cancer. Overexpressed circRNAs regulate gene expression, cell cycle progression, and drug response in breast cancer. This process is facilitated by the interaction between small RNA molecules (miRNAs) and proteins that can bind to RNA (RBPs), which target the main messenger RNA (mRNA). Consequently, they influence gene expression, cellular proliferation, and drug resistance. Dysregulated circRNA expression contributes to breast cancer progression by promoting tumor aggressiveness and treatment resistance.
期刊介绍：
Current Protein & Peptide Science publishes full-length/mini review articles on specific aspects involving proteins, peptides, and interactions between the enzymes, the binding interactions of hormones and their receptors; the properties of transcription factors and other molecules that regulate gene expression; the reactions leading to the immune response; the process of signal transduction; the structure and function of proteins involved in the cytoskeleton and molecular motors; the properties of membrane channels and transporters; and the generation and storage of metabolic energy. In addition, reviews of experimental studies of protein folding and design are given special emphasis. Manuscripts submitted to Current Protein and Peptide Science should cover a field by discussing research from the leading laboratories in a field and should pose questions for future studies. Original papers, research articles and letter articles/short communications are not considered for publication in Current Protein & Peptide Science.
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