Current Obesity Reports最新文献

{"title":"Synergistic Intervention for Obesity: Integrating Central Appetite Regulation and Peripheral Energy Expenditure.","authors":"Jiayan Xie, Yujing Yang, Wanting Chen, Lu Wang, Siying Weng, Qiang Lyu, Gang Cao","doi":"10.1007/s13679-026-00722-7","DOIUrl":"10.1007/s13679-026-00722-7","url":null,"abstract":"<p><strong>Purpose of review: </strong>Obesity stems from a chronic imbalance between energy intake and expenditure. Current therapeutic strategies primarily focus on reducing caloric intake, yet their long-term efficacy is often limited by compensatory metabolic adaptations that lead to weight regain. This review outlines the neural mechanisms through which the central nervous system regulates appetite and the peripheral metabolic pathways that drive adipose thermogenesis. Furthermore, it examines how integrated approaches-spanning from approved to preclinical and clinical-stage investigational agents (e.g., dual- or multi-target agonists), microbiome-targeted interventions (e.g., probiotics), and exercise therapy-can synergistically overcome the limitations of single-pathway strategies. Ultimately, this review provides a theoretical foundation for designing next-generation, personalized, multimodal obesity management regimens.</p><p><strong>Recent findings: </strong>Traditional weight-loss drugs primarily act by centrally suppressing appetite, reducing food intake through modulation of neural circuits in regions such as the hypothalamus. However, studies show that relying on appetite suppression often triggers compensatory metabolic adaptation, ultimately leading to weight regain. Current anti-obesity drug development is therefore shifting toward integrated central-peripheral dual mechanisms. GLP‑1/glucagon dual-receptor agonists and triple-receptor agonists (such as retatrutide) have exhibited unprecedented weight-loss efficacy in clinical trials. These novel agents overcome the limitations of single-target appetite suppression by synergistically integrating central anorexigenic signaling with peripherally mediated increases in energy expenditure, thereby achieving more potent and durable weight reduction. The sustainability of obesity treatment relies on a dual-pronged intervention strategy: suppressing appetite to reduce energy intake while actively promoting energy expenditure, thereby overcoming the metabolic adaptation and weight rebound associated with monotherapy.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":17.0,"publicationDate":"2026-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148175578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health Care Professionals' Barriers and Facilitators for the Implementation of Lifestyle Interventions Targeting Weight Loss in Primary Care - A Systematic Review of Qualitative Studies.","authors":"Maxime A M Van der Velden, Priya Gharbaran, Nuria Jansen, Maxim de Jong, Patrick J E Bindels, Marienke Van Middelkoop","doi":"10.1007/s13679-026-00721-8","DOIUrl":"10.1007/s13679-026-00721-8","url":null,"abstract":"<p><strong>Purpose of review: </strong>This systematic review aims to investigate barriers and facilitators that Health Care Professionals (HCPs) experience during the implementation of a lifestyle intervention for patients with overweight or obesity targeting weight loss in primary care.</p><p><strong>Recent findings: </strong>Overweight and obesity are one of the most pressing public health problems worldwide and have severe health consequences. Lifestyle interventions are the first treatment in line for patients with overweight and obesity. HCPs are trained to provide lifestyle interventions, but implementing these interventions in primary care remains challenging as HCPs face multiple barriers. There is no clear overview of the perceived barriers and facilitators experienced by HCPs to implement lifestyle interventions targeting weight loss for patients with overweight or obesity in primary care. Main reported barriers by HCPs were lack of time, unavailability of staff, lack of tools and limited financial resources. Interventions fitting HCPs workflow, structural financial support, training and tools were reported as facilitators for successful implementation of the intervention. Policy makers should ensure future lifestyle interventions take these barriers and facilitators into account enhancing the implementation and delivery of the intervention by HCPs to their patients in practice.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":17.0,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13236802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148155638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Fathers in the Intergenerational Transmission of Obesity.","authors":"Matthew J Landry, John James Parker","doi":"10.1007/s13679-026-00720-9","DOIUrl":"10.1007/s13679-026-00720-9","url":null,"abstract":"<p><strong>Purpose of review: </strong>This narrative review aims to synthesize recent evidence demonstrating that paternal influences can significantly affect child obesity risk through biological, psychosocial, and behavioral pathways and to highlight implications for clinical practice, public health, and research.</p><p><strong>Recent findings: </strong>Paternal obesity influences offspring metabolic health through three primary mechanisms. Biologically, paternal obesity alters sperm epigenetic signatures, which are transmissible to offspring and modifiable through preconception lifestyle interventions. Behaviorally, fathers' dietary quality, physical activity, feeding practices, and parenting styles directly shape children's eating patterns and activity levels, with the transition to fatherhood representing a critical period when paternal weight gain and lifestyle changes commonly occur. Socioecologically, social determinants of health including food insecurity, neighborhood characteristics, and paternal mental health create shared family-level exposures that simultaneously influence paternal physiology, parenting behaviors, and childhood adversity, compounding obesity risk across generations. Fathers play a pivotal role in shaping child obesity risk from preconception through childhood. Advancing obesity prevention requires expanding preconception counseling to include fathers, implementing father-inclusive perinatal education and obesity prevention programs, adopting workplace policies that support paternal engagement, and prioritizing research that elucidates paternal contributions to intergenerational obesity transmission.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":17.0,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13212774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148027935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Have Researchers Estimated the Impact of Excess Weight on Mortality? A Systematic Review.","authors":"Guadalupe García, Cristina Candal-Pedreira, Julia Rey-Brandariz, Lucía de Luis Cid, Mónica Pérez-Ríos","doi":"10.1007/s13679-026-00719-2","DOIUrl":"10.1007/s13679-026-00719-2","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this review is to describe and reflect on the methodology of the studies that estimate the attributable mortality (AM) to excess weight. The purpose was to provide a methodological framework and serve as a starting point to improve the estimation of AM to excess weight. This will lead to more comparable estimates over time and across countries.</p><p><strong>Methods: </strong>A systematic review was conducted considering MEDLINE (Ovid), Embase and Web of Science databases. Studies that had estimated AM to excess weight published until December 2024 were included. Data extraction was performed in an ad-hoc table based on the STREAMS-P tool, and a descriptive analysis of the methodology employed was performed.</p><p><strong>Results: </strong>The search strategy yielded 2,163 results. Twenty-three studies estimating AM in four continents were included. The majority estimated AM to all-cause mortality (n = 9) and for cardiovascular diseases (n = 9), followed by cancer without specifying which type of cancer (n = 7). Variation was observed in the body mass index (BMI) cut-off points used to define overweight, obesity and excess weight. Thirteen studies applied the population attributable fraction (PAF) formula denoted by PAF = [P (RR-1)] / [1 + P (RR-1)]. Most of the relative risks (RR) derived from meta-analysis (n = 14), and only a minority studies (n = 6) used RR from national studies based on the population for which AM was estimated.</p><p><strong>Conclusion: </strong>This review emphasizes methodological constraints on AM estimation to excess weight. Causes of death causally associated with excess weight should be prioritized rather than relying solely on all-cause mortality. The ideal scenario would be to consider lag times; RR derived from the population under study and to use WHO BMI cut-offs and measured data rather than self-reported weight and height. The absence of this data should not prevent AM estimation if limitations are acknowledged. Expanding available estimates worldwide is essential to improve understanding of the mortality burden associated with excess weight.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":17.0,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13201345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of Intrapancreatic Fat Deposition in Type 2 Diabetes and the Role of Obesity: A Systematic Review and Meta-Analysis.","authors":"Hyun Hee Sul, Saeed Ahmad, Pojsakorn Danpanichkul, Alessandro Mantovani, Matheus Souza, Maxim S Petrov","doi":"10.1007/s13679-026-00718-3","DOIUrl":"10.1007/s13679-026-00718-3","url":null,"abstract":"<p><strong>Background: </strong>Growing evidence supports a role for high intrapancreatic fat deposition (IPFD) in the pathogenesis of type 2 diabetes mellitus (T2DM); however, the magnitude of this association and the extent to which it is influenced by body mass index (BMI), liver fat content (LFC), and age remain uncertain.</p><p><strong>Objective: </strong>To quantitatively evaluate IPFD measured by magnetic resonance imaging (MRI) in individuals with T2DM and to investigate study-level factors contributing to between-study variability.</p><p><strong>Methods: </strong>We systematically searched PubMed and Embase for observational studies comparing MRI-measured IPFD in individuals with T2DM versus non-diabetic controls, excluding studies in which IPFD quantification was performed using AI-based models. Pooled standardized mean differences (SMDs) were estimated using a restricted maximum likelihood approach with Hartung-Knapp adjustment. Heterogeneity was explored through subgroup, meta-regression, and sensitivity analyses.</p><p><strong>Results: </strong>Thirty studies (n=3,980) were included. Individuals with T2DM had significantly higher IPFD than non-diabetic controls (SMD 1.13, 95% CI 0.74 to 1.51), with no significant differences when stratified by pancreatic region, MRI technique, geographic region, sample size, and risk of bias. In multivariable models, BMI remained the only consistent moderating covariate, and the excess IPFD in T2DM persisted after adjusting for BMI, LFC, and age (intercept=0.797, p=0.010, false discovery rate-adjusted p=0.018). Advanced heterogeneity exploration identified no structural outliers, and the pooled effect size remained consistent across multiple sensitivity analyses.</p><p><strong>Conclusion: </strong>T2DM is associated with substantially higher MRI-quantified IPFD, independent of study-level differences in BMI, LFC, and age. Although causality cannot be inferred, these findings support the hypothesis that IPFD may be involved in the underlying mechanism of T2DM. They also suggest that high IPFD could represent a metabolic hallmark, with potential implications for risk stratification and therapeutic targeting.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":17.0,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13190432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autophagy in Obesity and Type 2 Diabetes: Beyond the Protective Paradigm.","authors":"M Elena Angarita-Plánchez, Paula Sánchez-Rodríguez, Ana M Múnera-Rodríguez, Camila Leiva-Castro, Juan Manuel Benítez-Márquez, Icíar Reina-Pérez, Francisca Palomares, Soledad López-Enríquez","doi":"10.1007/s13679-026-00716-5","DOIUrl":"10.1007/s13679-026-00716-5","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review examines the current evidence on autophagy dysregulation in obesity and type 2 diabetes mellitus (T2DM), with particular emphasis on its tissue-specific nature and implications for clinical translation.</p><p><strong>Recent findings: </strong>Recent human and preclinical evidence indicates that autophagic alterations in metabolic disease are not uniformly suppressed but vary according to tissue type and disease stage. In adipose tissue, liver, skeletal muscle, pancreatic β cells, and immune cells, dysregulated mTORC1-AMPK signaling, defective mitophagy, and impaired lysosomal function contribute to insulin resistance, ectopic lipid accumulation, and metaflammation. However, most human studies rely on static markers such as LC3, p62, and Beclin-1, which do not reliably reflect dynamic autophagic flux. Recent advances, including organelle-specific biomarkers, ex vivo functional assays, and circulating exosomal cargo, offer new translational opportunities, although standardization remains limited. Autophagy in metabolic disease represents a context-dependent maladaptation rather than a uniformly protective pathway. Future progress will depend on harmonized biomarker panels, functional assessment of autophagic flux in humans, and integration with metabolic phenotyping to enable precision-based therapeutic strategies.</p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":17.0,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13156086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Epidemiology of the Global Syndemic in Africa: New Evidence and Key Insights.","authors":"Reuben Simfukwe, Felix P Chilunga, Charles Agyemang","doi":"10.1007/s13679-026-00717-4","DOIUrl":"10.1007/s13679-026-00717-4","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: Over the past decade, Sub-Saharan Africa has entered a new phase in the evolution of the global syndemic of undernutrition, obesity, and climate change. Earlier reviews, largely based on evidence before 2018, documented the emergence of overlapping nutritional and environmental vulnerabilities. This review provides an updated synthesis of epidemiological evidence published between 2019 and 2025 to capture recent shifts in magnitude, distribution, and interactions of the syndemic components across Africa. RECENT FINDINGS: Recent data indicate that adult obesity prevalence in the African region reached 12% in 2022, rising from 9% in 2010, with marked sex differences of approximately 17% among women and 7% among men. Overweight and obesity among children and adolescents remain lower but are increasing, with an estimated three million children affected in 2022. At the same time, undernutrition remains highly prevalent. Between 2019 and 2025, child stunting ranged from 9% to 46%, wasting from 4% to 43%, and anaemia from 19% to 61% across countries in the African region. Food insecurity increased from 17% in 2019 to 20% in 2025, affecting approximately 282 million people. During the same period, climate-related shocks intensified. Extreme weather events affected 34 million people in Africa in 2023 alone, further disrupting food systems, reducing dietary diversity, and reinforcing reliance on energy-dense, nutrient-poor diets. Evidence now more clearly demonstrates that undernutrition, obesity, and climate stressors co-occur within the same populations and households, rather than representing sequential transitions. This update highlights advances in surveillance, analytical methods, and early warning systems since 2019, while identifying persistent gaps in longitudinal data, integration of nutrition and climate information, and policy implementation. Addressing the contemporary global syndemic in Africa requires context-specific, multisectoral strategies that prioritise double- and triple-duty actions to simultaneously reduce nutritional and climate vulnerability. </p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":17.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13121359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prioritising Indicators for Large-scale Monitoring and Assessment of Food Environments for Public Health.","authors":"Lana Vanderlee, Kelly Garton, Mavra Ahmed, Kathryn Backholer, Carolina Batis, Marie A Bragg, Emma Boyland, Adrian J Cameron, Luciana Castronuovo, Elizabeth K Dunford, Clara Gómez-Donoso, Guanlan Hu, Alexandra Jones, Bridget Kelly, Amos Laar, Meron Lewis, Christiam Méndez-Lazarte, Sally Mackay, Christina M Pollard, Erica Reeve, Sally Schultz, Tailane Scapin, Suzanne Soares-Wynter, Rina Swart, Boyd Swinburn, Caroline Vaillancourt, Gary Sacks","doi":"10.1007/s13679-026-00705-8","DOIUrl":"10.1007/s13679-026-00705-8","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: This study aimed to prioritise key indicators for monitoring and assessing the healthiness of food environments, including at the country level. We conducted a literature review and engaged a consortium of researchers from the International Network for Food environments Research, Monitoring and Action Support (INFORMAS) as part of a prioritisation process. RECENT FINDINGS: We identified 375 existing indicators that had been used to measure food environments. Researchers were consulted on priorities and implementation considerations through a series of interviews, focus groups and an online survey. Sixteen indicators were short-listed for prioritisation, and five indicators were identified as key priorities: proportion of packaged food and drinks products classified as unhealthy; frequency of exposure to unhealthy food promotion; price of a healthy diet and the price of the current diet as a proportion of income; proportion of schools in which unhealthy foods are provided or available for sale regularly; and application of back of package and front of package food labelling. This study lays the groundwork for standardised and scalable food environment monitoring that can drive policy action to support healthier food environments globally. Future areas for inquiry include tools to classify healthy foods and outlets, which could be adapted across policy areas, and the establishment of evidence-informed benchmarks for assessment of each indicator. </p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":17.0,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147765056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Dysfunction-Associated Steatotic Liver Disease and Respiratory Disorders: A Systematic Review of Clinical and Pathophysiological Associations.","authors":"Vasiliki Epameinondas Georgakopoulou, Paschalis Steiropoulos, Theodoros Androutsakos, Irena Karabella, Konstantinos Reppas, Evangelos Cholongitas, Maria Dalamaga","doi":"10.1007/s13679-026-00713-8","DOIUrl":"10.1007/s13679-026-00713-8","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: Metabolic dysfunction–associated steatotic liver disease (MASLD) represents the hepatic manifestation of ectopic fat accumulation and adipose tissue dysfunction. Excess visceral adiposity promotes adipose tissue hypoxia, macrophage infiltration, and chronic low-grade systemic inflammation, generating systemic metabolic stress that may extend to the lung through a proposed liver–lung axis (hepatopulmonary crosstalk). This systematic review synthesizes current evidence on the associations between MASLD and major respiratory diseases, with emphasis on shared obesity-driven mechanisms. A systematic review was conducted in accordance with the PRISMA 2020 guidelines and registered in PROSPERO (CRD420261301893). PubMed/MEDLINE, Embase, Web of Science, and Google Scholar were searched from inception through February 28, 2026. RECENT FINDINGS: Twenty-two studies, 21 observational and 1 Mendelian randomization study (MRS) study reported associations between MASLD and several respiratory conditions, including chronic obstructive pulmonary disease (COPD), asthma, obstructive sleep apnea (OSA), interstitial lung disease, pulmonary hypertension, and respiratory mortality. MASLD prevalence was high among patients with COPD and OSA, and was associated with worse respiratory phenotypes, increased exacerbations, and higher respiratory mortality in several cohorts. Liver fibrosis appeared more strongly associated with impaired lung function and adverse outcomes than steatosis alone. MRS were critically re-evaluated, and do not consistently support causal relationships for most respiratory conditions, with the exception of OSA, which showed evidence suggestive of a potential causal association. Shared mechanisms include visceral adiposity, adipokine imbalance, insulin resistance, systemic cytokine activation (IL-6, TNF-α), endothelial dysfunction, oxidative stress, intermittent hypoxia, and profibrotic transforming growth factor-beta (TGF-β)–mediated pathways. Current evidence supports a clinically significant association between MASLD and respiratory disease, particularly COPD, OSA and asthma. Recognizing MASLD as a marker of systemic metabolic dysfunction may improve integrated cardiometabolic and pulmonary risk stratification. Prospective and interventional studies targeting weight reduction and metabolic signaling are needed to clarify causality and therapeutic implications. </p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":17.0,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intersectionality in Weight Stigma Research: A Systematic Review of Empirical Evidence.","authors":"Abdul-Hanan Saani Inusah, Menglin Shang, Xiaoming Li, Shan Qiao","doi":"10.1007/s13679-026-00715-6","DOIUrl":"10.1007/s13679-026-00715-6","url":null,"abstract":"<p><p>BACKGROUND: Social stigma and discrimination based on body weight or size (weight stigma) contribute to inequities in healthcare access, yet research often treats weight stigma as a uniform exposure. Intersectionality has been invoked to address this limitation by situating weight stigma within intersecting systems of power and marginalization. However, how intersectionality is operationalized in empirical weight stigma research remains unclear. OBJECTIVE: To examine how intersectionality is theoretically conceptualized and analytically operationalized in empirical studies of weight stigma, and to synthesize main intersectional findings. METHODS: A PRISMA-guided systematic review was conducted using PubMed, Embase, PsycINFO, and Web of Science, with searches through December 12, 2024. Studies applying intersectionality in the context of weight stigma were included. Data were extracted on theoretical grounding, analytic strategies, measurement approaches, intersectional axes, outcomes, findings, and study quality. RESULTS: Twenty-one studies met the inclusion criteria (10 qualitative, 11 quantitative). Analytic approaches to intersectionality varied across studies. Four themes emerged: co-occurring stigma across identities, context-specific manifestations, group differences in weight stigma, and cumulative intersectional disadvantage. Across these themes, weight stigma co-occurred with other forms of marginalization and varied across intersecting social identities, contributing to differences in healthcare access and everyday social experiences, with heterogeneous patterns observed across populations. CONCLUSIONS: Findings indicate that weight stigma operates through co-occurring systems of marginalization and varies across intersecting social identities, with important implications for health equity. However, approaches to operationalizing intersectionality remain inconsistent, highlighting a need for greater alignment between theoretical frameworks and analytic strategies. </p>","PeriodicalId":10846,"journal":{"name":"Current Obesity Reports","volume":"15 1","pages":""},"PeriodicalIF":17.0,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13079528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}