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In vivo gene delivery to immune cells 体内免疫细胞基因递送。
IF 7.1 2区 工程技术
Current opinion in biotechnology Pub Date : 2024-07-06 DOI: 10.1016/j.copbio.2024.103169
Jamison C Siebart , Ching S Chan , Xinyi Yao , Fang-Yi Su , Gabriel A Kwong
{"title":"In vivo gene delivery to immune cells","authors":"Jamison C Siebart ,&nbsp;Ching S Chan ,&nbsp;Xinyi Yao ,&nbsp;Fang-Yi Su ,&nbsp;Gabriel A Kwong","doi":"10.1016/j.copbio.2024.103169","DOIUrl":"10.1016/j.copbio.2024.103169","url":null,"abstract":"<div><p>Immune cell therapies are an emerging class of living drugs that rely on the delivery of therapeutic transgenes to enhance, modulate, or restore cell function, such as those that encode for tumor-targeting receptors or replacement proteins. However, many cellular immunotherapies are autologous treatments that are limited by high manufacturing costs, typical vein-to-vein time of 3–4 weeks, and severe immune-related adverse effects. To address these issues, different classes of gene delivery vehicles are being developed to target specific immune cell subsets <em>in vivo</em> to address the limitations of <em>ex vivo</em> manufacturing, modulate therapeutic responses <em>in situ</em>, and reduce on- and off-target toxicity. The success of <em>in vivo</em> gene delivery to immune cells — which is being tested at the preclinical and clinical stages of development for the treatment of cancer, infectious diseases, and autoimmunity — is paramount for the democratization of cellular immunotherapies.</p></div>","PeriodicalId":10833,"journal":{"name":"Current opinion in biotechnology","volume":null,"pages":null},"PeriodicalIF":7.1,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plant synthetic biology as a tool to help eliminate hidden hunger 以植物合成生物学为工具，帮助消除隐性饥饿。
IF 7.1 2区 工程技术
Current opinion in biotechnology Pub Date : 2024-07-02 DOI: 10.1016/j.copbio.2024.103168
Ryan A Edwards , Xiao Y Ng , Matthew R Tucker , Jenny C Mortimer
{"title":"Plant synthetic biology as a tool to help eliminate hidden hunger","authors":"Ryan A Edwards ,&nbsp;Xiao Y Ng ,&nbsp;Matthew R Tucker ,&nbsp;Jenny C Mortimer","doi":"10.1016/j.copbio.2024.103168","DOIUrl":"10.1016/j.copbio.2024.103168","url":null,"abstract":"<div><p>Agricultural systems are under increasing pressure from declining environmental conditions, a growing population, and changes in consumer preferences, resulting in widespread malnutrition-related illnesses. Improving plant nutritional content through biotechnology techniques such as synthetic biology is a promising strategy to help combat hidden hunger caused by the lack of affordable and healthy foods in human diets. Production of compounds usually found in animal-rich diets, such as vitamin D or omega-3 fatty acids, has been recently demonstrated <em>in planta</em>. Here, we review recent biotechnological approaches to biofortifying plants with vitamins, minerals, and other metabolites, and summarise synthetic biology advances that offer the opportunity to build on these early biofortification efforts.</p></div>","PeriodicalId":10833,"journal":{"name":"Current opinion in biotechnology","volume":null,"pages":null},"PeriodicalIF":7.1,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0958166924001046/pdfft?md5=56e11f0011719eac895f4829d4533464&pid=1-s2.0-S0958166924001046-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harnessing the potential of the microbial sulfur cycle for environmental biotechnology 将微生物硫循环的潜力用于环境生物技术。
IF 7.1 2区 工程技术
Current opinion in biotechnology Pub Date : 2024-07-02 DOI: 10.1016/j.copbio.2024.103164
Suyash Gupta , Caroline M Plugge , Gerard Muyzer , Irene Sánchez-Andrea
{"title":"Harnessing the potential of the microbial sulfur cycle for environmental biotechnology","authors":"Suyash Gupta ,&nbsp;Caroline M Plugge ,&nbsp;Gerard Muyzer ,&nbsp;Irene Sánchez-Andrea","doi":"10.1016/j.copbio.2024.103164","DOIUrl":"10.1016/j.copbio.2024.103164","url":null,"abstract":"<div><p>The sulfur cycle is a complex biogeochemical cycle characterized by the high variability in the oxidation states of sulfur. While sulfur is essential for life processes, certain sulfur compounds, such as hydrogen sulfide, are toxic to all life forms. Micro-organisms facilitate the sulfur cycle, playing a prominent role even in extreme environments, such as soda lakes, acid mine drainage sites, hot springs, and other harsh habitats. The activity of these micro-organisms presents unique opportunities for mitigating sulfur-based pollution and enhancing the recovery of sulfur and metals. This review highlights the application of sulfur-oxidizing and -reducing micro-organisms in environmental biotechnology through three illustrative examples. Additionally, it discusses the challenges, recent trends, and prospects associated with these applications.</p></div>","PeriodicalId":10833,"journal":{"name":"Current opinion in biotechnology","volume":null,"pages":null},"PeriodicalIF":7.1,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0958166924001009/pdfft?md5=d01290b291ced25a0278c2ed004ffcf9&pid=1-s2.0-S0958166924001009-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biofabrication strategies for cardiac tissue engineering 心脏组织工程的生物制造策略。
IF 7.1 2区 工程技术
Current opinion in biotechnology Pub Date : 2024-06-27 DOI: 10.1016/j.copbio.2024.103166
Sargol Okhovatian , Ramak Khosravi , Erika Y Wang , Yimu Zhao , Milica Radisic
{"title":"Biofabrication strategies for cardiac tissue engineering","authors":"Sargol Okhovatian ,&nbsp;Ramak Khosravi ,&nbsp;Erika Y Wang ,&nbsp;Yimu Zhao ,&nbsp;Milica Radisic","doi":"10.1016/j.copbio.2024.103166","DOIUrl":"10.1016/j.copbio.2024.103166","url":null,"abstract":"<div><p>Biofabrication technologies hold the potential to provide high-throughput, easy-to-operate, and cost-effective systems that recapitulate complexities of the native heart. The size of the fabricated model, printing resolution, biocompatibility, and ease-of-fabrication are some of the major parameters that can be improved to develop more sophisticated cardiac models. Here, we review recent cardiac engineering technologies ranging from microscaled organoids, millimeter-scaled heart-on-a-chip platforms, <em>in vitro</em> ventricle models sized to the fetal heart, larger cardiac patches seeded with billions of cells, and associated biofabrication technologies used to produce these models. Finally, advancements that facilitate model translation are discussed, such as their application as carriers for bioactive components and cells <em>in vivo</em> or their capability for drug testing and disease modeling <em>in vitro</em>.</p></div>","PeriodicalId":10833,"journal":{"name":"Current opinion in biotechnology","volume":null,"pages":null},"PeriodicalIF":7.1,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Something ‘Old, New, Borrowed, or Blue’, the Search for Mother Nature’s Bioactive Agents 新、旧、借、蓝"，寻找大自然母亲的生物活性物质。
IF 7.1 2区 工程技术
Current opinion in biotechnology Pub Date : 2024-06-24 DOI: 10.1016/j.copbio.2024.103162
David J Newman
{"title":"Something ‘Old, New, Borrowed, or Blue’, the Search for Mother Nature’s Bioactive Agents","authors":"David J Newman","doi":"10.1016/j.copbio.2024.103162","DOIUrl":"10.1016/j.copbio.2024.103162","url":null,"abstract":"<div><p>In the following examples, the time frames and ultimate results are measured in years, not days or months. In particular, the application of genetic techniques to complex systems requires many investigators and a multitude of false leads. The areas chosen are all related to the identification and use of techniques from many scientific fields. Except for the necessity of describing the many years of work required to identify and then utilize the genetic information from yet uncultivated microbes, and identifying the true sources of the dolastatins, the rest of the examples are quite short with commentaries on most of the references given.</p></div>","PeriodicalId":10833,"journal":{"name":"Current opinion in biotechnology","volume":null,"pages":null},"PeriodicalIF":7.1,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141449943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industrializing methanotrophs and other methylotrophic bacteria: from bioengineering to product recovery 甲烷营养菌和其他甲基营养菌的工业化：从生物工程到产品回收
IF 7.7 2区 工程技术
Current opinion in biotechnology Pub Date : 2024-06-18 DOI: 10.1016/j.copbio.2024.103167
Dominic Sauvageau , Lisa Y Stein , Elizabeth Arenas , Shibashis Das , Maryssa Iacobelli , Mark Lawley , Marina Lazic , Fabián L Rondón , Cerrise Weiblen
{"title":"Industrializing methanotrophs and other methylotrophic bacteria: from bioengineering to product recovery","authors":"Dominic Sauvageau ,&nbsp;Lisa Y Stein ,&nbsp;Elizabeth Arenas ,&nbsp;Shibashis Das ,&nbsp;Maryssa Iacobelli ,&nbsp;Mark Lawley ,&nbsp;Marina Lazic ,&nbsp;Fabián L Rondón ,&nbsp;Cerrise Weiblen","doi":"10.1016/j.copbio.2024.103167","DOIUrl":"https://doi.org/10.1016/j.copbio.2024.103167","url":null,"abstract":"<div><p>Microbes that use the single-carbon substrates methanol and methane offer great promise to bioindustry along with substantial environmental benefits. Methanotrophs and other methylotrophs can be engineered and optimized to produce a wide range of products, from biopolymers to biofuels and beyond. While significant limitations remain, including delivery of single-carbon feedstock to bioreactors, efficient growth, and scale-up, these challenges are being addressed and notable improvements have been rapid. Development of expression chassis, use of genome-scale and regulatory models based on omics data, improvements in bioreactor design and operation, and development of green product recovery schemes are enabling the rapid development of single-carbon bioconversion in the industrial space.</p></div>","PeriodicalId":10833,"journal":{"name":"Current opinion in biotechnology","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0958166924001034/pdfft?md5=e39e99cb46790df3e87c8fa4d0d96530&pid=1-s2.0-S0958166924001034-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141423209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Future directions in microbial nitrogen cycling in wastewater treatment 废水处理中微生物氮循环的未来方向
IF 7.7 2区 工程技术
Current opinion in biotechnology Pub Date : 2024-06-18 DOI: 10.1016/j.copbio.2024.103163
Dario R Shaw , Akihiko Terada , Pascal E Saikaly
{"title":"Future directions in microbial nitrogen cycling in wastewater treatment","authors":"Dario R Shaw ,&nbsp;Akihiko Terada ,&nbsp;Pascal E Saikaly","doi":"10.1016/j.copbio.2024.103163","DOIUrl":"https://doi.org/10.1016/j.copbio.2024.103163","url":null,"abstract":"<div><p>Discoveries in the past decade of novel reactions, processes, and micro-organisms have altered our understanding of microbial nitrogen cycling in wastewater treatment systems. These advancements pave the way for a transition toward more sustainable and energy-efficient wastewater treatment systems that also minimize greenhouse gas emissions. This review highlights these innovative directions in microbial nitrogen cycling within the context of wastewater treatment. Processes such as comammox, Feammox, electro-anammox, and nitrous oxide mitigation offer innovative approaches for sustainable, energy-efficient nitrogen removal. However, while these emerging processes show promise, advancing from laboratory research to practical applications, particularly in decentralized systems, remains a critical next step toward a sustainable and efficient wastewater management.</p></div>","PeriodicalId":10833,"journal":{"name":"Current opinion in biotechnology","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141423210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unleashing plant synthetic capacity: navigating regulatory mechanisms for enhanced bioproduction and secondary metabolite discovery 释放植物合成能力：探索调控机制，促进生物生产和次生代谢物的发现
IF 7.7 2区 工程技术
Current opinion in biotechnology Pub Date : 2024-06-05 DOI: 10.1016/j.copbio.2024.103148
Rongbin Hu , Xiaoxuan Teng , Yanran Li
{"title":"Unleashing plant synthetic capacity: navigating regulatory mechanisms for enhanced bioproduction and secondary metabolite discovery","authors":"Rongbin Hu ,&nbsp;Xiaoxuan Teng ,&nbsp;Yanran Li","doi":"10.1016/j.copbio.2024.103148","DOIUrl":"https://doi.org/10.1016/j.copbio.2024.103148","url":null,"abstract":"<div><p>Plant natural products (PNPs) hold significant pharmaceutical importance. The sessile nature of plants has led to the evolution of chemical defense mechanisms over millions of years to combat environmental challenges, making it a crucial and essential defense weapon. Despite their importance, the abundance of these bioactive molecules in plants is typically low, and conventional methods are time-consuming for enhancing production. Moreover, there is a pressing need for novel drug leads, exemplified by the shortage of antibiotics and anticancer drugs. Understanding how plants respond to stress and regulate metabolism to produce these molecules presents an opportunity to explore new avenues for discovering compounds that are typically under the detection limit or not naturally produced. Additionally, this knowledge can contribute to the advancement of plant engineering, enabling the development of new chassis for the biomanufacturing of these valuable molecules. In this perspective, we explore the intricate regulation of PNP biosynthesis in plants, and discuss the biotechnology strategies that have been and can be utilized for the discovery and production enhancement of PNPs in plants.</p></div>","PeriodicalId":10833,"journal":{"name":"Current opinion in biotechnology","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond co-expression: pathway discovery for plant pharmaceuticals 共同表达之外：植物制药的途径发现
IF 7.7 2区 工程技术
Current opinion in biotechnology Pub Date : 2024-06-03 DOI: 10.1016/j.copbio.2024.103147
Sandesh H Swamidatta, Benjamin R Lichman
{"title":"Beyond co-expression: pathway discovery for plant pharmaceuticals","authors":"Sandesh H Swamidatta,&nbsp;Benjamin R Lichman","doi":"10.1016/j.copbio.2024.103147","DOIUrl":"https://doi.org/10.1016/j.copbio.2024.103147","url":null,"abstract":"<div><p>Plant natural products have been an important source of medicinal molecules since ancient times. To gain access to the whole diversity of these molecules for pharmaceutical applications, it is important to understand their biosynthetic origins. Whilst co-expression is a reliable tool for identifying gene candidates, a variety of complementary methods can aid in screening or refining candidate selection. Here, we review recently employed plant biosynthetic pathway discovery approaches, and highlight future directions in the field.</p></div>","PeriodicalId":10833,"journal":{"name":"Current opinion in biotechnology","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0958166924000831/pdfft?md5=9a20f68b9089bdf9b266cf5aaa3e4090&pid=1-s2.0-S0958166924000831-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141241835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pleiotropy, a feature or a bug? Toward co-ordinating plant growth, development, and environmental responses through engineering plant hormone signaling 多态性，是特征还是缺陷？通过植物激素信号转导工程协调植物生长、发育和环境响应
IF 7.7 2区 工程技术
Current opinion in biotechnology Pub Date : 2024-05-31 DOI: 10.1016/j.copbio.2024.103151
Deisiany Ferriera Neres , R Clay Wright
{"title":"Pleiotropy, a feature or a bug? Toward co-ordinating plant growth, development, and environmental responses through engineering plant hormone signaling","authors":"Deisiany Ferriera Neres ,&nbsp;R Clay Wright","doi":"10.1016/j.copbio.2024.103151","DOIUrl":"10.1016/j.copbio.2024.103151","url":null,"abstract":"<div><p>The advent of gene editing technologies such as CRISPR has simplified co-ordinating trait development. However, identifying candidate genes remains a challenge due to complex gene networks and pathways. These networks exhibit pleiotropy, complicating the determination of specific gene and pathway functions. In this review, we explore how systems biology and single-cell sequencing technologies can aid in identifying candidate genes for co-ordinating specifics of plant growth and development within specific temporal and tissue contexts. Exploring sequence–function space of these candidate genes and pathway modules with synthetic biology allows us to test hypotheses and define genotype–phenotype relationships through reductionist approaches. Collectively, these techniques hold the potential to advance breeding and genetic engineering strategies while also addressing genetic diversity issues critical for adaptation and trait development.</p></div>","PeriodicalId":10833,"journal":{"name":"Current opinion in biotechnology","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0958166924000879/pdfft?md5=1aafe659f2cf5e25200fb647ed45a14c&pid=1-s2.0-S0958166924000879-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141186306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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