Current Neurology and Neuroscience Reports最新文献_第7页

Brain Sag: An Under-recognized Complication of Craniotomy. 脑凹陷：开颅手术未被充分认识的并发症。

IF 7.4 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2025-12-18 DOI: 10.1007/s11910-025-01474-y

Arnaldo Lopez-Ruiz, Maximilliano A Hawkes, Jennifer E Fugate

{"title":"Brain Sag: An Under-recognized Complication of Craniotomy.","authors":"Arnaldo Lopez-Ruiz, Maximilliano A Hawkes, Jennifer E Fugate","doi":"10.1007/s11910-025-01474-y","DOIUrl":"10.1007/s11910-025-01474-y","url":null,"abstract":"PURPOSE OF REVIEW: The review aims to summarize postoperative disturbances in cerebrospinal fluid (CSF) dynamics, including the pathophysiology, risk factors, and clinical implications of brain sag after craniotomy. RECENT FINDINGS: The literature on CSF hypovolemia and brain sag after craniotomy is comprised of single center retrospective studies and case reports with variable definitions. Brain sag, downward displacement of the brain due to CSF hypovolemia and loss of buoyancy, is an under-recognized cause of neurological deterioration after neurosurgery. This occurs most often in the context of perioperative CSF lumbar drainage but has occasionally been reported in the absence of lumbar drainage. CSF hypovolemia and brain sag can cause neurologic deterioration after craniotomy and treatment is opposite that of most other causes of deterioration and brain herniation in this population. For patients with signs of brain sag, immediate interventions such as Trendelenburg positioning and cessation of CSF drainage should be performed. Epidural blood patches or, more rarely, intrathecal saline infusions, have been used in severe cases. More research is needed, particularly on risk factors and effect on longer term outcomes. ","PeriodicalId":10831,"journal":{"name":"Current Neurology and Neuroscience Reports","volume":"26 1","pages":"2"},"PeriodicalIF":7.4,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145773334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early-Onset Parkinson's Disease: Unique Features and Management Approaches. 早发性帕金森病：独特的特征和管理方法。

IF 5.2 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2025-12-18 DOI: 10.1007/s11910-025-01470-2

Jordan Hickman, Andrew Tsai, Michelle Fullard, Michael Korsmo, Emily Forbes, Sana Aslam, Alexander J Baumgartner, Jeanne S Feuerstein, Ece Bayram

{"title":"Early-Onset Parkinson's Disease: Unique Features and Management Approaches.","authors":"Jordan Hickman, Andrew Tsai, Michelle Fullard, Michael Korsmo, Emily Forbes, Sana Aslam, Alexander J Baumgartner, Jeanne S Feuerstein, Ece Bayram","doi":"10.1007/s11910-025-01470-2","DOIUrl":"10.1007/s11910-025-01470-2","url":null,"abstract":"Purpose of review: To highlight the unique clinical features, risk factors, and management strategies associated with early-onset Parkinson's disease (EOPD), and contrast these with late-onset Parkinson's disease (LOPD). We outline how these differences influence diagnostic and therapeutic approaches and identify key knowledge gaps critical to improving clinical care.Recent findings: Compared to LOPD, EOPD (onset age 21-50) has a higher prevalence of monogenic risk factors, focal dystonia, depression, anxiety; slower motor progression; lower rates of cognitive decline; higher risk for delayed diagnosis. Treatment is complicated by earlier and more frequent dyskinesias, motor fluctuations, and unique considerations such as pregnancy and career impact. Risk factors, clinical presentation, progression, and management needs of EOPD can differ from LOPD. Despite advances in characterizing and diagnosing EOPD, most research remains focused on LOPD. There is a critical need to tailor research and clinical trials to address the distinct needs of people with EOPD.","PeriodicalId":10831,"journal":{"name":"Current Neurology and Neuroscience Reports","volume":"26 1","pages":"3"},"PeriodicalIF":5.2,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12714827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145773617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Headache After Stroke: An Update for the Clinician. 中风后头痛：临床医生的最新进展。

IF 7.4 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2025-12-09 DOI: 10.1007/s11910-025-01457-z

James Jh Im, William S Kingston

引用次数: 0

Emergency Reversal of Antithrombotics in Intracerebral Hemorrhage: An Update. 脑出血患者抗血栓药物的紧急逆转：最新进展

IF 7.4 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2025-11-18 DOI: 10.1007/s11910-025-01469-9

Melanie Li, Jennifer A Frontera

引用次数: 0

Nocturnal Hypokinesia and Early Morning OFF in Parkinson's Disease: State-of-the-Art and Systematic Review of Treatment Availability. 帕金森氏症的夜间运动不足和清晨OFF：最新的和系统的治疗评价。

IF 7.4 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2025-11-17 DOI: 10.1007/s11910-025-01467-x

Jirada Sringean, Russell Anne Marie Carandang, Eliza Zhunusova, Roongroj Bhidayasiri

{"title":"Nocturnal Hypokinesia and Early Morning OFF in Parkinson's Disease: State-of-the-Art and Systematic Review of Treatment Availability.","authors":"Jirada Sringean, Russell Anne Marie Carandang, Eliza Zhunusova, Roongroj Bhidayasiri","doi":"10.1007/s11910-025-01467-x","DOIUrl":"10.1007/s11910-025-01467-x","url":null,"abstract":"Purpose of review: To review the pathophysiology, clinical presentation, evaluation methods, and current treatment strategies of nocturnal hypokinesia and early morning OFF in Parkinson's disease. A comprehensive literature search was conducted using PubMed, ScienceDirect, and the Cochrane Library for relevant treatment strategies.Recent findings: We identified 31 clinical trials. Pharmacologic treatments include standard and sustained-release levodopa, dopamine agonists (rotigotine, ropinirol, pramipexole, and apomorphine), MAO-B inhibitors (rasagiline, safinamide), COMT inhibitors (opicapone), and rescue therapies like inhaled or dispersible levodopa or apomorphine injection. We propose a tiered treatment algorithm based on disease stage and symptom severity. Non-pharmacological treatment is recommended in all stages. For mild, disturbing symptoms in early PD, inhaled or dispersible levodopa or apomorphine injection are advised. In moderate to advanced stages, treatment options include long-acting dopamine agonists, MAO-B inhibitors, sustained-release levodopa, or COMT inhibitors selected based on factors such as daytime motor symptoms, and non-motor symptoms.","PeriodicalId":10831,"journal":{"name":"Current Neurology and Neuroscience Reports","volume":"25 1","pages":"80"},"PeriodicalIF":7.4,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145539237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-Invasive Neuromodulation in the Treatment of Headache. 无创神经调节治疗头痛。

IF 7.4 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2025-11-15 DOI: 10.1007/s11910-025-01465-z

Katrina Nayak, Victoria Phoumthipphavong, Christopher Oakley

{"title":"Non-Invasive Neuromodulation in the Treatment of Headache.","authors":"Katrina Nayak, Victoria Phoumthipphavong, Christopher Oakley","doi":"10.1007/s11910-025-01465-z","DOIUrl":"10.1007/s11910-025-01465-z","url":null,"abstract":"Purpose of review: This article aims to summarize the key evidence supporting the use of non-invasive neuromodulation devices in the treatment of various headache disorders in adults and children.Recent findings: Over the last decade, different modalities have emerged for the non-invasive management of various headache disorders, with increasing evidence in recent years demonstrating their safety and efficacy in the treatment of migraine and trigeminal autonomic cephalgias, as well as other headache disorders. These devices include external trigeminal nerve stimulation (eTNS), transcutaneous electrical nerve stimulator (TENS), single-pulse transcranial magnetic stimulation (sTMS), non-invasive vagus nerve stimulation (nVNS), remote electrical neuromodulation (REN), and external concurrent trigeminal and occipital nerve neurostimulation (eCOT-NS). These non-pharmacologic options for the management of headache are safe, have evidence to support their use, and they are a particularly appealing option for patients vulnerable to the side effects of pharmacologic treatments or those who are looking to avoid them.","PeriodicalId":10831,"journal":{"name":"Current Neurology and Neuroscience Reports","volume":"25 1","pages":"79"},"PeriodicalIF":7.4,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145523082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Continuous Ventricular Irrigation for Intraventricular Hemorrhage. 持续脑室灌洗治疗脑室内出血。

IF 5.2 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2025-11-13 DOI: 10.1007/s11910-025-01468-w

Emily G Dunbar, Tanvika Vegiraju, Andrew P Carlson

{"title":"Continuous Ventricular Irrigation for Intraventricular Hemorrhage.","authors":"Emily G Dunbar, Tanvika Vegiraju, Andrew P Carlson","doi":"10.1007/s11910-025-01468-w","DOIUrl":"10.1007/s11910-025-01468-w","url":null,"abstract":"Purpose of review: Despite decades of research, intraventricular hemorrhage (IVH) remains a devastating condition with high morbidity and mortality. Traditional external ventricular drains (EVDs) have long served as the cornerstone of surgical management but are limited by various complications. This review evaluates recent literature on continuous ventricular irrigation as an alternative approach to treating IVH.Recent findings: Early data surrounding continuous ventricular irrigation systems, including retrospective comparative studies and case series are encouraging. However, existing randomized data are limited by small sample size and methodological flaws. Larger, ongoing studies such as ACTIVE and ARCH aim to provide more definitive evidence. Continuous ventricular irrigation offers theoretical and practical advantages over static drainage in IVH patients, including enhanced clot clearance and improved catheter patency, particularly when combined with continuous thrombolytic therapy. Optimized protocols for irrigation rates, medication dosing, and timing are still being investigated. Robust clinical trials are necessary to validate the approach and establish best practices.","PeriodicalId":10831,"journal":{"name":"Current Neurology and Neuroscience Reports","volume":"25 1","pages":"78"},"PeriodicalIF":5.2,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12615550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145502436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurogenetic Disorders with Hearing Loss: Mechanisms, Classifications, and Emerging Insights. 听力损失的神经遗传疾病：机制、分类和新兴见解。

IF 5.2 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2025-11-05 DOI: 10.1007/s11910-025-01466-y

Daniel Owrang, Barbara Vona

{"title":"Neurogenetic Disorders with Hearing Loss: Mechanisms, Classifications, and Emerging Insights.","authors":"Daniel Owrang, Barbara Vona","doi":"10.1007/s11910-025-01466-y","DOIUrl":"10.1007/s11910-025-01466-y","url":null,"abstract":"Purpose of review: Neurogenetic disorders associated with hearing loss represent a rapidly expanding field, with recent gene discoveries revealing convergent mechanistic themes affecting both the nervous and auditory systems. Collectively, these findings highlight shared vulnerabilities of neural and auditory tissues. We summarize gene discoveries from 2021 to 2025, moving beyond classic syndromes to highlight newly implicated genes within mechanistic categories and discuss their implications for diagnosis, counseling, and therapeutic development.Recent findings: We describe 38 genes with combined neurodevelopmental and auditory phenotypes, providing an updated view of the field. We explore common developmental pathways and, when possible, propose explanations for the variable expression of hearing impairment observed across disorders. A deeper understanding of the mechanisms linking the nervous and auditory systems is essential for clarifying the pathogenesis of auditory syndromes. The emerging picture underscores that hearing loss can serve as an early marker of systemic neurogenetic disease that may offer a window of opportunity for timely intervention.","PeriodicalId":10831,"journal":{"name":"Current Neurology and Neuroscience Reports","volume":"25 1","pages":"77"},"PeriodicalIF":5.2,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12589251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145444112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensors in Multiple Sclerosis. 多发性硬化中的传感器。

IF 5.2 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2025-10-29 DOI: 10.1007/s11910-025-01448-0

Angeliki G Filippatou, Ellen M Mowry

{"title":"Sensors in Multiple Sclerosis.","authors":"Angeliki G Filippatou, Ellen M Mowry","doi":"10.1007/s11910-025-01448-0","DOIUrl":"10.1007/s11910-025-01448-0","url":null,"abstract":"Purpose of review: Biosensors and digital tools may enhance monitoring of people with multiple sclerosis (MS) and support timely, data-driven clinical decisions. We review current and emerging applications of biosensors to monitor function in MS.Recent rindings: Biosensors track diverse physiological and kinetic metrics, allowing assessment of function across several key domains in MS, including physical activity, circadian rhythmicity, gait, balance, fine motor function, and bladder control. A consistent cross-study finding is that novel technologies reliably capture subtle abnormalities that are often missed by traditional assessment methods. Digital health technologies hold significant promise for transforming MS care by enabling precise, continuous monitoring of functional status and disease progression. They may facilitate personalized management, allowing clinicians to tailor interventions based on each person's unique disease trajectory. Further studies are essential to validate the predictive value and responsiveness of these tools and ensure their effective integration into clinical practice and trials.","PeriodicalId":10831,"journal":{"name":"Current Neurology and Neuroscience Reports","volume":"25 1","pages":"76"},"PeriodicalIF":5.2,"publicationDate":"2025-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12568836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145387637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Migraine and Trauma-Informed Care: A Review of the Literature and Recommendations for Clinical Practice and Research. 偏头痛和创伤知情护理：文献综述及临床实践和研究建议。

IF 7.4 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2025-10-28 DOI: 10.1007/s11910-025-01459-x

Prachi Khanna, Melanie Noel, Serena L Orr

{"title":"Migraine and Trauma-Informed Care: A Review of the Literature and Recommendations for Clinical Practice and Research.","authors":"Prachi Khanna, Melanie Noel, Serena L Orr","doi":"10.1007/s11910-025-01459-x","DOIUrl":"10.1007/s11910-025-01459-x","url":null,"abstract":"Purpose of review: This article reviews recent literature on the association between migraine and trauma, particularly adverse childhood experiences (ACEs). It makes recommendations for research and clinical practice.Recent findings: ACEs are prevalent and associated with lifetime morbidity and mortality. Observational studies have elucidated the association between migraine and ACEs. Emerging literature highlights a dose-dependent relationship between incident migraine and ACEs. ACEs have been linked with migraine-related outcomes in both children and adolescents as well as adults. However, the mechanisms linking ACEs to migraine remain poorly understood. Principles of, and approaches to, trauma-informed care in other populations can be drawn from, expanded, and extended to the context of migraine. We highlight the need for trauma-informed clinical care. We provide specific suggestions for how clinicians can integrate trauma-informed approaches in their clinical practice to improve patient outcomes. Finally, we make recommendations on how the field can advance research.","PeriodicalId":10831,"journal":{"name":"Current Neurology and Neuroscience Reports","volume":"25 1","pages":"75"},"PeriodicalIF":7.4,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145387630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0