Current Neurology and Neuroscience Reports最新文献_第6页

Advanced Therapeutics in Parkinson's Disease: What's New? 帕金森病的先进疗法：有什么新进展？

IF 7.4 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2026-02-18 DOI: 10.1007/s11910-026-01483-5

Mariana H G Monje, Jessica A Karl, Christa S Cooper, Jacob Yomtoob, Juan Deliz, Lucy A Morse, Neil Shetty, Leonard Verhagen Metman

{"title":"Advanced Therapeutics in Parkinson's Disease: What's New?","authors":"Mariana H G Monje, Jessica A Karl, Christa S Cooper, Jacob Yomtoob, Juan Deliz, Lucy A Morse, Neil Shetty, Leonard Verhagen Metman","doi":"10.1007/s11910-026-01483-5","DOIUrl":"10.1007/s11910-026-01483-5","url":null,"abstract":"PURPOSE OF REVIEW: To provide a concise, clinically oriented update on advanced therapies for Parkinson’s disease. RECENT FINDINGS: Subcutaneous infusion of foscarbidopa/foslevodopa and apomorphine reduce OFF time and improve “good ON time”, though infusion site reactions remain of some concern. Image-guided programming may shorten programming time while matching motor outcomes; while adaptive/closed-loop deep brain stimulation using local field potential signals may improve symptoms and quality of life with a lower energy use. Remote programming accelerates clinical benefit and expands access. Approved magnetic resonance guided high intensity focused ultrasound targets now include the ventralis intermediate nucleus of the thalamus, the globus pallidus pars interna and, recently, the pallidothalamic tract; while research investigates the subthalamic nucleus, each target with distinct benefits and adverse event profiles. Early studies using magnetic resonance guided low intensity focused ultrasound show safe, transient blood brain barrier opening. First-in-human stem cells-derived dopaminergic grafts show safety and graft functioning. The advanced therapeutic landscape for Parkinson’s disease has evolved through innovations in established and novel therapies. Future priorities for the field include standardized biomarkers and protocols for adaptive deep brain stimulation, long-term evaluation of high intensity focused ultrasound outcomes, and rigorously controlled trials of low intensity focused ultrasound and cell-based therapies designed to assess disease-modifying potential. ","PeriodicalId":10831,"journal":{"name":"Current Neurology and Neuroscience Reports","volume":"26 1","pages":"11"},"PeriodicalIF":7.4,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12916957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146218593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of non-statin Therapy on the Composition and Characteristics of Carotid Atherosclerotic Plaques: A Systematic Review. 非他汀类药物治疗对颈动脉粥样硬化斑块组成和特征的影响：一项系统综述。

IF 7.4 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2026-01-31 DOI: 10.1007/s11910-025-01476-w

Fernando Garagoli, Walter Masson, Leandro Barbagelata

{"title":"Effect of non-statin Therapy on the Composition and Characteristics of Carotid Atherosclerotic Plaques: A Systematic Review.","authors":"Fernando Garagoli, Walter Masson, Leandro Barbagelata","doi":"10.1007/s11910-025-01476-w","DOIUrl":"10.1007/s11910-025-01476-w","url":null,"abstract":"Purpose of review: This systematic review aimed to assess the impact of non-statin lipid-lowering therapies on imaging-defined features of carotid plaque vulnerability.Recent findings: Only studies assessing the effects of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors or ezetimibe met inclusion criteria for this review. Recent clinical trials and cohort studies suggest that PCSK9 inhibitors are associated with reductions in lipid-rich necrotic core volume, intraplaque neovascularization, and inflammatory activity. In contrast, ezetimibe has shown neutral or inconsistent effects, particularly when combined with low- or moderate-intensity statins. PCSK9 inhibitors appear to contribute to early and multidimensional stabilization of vulnerable carotid plaques, whereas the evidence supporting ezetimibe remains limited. However, given the heterogeneity of imaging methods, study designs, and outcome definitions, further well-designed clinical studies with standardized imaging protocols are needed to better understand the role of these therapies in carotid plaque remodeling and stroke prevention.","PeriodicalId":10831,"journal":{"name":"Current Neurology and Neuroscience Reports","volume":"26 1","pages":"9"},"PeriodicalIF":7.4,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146092407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Mind-body Movement Interventions for Managing Symptoms in People with Multiple Sclerosis: An Overview of Reviews. 心身运动干预对多发性硬化症患者症状管理的影响：综述

IF 7.4 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2026-01-31 DOI: 10.1007/s11910-025-01478-8

Lita Buttolph, A M Bruton, P Filbin, R S Wexler, O Gray, T Mazure, L Wooliscroft, R Spain, G Y Yeh, H Zwickey, J Z Goldenberg

{"title":"Effects of Mind-body Movement Interventions for Managing Symptoms in People with Multiple Sclerosis: An Overview of Reviews.","authors":"Lita Buttolph, A M Bruton, P Filbin, R S Wexler, O Gray, T Mazure, L Wooliscroft, R Spain, G Y Yeh, H Zwickey, J Z Goldenberg","doi":"10.1007/s11910-025-01478-8","DOIUrl":"10.1007/s11910-025-01478-8","url":null,"abstract":"Purpose of review: Exercise is a recommended non-pharmacological approach to treat multiple sclerosis (MS) symptoms. Mind-body movement interventions (MBMIs) offer a multi-component exercise option that integrates movement, breathwork, and mindfulness. Using an umbrella review, we assessed the current best evidence on MBMIs (ai chi, dance, Pilates, qigong, tai chi, and yoga) for managing MS symptoms.Recent findings: MBMIs significantly improved balance, equal to or superior to active controls (AC) or usual care (UC). Ai chi/tai chi/qigong significantly improved depression. Analyzed with other mind-body therapies, yoga reduced pain compared to AC/UC. Mixed results were found for fatigue. Physical function and quality of life were comparable to AC/UC. The certainty of evidence was low to very low for most MBMIs. Most reviews were \"critically low\" quality. MBMIs are commonly included in MS exercise reviews and may improve balance, pain, and depression. However, larger trials with active comparators and comprehensive reporting are needed to improve quality and certainty.","PeriodicalId":10831,"journal":{"name":"Current Neurology and Neuroscience Reports","volume":"26 1","pages":"10"},"PeriodicalIF":7.4,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12860761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146092385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dystonia: Insights into Mechanisms and Novel Therapeutics. 肌张力障碍：机制和新疗法的见解。

IF 5.2 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2026-01-10 DOI: 10.1007/s11910-025-01479-7

Ivana Dzinovic, Michael Zech

引用次数: 0

Immunotherapies for Central Nervous System Tumors and their Neurologic Complications. 中枢神经系统肿瘤及其神经并发症的免疫治疗。

IF 7.4 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2026-01-03 DOI: 10.1007/s11910-025-01477-9

Kun-Wei Song, Brian J Scott

{"title":"Immunotherapies for Central Nervous System Tumors and their Neurologic Complications.","authors":"Kun-Wei Song, Brian J Scott","doi":"10.1007/s11910-025-01477-9","DOIUrl":"10.1007/s11910-025-01477-9","url":null,"abstract":"Purpose of review: To discuss the landscape of immunotherapy trials for central nervous system (CNS) tumors including immune checkpoint inhibitors, vaccine therapies, oncolytic viruses, and chimeric antigen receptor T-cell therapy as well as explore the corresponding spectrum of neurologic toxicities.Recent findings: As more clinical trials are underway in CNS tumors, we are starting to appreciate both the promise of immunotherapy and current limitations. While a subset of patients demonstrate benefit, immunotherapy trials have not transformed CNS tumor outcomes, which prompts the field to consider next generation therapies and combinatorial approaches. In addition, novel toxicities of CNS immunotherapy are being described such as tumor-inflammation associated neurotoxicity. Immunotherapy in CNS tumor is still in its nascent stages and shows early signs of promise. However, immunotherapeutic approaches in CNS tumors need to account for the unique physiology of the CNS and the corresponding neurologic toxicities that are associated with therapies targeting the CNS. Elucidating both will set the stage for advancement of safe and effective immunotherapy for CNS tumors.","PeriodicalId":10831,"journal":{"name":"Current Neurology and Neuroscience Reports","volume":"26 1","pages":"7"},"PeriodicalIF":7.4,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Genetic Discoveries in Cerebral Palsy: Implications for Diagnosis, Prognosis, and Counseling. 脑瘫基因研究进展：对诊断、预后和咨询的影响。

IF 7.4 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2026-01-03 DOI: 10.1007/s11910-025-01475-x

Juan Darío Ortigoza-Escobar

{"title":"Advances in Genetic Discoveries in Cerebral Palsy: Implications for Diagnosis, Prognosis, and Counseling.","authors":"Juan Darío Ortigoza-Escobar","doi":"10.1007/s11910-025-01475-x","DOIUrl":"10.1007/s11910-025-01475-x","url":null,"abstract":"Purpose of review: This review examines the expanding role of genetic factors in cerebral palsy (CP), with a focus on cryptogenic presentations and CP-masquerading conditions. It addresses how genomic insights refine diagnosis, guide management, and influence counseling.Recent findings: Emerging evidence demonstrates that de novo single-nucleotide variants, copy number variants, mitochondrial variants, and, rarely, repeat expansions contribute significantly to CP, particularly when neuroimaging is normal, progression is atypical, or additional neurodevelopmental features are present. Diagnostic yield is highest in these contexts. Trio-based whole-exome sequencing is recommended as first-line testing, supported by chromosomal microarray or whole-genome sequencing. Integration of genomic testing remains limited by inconsistent CP definitions, restricted test access, and under-recognition of genetic etiologies, especially in adults. Standardized CP classification frameworks, such as SCPE (Surveillance of Cerebral Palsy in Europe), combined with early genomic evaluation, can improve diagnostic accuracy, reveal treatable conditions, and enable precision care. This approach has potential to transform management and outcomes across the lifespan.","PeriodicalId":10831,"journal":{"name":"Current Neurology and Neuroscience Reports","volume":"26 1","pages":"6"},"PeriodicalIF":7.4,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145892476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What a "Landscape of Consciousness" Means for Neurology and Neuroscience. “意识景观”对神经学和神经科学意味着什么？

IF 5.2 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2025-12-20 DOI: 10.1007/s11910-025-01471-1

Robert Lawrence Kuhn

{"title":"What a \"Landscape of Consciousness\" Means for Neurology and Neuroscience.","authors":"Robert Lawrence Kuhn","doi":"10.1007/s11910-025-01471-1","DOIUrl":"10.1007/s11910-025-01471-1","url":null,"abstract":"Purpose of review: To gather (almost) all (reasonable) theories of phenomenal consciousness, describe them neutrally (largely in the words of their authors), and organize them in a comprehensive, cross-disciplinary taxonomy of categories-\"Landscape of Consciousness.\" Perhaps the process can encourage novel ways of thinking among medical (psychiatry/neurology) practitioners and neuroscientists.Recent findings: Landscape organizes more than 350 explanations of phenomenal consciousness across physicalist and non-physicalist traditions. There are 10 primary categories: Materialism. Non-Reductive Physicalism. Quantum & Dimensions. Information. Panpsychisms. Monisms. Dualisms. Idealisms. Anomalous & Altered States.Challenge: Materialism, with the largest number of theories by far, has 12 subcategories: Philosophical. Eliminative/Illusionism. Neurobiological. Electromagnetic Field. Computational & Functionalism. Homeostatic & Affective. Embodied & Enactive. Relational. First-order. Higher-order. Language. Phylogenetic/Evolutionary. Representative theories are here summarized as (non-exhaustive) examples. The Landscape of Consciousness is a work-in-process-permanently. Two central theses: (i) understanding phenomenal consciousness at this point should not be restricted to selected ways of thinking or constrained by approved modes of knowing, but should rather seek expansive yet rational diversity, and (ii) issues of sentience, such as AI consciousness, virtual immortality, meaning/purpose, free will, life after death, etc., cannot be understood except in the light of particular theories of consciousness. Implications for psychiatry/neurology and neuroscience may be considered.","PeriodicalId":10831,"journal":{"name":"Current Neurology and Neuroscience Reports","volume":"26 1","pages":"5"},"PeriodicalIF":5.2,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12718250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145793668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex Differences in Patient Reported Outcome Measures after Stroke: What's New and What's Next? 卒中后患者报告结果测量的性别差异：新发现和新趋势？

IF 7.4 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2025-12-19 DOI: 10.1007/s11910-025-01472-0

Seana Gall, Lachlan Dalli, Mathew Reeves

引用次数: 0

From Detection to Decision: Managing Device-Detected Atrial Fibrillation After Stroke. 从检测到决策：处理卒中后设备检测心房颤动。

IF 7.4 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2025-12-18 DOI: 10.1007/s11910-025-01473-z

Nadja Korajkic, Vincent Thijs

引用次数: 0

Brain Sag: An Under-recognized Complication of Craniotomy. 脑凹陷：开颅手术未被充分认识的并发症。

IF 7.4 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2025-12-18 DOI: 10.1007/s11910-025-01474-y

Arnaldo Lopez-Ruiz, Maximilliano A Hawkes, Jennifer E Fugate

{"title":"Brain Sag: An Under-recognized Complication of Craniotomy.","authors":"Arnaldo Lopez-Ruiz, Maximilliano A Hawkes, Jennifer E Fugate","doi":"10.1007/s11910-025-01474-y","DOIUrl":"10.1007/s11910-025-01474-y","url":null,"abstract":"PURPOSE OF REVIEW: The review aims to summarize postoperative disturbances in cerebrospinal fluid (CSF) dynamics, including the pathophysiology, risk factors, and clinical implications of brain sag after craniotomy. RECENT FINDINGS: The literature on CSF hypovolemia and brain sag after craniotomy is comprised of single center retrospective studies and case reports with variable definitions. Brain sag, downward displacement of the brain due to CSF hypovolemia and loss of buoyancy, is an under-recognized cause of neurological deterioration after neurosurgery. This occurs most often in the context of perioperative CSF lumbar drainage but has occasionally been reported in the absence of lumbar drainage. CSF hypovolemia and brain sag can cause neurologic deterioration after craniotomy and treatment is opposite that of most other causes of deterioration and brain herniation in this population. For patients with signs of brain sag, immediate interventions such as Trendelenburg positioning and cessation of CSF drainage should be performed. Epidural blood patches or, more rarely, intrathecal saline infusions, have been used in severe cases. More research is needed, particularly on risk factors and effect on longer term outcomes. ","PeriodicalId":10831,"journal":{"name":"Current Neurology and Neuroscience Reports","volume":"26 1","pages":"2"},"PeriodicalIF":7.4,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145773334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0