Current Neurology and Neuroscience Reports最新文献

Low-cost Rehabilitation Solutions: Lessons From LMIC Settings. 低成本的康复解决方案：来自低收入国家的经验教训。

IF 7.4 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2026-09-03 DOI: 10.1007/s11910-026-01516-z

Ayush Agarwal, M V Padma Srivastava

{"title":"Low-cost Rehabilitation Solutions: Lessons From LMIC Settings.","authors":"Ayush Agarwal, M V Padma Srivastava","doi":"10.1007/s11910-026-01516-z","DOIUrl":"https://doi.org/10.1007/s11910-026-01516-z","url":null,"abstract":"Purpose of review: Rehabilitation in LMICs is more important than in HICs due to the lack of access to acute stroke interventions (thrombolysis, endovascular thrombectomy, and stroke unit care) in most treated patients which leads to worse long-term outcomes, and thereby greater disability and functional impairment, therefore requiring specialized rehabilitation.Recent findings: The are barriers to rehabilitation in LMICs. These can be considered under healthcare- and patient-related factors. Healthcare factors include limited skilled rehabilitation specialists, negligible stroke unit care, lack of government policies, insurance for rehabilitation and adequate infrastructure for rehabilitation. Patient-related factors include lack of awareness about the benefits of rehabilitation, financial constraints and belief in alternate systems of care. The barriers to rehabilitation in LMICs can be overcome with LMIC specific solutions like community-based rehabilitation, task shifting, stroke unit care, telerehabilitation, offering integrated models of care and increased recruitment and training of rehabilitation professionals.","PeriodicalId":10831,"journal":{"name":"Current Neurology and Neuroscience Reports","volume":"26 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148886586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Traumatic Brain Injury in Austere Environments: a Review of Recent Advances. 严峻环境下的创伤性脑损伤：最新进展综述。

IF 7.4 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2026-08-29 DOI: 10.1007/s11910-026-01508-z

Laura M Loaiza-Cardona, Diego Felipe Batz Casia, Andres M Rubiano

{"title":"Traumatic Brain Injury in Austere Environments: a Review of Recent Advances.","authors":"Laura M Loaiza-Cardona, Diego Felipe Batz Casia, Andres M Rubiano","doi":"10.1007/s11910-026-01508-z","DOIUrl":"https://doi.org/10.1007/s11910-026-01508-z","url":null,"abstract":"Purpose of review: Traumatic brain injury (TBI) is still a leading cause of death and disability worldwide, with a disproportionate burden in low- and middle-income countries (LMICs) where access to imaging, invasive intracranial pressure (ICP) monitoring, and neurosurgical care is limited. This review examines recent advances in TBI management in austere environments, where standard high-resource paradigms are frequently impractical, and analyzes the quality of evidence supporting context-adapted approaches.Recent findings: Recent literature highlights the growing role of protocolized care pathways, noninvasive neuromonitoring adjuncts such as optic nerve sheath diameter ultrasonography, quantitative pupillometry, transcranial Doppler, and selected serum biomarkers, as well as alternative surgical strategies including hinge craniectomy. Emerging physiological frameworks, including stage-based models of intracranial decompensation, offer structured decision-making support when numeric ICP thresholds are unavailable. However, most supporting evidence remains observational, heterogeneous, and frequently extrapolated from high-income settings, with major limitations in external validation and implementation science. Enhancing outcomes in austere TBI care will depend less on technological development than on rigorous implementation science, context-specific validation, and sustainable health system strengthening to bridge the gap between evidence and clinical delivery.","PeriodicalId":10831,"journal":{"name":"Current Neurology and Neuroscience Reports","volume":"26 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148856985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep in Children with Neurodevelopmental Disorders: From Diagnostic Labels to Phenotype-directed Care. 神经发育障碍儿童的睡眠：从诊断标签到表型导向护理。

IF 7.4 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2026-08-24 DOI: 10.1007/s11910-026-01513-2

Oliviero Bruni, Maria Breda, Valeria Mammarella, Daniela Polese, Maria Paola Mogavero, Giuseppe Lanza, Raffaele Ferri

{"title":"Sleep in Children with Neurodevelopmental Disorders: From Diagnostic Labels to Phenotype-directed Care.","authors":"Oliviero Bruni, Maria Breda, Valeria Mammarella, Daniela Polese, Maria Paola Mogavero, Giuseppe Lanza, Raffaele Ferri","doi":"10.1007/s11910-026-01513-2","DOIUrl":"https://doi.org/10.1007/s11910-026-01513-2","url":null,"abstract":"Purpose of review: Sleep disorders are highly prevalent in children with neurodevelopmental disorders (NDDs), but diagnostic labels alone provide limited guidance for assessment or treatment. This review summarizes recent advances and proposes a diagnosis-informed, phenotype-directed clinical framework.Recent findings: Recent studies reinforce the heterogeneity of sleep disturbance within and across autism, attention-deficit/hyperactivity disorder, intellectual disability, and genetic syndromes. Clinically relevant phenotypes include insomnia and circadian dysregulation, sleep-disordered breathing, sleep-related movement disorders, hypersomnolence, and parasomnias. Emerging research points to convergence among circadian, arousal, synaptic, sensory, and dopamine-iron pathways. Evidence for adapted behavioral interventions is growing. Melatonin has the strongest pharmacological evidence, particularly for insomnia in ASD and selected neurogenetic conditions, whereas evidence for other sedating agents and for many other NDD populations remains limited. Management should integrate diagnosis-informed risk recognition with phenotype-directed assessment. The neurodevelopmental diagnosis can identify syndrome-specific risks and surveillance needs, whereas the dominant sleep phenotype, contributing medical and environmental factors, and functional consequences should guide investigation and treatment. Better trials must include children with severe disability and rare NDDs and use developmentally appropriate, objective, and family-centered outcomes.","PeriodicalId":10831,"journal":{"name":"Current Neurology and Neuroscience Reports","volume":"26 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148812325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges and Adjunctive Use of CT Perfusion (CTP) in Acute Stroke: Pitfalls, False Negatives, and Diagnostic Clues for Stroke Mimics. CT灌注（CTP）在急性卒中中的挑战和辅助应用：卒中模拟的陷阱、假阴性和诊断线索。

IF 7.4 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2026-08-15 DOI: 10.1007/s11910-026-01510-5

Hiroyuki Kawano, Teruyuki Hirano

引用次数: 0

Pulsed Radiofrequency for Post-Stroke Complications: From Neuromodulation to Functional Recovery. 脉冲射频治疗卒中后并发症：从神经调节到功能恢复。

IF 7.4 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2026-08-08 DOI: 10.1007/s11910-026-01509-y

Rujuan Liu, Huali Gu, Xingyu Kang, Wei Chen, Chengfei Gao, Xiao Han, Lijun Meng, Ting Zhu, Zhengyu Gao

{"title":"Pulsed Radiofrequency for Post-Stroke Complications: From Neuromodulation to Functional Recovery.","authors":"Rujuan Liu, Huali Gu, Xingyu Kang, Wei Chen, Chengfei Gao, Xiao Han, Lijun Meng, Ting Zhu, Zhengyu Gao","doi":"10.1007/s11910-026-01509-y","DOIUrl":"10.1007/s11910-026-01509-y","url":null,"abstract":"Purpose of review: This review synthesizes the mechanisms, applications, and evidence gaps regarding pulsed radiofrequency (PRF) in the rehabilitation of post-stroke complications to guide its standardized integration.Recent findings: PRF, a minimally invasive neuromodulation technique, modulates neuronal excitability without thermal damage. Emerging evidence highlights multi-target effects, including improved microcirculation, suppressed neuroinflammation, and regulated neurotrophic factors. Clinically, PRF effectively alleviates refractory post-stroke pain and may indirectly ameliorate post-stroke depression while facilitating motor recovery. Image-guided procedures targeting specific nerves demonstrate favorable safety profiles. Despite promising outcomes for stroke rehabilitation, current evidence relies primarily on small case series and preclinical studies. Significant gaps remain in standardized protocols and high-quality randomized controlled trials. Further validation of long-term efficacy and safety is essential to establish PRF's definitive role in comprehensive post-stroke management.","PeriodicalId":10831,"journal":{"name":"Current Neurology and Neuroscience Reports","volume":"26 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Neurology of Menopause. 更年期的神经学。

IF 7.4 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2026-07-24 DOI: 10.1007/s11910-026-01506-1

Hannah J Roeder, Enrique C Leira

{"title":"The Neurology of Menopause.","authors":"Hannah J Roeder, Enrique C Leira","doi":"10.1007/s11910-026-01506-1","DOIUrl":"10.1007/s11910-026-01506-1","url":null,"abstract":"Purpose of review: Menopause is a neuroendocrine process with important implications for neurological health. This review examines the complex, multidirectional relationships between menopause and major central nervous system conditions, including stroke, migraine, epilepsy, multiple sclerosis, Parkinson's disease, and Alzheimer's disease.Recent findings: Menopause may mark an inflection point for vascular injury, neurodegeneration, and disability accumulation in several neurological conditions. Perimenopausal hormonal fluctuations may exacerbate migraines and seizures in susceptible women. Research increasingly supports the critical window hypothesis for estrogen therapy and highlights the importance of distinguishing reproductive and chronological aging when interpreting neurologic trajectories. Menopause represents an important transition for many conditions. Hormone therapy has heterogenous effects with cognitive benefit in premature ovarian insufficiency, harm related to stroke risk in older women, and greater uncertainty in other conditions. Therefore, individualized risk-benefit assessment is essential. Research gaps remain significant, and menopause should be a priority area for neurologic research.","PeriodicalId":10831,"journal":{"name":"Current Neurology and Neuroscience Reports","volume":"26 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148577335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-Stroke Dysphagia: Moving Toward Evidence-Based, Recovery-Oriented Systems of Care. 中风后吞咽困难：走向循证、康复导向的护理系统。

IF 7.4 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2026-07-24 DOI: 10.1007/s11910-026-01507-0

Heather Shaw Bonilha, Brittany N Krekeler, Janina Wilmskoetter, Sandeep Kumar, Erin L Reedy, Wuwei Feng, Salman Ikramuddin, Fadi Nahab

{"title":"Post-Stroke Dysphagia: Moving Toward Evidence-Based, Recovery-Oriented Systems of Care.","authors":"Heather Shaw Bonilha, Brittany N Krekeler, Janina Wilmskoetter, Sandeep Kumar, Erin L Reedy, Wuwei Feng, Salman Ikramuddin, Fadi Nahab","doi":"10.1007/s11910-026-01507-0","DOIUrl":"10.1007/s11910-026-01507-0","url":null,"abstract":"Purpose of review: This review examines challenges in post-stroke dysphagia management, including access to swallowing imaging, enteral feeding decisions, and barriers to reassessment and rehabilitation. It evaluates how healthcare systems and practice patterns influence swallowing outcomes and stroke recovery.Recent findings: Recent literature emphasizes that post-stroke dysphagia is a dynamic condition requiring longitudinal management rather than a temporary acute complication. Evidence supports validated dysphagia screening followed by clinical swallowing evaluation and swallowing imaging for accurate diagnosis and treatment planning. Studies highlight variability in gastrostomy tube practices, post-acute access to swallowing imaging, continuity of care, and the psychosocial burden of oral restriction and feeding decisions after stroke. Dysphagia management systems remain fragmented, contributing to inconsistent diagnosis, reassessment, access to intervention, and prolonged unnecessary oral intake restrictions. Future efforts should prioritize rehabilitation pathways that support recovery-oriented dysphagia management.","PeriodicalId":10831,"journal":{"name":"Current Neurology and Neuroscience Reports","volume":"26 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148577261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Considerations in Alzheimer's Disease in Women. 女性阿尔茨海默病的注意事项。

IF 7.4 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2026-07-23 DOI: 10.1007/s11910-026-01504-3

Caroline Just, Kaitlin Seibert, Carol Chan, Carolina Maldonado-Correa, Danita Jones

{"title":"Considerations in Alzheimer's Disease in Women.","authors":"Caroline Just, Kaitlin Seibert, Carol Chan, Carolina Maldonado-Correa, Danita Jones","doi":"10.1007/s11910-026-01504-3","DOIUrl":"10.1007/s11910-026-01504-3","url":null,"abstract":"Purpose of review: To examine sex differences in Alzheimer's disease and cognition with a focus on hormonal transitions, biomarker trajectory, and implications for diagnosis and treatment.Recent findings: Women account for nearly two-thirds of individuals with Alzheimer's disease and demonstrate important biological and clinical differences compared with men. APOE ε4 confers greater risk in women, while menopause, depression, chronic stress, adverse pregnancy outcomes, and metabolic dysfunction may further increase vulnerability. Biomarker studies suggest that amyloid trajectories are broadly similar between sexes, but women exhibit earlier or greater tau accumulation once amyloid pathology is present. Women may maintain verbal memory performance longer than men despite underlying pathology, potentially delaying diagnosis. Emerging plasma biomarkers, particularly p-tau217, may improve early detection, monitoring, and treatment. Alzheimer's disease in women reflects a complex interaction between sex-specific biology, hormonal transitions, psychosocial factors, and neurodegenerative processes. Recognizing these differences has important implications for cognitive assessment, biomarker interpretation, diagnosis, and application of disease-modifying therapies.","PeriodicalId":10831,"journal":{"name":"Current Neurology and Neuroscience Reports","volume":"26 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13395889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148561108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental Exposures and Stroke Risk: Converging Pathways, Unequal Burdens, and Prevention Opportunities. 环境暴露与中风风险：趋同途径、不平等负担和预防机会。

IF 7.4 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2026-07-22 DOI: 10.1007/s11910-026-01505-2

Muaz Ali, Whitney Mayberry, Rebecca Achey, Jukka Putaala, Amre Nouh

{"title":"Environmental Exposures and Stroke Risk: Converging Pathways, Unequal Burdens, and Prevention Opportunities.","authors":"Muaz Ali, Whitney Mayberry, Rebecca Achey, Jukka Putaala, Amre Nouh","doi":"10.1007/s11910-026-01505-2","DOIUrl":"10.1007/s11910-026-01505-2","url":null,"abstract":"Purpose of review: To synthesize recent evidence on how environmental exposures influence stroke risk, with emphasis on air pollution, thermal stress, circadian and occupational disruption, built and social environments, and selected toxicants.Recent findings: Long-term and episodic air pollution, especially fine particulate matter with aerodynamic diameter ≤ 2.5 μm (PM₂.₅) and wildfire smoke, remain most consistently associated with stroke risk. Extreme heat combined with heat-humidity metrics is emerging as an important acute stroke trigger. Noise, artificial light at night, shift work, and long working hours show smaller but plausible associations, while greener and more walkable environments may be modestly protective. Social and structural disadvantage clusters, multiple exposures and inequities play an integrated role in risk and prevention. Environmental determinants are increasingly relevant to stroke risk. The strongest current links are realted to pollution, heat, sleep, and work disruption, as well as environmental inequity. Future research should move beyond single-exposure models toward combined-exposure as well as intervention-focused approaches.","PeriodicalId":10831,"journal":{"name":"Current Neurology and Neuroscience Reports","volume":"26 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13391753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148548143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postoperative Seizure Prophylaxis in Intracranial Tumors: Evaluating the Role of Anti-Seizure Medication in Seizure-Naïve Patients. 颅内肿瘤术后癫痫预防：评估抗癫痫药物在Seizure-Naïve患者中的作用。

IF 7.4 2区医学

Current Neurology and Neuroscience Reports Pub Date : 2026-07-20 DOI: 10.1007/s11910-026-01503-4

Nitish Seenarine, Samuel Latzman, Laura Mittelman, Vadim Zhigin, Emily Hirowski, Shoaib Syed, Heustein Sy, Randy S D'Amico

{"title":"Postoperative Seizure Prophylaxis in Intracranial Tumors: Evaluating the Role of Anti-Seizure Medication in Seizure-Naïve Patients.","authors":"Nitish Seenarine, Samuel Latzman, Laura Mittelman, Vadim Zhigin, Emily Hirowski, Shoaib Syed, Heustein Sy, Randy S D'Amico","doi":"10.1007/s11910-026-01503-4","DOIUrl":"10.1007/s11910-026-01503-4","url":null,"abstract":"Purpose of review: Postoperative seizures occur in up to 20% of seizure-naïve adult patients undergoing craniotomy for tumor resection, contributing to morbidity and readmissions. Yet, routine prophylactic use of anti-seizure medications (ASMs) in this population remains unsupported by current evidence-based guidelines. In this review, we synthesize current evidence on seizure incidence, timing, risk factors, and practical perioperative management strategies.Recent findings: Postoperative seizure risk varies by tumor type, cortical involvement, peritumoral edema, hemorrhage, and tumor grade. Across randomized trials and meta-analyses, prophylactic ASM administration has not been shown to consistently reduce postoperative seizure incidence, and older agents can increase toxicity and interaction risk. Some studies suggest a modest reduction of early seizures within the first postoperative week, though this benefit is not sustained long-term. When prophylaxis is employed, second-generation ASMs such as levetiracetam are often favored for their higher tolerability and fewer drug-drug interactions compared to older agents. Emerging evidence has described alternative agents to levetiracetam with greater blood-brain-barrier permeability, but further investigation is required. Routine ASM prophylaxis in seizure-naïve patients undergoing intracranial tumor resection is not supported by current evidence or clinical guidelines. A selective, risk-based approach with short-term prophylaxis may be considered in patients with high-risk features. Future prospective, risk-stratified trials are needed to better define subgroups that may benefit from targeted prophylactic strategies.","PeriodicalId":10831,"journal":{"name":"Current Neurology and Neuroscience Reports","volume":"26 1","pages":""},"PeriodicalIF":7.4,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148519855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0