Current Cardiology Reports最新文献_第5页

Pericardiocentesis: History, Current Practice, and Future Directions 心包穿刺术：历史、当前实践和未来方向

IF 3.7 3区医学

Current Cardiology Reports Pub Date : 2024-09-14 DOI: 10.1007/s11886-024-02134-2

Aravind Kalluri, Weili Zheng, Kelley Chen, Jason Katz, Mohamed Al-Kazaz, Paul C. Cremer, Daniel R. Schimmel

{"title":"Pericardiocentesis: History, Current Practice, and Future Directions","authors":"Aravind Kalluri, Weili Zheng, Kelley Chen, Jason Katz, Mohamed Al-Kazaz, Paul C. Cremer, Daniel R. Schimmel","doi":"10.1007/s11886-024-02134-2","DOIUrl":"https://doi.org/10.1007/s11886-024-02134-2","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose of Review</h3>To discuss the evolution in the approach to pericardial effusions and drainage from a historical perspective, the present state, and pathways for future innovative therapies.<h3 data-test=\"abstract-sub-heading\">Recent Findings</h3>Incorporation of advanced imaging tools has dramatically improved the safety profile of pericardial interventions. Outcome data allow for refined approaches to management of pericardial disease in special populations, such as pulmonary arterial hypertension. Consideration of intrapericardial interventions and pharmacotherapy represent novel and promising approaches to management of pericardial effusions moving forward.<h3 data-test=\"abstract-sub-heading\">Summary</h3>Although the impact of excess or rapidly accumulating pericardial fluid on hemodynamics has been recognized for centuries, the therapeutic approaches have only recently become more refined with the routine incorporation of such tools as echocardiography and fluoroscopy. The most utilized approaches for pericardiocentesis include the apical, subxiphoid, and parasternal, and the most favorable approach is that in which the pericardial fluid is closest to the body surface, where intervening vital structures are least likely to be damaged. With the notable exception of patients with pre-existing pulmonary hypertension, complete decompression of pericardial fluid with careful drain management reduces likelihood of pericardial effusion recurrence. In addition, percutaneous balloon pericardiotomies have been demonstrated to reduce recurrence in nonmalignant effusions.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating Prime Editing and Cellular Reprogramming as Novel Strategies for Genetic Cardiac Disease Modeling and Treatment 整合基因编辑和细胞重编程作为遗传性心脏病建模和治疗的新策略

IF 3.7 3区医学

Current Cardiology Reports Pub Date : 2024-09-11 DOI: 10.1007/s11886-024-02118-2

Bing Yao, Zhiyong Lei, Manuel A. F. V. Gonçalves, Joost P. G. Sluijter

{"title":"Integrating Prime Editing and Cellular Reprogramming as Novel Strategies for Genetic Cardiac Disease Modeling and Treatment","authors":"Bing Yao, Zhiyong Lei, Manuel A. F. V. Gonçalves, Joost P. G. Sluijter","doi":"10.1007/s11886-024-02118-2","DOIUrl":"https://doi.org/10.1007/s11886-024-02118-2","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose of review</h3>This review aims to evaluate the potential of CRISPR-based gene editing tools, particularly prime editors (PE), in treating genetic cardiac diseases. It seeks to answer how these tools can overcome current therapeutic limitations and explore the synergy between PE and induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) for personalized medicine.<h3 data-test=\"abstract-sub-heading\">Recent findings</h3>Recent advancements in CRISPR technology, including CRISPR-Cas9, base editors, and PE, have demonstrated precise genome correction capabilities. Notably, PE has shown exceptional precision in correcting genetic mutations. Combining PE with iPSC-CMs has emerged as a robust platform for disease modeling and developing innovative treatments for genetic cardiac diseases.<h3 data-test=\"abstract-sub-heading\">Summary</h3>The review finds that PE, when combined with iPSC-CMs, holds significant promise for treating genetic cardiac diseases by addressing their root causes. This approach could revolutionize personalized medicine, offering more effective and precise treatments. Future research should focus on refining these technologies and their clinical applications.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142195810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comprehensive Review on the Electrocardiographic Manifestations of Cardiac Sarcoidosis: Patterns and Prognosis. 心脏肉样瘤病心电图表现综述：模式与预后

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2024-09-01 Epub Date: 2024-07-02 DOI: 10.1007/s11886-024-02088-5

Hritvik Jain, Mohammed Dheyaa Marsool Marsool, Amogh Verma, Hamza Irfan, Abdullah Nadeem, Jyoti Jain, Aman Goyal, Siddhant Passey, Shrey Gole, Mahalaqua Nazli Khatib, Quazi Syed Zahiruddin, Abhay M Gaidhane, Sarvesh Rustagi, Prakasini Satapathy

{"title":"A Comprehensive Review on the Electrocardiographic Manifestations of Cardiac Sarcoidosis: Patterns and Prognosis.","authors":"Hritvik Jain, Mohammed Dheyaa Marsool Marsool, Amogh Verma, Hamza Irfan, Abdullah Nadeem, Jyoti Jain, Aman Goyal, Siddhant Passey, Shrey Gole, Mahalaqua Nazli Khatib, Quazi Syed Zahiruddin, Abhay M Gaidhane, Sarvesh Rustagi, Prakasini Satapathy","doi":"10.1007/s11886-024-02088-5","DOIUrl":"10.1007/s11886-024-02088-5","url":null,"abstract":"Purpose of review: Cardiac sarcoidosis (CS) refers to cardiac involvement in sarcoidosis and is usually associated with worse outcomes. This comprehensive review aims to elucidate the electrocardiographic (ECG) signs and features associated with CS, as well as examine modern techniques and their importance in CS evaluation.Recent findings: The exact pathogenesis of CS is still unclear, but it stems from an abnormal immunological response triggered by environmental factors in individuals with genetic predisposition. CS presents with non-cardiac symptoms; however, conduction system abnormalities are common in patients with CS. The most common electrocardiographic (ECG) signs include atrioventricular blocks and ventricular tachyarrhythmia. Distinct patterns, such as fragmented QRS complexes, T-wave alternans, and bundle branch blocks, are critical indicators of myocardial involvement. The application of advanced ECG techniques such as signal-averaged ECG, Holter monitoring, wavelet-transformed ECG, microvolt T-wave alternans, and artificial intelligence-supported analysis holds promising outcomes for opportune detection and monitoring of CS. Timely utilisation of inexpensive and readily available ECG possesses the potential to allow early detection and intervention for CS. The integration of artificial intelligence models into ECG analysis is a promising approach for improving the ECG diagnostic accuracy and further risk stratification of patients with CS.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac Sarcoidosis: Utilizing Cardiac MRI and PET-CT. 心脏肉样瘤病：利用心脏 MRI 和 PET-CT。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2024-09-01 Epub Date: 2024-07-16 DOI: 10.1007/s11886-024-02093-8

Kamari Ositelu, Sonu Abraham, Ike S Okwuosa

引用次数: 0

Precision Genetic Therapies: Balancing Risk and Benefit in Patients with Heart Failure. 精准基因疗法：平衡心力衰竭患者的风险与收益。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2024-09-01 Epub Date: 2024-08-07 DOI: 10.1007/s11886-024-02096-5

Jamie R Johnston, Eric D Adler

{"title":"Precision Genetic Therapies: Balancing Risk and Benefit in Patients with Heart Failure.","authors":"Jamie R Johnston, Eric D Adler","doi":"10.1007/s11886-024-02096-5","DOIUrl":"10.1007/s11886-024-02096-5","url":null,"abstract":"Purpose of review: Precision genetic medicine is evolving at a rapid pace and bears significant implications for clinical cardiology. Herein, we discuss the latest advancements and emerging strategies in gene therapy for cardiomyopathy and heart failure.Recent findings: Elucidating the genetic architecture of heart failure has paved the way for precision therapies in cardiovascular medicine. Recent preclinical studies and early-phase clinical trials have demonstrated encouraging results that support the development of gene therapies for heart failure arising from a variety of etiologies. In addition to the discovery of new therapeutic targets, innovative delivery platforms are being leveraged to improve the safety and efficacy of cardiac gene therapies. Precision genetic therapy represents a potentially safe and effective approach for improving outcomes in patients with heart failure. It holds promise for radically transforming the treatment paradigm for heart failure by directly targeting the underlying etiology. As this new generation of cardiovascular medicines progress to the clinic, it is especially important to carefully evaluate the benefits and risks for patients.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11379760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implementing a 'Lead [Apron]-Free' Cardiac Catheterization: Current Status. 实施 "无导联[围裙]"心导管检查：现状。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2024-09-01 Epub Date: 2024-07-25 DOI: 10.1007/s11886-024-02102-w

Akash H Patel, Vishal Patel, Yicheng Tang, Sai Shah, George Tang, Morton J Kern

引用次数: 0

Unraveling the Complex Relationship-Atrial Fibrillation and Pulmonary Hypertension. 解开复杂的关系--心房颤动与肺动脉高压。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2024-09-01 Epub Date: 2024-07-10 DOI: 10.1007/s11886-024-02089-4

Kanishk Aggarwal, Pushkar S Valleru, F N U Anamika, Priyanka Aggarwal, Ira Gupta, Vasu Gupta, Nikita Garg, Rohit Jain

{"title":"Unraveling the Complex Relationship-Atrial Fibrillation and Pulmonary Hypertension.","authors":"Kanishk Aggarwal, Pushkar S Valleru, F N U Anamika, Priyanka Aggarwal, Ira Gupta, Vasu Gupta, Nikita Garg, Rohit Jain","doi":"10.1007/s11886-024-02089-4","DOIUrl":"10.1007/s11886-024-02089-4","url":null,"abstract":"Purpose of review: In this article, we underscore the importance of identifying risk factors and monitoring pulmonary hypertension patients for signs of arrhythmias, as this proactive approach can reduce morbidity and mortality.Recent findings: Atrial fibrillation is the most prevalent among cardiac arrhythmias and is associated with an increased risk of stroke, morbidity, and mortality. Smoking, obesity, hypertension, a sedentary lifestyle, and diabetes mellitus are some of the modifiable risk factors for atrial fibrillation. Recent studies show that the risk of atrial fibrillation is rising in patients with parenchymal and vascular lung disease. Stretching in the atria and pulmonary veins may lead to the onset of atrial fibrillation in cardiac conditions like hypertension, heart failure, and valvular disease. Atrial fibrillation in patients with pulmonary hypertension (PH) denotes a more advanced disease. Patients with PH are more susceptible to hemodynamic stress caused by tachycardia and an uncoordinated atrioventricular contraction. Therefore, atrial arrhythmias need to be treated because inadequate control of cardiac arrhythmias may result in poor clinical outcomes and lead to disease progression in PH patients. Aside from being a sign of severe disease, AF can also speed up and exacerbate the condition.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141562887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obesity Paradox in Transcatheter Aortic Valve Replacement. 经导管主动脉瓣置换术中的肥胖悖论。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2024-09-01 Epub Date: 2024-07-29 DOI: 10.1007/s11886-024-02098-3

Luai Madanat, Ahmad Jabri, Ivan D Hanson, Houman Khalili, Josep Rodés-Cabau, Thomas Pilgrim, Taishi Okuno, Sammy Elmariah, Philippe Pibarot, Pedro Villablanca, Amr E Abbas

{"title":"Obesity Paradox in Transcatheter Aortic Valve Replacement.","authors":"Luai Madanat, Ahmad Jabri, Ivan D Hanson, Houman Khalili, Josep Rodés-Cabau, Thomas Pilgrim, Taishi Okuno, Sammy Elmariah, Philippe Pibarot, Pedro Villablanca, Amr E Abbas","doi":"10.1007/s11886-024-02098-3","DOIUrl":"10.1007/s11886-024-02098-3","url":null,"abstract":"Background: Obesity paradox in cardiovascular risk prediction has gained increasing attention in recent years. We aimed to investigate the impact of BMI on mortality following transcatheter aortic valve replacement (TAVR).Methods: We performed a multi-center retrospective analysis of patients with severe aortic stenosis undergoing TAVR. Patients were categorized into: Underweight (BMI < 18.5), normal weight (18.5 ≤ BMI < 25), overweight (25 ≤ BMI < 30) and obese (BMI ≥ 30). Multivariate cox-proportional hazard model was used to compare all-cause mortality.Results: Total of 6688 patients included (175 underweight, 2252 normal weight, 2368 overweight and 1893 with obesity). Mean age of patients was 81 ± 8 years with 55% males. Patients with obesity had higher prevalence of comorbidities but a lower overall STS score. Mortality at 30-days post-TAVR was lower in the obese population compared to underweight, normal weight, and overweight patients (1.6% vs. 6.9%, 3.6%, and 2.8%, respectively, p < 0.001). Similarly, 3-year mortality was lowest in patients with obesity (17.1% vs. 28.9%, 24.5% and 18.6%, respectively, p < 0.001). On multivariate analysis, long term all-cause mortality at 3-years remained significantly lower in patients with obesity compared to underweight (HR 1.74, 95% CI: 1.30-2.40, p < 0.001) and normal weight (HR: 1.41, 95% CI:1.21-1.63, p < 0.001) but not in overweight patients (HR: 1.10, 95% CI:0.94-1.28, p = 0.240).Conclusion: In conclusion, patients with obesity have improved short and long term mortality following TAVR with an observed progressive increase in mortality with lower BMI ranges.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Will Factor XI Inhibitors Replace Current Anticoagulants for Stroke Prevention in Atrial Fibrillation? 因子 XI 抑制剂能否取代目前的抗凝药预防心房颤动患者中风？

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2024-09-01 Epub Date: 2024-07-23 DOI: 10.1007/s11886-024-02100-y

Siddharth M Patel, Christian T Ruff

引用次数: 0

Electrophysiological Cardiovascular Magnetic Resonance (EP-CMR)-Guided Interventional Procedures: Challenges and Opportunities. 电生理心血管磁共振（EP-CMR）引导的介入手术：挑战与机遇。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2024-09-01 Epub Date: 2024-07-18 DOI: 10.1007/s11886-024-02092-9

Sabrina Oebel, Cosima Jahnke, Kerstin Bode, Ingo Paetsch

{"title":"Electrophysiological Cardiovascular Magnetic Resonance (EP-CMR)-Guided Interventional Procedures: Challenges and Opportunities.","authors":"Sabrina Oebel, Cosima Jahnke, Kerstin Bode, Ingo Paetsch","doi":"10.1007/s11886-024-02092-9","DOIUrl":"10.1007/s11886-024-02092-9","url":null,"abstract":"Purpose of review: Cardiovascular magnetic resonance (CMR) imaging excels in providing detailed three-dimensional anatomical information together with excellent soft tissue contrast and has already become a valuable tool for diagnostic evaluation, electrophysiological procedure (EP) planning, and therapeutical stratification of atrial or ventricular rhythm disorders. CMR-based identification of ablation targets may significantly impact existing concepts of interventional electrophysiology. In order to exploit the inherent advantages of CMR imaging to the fullest, CMR-guided ablation procedures (EP-CMR) are justly considered the ultimate goal.Recent findings: Electrophysiological cardiovascular magnetic resonance (EP-CMR) interventional procedures have more recently been introduced to the CMR armamentarium: in a single-center series of 30 patients, an EP-CMR guided ablation success of 93% has been reported, which is comparable to conventional ablation outcomes for typical atrial flutter and procedure and ablation time were also reported to be comparable. However, moving on from already established workflows for the ablation of typical atrial flutter in the interventional CMR environment to treatment of more complex ventricular arrhythmias calls for technical advances regarding development of catheters, sheaths and CMR-compatible defibrillator equipment. CMR imaging has already become an important diagnostic tool in the standard clinical assessment of cardiac arrhythmias. Previous studies have demonstrated the feasibility and safety of performing electrophysiological interventional procedures within the CMR environment and fully CMR-guided ablation of typical atrial flutter can be implemented as a routine procedure in experienced centers. Building upon established workflows, the market release of new, CMR-compatible interventional devices may finally enable targeting ventricular arrhythmias.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141632924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0