Cardiac Involvement in Eosinophilic Granulomatosis with Polyangiitis.

IF 3.1 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Cardiology Reports Pub Date : 2025-07-09 DOI:10.1007/s11886-025-02258-z

Mukunthan Srikantharajah, Deepa Gopalan, Harold Wilson-Morkeh, Salman Siddiqui, Stephen P McAdoo, Taryn Youngstein

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引用次数: 0

Abstract

Purpose of review: This review highlights recent advances in the pathophysiology, diagnosis, and treatment of cardiac disease in patients with Eosinophilic granulomatosis with polyangiitis (EGPA). We outline a diagnostic approach to facilitate early identification of affected patients.

Recent findings: Recent advancements in diagnostic techniques including cardiac magnetic resonance (CMR) have improved recognition of cardiac disease in patients with EGPA. CMR has demonstrated a high prevalence of cardiac abnormalities, even in the absence of clinical symptoms, electrocardiographic or echocardiographic findings. Cardiac disease is a major cause of mortality in patients with EGPA, accounting for around 50% of disease-related deaths. However, due to the lack of standardised screening and diagnostic criteria, the true incidence remains unknown. Systemic immunosuppressive therapy is warranted to prevent acute complications as well as mitigate the long-term impact of chronic inflammation and tissue damage. Given the challenges in early detection and the prognostic significance of cardiac involvement, we recommend including CMR in the baseline evaluation of all EGPA patients at diagnosis.

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嗜酸性肉芽肿病合并多血管炎累及心脏。

综述目的：本文综述了嗜酸性肉芽肿病合并多血管炎（EGPA）患者心脏疾病的病理生理学、诊断和治疗的最新进展。我们概述了一种诊断方法，以促进早期识别受影响的患者。最近的发现：包括心脏磁共振（CMR）在内的诊断技术的最新进展提高了EGPA患者对心脏病的认识。CMR已证明心脏异常的高患病率，即使在没有临床症状，心电图或超声心动图的发现。心脏病是EGPA患者死亡的主要原因，约占疾病相关死亡的50%。然而，由于缺乏标准化的筛查和诊断标准，真正的发病率仍然未知。全身免疫抑制治疗是必要的，以防止急性并发症，以及减轻慢性炎症和组织损伤的长期影响。考虑到早期发现的挑战和心脏受累的预后意义，我们建议在诊断时将CMR纳入所有EGPA患者的基线评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Cardiology Reports CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

6.20

自引率

2.70%

发文量

209

期刊介绍： The aim of this journal is to provide timely perspectives from experts on current advances in cardiovascular medicine. We also seek to provide reviews that highlight the most important recently published papers selected from the wealth of available cardiovascular literature. We accomplish this aim by appointing key authorities in major subject areas across the discipline. Section editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. We also provide commentaries from well-known figures in the field.