{"title":"Emergence of Triazole Resistance in <i>Aspergillus</i> spp. in Latin America.","authors":"Daiana Macedo, Florencia Leonardelli, Soledad Gamarra, Guillermo Garcia-Effron","doi":"10.1007/s12281-021-00418-6","DOIUrl":"https://doi.org/10.1007/s12281-021-00418-6","url":null,"abstract":"<p><strong>Purpose of review: </strong>Azole resistance in <i>Aspergillus</i> spp. is becoming a public health problem worldwide. However, data about this subject is lacking in Latin American countries. This review focuses in the epidemiology and molecular mechanisms of azole resistance in <i>Aspergillus</i> spp. emphasizing in Latin America. Data on <i>Aspergillus fumigatus</i> stands out because it is the most prevalent <i>Aspergillus</i> spp. pathogen.</p><p><strong>Recent findings: </strong>Azole resistance in <i>Aspergillus</i> spp. emergence was linked with intensive use of these antifungals both in the clinical setting and in the environment (as pesticides). Reports on azole-resistant <i>A. fumigatus</i> strains are being constantly published in different countries. Molecular mechanisms of resistance mainly involve substitution in the azole target (<i>CYP51A</i>) and/or overexpression of this gene. However, several other non-<i>CYP51A</i>-related mechanisms were described. Moreover, intrinsically resistant cryptic <i>Aspergillus</i> species are starting to be reported as human pathogens.</p><p><strong>Summary: </strong>After a comprehensive literature review, it is clear that azole resistance in <i>Aspergillus</i> spp. is emerging in Latin America and perhaps it is underestimated. All the main molecular mechanisms of azole resistance were described in patients and/or environmental samples. Moreover, one of the molecular mechanisms was described only in South America. Cryptic intrinsic azole-resistant species are also described.</p>","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":" ","pages":"93-103"},"PeriodicalIF":1.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12281-021-00418-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38940800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Implementation of Effective Antifungal Stewardship in Cancer Patients—A Review of Current Evidence","authors":"A. Khanina, A. Douglas, K. Thursky","doi":"10.1007/s12281-020-00408-0","DOIUrl":"https://doi.org/10.1007/s12281-020-00408-0","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"14 1","pages":"361 - 372"},"PeriodicalIF":1.4,"publicationDate":"2020-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12281-020-00408-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43852007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Interpretation and Understanding of Clinical Drug Interactions Between Azoles and Immunosuppressants in Solid Organ Transplant Recipients","authors":"Kathryn Dzintars, Lindsey P Toman","doi":"10.1007/s12281-020-00404-4","DOIUrl":"https://doi.org/10.1007/s12281-020-00404-4","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"14 1","pages":"391 - 396"},"PeriodicalIF":1.4,"publicationDate":"2020-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12281-020-00404-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44053196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Khalili, Seyed Mohammad Bagher Abtahi, Mehrnaz Atighehchian, S. Hosseini, M. Shirvani, E. Sadeghi, M. Ghanbari, M. Eghtedari
{"title":"Invasive Fungal Keratitis as an Uncommon Form of Mucormycosis Leading to Endophthalmitis: Report of Two Cases and Literature Review","authors":"M. Khalili, Seyed Mohammad Bagher Abtahi, Mehrnaz Atighehchian, S. Hosseini, M. Shirvani, E. Sadeghi, M. Ghanbari, M. Eghtedari","doi":"10.1007/s12281-020-00403-5","DOIUrl":"https://doi.org/10.1007/s12281-020-00403-5","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"14 1","pages":"384 - 390"},"PeriodicalIF":1.4,"publicationDate":"2020-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12281-020-00403-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48455438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dulcilena Matos Castro Silva, Raquel Keiko Luca Ito, L. Bonfietti, M. W. Szeszs, Artur Luiz Rocha, N. Viola, E. Abdala, Márcia Souza Carvalho Melhem
{"title":"Antifungal and Antibacterial Activity of Terpenes for Improvement of Indoor Air Quality","authors":"Dulcilena Matos Castro Silva, Raquel Keiko Luca Ito, L. Bonfietti, M. W. Szeszs, Artur Luiz Rocha, N. Viola, E. Abdala, Márcia Souza Carvalho Melhem","doi":"10.1007/s12281-020-00397-0","DOIUrl":"https://doi.org/10.1007/s12281-020-00397-0","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"1 1","pages":"1-11"},"PeriodicalIF":1.4,"publicationDate":"2020-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12281-020-00397-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41784948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pharmacokinetics and Pharmacodynamics of Antifungal Agents in Neonates and Children","authors":"C. Antachopoulos, E. Roilides","doi":"10.1007/s12281-020-00402-6","DOIUrl":"https://doi.org/10.1007/s12281-020-00402-6","url":null,"abstract":"","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"14 1","pages":"317-328"},"PeriodicalIF":1.4,"publicationDate":"2020-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12281-020-00402-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48782443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}