Current Fungal Infection Reports最新文献

Updates on Chromoblastomycosis: Evolving Insights in Clinical Management and Therapeutic Strategies. 关于嗜铬菌病的最新进展：临床管理和治疗策略的新见解。

IF 3.9

Current Fungal Infection Reports Pub Date : 2026-01-01 Epub Date: 2026-04-27 DOI: 10.1007/s12281-026-00532-3

Katarina Popovic, Andrés F Henao-Martínez, Marcus de Melo Teixeira, Elton Bill Amaral de Souza, Mendrika Rakotoarisaona, Nelson Iván Agudelo Higuita

{"title":"Updates on Chromoblastomycosis: Evolving Insights in Clinical Management and Therapeutic Strategies.","authors":"Katarina Popovic, Andrés F Henao-Martínez, Marcus de Melo Teixeira, Elton Bill Amaral de Souza, Mendrika Rakotoarisaona, Nelson Iván Agudelo Higuita","doi":"10.1007/s12281-026-00532-3","DOIUrl":"10.1007/s12281-026-00532-3","url":null,"abstract":"Purpose of review: The aim of this review is to provide an in-depth overview of chromoblastomycosis, with emphasis on emerging management strategies and therapeutic options, and to underscore potential gaps in the literature and priorities for future research.Recent findings: Among the newer triazoles, posaconazole has demonstrated greatest therapeutic potential in the treatment of chromoblastomycosis, including for severe and refractory disease. Adjunctive immunomodulatory therapies such as glucan, imiquimod, and acitretin have shown potential as well. Several novel and repurposed agents also have potential activity against dematiaceous fungi, including tricyclazole, HIV peptidase inhibitors, 1,10-phenanthroline-5,6-dione, and benzimidazoles. A recently proposed combination protocol with debulking, intralesional amphotericin B, and oral terbinafine (DAT protocol) achieved cure in all 16 included patients in a 2025 case series. While excisional surgery remains the preferred physical therapeutic modality, several reports have shown favorable results with both photodynamic and heat therapy.Summary: Chromoblastomycosis continues to pose a therapeutic challenge, requiring prolonged antifungal therapy often combined with physical therapeutic modalities. Improved access to diagnostics and early intervention remain essential to reducing global disease burden.","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"20 ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13148373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Current Landscape of Repurposed Drugs for Fungal Neglected Tropical Diseases. 被忽视的热带病真菌再利用药物的现状。

IF 3.3

Current Fungal Infection Reports Pub Date : 2025-12-01 Epub Date: 2025-05-29 DOI: 10.1007/s12281-025-00504-z

Tahsin Farid, Keyla C Tumas, Heather A Stone, Mili Duggal

{"title":"The Current Landscape of Repurposed Drugs for Fungal Neglected Tropical Diseases.","authors":"Tahsin Farid, Keyla C Tumas, Heather A Stone, Mili Duggal","doi":"10.1007/s12281-025-00504-z","DOIUrl":"https://doi.org/10.1007/s12281-025-00504-z","url":null,"abstract":"Purpose of review: Eumycetoma, chromoblastomycosis, and sporotrichosis are three of only four fungal infections recognized as Neglected Tropical Diseases (NTDs) by the World Health Organization. They are a significant source of morbidity in subtropical and tropical regions of the Americas, Africa, and Asia. There are very few treatments approved for these diseases. Clinicians often use drug repurposing, off-label use of existing drugs, for their treatment. This article is a systematic review of the published literature on the treatment of fungal NTDs from the last five years (2019-2024). It will provide an overview for each fungal NTD, their current treatment landscape, and the challenges associated with their treatment.Recent findings: Itraconazole remains the most widely used antifungal for the treatment of these fungal NTDs. Newer antifungals such as fosravuconazole have matched the efficacy of currently available drugs while reducing adverse events and pill burden. Other promising treatment strategies involve the use of immunomodulators (e.g., imiquimod), steroids (e.g., prednisolone), or non-steroidal anti-inflammatory agents in combination with traditional antifungal agents.Summary: Frequently repurposed drugs include itraconazole, posaconazole, voriconazole, amphotericin B, terbinafine, potassium iodide, and 5-flucytosine. Most of these drugs have significant side effects, unsatisfactory cure rates, and significant cost that restricts their use. Systematic collection of this drug repurposing data and analyzing it in aggregate using platforms such as CURE ID has the potential to generate efficacy signals for drugs. These promising candidates can then be studied comprehensively in clinical trials for drug approval.","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"19 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12363401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality of Life, Disability, and Fungal Neglected Tropical Diseases. 生活质量、残疾和被真菌忽视的热带病。

IF 3.9

Current Fungal Infection Reports Pub Date : 2025-04-01 DOI: 10.1007/s12281-025-00503-0

Alyson M Cavanaugh, Amanda Ribeiro Dos Santos, Dayvison Francis Saraiva Freitas, James Venturini, Ahmed Fahal, Conceição Azevedo, Jeremy A W Gold

{"title":"Quality of Life, Disability, and Fungal Neglected Tropical Diseases.","authors":"Alyson M Cavanaugh, Amanda Ribeiro Dos Santos, Dayvison Francis Saraiva Freitas, James Venturini, Ahmed Fahal, Conceição Azevedo, Jeremy A W Gold","doi":"10.1007/s12281-025-00503-0","DOIUrl":"10.1007/s12281-025-00503-0","url":null,"abstract":"Purpose of review: This review summarizes current literature about the disability burden of the fungal neglected tropical diseases (NTDs) sporotrichosis, chromoblastomycosis, eumycetoma, and paracoccidioidomycosis. The review highlights current knowledge gaps in global settings and describes available tools that could be adopted to fill these gaps.Recent findings: Sporotrichosis, chromoblastomycosis, and eumycetoma often present initially as skin lesions that can become progressively disfiguring, lead to stigmatization, and cause various sequalae affecting health and function. Chronic paracoccidioidomycosis can have systemic involvement and commonly results in impaired pulmonary function, which can limit activities of daily living and employment capacity. Use of standardized tools to quantify disability with fungal NTDs has been limited to date. Standardized tools to measure the impacts on quality of life and mental health are available and have been used for similar patient populations, including persons with other fungal diseases and persons with non-fungal skin NTDs.Summary: Fungal NTDs can be disabling. Improved understanding of the quality of life and mental health consequences might lead to greater awareness of the burden of fungal NTDs and enhance health planning to address the health and rehabilitation needs of persons affected by these diseases.","PeriodicalId":10813,"journal":{"name":"Current Fungal Infection Reports","volume":"19 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Update on COVID‐19 Associated Mucormycosis Characteristics, Risk Factors, and Outcomes: a Systematic Review and Meta-Analysis 与 COVID-19 相关的粘孢子菌病特征、风险因素和结果的最新进展：系统回顾和元分析

IF 1.4

Current Fungal Infection Reports Pub Date : 2023-12-19 DOI: 10.1007/s12281-023-00477-x

Kazem Khiabani, Mohammad Hosein Amirzade-Iranaq, Hanie Ahmadi

引用次数: 0

Candida in COVID-19: Gut-Lung Axis, Dysbiosis, and Infections 2019冠状病毒病中的念珠菌:肠-肺轴、生态失调和感染

Current Fungal Infection Reports Pub Date : 2023-10-17 DOI: 10.1007/s12281-023-00476-y

Milena Kordalewska, David S. Perlin

引用次数: 0

Emerging Challenges in Diagnosis and Treatment of Invasive Fungal Infections: Addressing the Impact of COVID-19 and New Pathogens 侵袭性真菌感染诊断和治疗中的新挑战:应对COVID-19和新病原体的影响

Current Fungal Infection Reports Pub Date : 2023-09-21 DOI: 10.1007/s12281-023-00475-z

Ali Ahmadi, Bahareh Bashardoust, Mahsa Abdorahimi, Selva Aminizadeh, Mohammadreza Salehi, Sadegh Khodavaisy

引用次数: 0

Tinea Nigra in Children 儿童黑体病

Current Fungal Infection Reports Pub Date : 2023-09-11 DOI: 10.1007/s12281-023-00473-1

Norma Olivia de la O-Escamilla, Dulce Melissa Martínez–Téllez, Miguel Ángel Sánchez-Romero, Elizabeth Esther Cortés-Salazar, Mirna Eréndira Toledo-Bahena, Carlos Alfredo Mena-Cedillos, Sonia Toussaint–Caire, Marcela Salazar–García, Adriana Valencia-Herrera, Alexandro Bonifaz

引用次数: 0

Antifungal Prophylaxis in the Era of Targeted Chemotherapy for Acute Myelogenous Leukemia 急性髓性白血病靶向化疗时代的抗真菌预防

IF 1.4

Current Fungal Infection Reports Pub Date : 2023-07-27 DOI: 10.1007/s12281-023-00474-0

R. Lewis, M. Stanzani

引用次数: 0

Respiratory Fungal Infections in Cystic Fibrosis: Diagnostic and Therapeutic Challenges 囊性纤维化的呼吸道真菌感染:诊断和治疗的挑战

IF 1.4

Current Fungal Infection Reports Pub Date : 2023-07-27 DOI: 10.1007/s12281-023-00467-z

Schwarz, Mainz, Romanowska, Rosseau, Schuette, Martin ‐ Souto, Ramirez ‐ Garcia, Eschenhagen

引用次数: 0

A Scoping Review of the Changing Epidemiology and Risk Factors of Endogenous Candida Ocular Infections 内源性念珠菌眼部感染流行病学变化及危险因素的综述

IF 1.4

Current Fungal Infection Reports Pub Date : 2023-07-26 DOI: 10.1007/s12281-023-00468-y

Z. Pek, J. Bork

引用次数: 0