Current Bioactive Compounds最新文献

{"title":"Neuroprotective Effect of Boswellia serrata against 3-NP Induced Experimental\u0000Huntington’s Disease","authors":"Vinay Kumar, Chanchal Sharma, M. Taleuzzaman, Kandasamy Nagarajan, Anzarul Haque, Mamta Bhatia, Sumayya Khan, Mohammad Ayman A. Salkini, pankaj bhatt","doi":"10.2174/0115734072272233231119161319","DOIUrl":"https://doi.org/10.2174/0115734072272233231119161319","url":null,"abstract":"\u0000\u0000The study aimed to assess the neuroprotective effect of Boswellia serrata\u0000against 3-NP-induced experimental Huntington’s disease.\u0000\u0000\u0000\u0000Previous studies have shown Boswellia to have sedative, analgesic, and anti-tumour\u0000effects. Boswellia serrata yields four pentacyclic triterpene acids and boswellic acid, a bioactive\u0000substance that prevents leukotriene biogenesis.\u0000\u0000\u0000\u0000The potential neuroprotective effect of Boswellia serrata against 3-nitro propionic acid\u0000(3-NP)-induced Huntington's disease (HD) was examined at oral doses of 45 mg/kg, 90 mg/kg,\u0000and 180 mg/kg. In this study, HD was induced by 3-NP at a dose of 10 mg/kg in Wistar rats. The\u0000study used 56 Wistar rats (8 per group) for biochemical (inflammatory markers, acetylcholinesterase\u0000activity) and behavioural (elevated plus maze, Y-maze, open-field, tail suspension tests,\u0000etc.) assessments. Additionally, a histological examination of the brain was carried out. In addition,\u0000the analysis of Boswellia serrata extract was performed by different analytical techniques,\u0000like UV spectrophotometer, FTIR, and HPLC methods.\u0000\u0000\u0000\u0000In the brain, succinate dehydrogenase is a mitochondrial enzyme irreversibly inhibited\u0000by 3-NP. Administration of 3-NP resulted in HD with altered behavioural and motor changes\u0000in rats. Treatment with Boswellia serrata resulted in remarkable protection of rats against\u00003-NP-induced behaviour and motor deficits in a dose-dependent manner. Moreover, in rats\u0000administered with 3-NP, Boswellia serrata improved memory performance and lowered levels of\u0000inflammatory biomarkers. These results have also been supported by histopathological analysis.\u0000Acetyl-11-keto-p-boswellic acid was found to be the main active component of Boswellia serrata\u0000extract.\u0000\u0000\u0000\u0000Boswellia serrata at a dose of 180 mg/kg exhibited better protection compared to the\u0000other doses against HD induced by 3-NP. More detailed studies based on molecular targets are\u0000needed for the Boswellia serrata to transition from the bench to the bedside for use as an adjuvant\u0000in HD patients.\u0000","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":"104 43","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139616009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural Polysaccharides Derived from Fruits and Mushrooms with Antiinflammatory\u0000and Antioxidant Effects","authors":"Taranjit Singh, Gagandeep Kaur, Amandeep Singh, Harshita Mathur, Pallavi Sandal, Rajveer Singh, Arka Bhattacharya","doi":"10.2174/0115734072275195231118083314","DOIUrl":"https://doi.org/10.2174/0115734072275195231118083314","url":null,"abstract":"\u0000\u0000A large class of substances known as polysaccharides have a wide range of advantageous\u0000therapeutic and nutritional properties. Polysaccharides found in plants and plant components\u0000are extracted for the use in treating a number of diseases. Since ancient times, these polysaccharides\u0000have been utilized for human wellness. With no or minimal adverse effects, the polysaccharides\u0000that were extracted and refined from the fruits exhibit strong antioxidant, antiinflammatory,\u0000immunoregulatory, and hepatoprotective action. These fruit polysaccharides are\u0000isolated and purified using numerous chromatographic methods. In this review, the polysaccharide\u0000obtained from sources such as Rubus chingii, Mulberry, Glycyrrhiza glabra, Lilium davidii,\u0000Flammulina velutipes, Angelica sinesis, and Diospyros kaki have been discussed along with their\u0000biological activities including DPPH radical scavenging activity, ABTS free radical scavenging\u0000assay, Hydroxyl radical scavenging activity and assay for oxygen free radical absorption capacity\u0000(ORAC) listed in various studies.\u0000","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":"108 34","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139614450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theaflavins Induce Autophagy in Ehrlich’s Ascites Carcinoma Cells both\u0000In vivo and In vitro","authors":"Arijit Kumar Ghosh, Aanchal Verma, Debabrata Majumder, Debasish Maiti, Tathagata Choudhuri, Antara Banerjee, Samiran Saha","doi":"10.2174/0115734072277726240102062944","DOIUrl":"https://doi.org/10.2174/0115734072277726240102062944","url":null,"abstract":"\u0000\u0000To investigate the efficacy of Theaflavins to induce autophagy and its tumoricidal activity towards Ehrlich’s Ascites Carcinoma cells.\u0000\u0000\u0000\u0000The apoptosis-inducing role of Theaflavins against cancer is reported. Autophagy,\u0000a cellular mechanism under stress, occurs either as a survival process or Type-II programmed-cell\u0000death in the presence/absence of apoptosis. The report of Theaflavins inducing autophagy against\u0000cancer is poor.\u0000\u0000\u0000\u0000Here, for the first time, the investigation for the anti-tumor efficacy of Theaflavins via\u0000autophagy in EAC was attempted.\u0000\u0000\u0000\u0000EAC-bearing mice were treated orally with Theaflavins (10 mg/kg b.w.) every alternate\u0000day with a total of 27 doses. Body weight, tumor volume and survivability were recorded. Tumoricidal\u0000and cellular dehydrogenase activity, in vivo and in vitro, were studied using Trypan-blue\u0000exclusion and MTT assay respectively. Theaflavins-treated EAC cells were subjected to Monodansylcadaverine-\u0000staining. LC3II turnover and LC3I conversion were detected by western blotting.\u0000Apoptosis up to 12 h TF-treatment was estimated by AnnexinV binding.\u0000\u0000\u0000\u0000This is the first report of Theaflavins inducing autophagy in EAC cells in vivo and in\u0000vitro. Oral Theaflavins treatment restricted excessive body-weight increase due to tumors, reduced\u0000tumor volume, and increased survivability of tumor-bearing mice. Theaflavins caused EAC\u0000cell death (~8% in vitro, ~30% in vivo), significantly reduced metabolic activity, and created conspicuous\u0000vacuolization in surviving cells. Resultant vacuoles (in vitro, 6 h) were marked as autophagosomes\u0000by Monodansylcadaverine-staining. Autophagy was confirmed by LC3II augmentation.\u0000No significant apoptosis was observed up to 12 h TF-treatment in vitro.\u0000\u0000\u0000\u0000Theaflavins were efficient inducing autophagy and Type-II PCD in EAC cells. Notably,\u0000Theaflavins induced autophagy prior to apoptosis in vitro.\u0000","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":"1 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139616752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wide-ranging Study on Synthesis and Biological Evaluation of 1, 2, 3-Triazole","authors":"A. Dudhe, R. Dudhe, Renuka Mahajan, Neha Pathak, Vaibhav Uplanchiwar, Mohammad Hashim Mansoori","doi":"10.2174/0115734072275678231214051003","DOIUrl":"https://doi.org/10.2174/0115734072275678231214051003","url":null,"abstract":"\u0000\u00001, 2, 3-Traizole is five-membered heterocyclic compounds having three nitrogen at 1, 2\u0000and 3 positions. 1, 2, 3-Triazoles are important five-membered heterocyclic scaffolds due to their\u0000widespread biological activities. 1, 2, 3-Triazole derivative can be readily obtained in good to\u0000excellent yields through click chemistry, 1, 3-dipolar cycloaddition, Metal Catalysed azide-alyne\u0000cycloaddition method. 1, 2, 3-Triazoles showed various biological activities, such as antiinflammatory, anticonvulsant, antineoplastic, antimicrobial, analgesic, antimalarial, antiviral, antiproliferative, and anticancer activities. The objective of this review is to synthesize pharmacological activity of 1,2,3-triazole derivatives documented in recent literature.\u0000","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":"88 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139450480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, Synthesis, and in vitro Evaluation of Derivatives of Quinoxaline-2- One as a Myeloperoxidase Modulator Using in silico Methods","authors":"Dakshinesh Parameswaran, Saravanan Thangavelu, Jubie Selvaraj, Selvinthanuja Chellappa, L. Vivekanandan, R. Veerasamy, Prabha Thangavelu","doi":"10.2174/0115734072272382231108064229","DOIUrl":"https://doi.org/10.2174/0115734072272382231108064229","url":null,"abstract":"Our study aimed to design, synthesis, and in vitro evaluation of derivatives of quinoxaline-2-one as a myeloperoxidase modulator using in silico methods. In some pathological situations, the overproduction of oxidising agents also results in oxidative damage to host cell proteins and DNA, which induces abnormal expression of inflammatory cytokines and chemokines. A recently discovered biomarker of inflammation is myeloperoxidase. Various inflammatory conditions cause the release of this enzyme into the extracellular environment. Our study aimed to design, synthesis, and in vitro evaluation of derivatives of quinoxaline-2-one as a myeloperoxidase modulator using in silico methods. A series of quinoxaline-2-one derivatives was synthesised and characterised by various analytical techniques. Further, to confirm and explore the molecular mechanism, an in silico docking study against the myeloperoxidase enzyme was performed (PDB ID: 1DNU). The compounds Q1, Q2, and Q5 showed better antioxidant activity in the DPPH assay, whereas the nitric oxide scavenging assay showed the compounds Q2, Q4, and Q5 had significant activity when compared to the standard IC50 value (28.8 µg/ml). Beside, the anti-inflammatory studies showed the compounds Q1, Q3, and Q5 showed better inhibition (89.79%) when compared to the standard drug aceclofenac (85.37%) at 1000 µg/ml concentration. The top three ligands for myeloperoxidase (PDB ID: 1DNU) with the highest scores in activity were found as Q2, Q1, and Q5, with scores of -13.2838, -12.5841, and -11.6906 Kcal/mol, respectively. The compounds were efficiently bound to the myeloperoxidase active site with arene-arene, arene-cation, hydrogen bonding, and etc. interactions. By introducing the various heterocyclic rings and deactivating and activating groups, we may produce a newer class of candidates for many infectious diseases. Thus, from the computational studies carried out, we may obtain hints for optimising the molecular selectivity of the quinoxaline-2-one derivatives to provide help in the design of new compounds for effective myeloperoxidase enzyme modulators. However, further pharmacokinetics, pharmacodynamics, preclinical, and clinical studies permit the design of the new agents without undesirable interactions. Nil","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":"253 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139246355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical Composition and Therapeutic Potential of Syngonium podophyllum L. Leaves against Hypercholesterolemia in Rats: Liver, Kidney, and Heart Crosstalk","authors":"Yomna R. Ahmed, Ali M. El-Hagrassi, Noha N. Nasr, Walid E. Abdallah, Manal A. Hamed","doi":"10.2174/0115734072270545231107044558","DOIUrl":"https://doi.org/10.2174/0115734072270545231107044558","url":null,"abstract":"One of the main risk factors for atherosclerosis is hypercholesterolemia This study aimed to assess hypercholesterolemia's effect on the liver, heart, and kidney and the impact of Syngonium podophyllum L. leaves methanolic extract as a treating agent in a rat model. Flavonoid components were isolated and identified from the methanolic extract of Syngonium podophyllum L. leaves. Total serum leptin, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), aspartate and alanine aminotransferases (AST and ALT), urea, and creatinine levels were all measured as part of the biochemical evaluation. The liver tissue was tested for levels of malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), and DNA fragmentation. Thirty-nine compounds were identified by GC/MS profiling of the n-hexane fraction of Syngonium podophyllum L leaves. The major volatile constituents were decane, 4-methyl, decane, N-acetyl 3-pentenyl, 1-amine, 2-methyl, 1-hexene, and 3-hydroxy, propanenitrile, while the major phenolic compounds isolated from methanolic extract were luteolin-7- α-L rhamnoside-4'- O-β-glucopyranoside (1), apigenin 6, 8-di-C-β-glucopyranoside (vicenin 2) (2), quercetin-3-Oα-L-rhamnoside (3), quercetin-7-O-β-glucoside compound (4), luteolin-7-O-β-glucoside (5), 5- hydroxy-6,7,8,4'-tetramethoxy flavone (6), gallic acid (7) and quercetin (8). Hypercholesterolemic rats revealed significant alterations (p ≤ 0.05) in the lipid profile, liver and kidney function, DNA fragmentation pattern and antioxidant indices. With oral cholesterol administration of 30 mg/0.3 mL, 0.7% tween/rats fed a high-fat diet for nine weeks, treatment with leaves extract (250 mg/kg body weight) was able to restore all biochemical parameters as well as the architectures of the liver and heart. Due to its abundance in physiologically active phenolic and flavonoid components, the methanolic extract of Syngonium podophyllum L. leaves successfully served as a hypolipidemic, anti-atherosclerotic, and antioxidant therapeutic agent.","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":"5 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139252508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Therapeutic Potential of Chalcones in Oncology: A Comprehensive Review","authors":"Chandra Shekhar Yadav, Iqbal Azad, Abdul Rahman Khan, Naseem Ahmad, Shishir Kumar Gupta, Vijay Kumar Verma, Dhananjoy Hansda, Minaxi B. Lohani","doi":"10.2174/0115734072266590231023094928","DOIUrl":"https://doi.org/10.2174/0115734072266590231023094928","url":null,"abstract":"Abstract:: Chalcone is a bioactive flavonoid contained in various plants such as Angelica archangelica, Pueraria lobata, and Glycyrrhiza glabra. It has been studied extensively in the field of pharmaceutical sciences due to its significant role in therapeutic potential including antibacterial, antiinflammatory, analgesic, cytotoxic, and anti-tumour properties. A plenty of study indicated numerous chalcone derivatives exhibit enhanced potency and reduced toxicity as compared to natural analogues. In this review, we introduce chalcone and its various derivatives including 1- naphthylacetophenone, 2-benzimidazolyl, 2-furoyloxy, 3-(furan-2-yl)pyrazol-4-yl, 4'-alkoxy, 4- anilinoquinolinyl, 4-aryloxyquinazolines, acridine, benzamide, benzenesulfonamide, bischalcone, cinnamoylthiazoles, D-glucosyl azides, dialkylamino, dihydropyrimidinone, indole, isoquinoline, ligustrazine, morpholinothiazole, naphthalene, quinoline, sulphonamide, thiazoleimidazopyridine, thienyl, thiophene, triazines, triazole-benzimidazole, tri-methoxyphenyl, and α- trifluoromethyl hybrids and display their promising activity against various cancer cell lines, such as breast cancer, prostate cancer, colon cancer, lung cancer, cervical cancer, and liver cancer.","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":"6 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135875258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of in vitro Antioxidant and Hypoglycemic Activities of Methanol Extract of Root of Cryptolepis buchanani in Streptozotocin-induced Diabetic Rats","authors":"Smriti Ojha, None Ajeet, Saurabh Kumar Gupta, Sudhanshu Mishra","doi":"10.2174/1573407219666230420121240","DOIUrl":"https://doi.org/10.2174/1573407219666230420121240","url":null,"abstract":"Background: The present research aimed to assess the relationship between free radical scavenging activity and oral hypoglycemic potential of methanol extract of the root of Cryptolepis buchanani in Albino Wistar rats. Objective: The following research aimed to study and evaluate the antidiabetic efficacy of the natural plant extracts Cryptolepis buchanani. Methods: Phytochemical screening was done to analyze, and in vitro, the antioxidant activity of plant root extract has been evaluated using DPPH assay and Fe+3 Reducing Power Assay. Streptozotocin at a 60 mg/kg dose was used to induce diabetes in albino Wistar rats, which was then treated with methanol extracts (125 and 250 mg/kg, PO) to evaluate antidiabetic activity. Results: The results indicated that methanol extract of the root of Cryptolepis Buchanan had shown its promising antidiabetic potential at a dose of 250 mg/kg in experimental diabetic Wistar rats, which may be linked to its antioxidant property. Conclusion: This experimental study revealed that the extract could potentially alleviate the augmented oxidative state correlated with diabetes. The marked reduction in blood glucose levels proves the hypoglycemic activity of the plant.","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":"62 18","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135062792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meet the Editorial Board Member","authors":"Tiziano Tuccinardi","doi":"10.2174/157340721909231009100815","DOIUrl":"https://doi.org/10.2174/157340721909231009100815","url":null,"abstract":"","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":"62 19","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135062791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive Review on Herbal Nanoparticulate System through Intranasal Route for Management of Congenital-Neuro Zika Therapy","authors":"Deepika Joshi, Priya Sharma","doi":"10.2174/1573407219666230420114706","DOIUrl":"https://doi.org/10.2174/1573407219666230420114706","url":null,"abstract":"Backgroud: An arbovirus called the Zika virus is spread by Aedes mosquitoes. The Zika virus (ZIKV) epidemic that has recently spread over the Western Hemisphere (the Americas and the ongoing outbreak in Brazil) is now recognised as one of the main causes of neurologic disease and other potential neurologic consequences. Methods: There are currently no antivirals available, and vaccines are only available for some. Currently, only symptomatic treatment is available. Various herbal plants, vegetables, fruits, flowers, and microbes have been documented to exhibit antiviral activities possessing good tolerability and minimal side effects. Polyphenols and other phyto-constituents have been extensively studied against arboviruses and have demonstrated promising results. Results: This review article focuses on a potential new herbal formulation with strong antiviral properties against the current zika virus and accompanying symptoms, with intranasal administration as the preferred method for treating neurological symptoms. Conclusion: Natural anti-viral therapy plays an important role in contributing to antiviral drug development and in reducing the global infection burden of arboviruses.","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":"447 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136132977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}