隐豆根甲醇提取物对链脲佐菌素诱导的糖尿病大鼠体外抗氧化和降糖活性的评价

Q2 Pharmacology, Toxicology and Pharmaceutics

Current Bioactive Compounds Pub Date : 2023-11-01 DOI:10.2174/1573407219666230420121240

Smriti Ojha, None Ajeet, Saurabh Kumar Gupta, Sudhanshu Mishra

{"title":"隐豆根甲醇提取物对链脲佐菌素诱导的糖尿病大鼠体外抗氧化和降糖活性的评价","authors":"Smriti Ojha, None Ajeet, Saurabh Kumar Gupta, Sudhanshu Mishra","doi":"10.2174/1573407219666230420121240","DOIUrl":null,"url":null,"abstract":"Background: The present research aimed to assess the relationship between free radical scavenging activity and oral hypoglycemic potential of methanol extract of the root of Cryptolepis buchanani in Albino Wistar rats. Objective: The following research aimed to study and evaluate the antidiabetic efficacy of the natural plant extracts Cryptolepis buchanani. Methods: Phytochemical screening was done to analyze, and in vitro, the antioxidant activity of plant root extract has been evaluated using DPPH assay and Fe+3 Reducing Power Assay. Streptozotocin at a 60 mg/kg dose was used to induce diabetes in albino Wistar rats, which was then treated with methanol extracts (125 and 250 mg/kg, PO) to evaluate antidiabetic activity. Results: The results indicated that methanol extract of the root of Cryptolepis Buchanan had shown its promising antidiabetic potential at a dose of 250 mg/kg in experimental diabetic Wistar rats, which may be linked to its antioxidant property. Conclusion: This experimental study revealed that the extract could potentially alleviate the augmented oxidative state correlated with diabetes. The marked reduction in blood glucose levels proves the hypoglycemic activity of the plant.","PeriodicalId":10772,"journal":{"name":"Current Bioactive Compounds","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of in vitro Antioxidant and Hypoglycemic Activities of Methanol Extract of Root of Cryptolepis buchanani in Streptozotocin-induced Diabetic Rats\",\"authors\":\"Smriti Ojha, None Ajeet, Saurabh Kumar Gupta, Sudhanshu Mishra\",\"doi\":\"10.2174/1573407219666230420121240\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: The present research aimed to assess the relationship between free radical scavenging activity and oral hypoglycemic potential of methanol extract of the root of Cryptolepis buchanani in Albino Wistar rats. Objective: The following research aimed to study and evaluate the antidiabetic efficacy of the natural plant extracts Cryptolepis buchanani. Methods: Phytochemical screening was done to analyze, and in vitro, the antioxidant activity of plant root extract has been evaluated using DPPH assay and Fe+3 Reducing Power Assay. Streptozotocin at a 60 mg/kg dose was used to induce diabetes in albino Wistar rats, which was then treated with methanol extracts (125 and 250 mg/kg, PO) to evaluate antidiabetic activity. Results: The results indicated that methanol extract of the root of Cryptolepis Buchanan had shown its promising antidiabetic potential at a dose of 250 mg/kg in experimental diabetic Wistar rats, which may be linked to its antioxidant property. Conclusion: This experimental study revealed that the extract could potentially alleviate the augmented oxidative state correlated with diabetes. The marked reduction in blood glucose levels proves the hypoglycemic activity of the plant.\",\"PeriodicalId\":10772,\"journal\":{\"name\":\"Current Bioactive Compounds\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Bioactive Compounds\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1573407219666230420121240\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Pharmacology, Toxicology and Pharmaceutics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Bioactive Compounds","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1573407219666230420121240","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}

引用次数: 0

摘要

背景:本研究旨在探讨隐皮根甲醇提取物对白化Wistar大鼠自由基清除活性与口服降糖潜能的关系。目的:研究和评价天然植物隐皮草提取物的抗糖尿病作用。方法:采用植物化学筛选法进行分析，并采用DPPH法和Fe+3还原力法对植物根提取物进行体外抗氧化活性评价。用60 mg/kg剂量链脲佐菌素诱导白化Wistar大鼠糖尿病，然后用甲醇提取物(125和250 mg/kg, PO)处理，观察其抗糖尿病活性。结果:隐皮根甲醇提取物在250 mg/kg剂量下对实验性糖尿病Wistar大鼠显示出良好的抗糖尿病作用，这可能与其抗氧化作用有关。结论:本实验研究表明，黄芪提取物对糖尿病相关的氧化状态增强具有潜在的缓解作用。血糖水平的显著降低证明了这种植物的降糖活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Evaluation of in vitro Antioxidant and Hypoglycemic Activities of Methanol Extract of Root of Cryptolepis buchanani in Streptozotocin-induced Diabetic Rats

Background: The present research aimed to assess the relationship between free radical scavenging activity and oral hypoglycemic potential of methanol extract of the root of Cryptolepis buchanani in Albino Wistar rats. Objective: The following research aimed to study and evaluate the antidiabetic efficacy of the natural plant extracts Cryptolepis buchanani. Methods: Phytochemical screening was done to analyze, and in vitro, the antioxidant activity of plant root extract has been evaluated using DPPH assay and Fe+3 Reducing Power Assay. Streptozotocin at a 60 mg/kg dose was used to induce diabetes in albino Wistar rats, which was then treated with methanol extracts (125 and 250 mg/kg, PO) to evaluate antidiabetic activity. Results: The results indicated that methanol extract of the root of Cryptolepis Buchanan had shown its promising antidiabetic potential at a dose of 250 mg/kg in experimental diabetic Wistar rats, which may be linked to its antioxidant property. Conclusion: This experimental study revealed that the extract could potentially alleviate the augmented oxidative state correlated with diabetes. The marked reduction in blood glucose levels proves the hypoglycemic activity of the plant.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Current Bioactive Compounds Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

1.90

自引率

0.00%

发文量

112

期刊介绍： The journal aims to provide comprehensive review articles on new bioactive compounds with proven activities in various biological screenings and pharmacological models with a special emphasis on stereoeselective synthesis. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia. The journal should prove to be essential reading for pharmacologists, natural product chemists and medicinal chemists who wish to be kept informed and up-to-date with the most important developments on new bioactive compounds of natural or synthetic origin, including their stereoeselective synthesis.