Exploring the Therapeutic Potential of Chalcones in Oncology: A Comprehensive Review

Q2 Pharmacology, Toxicology and Pharmaceutics

Current Bioactive Compounds Pub Date : 2023-11-03 DOI:10.2174/0115734072266590231023094928

Chandra Shekhar Yadav, Iqbal Azad, Abdul Rahman Khan, Naseem Ahmad, Shishir Kumar Gupta, Vijay Kumar Verma, Dhananjoy Hansda, Minaxi B. Lohani

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引用次数: 0

Abstract

Abstract:: Chalcone is a bioactive flavonoid contained in various plants such as Angelica archangelica, Pueraria lobata, and Glycyrrhiza glabra. It has been studied extensively in the field of pharmaceutical sciences due to its significant role in therapeutic potential including antibacterial, antiinflammatory, analgesic, cytotoxic, and anti-tumour properties. A plenty of study indicated numerous chalcone derivatives exhibit enhanced potency and reduced toxicity as compared to natural analogues. In this review, we introduce chalcone and its various derivatives including 1- naphthylacetophenone, 2-benzimidazolyl, 2-furoyloxy, 3-(furan-2-yl)pyrazol-4-yl, 4'-alkoxy, 4- anilinoquinolinyl, 4-aryloxyquinazolines, acridine, benzamide, benzenesulfonamide, bischalcone, cinnamoylthiazoles, D-glucosyl azides, dialkylamino, dihydropyrimidinone, indole, isoquinoline, ligustrazine, morpholinothiazole, naphthalene, quinoline, sulphonamide, thiazoleimidazopyridine, thienyl, thiophene, triazines, triazole-benzimidazole, tri-methoxyphenyl, and α- trifluoromethyl hybrids and display their promising activity against various cancer cell lines, such as breast cancer, prostate cancer, colon cancer, lung cancer, cervical cancer, and liver cancer.

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探索查尔酮在肿瘤中的治疗潜力:综述

摘要:查尔酮是一种生物活性类黄酮，广泛存在于白芷、葛根、甘草等多种植物中。由于其在抗菌、抗炎、镇痛、细胞毒性和抗肿瘤等治疗方面的重要作用，它在制药科学领域得到了广泛的研究。大量研究表明，与天然类似物相比，许多查尔酮衍生物表现出增强的效力和降低的毒性。本文介绍了查尔酮及其衍生物，包括1-萘基苯乙酮、2-苯并咪唑、2-呋喃氧基、3-(呋喃-2-基)吡唑-4-基、4'-烷氧基、4-苯胺喹啉基、4-芳基氧基喹唑啉、吖啶、苯酰胺、苯磺酰胺、双查尔酮、肉桂基噻唑、d -葡萄糖基叠氮、二烷基胺、二氢嘧啶、吲哚、异喹啉、哌嗪、萘、喹啉、磺胺、噻唑-咪唑吡啶、噻吩、噻吩、三嗪、三唑-苯并咪唑、三甲氧基苯基和α-三氟甲基杂交体，对乳腺癌、前列腺癌、结肠癌、肺癌、宫颈癌和肝癌等多种癌症细胞系显示出良好的抗肿瘤活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Bioactive Compounds Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

1.90

自引率

0.00%

发文量

112

期刊介绍： The journal aims to provide comprehensive review articles on new bioactive compounds with proven activities in various biological screenings and pharmacological models with a special emphasis on stereoeselective synthesis. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia. The journal should prove to be essential reading for pharmacologists, natural product chemists and medicinal chemists who wish to be kept informed and up-to-date with the most important developments on new bioactive compounds of natural or synthetic origin, including their stereoeselective synthesis.