关于 1, 2, 3-三唑的合成和生物学评价的广泛研究

Q2 Pharmacology, Toxicology and Pharmaceutics

Current Bioactive Compounds Pub Date : 2024-01-05 DOI:10.2174/0115734072275678231214051003

A. Dudhe, R. Dudhe, Renuka Mahajan, Neha Pathak, Vaibhav Uplanchiwar, Mohammad Hashim Mansoori

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引用次数: 0

摘要

1、2、3-三唑是五元杂环化合物，在 1、2 和 3 位上有三个氮。由于具有广泛的生物活性，1, 2, 3-三唑是重要的五元杂环支架。通过点击化学、1, 3-二极环加成法、金属催化叠氮-氮杂环加成法等方法，1, 2, 3-三唑衍生物可以很容易地获得良好的收率。1, 2, 3-三唑类化合物具有多种生物活性，如抗炎、抗惊厥、抗肿瘤、抗菌、镇痛、抗疟、抗病毒、抗增殖和抗癌活性。本综述旨在合成近期文献中记载的具有药理活性的 1,2,3-三唑衍生物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Wide-ranging Study on Synthesis and Biological Evaluation of 1, 2, 3-Triazole

1, 2, 3-Traizole is five-membered heterocyclic compounds having three nitrogen at 1, 2 and 3 positions. 1, 2, 3-Triazoles are important five-membered heterocyclic scaffolds due to their widespread biological activities. 1, 2, 3-Triazole derivative can be readily obtained in good to excellent yields through click chemistry, 1, 3-dipolar cycloaddition, Metal Catalysed azide-alyne cycloaddition method. 1, 2, 3-Triazoles showed various biological activities, such as antiinflammatory, anticonvulsant, antineoplastic, antimicrobial, analgesic, antimalarial, antiviral, antiproliferative, and anticancer activities. The objective of this review is to synthesize pharmacological activity of 1,2,3-triazole derivatives documented in recent literature.

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来源期刊

Current Bioactive Compounds Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

1.90

自引率

0.00%

发文量

112

期刊介绍： The journal aims to provide comprehensive review articles on new bioactive compounds with proven activities in various biological screenings and pharmacological models with a special emphasis on stereoeselective synthesis. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia. The journal should prove to be essential reading for pharmacologists, natural product chemists and medicinal chemists who wish to be kept informed and up-to-date with the most important developments on new bioactive compounds of natural or synthetic origin, including their stereoeselective synthesis.