Critical Care Medicine最新文献

{"title":"Plasma Levels of Soluble ST2 Reflect Extrapulmonary Organ Dysfunction and Predict Outcomes in Acute Respiratory Failure.","authors":"Amy S Labar, Bryan C Ulrich, Tyler C Lovelace, William G Bain, Faraaz A Shah, Emma B White, Elizabeth A Abe, Francesca Giacona, George A Alba, B Taylor Thompson, Eric P Schmidt, Benjamin E Zuchelkowski, John W Evankovich, Haopu Yang, Raj Ramanan, Holt Murray, Ghady Haidar, Mark E Snyder, Shulin Qin, Xiahong Wang, Yingze Zhang, Seyed M Nouraie, Charles Dela Cruz, Hēth R Turnquist, Prabir Ray, Anuradha Ray, Barbara Methé, Panayiotis V Benos, Alison Morris, Bryan J McVerry, Jehan Alladina, Georgios D Kitsios","doi":"10.1097/CCM.0000000000006716","DOIUrl":"https://doi.org/10.1097/CCM.0000000000006716","url":null,"abstract":"<p><strong>Objectives: </strong>Soluble ST2 (sST2), a decoy receptor for the alarmin interleukin-33 (IL-33), has been implicated in adverse clinical outcomes in acute respiratory failure (ARF). We evaluated sST2 distribution across diverse cohorts of patients with different etiologies of ARF, compared plasma and lower respiratory tract (LRT) concentrations, and examined associations with individual organ dysfunction, biological subphenotypes, and outcomes.</p><p><strong>Design: </strong>Observational study.</p><p><strong>Setting: </strong>Multicenter cohorts of ARF patients.</p><p><strong>Patients: </strong>A total of 1432 ARF patients, including 863 non-COVID and 569 COVID-19 cases, from five cohorts.</p><p><strong>Interventions: </strong>None.</p><p><strong>Measurements and main results: </strong>sST2 levels were measured in plasma and LRT specimens (when available) and analyzed for associations with ARF etiology, severity, organ dysfunction, systemic host response, subphenotypes, and 30-day mortality. Plasma sST2 levels were higher in non-COVID ARF patients compared with COVID-19 patients (p < 0.05) and were markedly elevated compared with LRT levels (> 19-fold), with weak intercompartmental correlation. Elevated plasma sST2 levels were associated with extrapulmonary organ dysfunction and a hyperinflammatory ARF subphenotype but not with respiratory indices, including hypoxemia. Plasma sST2 independently predicted 30-day mortality in pooled cohort data, adjusted for age, sex, and illness severity. In longitudinal measurements, nonsurvivors had persistently elevated plasma sST2 levels in the first 2 weeks of critical illness compared with survivors.</p><p><strong>Conclusions: </strong>Plasma sST2 levels independently predict outcomes in ARF and are strongly associated with extrapulmonary organ dysfunction. The weak correlation between plasma and LRT sST2 levels suggests a predominantly systemic source. These findings highlight the potential of the IL-33/ST2 axis as a therapeutic target and warrant further investigation into its role in multiple organ dysfunction in ARF.</p>","PeriodicalId":10765,"journal":{"name":"Critical Care Medicine","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Recovery and Outcomes Every Day After the ICU (IMPROVE): A Randomized Controlled Trial.","authors":"Sikandar H Khan, Anthony J Perkins, Frederick W Unverzagt, Sophia Wang, Lyndsi R Moser, Salwa Moiz, Samreen Jawaid, Dexter Corlett, Daniel O Clark, Malaz A Boustani, Sujuan Gao, Babar A Khan","doi":"10.1097/CCM.0000000000006698","DOIUrl":"https://doi.org/10.1097/CCM.0000000000006698","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the effects of a 12-week, web-based, combined cognitive and physical training intervention on cognitive performance among ICU delirium survivors.</p><p><strong>Design: </strong>Prospective, four-arm randomized controlled trial.</p><p><strong>Setting: </strong>Four sites (academic, county, community ICUs).</p><p><strong>Patients: </strong>ICU adults 50 years old or older with at least one instance of ICU delirium or subsyndromal delirium.</p><p><strong>Interventions: </strong>Patients were randomized to one of four groups: physical exercise-cognitive training (PE-CT), physical exercise-cognitive control (PE-CC), stretching control-cognitive training (SC-CT), or stretching control-cognitive control (SC-CC).</p><p><strong>Measurements and main results: </strong>The primary outcome was cognitive function at 3 and 6 months after start of intervention, as assessed by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). One hundred fifty-three patients were randomized to either: PE-CT, n = 41; PE-CC, n = 41; SC-CT, n = 36; or SC-CC, n = 35. There was a significant difference on changes in RBANS z scores among the four arms (interaction term p = 0.012). The mean RBANS z scores ranged from -2.66 to +1.43 (change in RBANS z score of ± 0.5-0.6 may be clinically significant). The SC-CT group had statistically significant worsening in cognitive scores compared with the SC-CC group at 3 (mean estimated difference in change from baseline, -0.28; 95% CI, -0.53 to -0.02; p = 0.035) and 6 months (mean estimated difference in change from baseline, -0.29; 95% CI, -0.53 to -0.04; p = 0.021). Compared with the SC-CC group, the PE-CC group had statistically significant worsening in cognitive scores at 6 month (mean estimated difference in change from baseline, -0.26; 95% CI, -0.49 to -0.02; p = 0.035). There were no significant differences between groups in physical or mental quality of life, depression, or anxiety outcomes at any of the timepoints.</p><p><strong>Conclusions: </strong>The Improving Recovery and Outcomes Every Day After the ICU (IMPROVE) trial did not result in improved cognitive, physical, mental health, or quality of life measures at 3 or 6 months. We found a drop in cognitive performance among patients receiving cognitive training from baseline to 3 months postintervention.</p>","PeriodicalId":10765,"journal":{"name":"Critical Care Medicine","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methylprednisolone for Infant Heart Surgery: Subpopulation Analyses of a Randomized Controlled Trial.","authors":"Sudeep D Sunthankar, Kevin D Hill, Jeffrey P Jacobs, H Scott Baldwin, Marshall L Jacobs, Jennifer S Li, Eric M Graham, Brian Blasiole, S Adil Husain, Mark S Bleiweis, Bret Mettler, Alexis Benscoter, Eric Wald, Tara Karamlou, Andrew H Van Bergen, Pirooz Eghtesady, John P Scott, Brett R Anderson, George Alfieris, David F Vener, Prince J Kannankeril","doi":"10.1097/CCM.0000000000006721","DOIUrl":"https://doi.org/10.1097/CCM.0000000000006721","url":null,"abstract":"<p><strong>Objectives: </strong>Evaluate benefits and harms of prophylactic intraoperative methylprednisolone in subpopulations undergoing infant heart surgery.</p><p><strong>Design: </strong>Subpopulation analyses of The Steroids to Reduce Systemic Inflammation after Infant Heart Surgery (STRESS) trial, a double-blind randomized placebo-controlled trial.</p><p><strong>Setting: </strong>Twenty-four congenital heart centers.</p><p><strong>Patients: </strong>Infants (< 1 yr old) undergoing heart surgery with cardiopulmonary bypass. Patients stratified by Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery Congenital Heart Surgery (STAT) mortality category, age, gestational age, and presence of chromosomal or syndromic diagnosis (CSD).</p><p><strong>Interventions: </strong>Methylprednisolone (30 mg/kg) vs. placebo administered into cardiopulmonary bypass pump-priming fluid.</p><p><strong>Measurements and main results: </strong>Six postoperative outcomes: steroid use, acute kidney injury (AKI), thrombosis, infections, prolonged mechanical ventilation, peak blood glucose levels, and insulin exposure. One thousand two hundred patients received methylprednisolone or placebo. Beneficial effects associated with methylprednisolone included reduced use of postoperative hydrocortisone in neonates (odds ratio [OR], 0.39 [0.25-0.60]), both STAT category groups (1-3: OR, 0.64 [0.46-0.89]; 4-5: OR, 0.57 [0.34-0.97]), term infants (OR, 0.63 [0.47-0.83]), and those without CSD (OR, 0.63 [0.46-0.86]). Methylprednisolone was associated with lower thrombosis occurrence among neonates (OR, 0.37 [0.16-0.87]) and term infants (OR, 0.38 [0.19-0.75]). Adverse associations included increased thrombosis among premature infants (p = 0.005), increased AKI among neonates (OR, 1.55 [1.02-2.37]) and those following STAT category 1-3 operations (OR, 1.34 [1.02-1.75]), and increased peak blood glucose levels and insulin exposure (all subgroups; p < 0.001). No increase in overall infection or reduction in prolonged mechanical ventilation with methylprednisolone.</p><p><strong>Conclusions: </strong>Both beneficial and adverse associations were observed with prophylactic methylprednisolone. Reduction in postoperative hydrocortisone administration and absence of increased infection rates are arguments favoring prophylactic methylprednisolone use. Methylprednisolone was associated with increased peak blood glucose levels and a neutral to harmful association with odds of AKI. These data suggest certain subpopulations may benefit from prophylactic intraoperative methylprednisolone without significant harm.</p>","PeriodicalId":10765,"journal":{"name":"Critical Care Medicine","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary Rationale for Delivering Enteral Nutrition in Critically Ill Adults.","authors":"Jayshil J Patel, Robert G Martindale, Stephen A McClave","doi":"10.1097/CCM.0000000000006711","DOIUrl":"https://doi.org/10.1097/CCM.0000000000006711","url":null,"abstract":"<p><strong>Objectives: </strong>To review the rationale for and timing, dose, and monitoring of enteral nutrition and protein delivery in critically ill adults.</p><p><strong>Data sources: </strong>Medline searches to identify relevant studies, systematic reviews and meta-analyses, and guidelines informing the phases of critical illness, enteral nutrition and protein doses, and monitoring enteral nutrition.</p><p><strong>Study selection: </strong>Preclinical and contemporary clinical literature informing the rationale for and timing, dose, and monitoring of enteral nutrition and protein dose in critically ill adults.</p><p><strong>Data extraction: </strong>The evidence describing the rationale for and timing, dose, and monitoring of enteral nutrition and protein dose in critically ill adults is summarized.</p><p><strong>Data synthesis: </strong>The early delivery of enteral nutrition remains a cornerstone of therapy for critically ill adults. Historically, critical care nutrition guidelines have recommended achieving full-dose enteral nutrition within the first 72 hours of ICU admission. The rationale for delivering early enteral nutrition depends on the phase of critical illness, and providing a restrictive dose during the acute phase preserves gut integrity, supports the microbiome, and modulates immune dysregulation. Contemporary randomized controlled trials comparing enteral nutrition doses during the acute phase of critical illness have found full-dose enteral nutrition, compared with restrictive dose, and may offset the benefit from enteral feeding, causing iatrogenic stresses to the system leading to worse outcomes. Even though critically ill adults have anabolic resistance and undergo skeletal muscle proteolysis, recent trials have found that high-dose protein, compared with standard, does not improve clinical outcomes and may be harmful in certain subsets of critically ill adults.</p><p><strong>Conclusions: </strong>Contemporary data support the use of restrictive dose enteral nutrition during the acute phase of critical illness. High-dose protein is not superior to lower and is associated with worse outcomes in critically ill adults with acute kidney injury and those with greater severity of illness.</p>","PeriodicalId":10765,"journal":{"name":"Critical Care Medicine","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potassium Levels and In-Hospital Cardiac Arrest: A Matched Case-Control Study.","authors":"Peter C Lind, Nikola Stankovic, Mathias J Holmberg, Lars W Andersen, Asger Granfeldt","doi":"10.1097/CCM.0000000000006713","DOIUrl":"https://doi.org/10.1097/CCM.0000000000006713","url":null,"abstract":"<p><strong>Objectives: </strong>Hyperkalemia and hypokalemia are common in admitted patients and recognized as a reversible cause of cardiac arrest. How the risk of in-hospital cardiac arrest changes relative to the severity of hyperkalemia and hypokalemia remains uncertain. The objective of this study was to estimate the association between pre-cardiac arrest hyperkalemia and hypokalemia and in-hospital cardiac arrest and outcomes after in-hospital cardiac arrest.</p><p><strong>Design: </strong>Registry-based matched case-control study.</p><p><strong>Setting: </strong>Hospitalized patients in Denmark from 2017 to 2021.</p><p><strong>Patients: </strong>Cases were adults with in-hospital cardiac arrest identified through the Danish in-hospital cardiac arrest Registry. These were matched with controls on age, sex, and length and time of admission. The index time was defined for cases as their time of cardiac arrest. A corresponding index time was assigned to matched controls.</p><p><strong>Interventions: </strong>None.</p><p><strong>Measurements and main results: </strong>The exposure was potassium levels within 24 hours of the index time. Outcomes were in-hospital cardiac arrest and return of spontaneous circulation, 30-day survival, and 1-year survival in those with cardiac arrest. A total of 6,658 cases and 49,906 controls were included. Severe hyperkalemia (K+ > 6.5) and hypokalemia (K+ < 2.5) were associated with 2.03 (95% CI, 1.28-3.23) and 2.65 (95% CI, 1.61-4.38) times the odds of in-hospital cardiac arrest compared with normokalemia, respectively. Increasing severity of hyperkalemia was associated with decreased odds of return of spontaneous circulation, 30-day survival, and 1-year survival after in-hospital cardiac arrest. There was no clear association between hypokalemia and these outcomes.</p><p><strong>Conclusions: </strong>Hyperkalemia was associated with an increased risk of in-hospital cardiac arrest and with worse outcomes after cardiac arrest. Hypokalemia was associated with an increased risk of in-hospital cardiac arrest but was not associated with outcomes after cardiac arrest.</p>","PeriodicalId":10765,"journal":{"name":"Critical Care Medicine","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multicomponent Communication Intervention to Support Family Members of the Critically Ill: A Controlled Pre-Post Study.","authors":"Eyleen Reifarth, Boris Böll, Sascha Köpke, Lisa Altenrath, Jorge Garcia Borrega, Matthias Kochanek, Jan-Hendrik Naendrup","doi":"10.1097/CCM.0000000000006714","DOIUrl":"https://doi.org/10.1097/CCM.0000000000006714","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the effect of a communication intervention for family members of ICU patients, assessing comprehension of patient information within the first week of ICU admission, symptoms of anxiety and depression at 90 days post-ICU discharge, and corresponding risk factors.</p><p><strong>Design: </strong>Controlled pre-post study.</p><p><strong>Setting: </strong>Single academic tertiary care center in Germany, between January 2023 and July 2024.</p><p><strong>Subjects: </strong>ICU patients' family members.</p><p><strong>Interventions: </strong>The intervention comprised a communication manual and skills training for ICU physicians and nurses as well as a supplementary information brochure for ICU patients' families.</p><p><strong>Measurement and main results: </strong>Within the first week of ICU admission, data of 140 family members (70 control/70 intervention group) were collected via in-person interview on site using the Hospital Anxiety and Depression Scale and a validated questionnaire assessing information comprehension. Overall, in the control and intervention group, 46 (65.7%) and 31 (44.3%) family members, respectively, could not state the patients' diagnosis, therapy, or prognosis following a family-physician conversation in the ICU (p = 0.011; r = 0.215). On day 90, 67 (95.7%) and 64 (91.4%) family members in the control and intervention group, respectively, participated in the follow-up telephone interview. There was no statistically significant difference between groups regarding symptoms of anxiety or depression (p > 0.268). The family members' baseline anxiety and depression scores, their age, and their comprehension of the patients' main reason for ICU admission were identified as predictors of increased anxiety and depression scores at 90-day follow-up. In addition, higher education was associated with increased anxiety symptoms at 90-day follow-up.</p><p><strong>Conclusions: </strong>The intervention improved the family members' level of comprehension but did not decrease their symptoms of anxiety or depression at 90 days post-ICU discharge.</p>","PeriodicalId":10765,"journal":{"name":"Critical Care Medicine","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of High-Flow Oxygen Therapy in Apnea Testing for Brain Death Diagnosis.","authors":"Damien Barrier, Ludivine Vanacker, Grégoire Muller, Piotr Szychowiak, Anne Bretagnol, Isabelle Levebvre, Éric Narcisse, Léa Pascot, Thierry Boulain, Mai-Anh Nay","doi":"10.1097/CCM.0000000000006717","DOIUrl":"https://doi.org/10.1097/CCM.0000000000006717","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to assess the feasibility and safety of use of high-flow oxygen (HFO) through the endotracheal tube for apnea testing during brain death evaluation.</p><p><strong>Design: </strong>Prospective, interventional, single-center study.</p><p><strong>Setting: </strong>ICUs at the Orléans University Hospital, France.</p><p><strong>Patients: </strong>All adult patients meeting the criteria for clinical brain death and requiring an apnea test were eligible.</p><p><strong>Interventions: </strong>Fifteen patients underwent two successive apnea tests in the same order, each lasting 10 minutes: The first apnea test used 8 L/min of oxygen via a T-piece without a positive end-expiratory pressure valve connected to the endotracheal tube (standard test). The second apnea test used HFO at 50 L/min and Fio2 of 1.0 through a specialized device connected to the endotracheal tube. Arterial blood gases were measured every 2 minutes during both apnea tests. The primary objective was to investigate the feasibility and safety of use of HFO through the endotracheal tube for apnea testing compared with use of a T-piece in patients whose clinical examination was consistent with brain death and required an apnea test.</p><p><strong>Measurements and main results: </strong>All patients reached Paco2 greater than 60 mm Hg by the end of both apnea tests. At 10 minutes, Paco2 was 69.1 ± 5.9 mm Hg with the T-piece and 71.3 ± 6.0 mm Hg with HFO. Pao2 decreased significantly during the T-piece apnea test (from 404 ± 115 to 215 ± 118 mm Hg) but remained stable with HFO apnea test (from 342 ± 114 to 308 ± 92 mm Hg).</p><p><strong>Conclusions: </strong>HFO through the endotracheal tube is feasible and safe method for apnea testing. In patients with confirmed brain death via the standard apnea test, HFO yielded consistent diagnostic results while maintaining better oxygenation. Further research, particularly randomized trials, is needed to confirm the benefits of HFO in apnea testing.</p>","PeriodicalId":10765,"journal":{"name":"Critical Care Medicine","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Algorithmic Centralization of Sepsis Care Is Not a Promising Public Health Strategy.","authors":"David J Wallace","doi":"10.1097/CCM.0000000000006697","DOIUrl":"https://doi.org/10.1097/CCM.0000000000006697","url":null,"abstract":"","PeriodicalId":10765,"journal":{"name":"Critical Care Medicine","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Prediction to Practice: Evaluating Real-Time Clinical Decision Support in Pediatric Cardiac Intensive Care.","authors":"Fabio Savorgnan, Paul A Checchia","doi":"10.1097/CCM.0000000000006696","DOIUrl":"https://doi.org/10.1097/CCM.0000000000006696","url":null,"abstract":"","PeriodicalId":10765,"journal":{"name":"Critical Care Medicine","volume":" ","pages":""},"PeriodicalIF":7.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward a Precision Approach in Managing Acute Respiratory Failure in the Immunocompromised Patient.","authors":"Ambika Tejpal, Laveena Munshi, Bruno L Ferreyro, Patrick R Lawler, Michael C Sklar","doi":"10.1097/CCM.0000000000006657","DOIUrl":"10.1097/CCM.0000000000006657","url":null,"abstract":"","PeriodicalId":10765,"journal":{"name":"Critical Care Medicine","volume":" ","pages":"e1148-e1150"},"PeriodicalIF":7.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}