Current Rheumatology Reports最新文献_第5页

Unveiling the Potential of Probiotics in Osteoarthritis Management. 揭示益生菌在骨关节炎治疗中的潜力。

IF 5.7 2区医学

Current Rheumatology Reports Pub Date : 2024-11-23 DOI: 10.1007/s11926-024-01166-5

Asima Karim

{"title":"Unveiling the Potential of Probiotics in Osteoarthritis Management.","authors":"Asima Karim","doi":"10.1007/s11926-024-01166-5","DOIUrl":"10.1007/s11926-024-01166-5","url":null,"abstract":"Purpose of review: Osteoarthritis (OA), a highly prevalent degenerative joint disease, is of increasing concern due to its debilitating nature and negative impact on quality of life. Recent investigations have explored the therapeutic potential of probiotics to alleviate OA. This review summarizes the emerging evidence for the potential role of probiotics in managing OA symptoms and disease progression. The link between gut dysbiosis and chronic inflammation, a key player in OA progression is discussed in this review.Recent findings: Probiotics may modulate gut microbiota composition, potentially reducing systemic inflammation and alleviating OA symptoms, including joint pain and function. Possible mechanisms through which probiotics may exert these effects, including dampening inflammatory pathways and enhancing intestinal barrier integrity have been highlighted. Promising results from preclinical and clinical studies investigating the specific beneficial effects of specific probiotic strain(s) for OA management have been highlighted. Finally, limitations in current research and future directions, emphasizing the need for well-designed, large-scale clinical trials to definitively establish the therapeutic potential of probiotics in OA treatment have been discussed.","PeriodicalId":10761,"journal":{"name":"Current Rheumatology Reports","volume":"27 1","pages":"2"},"PeriodicalIF":5.7,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Keratinocytes - Amplifiers of Immune Responses in Systemic Lupus Erythematosus. 角质形成细胞--系统性红斑狼疮免疫反应的放大器。

IF 5.7 2区医学

Current Rheumatology Reports Pub Date : 2024-11-21 DOI: 10.1007/s11926-024-01168-3

Benjamin Klein, Nguyen Thi Kim Nguyen, Rezvan Moallemian, J Michelle Kahlenberg

引用次数: 0

Digital Health and Self-Management in Idiopathic Inflammatory Myopathies: A Missed Opportunity? 特发性炎症性肌病的数字健康与自我管理：错失良机？

IF 5.7 2区医学

Current Rheumatology Reports Pub Date : 2024-11-01 Epub Date: 2024-08-08 DOI: 10.1007/s11926-024-01157-6

Simone Battista, Benedetto Giardulli, Cristiana Sieiro Santos, Or Aharonov, Darshan Puttaswamy, Anne -Marie Russell, Latika Gupta

{"title":"Digital Health and Self-Management in Idiopathic Inflammatory Myopathies: A Missed Opportunity?","authors":"Simone Battista, Benedetto Giardulli, Cristiana Sieiro Santos, Or Aharonov, Darshan Puttaswamy, Anne -Marie Russell, Latika Gupta","doi":"10.1007/s11926-024-01157-6","DOIUrl":"10.1007/s11926-024-01157-6","url":null,"abstract":"Purpose of review: This paper explored the potential of digital health in idiopathic inflammatory myopathies (IIMs), with a focus on self-management. Digital self-management technology includes tailored treatment plans, symptom tracking, educational resources, enhanced communication, and support for long-term planning.Recent findings: After arguing the importance of digital health in IIMs management, from diagnosis until treatment, our literature review revealed a notable gap in research focusing on the efficacy of digital self-management interventions for individuals with IIMs, with no randomised controlled trials or observational studies addressing this topic. Our review further highlighted the significant unmet need for research in self-management interventions for individuals with IIMs. The absence of studies underscores the necessity for collaborative efforts to address this gap and develop personalised, effective strategies for managing IIMs using digital technology. Individuals with IIMs deserve tailored self-management approaches akin to those available for other rheumatic and musculoskeletal diseases.","PeriodicalId":10761,"journal":{"name":"Current Rheumatology Reports","volume":" ","pages":"383-391"},"PeriodicalIF":5.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11469974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calcium Pyrophosphate Crystal Deposition: Insights to Risks Factors and Associated Conditions. 焦磷酸钙晶体沉积：洞察风险因素和相关条件。

IF 5.7 2区医学

Current Rheumatology Reports Pub Date : 2024-11-01 Epub Date: 2024-08-05 DOI: 10.1007/s11926-024-01158-5

Konstantinos Parperis, Argyris Constantinou

{"title":"Calcium Pyrophosphate Crystal Deposition: Insights to Risks Factors and Associated Conditions.","authors":"Konstantinos Parperis, Argyris Constantinou","doi":"10.1007/s11926-024-01158-5","DOIUrl":"10.1007/s11926-024-01158-5","url":null,"abstract":"Purpose of the review: This review provides an overview of medical conditions and risk factors associated with CPPD.Recent findings: Recent studies have indicated that CPPD patients may have a higher risk for systemic conditions such as cardiovascular diseases. Calcium pyrophosphate deposition disease (CPPD) is a common crystal arthropathy that primarily affects older adults, and, in most cases, the aetiology is idiopathic. Age is the most remarkable risk factor and due to the aging population, the prevalence of this condition is expected to increase. Strong evidence supports an association between CPPD and several metabolic and endocrine conditions, including hemochromatosis, hyperparathyroidism, hypomagnesemia, and hypophosphatasia. Additionally, there is growing evidence of an increased risk for cardiovascular diseases among CPPD patients, alongside potential links to rheumatic disorders, gender, medications, and joint trauma. Further research is needed to explore the underlying mechanisms linking CPPD to associated conditions and to develop targeted therapies with the aim of improving patient outcomes.","PeriodicalId":10761,"journal":{"name":"Current Rheumatology Reports","volume":" ","pages":"375-382"},"PeriodicalIF":5.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Elusive Truth of Cannabinoids for Rheumatic Pain. 大麻素治疗风湿痛的神秘真相

IF 5.7 2区医学

Current Rheumatology Reports Pub Date : 2024-11-01 Epub Date: 2024-08-09 DOI: 10.1007/s11926-024-01162-9

Hance Clarke, Sarah Miles, Miki Peer, Mary-Ann Fitzcharles

{"title":"The Elusive Truth of Cannabinoids for Rheumatic Pain.","authors":"Hance Clarke, Sarah Miles, Miki Peer, Mary-Ann Fitzcharles","doi":"10.1007/s11926-024-01162-9","DOIUrl":"10.1007/s11926-024-01162-9","url":null,"abstract":"Purpose of review: Medical cannabis (MC) has entered mainstream medicine by a unique route. Regulatory acceptance as a medical product in many jurisdictions has bypassed the traditional evidence-based pathway required for therapies. Easier access to MC, especially related to recreational legalization of cannabis, has led to widespread use by patients for symptom relief of a variety of medical conditions and often without medical oversight. Musculoskeletal pain remains the most common reason for MC use. This review examines real-world issues pertaining to MC and offers some guidance for clinical care of patients with rheumatic diseases being treated with MC.Recent findings: Controlled clinical studies of cannabis products in patients with rheumatic diseases have been small and tested a range of compounds, routes of administration, and clinical populations, limiting our ability to generate conclusions on MC's effectiveness in this population. Observational cohort studies and surveys suggest that use of MC and related products in patients with rheumatic diseases improves pain and associated symptoms but is commonly accompanied by mild to moderate side effects. Conflicting evidence contributes to practitioner and patient uncertainty regarding the use of MC for rheumatic disease-related pain. Despite promising preclinical and observational evidence that MC and cannabis-derived compounds are useful in the management of rheumatic disease-related pain, there remains limited high-quality clinical evidence to substantiate these findings. There are a significant number of clinical trials on this topic currently planned or underway, however, suggesting the next decade may yield more clarity. Nevertheless, given that many people with rheumatic diseases are using cannabis products, healthcare professionals must remain apprised of the evidence pertaining to cannabinoids, communicate such evidence to patients in a meaningful way that is free from personal bias and stigma, and maintain strong collaborative clinical care pertaining to MC.","PeriodicalId":10761,"journal":{"name":"Current Rheumatology Reports","volume":" ","pages":"392-402"},"PeriodicalIF":5.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calcium Pyrophosphate Crystal Formation and Deposition: Where Do we Stand and What Does the Future hold? 焦磷酸钙晶体的形成与沉积：我们的现状和未来如何？

IF 5.7 2区医学

Current Rheumatology Reports Pub Date : 2024-10-01 Epub Date: 2024-08-01 DOI: 10.1007/s11926-024-01161-w

Silvia Sirotti, Anna Scanu, Tristan Pascart, Tom Niessink, Paola Maroni, Giovanni Lombardi, Georgios Filippou

{"title":"Calcium Pyrophosphate Crystal Formation and Deposition: Where Do we Stand and What Does the Future hold?","authors":"Silvia Sirotti, Anna Scanu, Tristan Pascart, Tom Niessink, Paola Maroni, Giovanni Lombardi, Georgios Filippou","doi":"10.1007/s11926-024-01161-w","DOIUrl":"10.1007/s11926-024-01161-w","url":null,"abstract":"Purpose of the review: Although calcium pyrophosphate deposition (CPPD) has been known since the 1960s, our understanding of its pathogenesis remains rudimentary. This review aims to illustrate the known mechanisms underlying calcium pyrophosphate (CPP) crystal formation and deposition and explore future directions in research. By examining various perspectives, from basic research to clinical and imaging assessments, as well as new emerging methodologies, we can establish a starting point for a deeper understanding of CPPD pathogenesis.Recent findings: Recent years have seen significant advances in CPPD research, particularly in the clinical field with the development of the 2023 ACR/EULAR classification criteria for CPPD disease, and in imaging with the introduction of the OMERACT ultrasonographic definitions and scoring system. However, progress in basic research has been slower. New laboratory approaches, such as Raman spectroscopy and omics sciences, offer promising insights that may help piece together the puzzle of CPPD. CPPD is a common yet understudied condition. As the population ages and CPPD becomes more prevalent, there is an urgent need to better understand the disease and the mechanisms involved in crystal formation and deposition, in order to improve diagnosis and therapeutic approaches.","PeriodicalId":10761,"journal":{"name":"Current Rheumatology Reports","volume":" ","pages":"354-365"},"PeriodicalIF":5.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Air Pollution and Rheumatoid Arthritis Risk and Progression: Implications for the Mucosal Origins Hypothesis and Climate Change for RA Pathogenesis. 空气污染与类风湿关节炎的风险和进展：粘膜起源假说和气候变化对类风湿关节炎发病机制的影响》。

IF 5.7 2区医学

Current Rheumatology Reports Pub Date : 2024-10-01 Epub Date: 2024-08-02 DOI: 10.1007/s11926-024-01160-x

Katarina J Bade, Kevin T Mueller, Jeffrey A Sparks

{"title":"Air Pollution and Rheumatoid Arthritis Risk and Progression: Implications for the Mucosal Origins Hypothesis and Climate Change for RA Pathogenesis.","authors":"Katarina J Bade, Kevin T Mueller, Jeffrey A Sparks","doi":"10.1007/s11926-024-01160-x","DOIUrl":"10.1007/s11926-024-01160-x","url":null,"abstract":"Purpose of review: The goal of this review paper is to summarize the main research and findings regarding air pollution and its association with the risk and progression of rheumatoid arthritis (RA).Recent findings: The most studied components of air pollution included particulate matter of ≤ 2.5 microns in diameter (PM2.5), PM10, carbon monoxide (CO), nitrogen dioxide (NO2), nitric oxide (NOx), sulfur dioxide (SO2), and ozone (O3). In addition, specific occupations and occupational inhalants have been investigated for RA risk. Several studies showed that increased exposure to air pollutants increased the risk of developing RA, particularly seropositive RA. There was evidence of gene-inhalant interactions for seropositive RA risk. Fewer studies have been conducted on RA disease activity and bone erosions. Some studies suggest that patients with RA-associated interstitial lung disease may have worse outcomes if exposed to air pollution. We summarized associations between air pollution and increased RA risk, including RA-associated interstitial lung disease. Relatively few studies investigated air pollution and RA disease activity or other outcomes. These results suggest an important role of air pollution for seropositive RA development and suggest that climate change could be a driver in increasing RA incidence as air pollution increases.","PeriodicalId":10761,"journal":{"name":"Current Rheumatology Reports","volume":" ","pages":"343-353"},"PeriodicalIF":5.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141874374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Updates in diagnosis and treatment of pediatric antiphospholipid syndrome. 诊断和治疗小儿抗磷脂综合征的最新进展。

IF 5.7 2区医学

Current Rheumatology Reports Pub Date : 2024-10-01 Epub Date: 2024-07-24 DOI: 10.1007/s11926-024-01156-7

Lucia M Campos, Paula S Marra, Clara R Doria, Sebastian D Cordoba, Clovis A Silva

{"title":"Updates in diagnosis and treatment of pediatric antiphospholipid syndrome.","authors":"Lucia M Campos, Paula S Marra, Clara R Doria, Sebastian D Cordoba, Clovis A Silva","doi":"10.1007/s11926-024-01156-7","DOIUrl":"10.1007/s11926-024-01156-7","url":null,"abstract":"Purpose of review: This review offers an overview of the most important recent articles on pediatric APS.Recent findings: Non-thrombotic extra criteria manifestations were prevalent in pediatric APS. Pregnancy morbidity has been described as the first manifestation of APS at youth age, impairing gestational outcomes. The 2023 APS criteria were developed for adult APS patients, and there is still a lack of pediatric-specific APS criteria. Catastrophic APS was more commonly reported as the initial manifestation of pediatric APS than in adults. Regarding treatment, direct oral anticoagulants have been recently approval for pediatric patients with venous thrombosis. New approaches have been proposed for severe cases, for arterial thrombosis, and rituximab for refractory cases. Recurrences typically occurred early and were associated with older age at diagnosis. Current studies highlighted the multifaceted nature of pediatric APS. Further large prospective multicenter studies evaluating new medications capable of reducing recurrence risk and improving prognosis in this population will be required.","PeriodicalId":10761,"journal":{"name":"Current Rheumatology Reports","volume":" ","pages":"366-374"},"PeriodicalIF":5.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gaining Insight into Updated MR Imaging for Quantitative Assessment of Cartilage Injury in Knee Osteoarthritis. 深入了解用于定量评估膝关节骨关节炎软骨损伤的最新磁共振成像技术。

IF 5.7 2区医学

Current Rheumatology Reports Pub Date : 2024-09-01 Epub Date: 2024-05-29 DOI: 10.1007/s11926-024-01152-x

Peng Luo, Li Lu, Run Xu, Lei Jiang, Guanwu Li

{"title":"Gaining Insight into Updated MR Imaging for Quantitative Assessment of Cartilage Injury in Knee Osteoarthritis.","authors":"Peng Luo, Li Lu, Run Xu, Lei Jiang, Guanwu Li","doi":"10.1007/s11926-024-01152-x","DOIUrl":"10.1007/s11926-024-01152-x","url":null,"abstract":"Purpose of the review: Knee Osteoarthritis (KOA) entails progressive cartilage degradation, reviewed via MRI for morphology, biochemical composition, and microtissue alterations, discussing clinical advantages, limitations, and research applicability.Recent findings: Compositional MRI, like T2/T2* mapping, T1rho mapping, gagCEST, dGEMRIC, sodium imaging, diffusion-weighted imaging, and diffusion-tensor imaging, provide insights into cartilage injury in KOA. These methods quantitatively measure collagen, glycosaminoglycans, and water content, revealing important information about biochemical compositional and microstructural alterations. Innovative techniques like hybrid multi-dimensional MRI and diffusion-relaxation correlation spectrum imaging show potential in depicting initial cartilage changes at a sub-voxel level. Integration of automated image analysis tools addressed limitations in manual cartilage segmentation, ensuring robust and reproducible assessments of KOA cartilage. Compositional MRI techniques reveal microstructural changes in cartilage. Multi-dimensional MR imaging assesses biochemical alterations in KOA-afflicted cartilage, aiding early degeneration identification. Integrating artificial intelligence enhances cartilage analysis, optimal diagnostic accuracy for early KOA detection and monitoring.","PeriodicalId":10761,"journal":{"name":"Current Rheumatology Reports","volume":" ","pages":"311-320"},"PeriodicalIF":5.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Classification Criteria for ANCA Associated Vasculitis - Ready for Prime Time? ANCA 相关性血管炎的分类标准--准备好了吗？

IF 5.7 2区医学

Current Rheumatology Reports Pub Date : 2024-09-01 Epub Date: 2024-06-24 DOI: 10.1007/s11926-024-01154-9

Jens Rathmann, Aladdin J Mohammad

{"title":"Classification Criteria for ANCA Associated Vasculitis - Ready for Prime Time?","authors":"Jens Rathmann, Aladdin J Mohammad","doi":"10.1007/s11926-024-01154-9","DOIUrl":"10.1007/s11926-024-01154-9","url":null,"abstract":"Purpose of review: This review aims to summarize the evolution and recent developments in the classification of ANCA associated vasculitis (AAV) and to summarize evaluations of the 2022 ACR/EULAR classification criteria of AAV in several cohorts.Recent findings: The classification of AAV has been a field of controversy for some time. The parallel existence of classification criteria and disease definitions produced some overlap in classification, leading to challenges when comparing different cohorts. The 2022 ACR/EULAR classification criteria derived from the largest study ever conducted in vasculitis account for significant changes in vasculitis classification with the integration of ANCA and modern imaging. These criteria show good performance compared to previous ones but also raise questions as ANCA serotypes have substantial impact on classification. In addition, there are some discrepancies with earlier agreed histopathological features of AAV disease phenotypes. During the last 35 years, several sets of classification criteria have evolved to facilitate epidemiologic studies and clinical trials in AAV. While some of these criteria have been in use for many years, they were criticized due to either not using ANCA or not integrating surrogate markers for vasculitis but also due to overlapping when used in parallel. The long-awaited new ACR/EULAR criteria for AAV were published in 2022 and are the result of a large international study, introducing for the first time ANCA and modern imaging in the classification of AAV. Though the criteria show good performance, they bring several other challenges with practical application.","PeriodicalId":10761,"journal":{"name":"Current Rheumatology Reports","volume":" ","pages":"332-342"},"PeriodicalIF":5.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11310294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0