Unveiling the Potential of Probiotics in Osteoarthritis Management.

IF 5.7 2区医学 Q1 RHEUMATOLOGY

Current Rheumatology Reports Pub Date : 2024-11-23 DOI:10.1007/s11926-024-01166-5

Asima Karim

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引用次数: 0

Abstract

Purpose of review: Osteoarthritis (OA), a highly prevalent degenerative joint disease, is of increasing concern due to its debilitating nature and negative impact on quality of life. Recent investigations have explored the therapeutic potential of probiotics to alleviate OA. This review summarizes the emerging evidence for the potential role of probiotics in managing OA symptoms and disease progression. The link between gut dysbiosis and chronic inflammation, a key player in OA progression is discussed in this review.

Recent findings: Probiotics may modulate gut microbiota composition, potentially reducing systemic inflammation and alleviating OA symptoms, including joint pain and function. Possible mechanisms through which probiotics may exert these effects, including dampening inflammatory pathways and enhancing intestinal barrier integrity have been highlighted. Promising results from preclinical and clinical studies investigating the specific beneficial effects of specific probiotic strain(s) for OA management have been highlighted. Finally, limitations in current research and future directions, emphasizing the need for well-designed, large-scale clinical trials to definitively establish the therapeutic potential of probiotics in OA treatment have been discussed.

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揭示益生菌在骨关节炎治疗中的潜力。

审查目的：骨关节炎（OA）是一种高发的退行性关节疾病，由于其使人衰弱的性质和对生活质量的负面影响，越来越受到人们的关注。最近的研究探索了益生菌缓解 OA 的治疗潜力。本综述总结了益生菌在控制 OA 症状和疾病进展方面的潜在作用的新证据。本综述还讨论了肠道菌群失调与慢性炎症之间的联系，慢性炎症是导致 OA 进展的关键因素：益生菌可调节肠道微生物群的组成，从而有可能减轻全身炎症并缓解 OA 症状，包括关节疼痛和功能。益生菌发挥这些作用的可能机制，包括抑制炎症途径和增强肠道屏障完整性，已得到强调。此外，还重点介绍了临床前研究和临床研究的成果，这些研究调查了特定益生菌菌株对治疗 OA 的具体益处。最后，还讨论了当前研究的局限性和未来发展方向，强调需要进行精心设计的大规模临床试验，以最终确定益生菌在治疗 OA 方面的治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Rheumatology Reports RHEUMATOLOGY-

CiteScore

11.20

自引率

0.00%

发文量

期刊介绍： This journal aims to review the most important, recently published research in the field of rheumatology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of rheumatologic conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas such as the many forms of arthritis, osteoporosis and metabolic bone disease, and systemic lupus erythematosus. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also occasionally provided.