Calcium Pyrophosphate Crystal Deposition: Insights to Risks Factors and Associated Conditions.

IF 5.7 2区医学 Q1 RHEUMATOLOGY

Current Rheumatology Reports Pub Date : 2024-11-01 Epub Date: 2024-08-05 DOI:10.1007/s11926-024-01158-5

Konstantinos Parperis, Argyris Constantinou

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引用次数: 0

Abstract

Purpose of the review: This review provides an overview of medical conditions and risk factors associated with CPPD.

Recent findings: Recent studies have indicated that CPPD patients may have a higher risk for systemic conditions such as cardiovascular diseases. Calcium pyrophosphate deposition disease (CPPD) is a common crystal arthropathy that primarily affects older adults, and, in most cases, the aetiology is idiopathic. Age is the most remarkable risk factor and due to the aging population, the prevalence of this condition is expected to increase. Strong evidence supports an association between CPPD and several metabolic and endocrine conditions, including hemochromatosis, hyperparathyroidism, hypomagnesemia, and hypophosphatasia. Additionally, there is growing evidence of an increased risk for cardiovascular diseases among CPPD patients, alongside potential links to rheumatic disorders, gender, medications, and joint trauma. Further research is needed to explore the underlying mechanisms linking CPPD to associated conditions and to develop targeted therapies with the aim of improving patient outcomes.

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焦磷酸钙晶体沉积：洞察风险因素和相关条件。

综述的目的：本综述概述了与 CPPD 相关的医疗条件和风险因素：最近的研究表明，CPPD 患者罹患心血管疾病等全身性疾病的风险较高。焦磷酸钙沉积病（CPPD）是一种常见的晶体关节病，主要影响老年人，大多数病例的病因是特发性的。年龄是最显著的风险因素，由于人口老龄化，预计这种疾病的发病率还会增加。大量证据表明，CPPD 与多种代谢和内分泌疾病有关，包括血色素沉着病、甲状旁腺功能亢进、低镁血症和低磷血症。此外，越来越多的证据表明，CPPD 患者罹患心血管疾病的风险增加，同时还可能与风湿性疾病、性别、药物和关节创伤有关。我们需要开展进一步的研究，探索 CPPD 与相关疾病的内在联系机制，并开发有针对性的疗法，以改善患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Rheumatology Reports RHEUMATOLOGY-

CiteScore

11.20

自引率

0.00%

发文量

期刊介绍： This journal aims to review the most important, recently published research in the field of rheumatology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of rheumatologic conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas such as the many forms of arthritis, osteoporosis and metabolic bone disease, and systemic lupus erythematosus. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also occasionally provided.