Critical reviews in analytical chemistry最新文献

{"title":"A Review of the Implementation of the USEPA Quality-Corrective Direction Performance Approach into Molecular Isotope-Dilution Mass Spectrometry Assays.","authors":"Yves Tondeur","doi":"10.1080/10408347.2026.2714239","DOIUrl":"https://doi.org/10.1080/10408347.2026.2714239","url":null,"abstract":"<p><p>The U.S. Environmental Protection Agency's (EPA) Performance-Based Measurement System (PBMS), now known as the Performance Approach, is approaching its 30^th anniversary. This critical review examines its origins, goals, and the obstacles that have hindered its implementation, while assessing the progress made to date and its status. By addressing key questions and providing specific illustrations, this review offers insights into reinvigorating the initiative, with an emphasis on regulating flexibility and fostering a culture of accountability. Furthermore, this analysis informs the testing community and data users of how outdated mental models continue to negatively influence stakeholders during the generation and application of isotope-dilution mass spectrometry (ID-MS) analytical data. The proposed solutions call for a shift in attitude, encouraging practitioners and users to responsibly prioritize specific results and data fitness-for-purpose over the strict adherence to dictated procedures.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-11"},"PeriodicalIF":7.7,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148789243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomaterial-Based Electrochemical and Optical Biosensors for Sedative Drug Detection: Mechanistic Insights and Point-of-Care Applications.","authors":"Hritik Kumar, Tileshwar Sahare, Abhijeet Joshi","doi":"10.1080/10408347.2026.2715149","DOIUrl":"https://doi.org/10.1080/10408347.2026.2715149","url":null,"abstract":"<p><p>Therapeutic sedatives, including benzodiazepines, barbiturates, and Z-drugs, are widely prescribed for anxiety, insomnia, and related disorders but are associated with dependence, overdose, and abuse, creating a need for rapid and selective monitoring. Conventional analytical techniques provide high accuracy but remain limited by cost, infrastructure requirements, and poor portability. Recent advances in nanomaterial-based electrochemical and optical biosensors have enabled sensitive and point-of-care detection of sedatives in complex biological and environmental matrices. This review critically evaluates electrochemical, fluorescence, colorimetric, and SERS-based sensing platforms, with emphasis on nanomaterial-analyte interactions, sensing mechanisms, and structure-function relationships governing analytical performance. Platform-specific advantages, limitations, multiplexing capability, and challenges associated with real-sample analysis and point-of-care translation are discussed, together with emerging directions in AI-assisted, smartphone-integrated, and wearable biosensing.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-43"},"PeriodicalIF":7.7,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal Oxide, Doped Metal Oxide, and Carbon-Based Electrochemical Sensors for Food Additive Detection: Recent Advances, Challenges, and Future Perspectives.","authors":"Anula Anil Dodamani, Divyashree Somashekara, Madhusudan B Kulkarni, Akshatha R Shetty, Ganesha Aroor, Meghana K Navada","doi":"10.1080/10408347.2026.2711057","DOIUrl":"https://doi.org/10.1080/10408347.2026.2711057","url":null,"abstract":"<p><p>Food safety can be ensured by rapid, accurate, and inexpensive methods to detect food additives, which can be harmful when consumed beyond a permissible limit. Although variety of highly sensitive traditional techniques are available for the quantification of food additives, their application is limited due to high instrumentation cost, time-consuming procedure, and complex sample preparation. In contrast, electrochemical sensors have gained prominence and are used as an alternative technique due to their portability, inexpensive nature, high sensitivity, and real-time detection capabilities. This review explores the use of metal oxides, doped metal oxides, and carbon-based nanomaterials to enhance the performance of an electrochemical sensor. It emphasizes the role of dopants, hybrid nanocomposites, their structural features, and synergistic effects to improve the electron transfer, selectivity, and sensitivity. The importance of electroanalytical techniques, including CV, DPV, SWV, and EIS, is highlighted for monitoring food safety. Furthermore, the review discusses the current challenges such as reproducibility, electrode fouling, environmental impact, and stability when used in real food matrices. Further, it discusses the new developments for fabricating next-generation sustainable electrochemical sensors for food monitoring, such as integration of nanomaterials with IoT- and IoT-based platform offering a future perspective on the development of electrochemical sensors.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-23"},"PeriodicalIF":7.7,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148758091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mass Spectrometry-Based Anti-Doping Analysis: A Critical Review of Emerging Analytical and Sample Pretreatment Strategies.","authors":"Dnyaneshwar Maykar, Pratik Vilas Gore, Suraj R Chaudhari, Pramod Kumar","doi":"10.1080/10408347.2026.2715148","DOIUrl":"https://doi.org/10.1080/10408347.2026.2715148","url":null,"abstract":"<p><p>Illicit use of doping substances has raised significant ethical and health concerns in sports. Therefore, continuous doping control is essential for maintaining fairness and athlete's safety. Accurate and rapid detection of prohibited substances at their lowest levels in complex biological matrices, such as blood, urine, and plasma, is crucial for reliable anti-doping analysis. This critical review focuses on the applications of mass spectrometry (MS) for the detection of doping agents across diverse biological matrices. Special emphasis is given to advanced mass spectrometry platforms, particularly LC-QQQ-MS, LC-QTOF-MS, Orbitrap-MS/MS, and IRMS which are widely used for the routine screening, confirmation, and identification of emerging doping agents. Microsampling approaches such as dried blood spots (DBS) and volumetric absorptive microsampling (VAMS) provide superior alternatives to traditional sampling. Furthermore, comprehensive understanding of sample pretreatment and analytical techniques is essential. In this regard, novel microextraction techniques, including solid-phase microextraction (SPME), liquid-phase microextraction (LPME), supramolecular solvents (SUPRAS), and deep eutectic solvents (DES), have improved multi-analyte sample pretreatment strategies and facilitated advanced automation. This review also offers valuable guidance in selecting appropriate chromatography coupled mass spectrometry‑based analytical methods with sensitive detection, sample pretreatment techniques, and storage conditions during sports drug testing.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-50"},"PeriodicalIF":7.7,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148789319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laser-Induced Graphene Electrochemical Sensors for Rapid and Portable Environmental Pollutant Detection.","authors":"Sofiene Mansouri, Yousef Alharbi, Abdulrahman Alqahtani, Amira Ouerhani","doi":"10.1080/10408347.2026.2708847","DOIUrl":"10.1080/10408347.2026.2708847","url":null,"abstract":"<p><p>Environmental pollution is a major global challenge that adversely affects human health, biodiversity, and ecosystems. In this regard, the development of portable and wearable sensing technologies has become increasingly important for real-time, on-site monitoring of environmental pollutants. Laser-induced graphene (LIG) has recently emerged as a promising carbon nanomaterial distinguished by its porous architecture, high conductivity, and exceptional electrochemical performance. Its ability to immobilize diverse biological and chemical probes has established LIG as a powerful platform for next-generation portable sensors. This study outlines recent advances in LIG electrodes used in portable and wearable electrochemical devices, with a particular focus on the functionalization of electrode materials and their application in detecting environmental pollutants. The advancement of LIG electrodes is thoroughly examined through various surface functionalization techniques, including the incorporation of polymers, metal nanoparticles, and metal complexes. Moreover, the review explores the practical implementation of LIG-based electrochemical platforms for quantifying and detecting pesticides, phenolic compounds, antibiotic residues, and heavy metals. Finally, it outlines existing limitations and emerging challenges in translating LIG technologies into fully portable and wearable systems, and proposes future research directions to accelerate their deployment in real-world environmental monitoring.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-22"},"PeriodicalIF":7.7,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of pretreatment and analytical techniques for amphetamine type stimulants in complex samples.","authors":"Zhen-Zhen Guo, Yu Bian, Yuan Zhang, Xue-Song Feng","doi":"10.1080/10408347.2026.2714553","DOIUrl":"https://doi.org/10.1080/10408347.2026.2714553","url":null,"abstract":"<p><p>Amphetamine-type stimulants (ATSs) are among the most widely abused drugs globally, posing serious threats to public health through addiction, physical and psychological harm, and associated social problems such as increased crime rates. Effective clinical management of ATSs overdose and abuse monitoring demand analytical methods that are not only sensitive, accurate, but also rapid and adaptable to real‑world settings. However, conventional detection approaches often face challenges including limited sensitivity, prolonged analysis time, insufficient selectivity in complex matrices, and poor suitability for on‑site or point‑of‑care testing. These limitations underscore the urgent need for advanced analytical strategies that can overcome such hurdles. This review comprehensively summarizes progress since 2017 in sample pretreatment and detection techniques for ATSs. It covers established methods such as ultrasonic‑assisted extraction and liquid‑liquid extraction, as well as emerging approaches including solid‑phase microextraction and liquid-phase microextraction, with a particular focus on the role of innovative materials-such as multi‑walled carbon nanotubes and metal‑organic frameworks-in improving extraction efficiency and analytical performance. For detection, chromatographic-based methods are discussed, alongside the rapidly evolving field of high-resolution mass spectrometry technology. Finally, the review critically compares the advantages and limitations of current techniques and outlines promising directions for future development.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-27"},"PeriodicalIF":7.7,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advances in Electrochemical and Optical Detection of Bisphenol A in Water Samples.","authors":"Paweł Cwynar, Min Ying Tsang, Katarzyna Matczyszyn","doi":"10.1080/10408347.2026.2704098","DOIUrl":"https://doi.org/10.1080/10408347.2026.2704098","url":null,"abstract":"<p><p>Bisphenol A (BPA) is a well-known endocrine-disrupting chemical that poses risks to human health by interfering with hormonal systems. Despite regulatory restrictions, BPA remains widely used in polycarbonates and epoxy resins, leading to its continuous release into the environment. Its presence in aquatic systems and subsequent transfer through ecosystems highlight the need for effective detection methods. Sensing of BPA in environmental samples remains challenging due to complex matrices, low concentration levels, and the requirements for high selectivity and sensitivity. These demands have driven the rapid development of advanced functional materials for sensing applications. This review provides a critical overview of recent strategies for BPA detection, with focuses on electrochemical and optical sensing methodologies. Emphasis is placed on the development and application of different types of functional materials, including organic, inorganic, and metal-organic based systems. The advantages and limitations of these approaches are discussed to highlight current challenges and future perspectives in BPA monitoring.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-18"},"PeriodicalIF":7.7,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148683609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fit-for-purpose analytics for cannabis: identification, quantification, and standardization of cannabinoids, flavonoids and terpenes.","authors":"Eman Shawky, Lutfun Nahar, Satyajit D Sarker, Dina A Selim","doi":"10.1080/10408347.2026.2714459","DOIUrl":"https://doi.org/10.1080/10408347.2026.2714459","url":null,"abstract":"<p><p>Cannabis-based products used in medicine and wellness are chemically complex mixtures of cannabinoids, terpenes, flavonoids (including cannflavins), and degradation products whose profiles can shift substantially with cultivar genetics, cultivation conditions, extraction workflows, formulation choices, and storage history. This field-to-field and lab-to-lab variability, compounded by inconsistent analytical practices and uneven validation standards, can undermine potency labeling, cross-product comparability, and the interpretation of clinical and pharmacological findings. This review critically summarizes current quantitative and fingerprint-based strategies for measuring cannabinoids and related constituents across major product types (flowers/biomass, oils, edibles, and vape products) and proposes a practical \"field-to-result\" framework spanning sampling, method selection, validation, and lifecycle quality control. Drawing on peer-reviewed literature and metrological guidance, we evaluate LC-UV/LC-MS/MS, GC-FID/GC-MS, quantitative and structural NMR, and selected spectroscopic and aerosol approaches, with emphasis on isotope-dilution concepts, calibration design, matrix effects, validation criteria, and chemometric tools for multivariate fingerprints. The evidence is synthesized to map analyte classes and matrices to fit-for-purpose platforms and sample preparation schemes, highlight best practices for internal standards and matrix-matched calibration, and summarize commonly applied acceptance expectations for accuracy and precision. Strategies to reduce or correct matrix effects are detailed, and the role of high-dimensional fingerprints is explained as a complement to targeted potency panels for identity confirmation, process drift monitoring, lot release decisions, and traceability. Overall, combining validated potency assays with statistically governed fingerprinting offers a pragmatic route to harmonize cannabinoid testing, improve data integrity, and better support future phytomedicine research, clinical translation, and regulatory oversight.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-22"},"PeriodicalIF":7.7,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148683613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Switchable Solvents in Novel Approaches to Sustainable Analytical Practices: A Comparative Review Applying SPMS, NQS, SAMI, and SIX Score Metrics.","authors":"Ekhlas A Abdulkareem, Ghusoon Jawad Shabaa, Rana Kadhim Ridha, Manar A Muninir, Melath K Al-Gufaili, Mushtaq Ali Hussein, Mehdi Hosseini, Ebaa Adnan Azooz","doi":"10.1080/10408347.2026.2711888","DOIUrl":"https://doi.org/10.1080/10408347.2026.2711888","url":null,"abstract":"<p><p>Sustainability has become an essential consideration in modern chemical analysis. The green analysis focused on reducing pollution, energy consumption, and waste generation. In addition, the sustainability rules take into account both economic and societal ramifications. Switchable Solvents (SSs) are green solvents developed last year to address pollution issues. This study provides a full examination of SSs, including their designation, characteristics, and applications, with a focus on their importance in sustainability. In this context, the present review examines the types of SS solvents used in sample preparation processes. In contrast, this work shifts the focus from \"what\" these solvents can do to \"how\" they align with global sustainability standards. This work introduces the computational tools necessary to measure environmental impact. By applying the Sustainability of Analytical Methods Index (SAMI) software and SIX Score tool for the first time, these provide an objective, data-driven score for sample preparation. In addition, this review adds strategic evaluation by using tools like the sample preparation metric of sustainability (SPMS) and need-quality-sustainability (NQS). This transition from a purely chemical perspective to a \"sustainability-first\" perspective is essential for the future. Furthermore, this review critically examines sustainability goals, sustainability tools, study cases, reproducibility analysis, conclusions, and future perspectives.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-17"},"PeriodicalIF":7.7,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Nucleic Acid-Based Amplification Strategies for Dual-Mode Biosensing of Pathogenic Bacteria: From Molecular Mechanisms to Integrated Analytical Systems.","authors":"Salah Tofik Jalal Balaky, Ban Hussein Alwash, Faisal Faruq Sadiq Zamzamokey, Amer Ali Khaleel, Hasanain Saadi Abbas Al-Qaysi, Mehregan Babamohamadi","doi":"10.1080/10408347.2026.2706684","DOIUrl":"https://doi.org/10.1080/10408347.2026.2706684","url":null,"abstract":"<p><p>Rapid, accurate, and reliable detection of pathogenic bacteria remains a critical need in clinical, food, and environmental monitoring. In today's context, nucleic acid amplification-mediated biosensing have emerged as a prominent approach to improve detection sensitivity, whereas dual-mode signal readout approaches have more enhanced analytical robustness and reliability. This review outlines recent advances in nucleic acid signal amplification strategies, including enzyme-based methods like LAMP, RPA, and RCA, as well as enzyme-free approaches like HCR, CHA, and EDR. Special attention is given to incorporating these amplification methods into dual-mode biosensing systems that combine both optical and electrochemical transduction mechanisms. This integration enables complementary signal generation and improves detection accuracy by reducing false-positive and false-negative results. This study critically examines the advancement of nucleic acid signal amplification strategies (NASAS)-mediated dual-mode sensing systems for detecting major pathogenic bacteria, including <i>Escherichia coli, Salmonella, Listeria monocytogenes, Staphylococcus aureus</i>, and <i>Vibrio species</i>, focusing on selectivity, sensitivity, assay design, and real-sample applicability. Finally, the review highlights present challenges related to system integration, standardization, and point-of-care applications. Additionally, it outlines potential future directions for rendering nucleic acid amplification-based dual-mode probes into practical diagnostic devices. Overall, this study affords a comprehensive synthesis of emerging approaches and design mechanisms for next-generation diagnostic scaffold for pathogen analysis.</p>","PeriodicalId":10744,"journal":{"name":"Critical reviews in analytical chemistry","volume":" ","pages":"1-22"},"PeriodicalIF":7.7,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}