Contemporary topics in immunobiology最新文献

{"title":"Mechanisms of microbial entry and endocytosis by mononuclear phagocytes.","authors":"D M Mosser, P J Edelson","doi":"10.1007/978-1-4757-1445-6_4","DOIUrl":"https://doi.org/10.1007/978-1-4757-1445-6_4","url":null,"abstract":"","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":"13 ","pages":"71-96"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17435888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunobiology of parasites and parasitic infections.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":"12 ","pages":"1-497"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17752281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations of surface properties by macrophage activation: expression of receptors for Fc and mannose-terminal glycoproteins and differentiation antigens.","authors":"R A Ezekowitz, S Gordon","doi":"10.1007/978-1-4757-1445-6_2","DOIUrl":"https://doi.org/10.1007/978-1-4757-1445-6_2","url":null,"abstract":"","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":"13 ","pages":"33-56"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-1-4757-1445-6_2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17390390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antigenic characterization of plasmodia.","authors":"L H Perrin, L Rodriguez da Silva, R Dayal","doi":"10.1007/978-1-4684-4571-8_4","DOIUrl":"https://doi.org/10.1007/978-1-4684-4571-8_4","url":null,"abstract":"","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":"12 ","pages":"109-25"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17424730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roles of surface antigens on malaria-infected red blood cells in evasion of immunity.","authors":"R J Howard, J W Barnwell","doi":"10.1007/978-1-4684-4571-8_5","DOIUrl":"https://doi.org/10.1007/978-1-4684-4571-8_5","url":null,"abstract":"","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":"12 ","pages":"127-200"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17424731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of human leukocyte function by lipoxygenase products of arachidonic acid.","authors":"F H Valone","doi":"10.1007/978-1-4757-4862-8_5","DOIUrl":"https://doi.org/10.1007/978-1-4757-4862-8_5","url":null,"abstract":"<p><p>Oxygenation of arachidonic acid via the 5- and 15-lipoxygenase pathways yields a variety of products, including monohydroxyeicosatetraenoic acids (HETEs) and more complex products termed leukotrienes. Of these products leukotriene B4 (LTB4) is the most potent modulator of PMN function. Nanomolar concentrations of LTB4 elicit PMN chemotaxis both in vitro and in vivo, and 3- to 10-fold higher concentrations of LTB4 promote lysosomal degranulation, PMN leukocyte aggregation, and adherence, in addition to enhancing the expression of neutrophil and eosinophil C3b receptors. The PMN-directed effects of LTB4 are mediated by binding to a distinct subset of PMN receptors. LTB4 is bound stereospecifically by 26,000-40,000 receptors per PMN, and the receptors have a KD of 10.8-13.9 nM. The receptor for LTB4 may also mediate PMN activation by other 5-lipoxygenase products, as the capacity of these products to activate PMN leukocyte function correlates with their capacity to compete with LTB4 for binding by the receptor. Several observations suggest that LTB4 may function both as an extracellular mediator of PMN function and as a critical intracellular intermediate in cellular activation by other agents. These observations include the localization of the LTB4 receptor in neutrophil granules, the dependence of PMN activation by different stimuli on the lipoxygenation of arachidonic acid, and the capacity of LTB4 to promote calcium flux in liposomes. Arachidonic acid oxygenation products have complex effects on T-lymphocyte function. LTB4 enhances T-lymphocyte chemokinesis and inhibits the generation of lymphokines and cellular transformation. LTC4 inhibits the generation of lymphokines without affecting transformation or chemokinesis. 5-HETE enhances and 15-HETE inhibits chemokinesis, whereas these products have no effects on the other lymphocyte functions. Thus, the lipoxygenase products of arachidonic acid are potent modulators of T-lymphocyte and PMN-function; these products may function both as extracellular mediators and as intracellular intermediates in cellular activation.</p>","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":"14 ","pages":"155-70"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17155272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of regulating the respiratory burst in leukocytes.","authors":"L C McPhail,&nbsp;R Snyderman","doi":"10.1007/978-1-4757-4862-8_9","DOIUrl":"https://doi.org/10.1007/978-1-4757-4862-8_9","url":null,"abstract":"","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":"14 ","pages":"247-81"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17155273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression and development of macrophage activation for tumor cytotoxicity.","authors":"W J Johnson,&nbsp;S D Somers,&nbsp;D O Adams","doi":"10.1007/978-1-4757-1445-6_7","DOIUrl":"https://doi.org/10.1007/978-1-4757-1445-6_7","url":null,"abstract":"","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":"13 ","pages":"127-46"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17435883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of Leukocyte Function","authors":"R. Snyderman","doi":"10.1007/978-1-4757-4862-8","DOIUrl":"https://doi.org/10.1007/978-1-4757-4862-8","url":null,"abstract":"","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":"76 1","pages":"1-410"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88103340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunopathology of parasitic diseases: a conceptual approach.","authors":"S M Phillips,&nbsp;E G Fox","doi":"10.1007/978-1-4684-4571-8_11","DOIUrl":"https://doi.org/10.1007/978-1-4684-4571-8_11","url":null,"abstract":"<p><p>These studies would indicate tremendous variations in the clinical manifestations of parasitic disease, resulting from characteristics of the parasite, the host, and their interaction. They further suggest that the conceptual mechanistic model described in the introduction is highly applicable. Previous evidence to substantiate the validity of such a model in schistosomiasis, a variety of protozoan diseases, and leprosy has already been presented (Phillips and Fox, 1982). This report would appear to lend additional credence to the postulates and suggests that upon scrutiny, the model represents a reasonable explanation for a wide variety of clinical manifestations of a parasitic disease. In addition, it may provide a working hypothesis for the interpretation of the immunopathology found in other diseases such as filariasis. Figure 3 compares and contrasts schistosomiasis and filariasis within the context of this hypothesis. Immunopathology results from the relative balance of host-parasite immunogenic factors and modulatory specific and nonspecific factors. The resultant immunopathology results from a number of immunologic mechanisms, but for the sake of comparison can be placed in certain analogous groups. Clearly, although a number of experimental questions still exist, vis-à-vis these analogies, it would appear that they are reasonable comparisons. It is hoped that such a conceptual approach might provide a useful framework for an understanding of the spectrum of immunopathology resulting from parasitic disease. These concepts might possibly lead to the eventual control of immunopathology.</p>","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":"12 ","pages":"421-61"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17424735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}