Contemporary topics in immunobiology最新文献_第4页

Intracellular mechanisms of killing. 细胞内杀伤机制。

Contemporary topics in immunobiology Pub Date : 1984-01-01 DOI: 10.1007/978-1-4684-4571-8_2

N Nogueira

引用次数: 6

Macrophage activation. 巨噬细胞激活。

Contemporary topics in immunobiology Pub Date : 1984-01-01

引用次数: 0

Mechanisms of leukocyte regulation by complement-derived factors. 补体衍生因子调控白细胞的机制。

Contemporary topics in immunobiology Pub Date : 1984-01-01 DOI: 10.1007/978-1-4757-4862-8_4

T E Hugli, E L Morgan

{"title":"Mechanisms of leukocyte regulation by complement-derived factors.","authors":"T E Hugli, E L Morgan","doi":"10.1007/978-1-4757-4862-8_4","DOIUrl":"https://doi.org/10.1007/978-1-4757-4862-8_4","url":null,"abstract":"Progress over the past five years has drawn attention to the fact that the anaplylatoxins are important factors in both leukocyte activation and regulation events. The C5 anaphylatoxin has been proposed to play major role in leukocyte aggregation and adherence phenomenon. Influences of C5a on the leukocyte may lead to clinical manifestations such as respiratory distress syndrome after trauma or postpump syndrome after cardiopulmonary bypass, both effects derived from leukocyte sequestration. Many other clinical conditions involving repeated transient sequestration of leukocytes, particularly in the pulmonary vasculature, may eventually be recognized as a complication of systemic complement activation. Dramatic pathologic changes observed in the lungs of animals exposed to either C3a or C5a emphasizes the potential damage that these factors may exert via cellular activation mechanisms (Huey et al., 1983). More recent evidence that the anaphylatoxins are potent immunoregulatory factors under in vitro conditions suggests a physiologic role for these humoral factors in nonspecific modulation of the immune response. It is an attractive hypothesis to suggest that once activated, complement is capable of relaying information to the cellular immune system via the anaphylatoxins. Other components of the complement system have long been known to exert regulatory influences on the immune system, and perhaps molecular description of such entities as the C3d-K fragment will serve to unravel this seemingly more complex effector system. In any case, as our understanding of both the chemical and biologic nature of factors derived from blood complement components advances, it has become apparent that a major function of complement may be to modulate the immune response. We have already demonstrated that these factors are selective both for cell type and for eliciting a variety of cellular responses. From this, one can infer that manipulation of the cellular events will eventually be possible. Hence a therapeutic value may be realized once involvement of these complement factors under in vivo conditions is better characterized.","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":"14 ","pages":"109-53"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17393455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 39

Analysis of macrophage differentiation and function with monoclonal antibodies. 单克隆抗体对巨噬细胞分化及功能的分析。

Contemporary topics in immunobiology Pub Date : 1984-01-01 DOI: 10.1007/978-1-4757-1445-6_1

T A Springer, J C Unkeless

引用次数: 28

Activation of macrophages to kill rickettsiae and Leishmania: dissociation of intracellular microbicidal activities and extracellular destruction of neoplastic and helminth targets. 激活巨噬细胞杀死立克次体和利什曼原虫:细胞内杀微生物活性的分离和肿瘤和蠕虫目标的细胞外破坏。

Contemporary topics in immunobiology Pub Date : 1984-01-01 DOI: 10.1007/978-1-4757-1445-6_8

C A Nacy, C N Oster, S L James, M S Meltzer

{"title":"Activation of macrophages to kill rickettsiae and Leishmania: dissociation of intracellular microbicidal activities and extracellular destruction of neoplastic and helminth targets.","authors":"C A Nacy, C N Oster, S L James, M S Meltzer","doi":"10.1007/978-1-4757-1445-6_8","DOIUrl":"https://doi.org/10.1007/978-1-4757-1445-6_8","url":null,"abstract":"Mononuclear phagocytes undergo dramatic changes during differentiation from bone marrow stem cells to resident tissue macrophages. Throughout differentiation, cells lose or acquire numerous morphologic, metabolic and functional capacities such that mature, resident macrophages of one tissue often bear little resemblance to resident cells of another. Superimposed on the intrinsic continuum of mononuclear phagocyte differentiation are the reactive changes in macrophages induced by endogenous and exogenous stimuli: the ability of mononuclear phagocytes to respond to a particular stimulus may also change with cell differentiation. This dynamic interaction of cell differentiation and response to a micro-environment, and the resulting heterogeneity among mononuclear phagocytes for many functional characteristics, is clearly illustrated by the effector activities of activated macrophages that we describe in this report. Despite the common regulatory events for induction and expression of transient nonspecific cytotoxic reactions effective against such diverse targets as rickettsiae, leishmania, schistosomula, and neoplastic cells, these effector functions can be dissociated by the cells that perform the effector activity, and the signals that regulate these activities. The differential susceptibility of the various targets to particular killing mechanisms induced by LK in responsive populations only adds to the complexity of these in vitro analyses. The details of effector functions of activated macrophages are unique for each target.","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":"13 ","pages":"147-70"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-1-4757-1445-6_8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17435885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37

Immunobiology of African trypanosomiasis. 非洲锥虫病的免疫生物学。

Contemporary topics in immunobiology Pub Date : 1984-01-01 DOI: 10.1007/978-1-4684-4571-8_7

G E Roelants, M Pinder

引用次数: 32

Identification of gamma-interferon as a murine macrophage-activating factor for tumor cytotoxicity. γ -干扰素作为小鼠肿瘤细胞毒性巨噬细胞激活因子的鉴定。

Contemporary topics in immunobiology Pub Date : 1984-01-01 DOI: 10.1007/978-1-4757-1445-6_9

R D Schreiber

引用次数: 44

Surveillance role of various leukocytes in preventing the outgrowth of potentially malignant cells. 各种白细胞在预防潜在恶性细胞生长中的监视作用。

Contemporary topics in immunobiology Pub Date : 1984-01-01 DOI: 10.1007/978-1-4757-1445-6_11

J Urban, H Schreiber

引用次数: 3

Models of adoptive T-cell-mediated regression of established tumors. 过继性t细胞介导的肿瘤消退模型。

Contemporary topics in immunobiology Pub Date : 1984-01-01 DOI: 10.1007/978-1-4757-1445-6_12

R J North

引用次数: 16

Activation of mononuclear phagocytes for the destruction of intracellular parasites: studies with Trypanosoma cruzi. 激活单核吞噬细胞破坏细胞内寄生虫:克氏锥虫的研究。

Contemporary topics in immunobiology Pub Date : 1984-01-01 DOI: 10.1007/978-1-4757-1445-6_6

N Nogueira, Z A Cohn

引用次数: 6