Contemporary topics in immunobiology最新文献

Protein A immunoadsorption/immunoactivation: a critical review. 蛋白A免疫吸附/免疫活化:综述

Contemporary topics in immunobiology Pub Date : 1985-01-01 DOI: 10.1007/978-1-4684-4931-0_8

M F Fer, R K Oldham

引用次数: 7

Immune Complexes and Human Cancer 免疫复合物与人类癌症

Contemporary topics in immunobiology Pub Date : 1985-01-01 DOI: 10.1007/978-1-4684-4931-0

F. A. Salinas, M. Hanna

引用次数: 12

Immune complexes and human cancer. 免疫复合物和人类癌症。

Contemporary topics in immunobiology Pub Date : 1985-01-01

引用次数: 0

Trials of staphylococcal protein A-treated plasma infusions in cancer therapy: clinical effects and implications for mode of action. 葡萄球菌蛋白a治疗的血浆输注在癌症治疗中的试验:临床效果和作用方式的意义。

Contemporary topics in immunobiology Pub Date : 1985-01-01 DOI: 10.1007/978-1-4684-4931-0_7

F R MacKintosh, K Bennett, S W Hall

{"title":"Trials of staphylococcal protein A-treated plasma infusions in cancer therapy: clinical effects and implications for mode of action.","authors":"F R MacKintosh, K Bennett, S W Hall","doi":"10.1007/978-1-4684-4931-0_7","DOIUrl":"https://doi.org/10.1007/978-1-4684-4931-0_7","url":null,"abstract":"The data presented here indicate that patients with advanced cancer exhibit a modest but definite objective response rate to biweekly infusions of autologous plasma treated with purified, covalently bound staphylococcal protein A in a relatively nontoxic treatment program. The possibility that responses could be enhanced by alteration of treatment parameters, improved patient selection, and/or combined therapy remains to be explored. In vitro studies indicate that tumor cell killing can be produced in an ovarian cancer cell line using ascitic fluid of some ovarian cancer patients that has been treated with small amounts of protein A covalently linked to silica gel or agarose. This may be a suitable model system for exploration of possible humoral mechanisms of protein A-associated tumoricidal effects. The available literature indicates an antitumor effect of protein A-treated patient plasma in a variety of in vitro systems, as well as in animal and human tumors in vivo. Preliminary investigations of the mechanism of these effects are inconsistent and support the view that several different mechanisms of tumor cell killing may be operative in different settings.","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15012509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Clinical relevance of immune complexes, associated antigen, and antibody in cancer. 免疫复合物、相关抗原和抗体在癌症中的临床意义。

Contemporary topics in immunobiology Pub Date : 1985-01-01 DOI: 10.1007/978-1-4684-4931-0_2

F A Salinas, K H Wee, H K Silver

引用次数: 24

Immunosuppressor control as a modality of cancer treatment: effect of plasma adsorption with Staphylococcus aureus protein A. 免疫抑制剂控制作为癌症治疗的一种方式:金黄色葡萄球菌蛋白a血浆吸附的效果。

Contemporary topics in immunobiology Pub Date : 1985-01-01 DOI: 10.1007/978-1-4684-4931-0_5

P K Ray

{"title":"Immunosuppressor control as a modality of cancer treatment: effect of plasma adsorption with Staphylococcus aureus protein A.","authors":"P K Ray","doi":"10.1007/978-1-4684-4931-0_5","DOIUrl":"https://doi.org/10.1007/978-1-4684-4931-0_5","url":null,"abstract":"In tumor-bearing hosts both cellular and humoral tumor-growth-enhancing factors are present. They cause immunosuppression and facilitate the growth of tumors. Very early during tumor growth these factors are either elicited by the tumor cells or induced by the host immunocytes. Among these immunosuppressive agents, circulating immune complexes appear to play a predominant role. They also activate suppressor cell activity. Plasma adsorption of CIC and IgG by protein A of Staphylococcus aureus has been reported to cause tumor regression. Plasma adsorption with protein A-collodion charcoal, protein A-silica, or protein A-Sepharose also induced tumorilytic reactions. Even direct infusion of protein A induced tumor regressions in rat mammary tumors. Recent studies showing tumor regressions following S. aureus Wood 46 plasma adsorption or infusion of normal plasma adsorbed over S. aureus indicate that specific blocking factor removal by plasma adsorption may not be the mechanism for causing tumor destruction. Results indicate that S. aureus plasma adsorption leaches a number of staphylococcal agents. Thus, it appears that staphylococcal agents, protein A, enterotoxin, and other factors are responsible for the induction of reactions leading to tumor destruction. A unified mechanism explaining the results obtained with plasma adsorption using protein A of S. aureus, or S. aureus Wood, or direct protein A infusion, was presented.","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14290656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Clinical significance and nature of circulating immune complexes in melanoma patients. 黑色素瘤患者循环免疫复合物的临床意义和性质。

Contemporary topics in immunobiology Pub Date : 1985-01-01 DOI: 10.1007/978-1-4684-4931-0_1

R K Gupta, D L Morton

引用次数: 13

Immune complexes in patients bearing solid tumors. 实体瘤患者的免疫复合物。

Contemporary topics in immunobiology Pub Date : 1985-01-01 DOI: 10.1007/978-1-4684-4931-0_4

D Cupissol, C Thierry, B C Serrou

引用次数: 3

Blocking (suppressor) factors, immune complexes, and extracorporeal immunoadsorption in tumor immunity. 肿瘤免疫中的阻断(抑制)因子、免疫复合物和体外免疫吸附。

Contemporary topics in immunobiology Pub Date : 1985-01-01 DOI: 10.1007/978-1-4684-4931-0_6

K E Hellström, I Hellström, H W Snyder, J P Balint, F R Jones

引用次数: 14

The pathophysiology of circulating immune complexes: their role in host-tumor interactions and removal by immunoadsorption therapy. 循环免疫复合物的病理生理学:它们在宿主-肿瘤相互作用和免疫吸附治疗中的作用。

Contemporary topics in immunobiology Pub Date : 1985-01-01 DOI: 10.1007/978-1-4684-4931-0_3

T M Phillips, T V Holohan, S Korac, N S More, W D Queen

引用次数: 16