Immunosuppressor control as a modality of cancer treatment: effect of plasma adsorption with Staphylococcus aureus protein A.

P K Ray
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引用次数: 14

Abstract

In tumor-bearing hosts both cellular and humoral tumor-growth-enhancing factors are present. They cause immunosuppression and facilitate the growth of tumors. Very early during tumor growth these factors are either elicited by the tumor cells or induced by the host immunocytes. Among these immunosuppressive agents, circulating immune complexes appear to play a predominant role. They also activate suppressor cell activity. Plasma adsorption of CIC and IgG by protein A of Staphylococcus aureus has been reported to cause tumor regression. Plasma adsorption with protein A-collodion charcoal, protein A-silica, or protein A-Sepharose also induced tumorilytic reactions. Even direct infusion of protein A induced tumor regressions in rat mammary tumors. Recent studies showing tumor regressions following S. aureus Wood 46 plasma adsorption or infusion of normal plasma adsorbed over S. aureus indicate that specific blocking factor removal by plasma adsorption may not be the mechanism for causing tumor destruction. Results indicate that S. aureus plasma adsorption leaches a number of staphylococcal agents. Thus, it appears that staphylococcal agents, protein A, enterotoxin, and other factors are responsible for the induction of reactions leading to tumor destruction. A unified mechanism explaining the results obtained with plasma adsorption using protein A of S. aureus, or S. aureus Wood, or direct protein A infusion, was presented.

免疫抑制剂控制作为癌症治疗的一种方式:金黄色葡萄球菌蛋白a血浆吸附的效果。
在携带肿瘤的宿主中存在细胞和体液肿瘤生长促进因子。它们会导致免疫抑制,促进肿瘤的生长。在肿瘤生长的早期,这些因子要么是由肿瘤细胞引起的,要么是由宿主免疫细胞诱导的。在这些免疫抑制剂中,循环免疫复合物似乎起主要作用。它们还能激活抑制细胞的活性。据报道,金黄色葡萄球菌蛋白A在血浆中吸附CIC和IgG可引起肿瘤消退。蛋白a -胶炭、蛋白a -二氧化硅或蛋白A-Sepharose的血浆吸附也可诱导溶瘤反应。甚至直接输注蛋白A也能诱导大鼠乳腺肿瘤的肿瘤消退。最近的研究显示金黄色葡萄球菌Wood 46血浆吸附或输注金黄色葡萄球菌吸附的正常血浆后肿瘤消退,这表明通过血浆吸附去除特异性阻断因子可能不是导致肿瘤破坏的机制。结果表明,金黄色葡萄球菌血浆吸附滤出多种葡萄球菌药物。因此,似乎葡萄球菌制剂、蛋白A、肠毒素和其他因素是诱导导致肿瘤破坏的反应的原因。提出了一个统一的机制来解释用金黄色葡萄球菌的蛋白A或金黄色葡萄球菌木材或直接输注蛋白A进行血浆吸附所获得的结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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