Comprehensive psychiatryPub Date : 2025-08-01Epub Date: 2025-05-23DOI: 10.1016/j.comppsych.2025.152609
Guifeng Li , Mengya Li , Xin Xu , Junhong Zhang , Qifang Li , Qing Cai
{"title":"Inpatient vs outpatient cognitive behavioral therapy for insomnia: A two-arm parallel randomized controlled trial","authors":"Guifeng Li , Mengya Li , Xin Xu , Junhong Zhang , Qifang Li , Qing Cai","doi":"10.1016/j.comppsych.2025.152609","DOIUrl":"10.1016/j.comppsych.2025.152609","url":null,"abstract":"<div><h3>Objective</h3><div>While outpatient cognitive behavioral therapy for insomnia (CBT-I) represents the most efficacious delivery method, approximately 50 % of patients are unable to achieve clinical remission. There is a pressing need to develop more effective approaches to CBT-I delivery. This study assessed the comparative efficacy of one-week inpatient CBT-I and eight-week standard outpatient CBT-I.</div></div><div><h3>Methods</h3><div>A randomized controlled trial was conducted with 200 adults with chronic insomnia disorder. These participants were randomly allocated to either the inpatient group (<em>n</em> = 100) or the outpatient group (n = 100). The inpatient group underwent a one-week intensive inpatient CBT-I followed by weekly follow-ups program. The outpatient group participated in a standard outpatient CBT-I program conducted on an individual basis over an eight-week period. The primary outcome was the insomnia severity index score at 9 weeks after the start of intervention. Linear mixed effects model was employed for the intention-to-treat analysis.</div></div><div><h3>Results</h3><div>At the 9-week assessment, the inpatient CBT-I group demonstrated a mean change in insomnia severity index score of −13.31 (95 % confidence interval [CI], −14.47 to −12.16; Cohen's <em>d =</em> −3.18; <em>P</em> < .001). The outpatient group showed a mean change of −11.14 (95 % CI, −12.30 to −9.98; Cohen's <em>d</em> = −2.66; <em>P</em> < .001). The mean difference between groups was −2.03 (95 % CI, −3.21 to −0.85; Cohen's <em>d</em> = −0.48; <em>P</em> < .001), indicating a statistically significant improvement in the inpatient group compared to the outpatient group.</div></div><div><h3>Conclusions</h3><div>This study demonstrated that inpatient CBT-I exhibited superior efficacy compared to outpatient CBT-I in alleviating insomnia severity.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"141 ","pages":"Article 152609"},"PeriodicalIF":4.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Comprehensive psychiatryPub Date : 2025-08-01Epub Date: 2025-05-18DOI: 10.1016/j.comppsych.2025.152607
M.W. Stratmann , J. Heeg , M. Härter , L. Kriston , U. Verthein , C. Lindemann
{"title":"Screening accuracy of the German version of the benzodiazepine self-report questionnaire","authors":"M.W. Stratmann , J. Heeg , M. Härter , L. Kriston , U. Verthein , C. Lindemann","doi":"10.1016/j.comppsych.2025.152607","DOIUrl":"10.1016/j.comppsych.2025.152607","url":null,"abstract":"<div><h3>Background and aims</h3><div>We aimed to assess the accuracy for the German version of the Benzodiazepine Dependence Self-Report Questionnaire (Bendep-SRQ-GV) as a possible screening instrument for benzodiazepine or <em>Z</em>-drug substance use disorder.</div></div><div><h3>Method</h3><div>This study includes a convenience sample of adults who had used benzodiazepines or <em>Z</em>-drugs at least once in the last year. Participants were recruited through notice boards, social media, newspaper, and a digital health information platform. All participants answered the Bendep-SRQ-GV and were assessed for benzodiazepine or <em>Z</em>-drug substance use disorder using the Structured Clinical Interview for DSM-5 Disorders – Clinical Version. We performed receiver operating characteristics curve analyses and calculated the area under the curve (AUC).</div></div><div><h3>Results</h3><div>42 out of 60 participants fulfilled the criteria for benzodiazepine or <em>Z</em>-drug substance use disorder according to Structured Clinical Interview. AUCs varied among the 4 subscales of the Bendep-SRQ-GV: Problematic Use (0.893 [0.819–0.975]), Preoccupation (0.751 [0.609–0.892]), Lack of Compliance (0.804 [0.699–0.919]), Withdrawal (0.743 [0.622–0.864]) and Total Score (0.860 [0.762–0.963]). For Problematic Use and Total Score selected cut-offs (5.5 and 16.5) showed best results: sensitivity (83 % [71–93 %] and 79 % [67–90 %]), high specificity (83 % [61–100 %] and 83 % [67–100 %], positive predictive value (92 % [84–100 %] and 92 % [83–100 %]), and negative predictive value (68 % [54–85 %] and 63 % [50–77 %]).</div></div><div><h3>Discussion</h3><div>The subscale Problematic Use and the Total Score seem promising for detecting benzodiazepine or <em>Z</em>-drug substance use disorder in adults. Precise cut-offs should be determined with a larger sample. The Bendep-SRQ-GV could be of great value as a screening questionnaire in clinical settings, counselling sites, and for scientific purposes.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"141 ","pages":"Article 152607"},"PeriodicalIF":4.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144107116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Comprehensive psychiatryPub Date : 2025-08-01Epub Date: 2025-06-06DOI: 10.1016/j.comppsych.2025.152610
Harin Chung, Gyumyoung Kim, Da-In Kim, Ji-Won Hur
{"title":"The double-edged sword of distress tolerance: Exploring the role of distress overtolerance in nonsuicidal self-injury","authors":"Harin Chung, Gyumyoung Kim, Da-In Kim, Ji-Won Hur","doi":"10.1016/j.comppsych.2025.152610","DOIUrl":"10.1016/j.comppsych.2025.152610","url":null,"abstract":"<div><h3>Background</h3><div>While low distress tolerance has been widely studied as a risk factor for nonsuicidal self-injury (NSSI), recent attention has shifted toward distress overtolerance—an individual's excessive endurance to distress despite severe adverse effects. Understanding this double-edged nature of distress tolerance is critical for developing effective intervention strategies to address the growing burden of NSSI. This study investigated the role of distress overtolerance in NSSI pathology.</div></div><div><h3>Methods</h3><div>The study comprised 1818 female participants, including 918 and 900 participants with and without a history of NSSI, respectively. Binary logistic regression models were utilized to analyze distress overtolerance as a predictor of NSSI engagement, versatility, and frequency while controlling for demographic variables, depression, anxiety, and emotion dysregulation. Among the participants with a history of NSSI, Pearson's correlation analyses were conducted to identify the functions of NSSI that were the most associated with distress overtolerance.</div></div><div><h3>Results</h3><div>Distress overtolerance was identified as a significant predictor of NSSI engagement, versatility, and frequency even after controlling for other risk factors. Distress overtolerance was most strongly linked to self-punishment function in individuals with a history of NSSI.</div></div><div><h3>Conclusions</h3><div>Distress overtolerance is a distinct and significant risk factor for NSSI, highlighting the need for its inclusion in mechanisms and intervention models for NSSI. Addressing distress overtolerance in therapeutic settings to achieve an optimal balance in distress regulation could provide innovative and more effective strategies for the treatment of NSSI.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"141 ","pages":"Article 152610"},"PeriodicalIF":4.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144239686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mapping psychiatric comorbidity network: A pilot multi-method weighted network analysis with a focus on key disorders","authors":"Yu Chang , Si-Sheng Huang , Wen-Yu Hsu , Yi-Chun Liu","doi":"10.1016/j.comppsych.2025.152608","DOIUrl":"10.1016/j.comppsych.2025.152608","url":null,"abstract":"<div><h3>Background</h3><div>Psychiatric comorbidity is a prevalent phenomenon that imposes a significant burden on patients, healthcare systems, and society. However, current research on psychiatric comorbidity is often limited to single disorders or partial associations. This study aims to utilize network analysis methods to construct a psychiatric comorbidity network and explore the network structural characteristics under different network weight definitions.</div></div><div><h3>Method</h3><div>Based on the psychiatric outpatient data from Changhua Christian Hospital in Taiwan from January 1, 2016, to June 30, 2024, the ICD-10 diagnostic codes (F00-F99) of all patients that appeared at least three times were extracted. Three different comorbidity networks were constructed using co-occurrence counts, Jaccard index, and partial correlation coefficient estimated by the mixed graphical model (MGM) as the weights of the network edges. Network structure was analyzed using indicators such as degree centrality, modularity, and community detection.</div></div><div><h3>Results</h3><div>The dataset included 16,954 patients. The comorbidity frequency network showed that mood disorders (F34) and anxiety disorders (F41) had the highest weighted degree centrality. In the Jaccard coefficient network, the weighted degree centrality of developmental disorders (F8x) increased. The MGM network highlighted the central role of substance use disorders (F1x).</div></div><div><h3>Conclusion</h3><div>Our findings suggested the roles and interrelationships of different disease categories in the comorbidity network. The results provide new perspectives and data support for clinical practice and future research.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"141 ","pages":"Article 152608"},"PeriodicalIF":4.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Adapting the group traumatic episode protocol approach as a paraprofessional-led early intervention for law enforcement personnel","authors":"Monika Ozga , Maryjo Hart , Theo Niyonsenga , Larissa Coulter","doi":"10.1016/j.comppsych.2025.152596","DOIUrl":"10.1016/j.comppsych.2025.152596","url":null,"abstract":"<div><h3>Background</h3><div>Law enforcement personnel experience high levels of occupational stress and frequent exposure to potentially traumatic events, requiring effective early interventions. The Modified Group Traumatic Episode Protocol (mGTEP) is an adaptation of Eye Movement Desensitization and Reprocessing (EMDR) designed to help individuals process traumatic experiences in a group setting. This study evaluated the feasibility and effectiveness of a paraprofessional-led mGTEP within the law enforcement population.</div></div><div><h3>Methods</h3><div>Police officers and staff, with peer support background, were trained as paraprofessionals to facilitate mGTEP as early mental health support for their colleagues. Their role bridges the gap between informal peer support and professional mental health services. Psychological distress (single-item scale), depression (PHQ-9), anxiety (GAD-7), and trauma-related stress (PCL-5) were assessed at baseline (T1), post-intervention (T2), and follow-up (T3). Multilevel statistical analyses were conducted to evaluate changes over time. A sample of 40 law enforcement personnel participated in online mGTEP sessions. The sample consisted of mostly males (54 %), ranging from age 28 to 53 with an average of 14 years working in the police. Multilevel modelling was applied to the repeated measures design to analyse changes across three time points, combining both random (e.g., participant) and fixed (e.g., time) effects.</div></div><div><h3>Results</h3><div>Significant reductions were observed from T1 to T2 in distress (d = 0.69, large), anxiety (d = 0.65, large), and trauma-related stress (d = 0.48, medium), with sustained improvements in depression (d = 0.26, small) and trauma-related stress (d = 0.48, medium) at follow-up. Anxiety scores slightly increased between T2 and T3 (d = 0.36, small). Similarly, distress scores did not continue to decline beyond T2. These results potentially reflect the ongoing demands of policing and continued exposure to trauma.</div></div><div><h3>Conclusion</h3><div>This study highlights the feasibility of mGTEP as a paraprofessional-led early intervention for law enforcement personnel, demonstrating significant symptom reductions. While improvements in depression and trauma-related stress persisted, fluctuations in anxiety and distress levels suggest the need for continued support post-intervention. Given the cumulative nature of occupational stress in policing, regular implementation may be necessary to sustain benefits. Integrating mGTEP into existing mental health programs could enhance accessibility, allowing it to complement other psychological support initiatives.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"140 ","pages":"Article 152596"},"PeriodicalIF":4.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Comprehensive psychiatryPub Date : 2025-07-01Epub Date: 2025-04-16DOI: 10.1016/j.comppsych.2025.152597
Turan Deniz Ergun , Peter M. ten Klooster , Ernst T. Bohlmeijer , Gerben J. Westerhof , Minita Franzen , Lonneke I.M. Lenferink
{"title":"Assessing prolonged grief symptoms using experience sampling methodology: The development of the prolonged grief symptoms - short ecological assessment (PGS-SEA) scale","authors":"Turan Deniz Ergun , Peter M. ten Klooster , Ernst T. Bohlmeijer , Gerben J. Westerhof , Minita Franzen , Lonneke I.M. Lenferink","doi":"10.1016/j.comppsych.2025.152597","DOIUrl":"10.1016/j.comppsych.2025.152597","url":null,"abstract":"<div><div>Early grief reactions have been hypothesized to fluctuate within persons and to be one of the strongest predictors of Prolonged Grief Disorder (PGD). Experience Sampling Methodology (ESM) offers an opportunity to examine (early) PGD dynamics in daily contexts. For this, however, a brief and valid ESM scale is needed to accurately assess PGD symptoms in everyday life. We investigated the psychometric properties of ESM items developed to assess momentary prolonged grief symptoms in daily life (ESM-PGD). Additionally, we aimed to create a valid brief scale for future ESM studies. Bereaved adults (<em>N</em> = 169) whose loved ones died 3–6 months earlier completed 11 ESM-PGD items based on 10 PGD symptoms, as defined in DSM-5-TR, five times a day for 14 consecutive days at semi-random intervals. We performed multilevel confirmatory factor analysis (MCFA), calculated root-mean-square of successive differences (RMSSD) and intraclass correlations (ICC), and conducted correlational analyses of ESM-PGD items with related mental health symptoms (e.g., depression) to identify the best-performing items. MCFA confirmed that the hypothesized one-factor model fits the data well with good composite reliability at the between- and within-person levels. All ESM-PGD items were able to distinguish between people with and without early PGD. Examination of within-person level factor loadings, ICCs and RMSSDs revealed that not all ESM-PGD items were able to capture fluctuations of momentary PGD symptoms. The best-performing items were selected, resulting in a valid 2-item Prolonged Grief Symptoms – Short Ecological Assessment (PGS-SEA) scale for assessing PGD in daily life to facilitate ESM-research on PGD.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"140 ","pages":"Article 152597"},"PeriodicalIF":4.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Comprehensive psychiatryPub Date : 2025-07-01Epub Date: 2025-04-30DOI: 10.1016/j.comppsych.2025.152600
Aaro Hazak , Johanna Liuhanen , Katri Kantojärvi , Sonja Sulkava , Tuija Jääskeläinen , Veikko Salomaa , Seppo Koskinen , Markus Perola , Tiina Paunio
{"title":"Schizophrenia genetic risk and labour market outcomes in the Finnish general population: Are schizophrenia-related traits penalised or rewarded?","authors":"Aaro Hazak , Johanna Liuhanen , Katri Kantojärvi , Sonja Sulkava , Tuija Jääskeläinen , Veikko Salomaa , Seppo Koskinen , Markus Perola , Tiina Paunio","doi":"10.1016/j.comppsych.2025.152600","DOIUrl":"10.1016/j.comppsych.2025.152600","url":null,"abstract":"<div><h3>Background</h3><div>Schizophrenia polygenic risk scores (SCZ<sub>PRS</sub>) have been linked to cognitive functioning, creativity, behavioural traits, and psychiatric conditions beyond schizophrenia. This study examines how labour market segments reward or penalise traits associated with SCZ<sub>PRS</sub> in the general population.</div></div><div><h3>Methods</h3><div>We merged genetic, socio-economic and health registry data with repeated cross-sectional survey data from six Finnish cohorts (1992 to 2017), representing individuals aged 25–64 across Finnish regions (<em>N</em> = 20,121). Various regression models were employed to study labour market outcomes.</div></div><div><h3>Results</h3><div>Individuals in the highest SCZ<sub>PRS</sub> quintile were 6.4 percentage points less likely to be employed than those in the lowest quintile (<em>P</em> < 0.001; 99.5 % CI: 3.9–9.0 pp). Among employed individuals in knowledge-based occupations, an inverse U-shaped relationship between SCZ<sub>PRS</sub> and income emerged after 2000. Knowledge workers in both the lowest (<em>P</em> = 0.004) and highest (<em>P</em> = 0.03) SCZ<sub>PRS</sub> quintiles were 4–5 percentage points less likely to be in the highest income tertile than those in the middle quintile. No significant association was found between SCZ<sub>PRS</sub> and income in physical labour.</div></div><div><h3>Conclusions</h3><div>Beyond its overall negative association with employment, SCZ<sub>PRS</sub> exhibits a non-linear relationship with income in cognitive-intensive occupations, where both low and high SCZ<sub>PRS</sub> appear to be penalised. This pattern became more pronounced post-2000, coinciding with rising income inequality and technological advancements, likely reshaping labour market demands. While effect sizes are substantial, compensatory factors may mitigate these outcomes. Greater awareness of these associations and individual differences in labour market experiences could contribute to a more inclusive society.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"140 ","pages":"Article 152600"},"PeriodicalIF":4.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Resilient coping during the Russian-Ukrainian war: Does it buffer the effects of cumulative trauma on ICD-11 posttraumatic stress disorder symptoms?","authors":"Annett Lotzin , Olha Morozova-Larina , Antje Paetow , Lisa Schratz , Vladyslava Keller , Illia Zarubin , Liudmyla Krupelnytska","doi":"10.1016/j.comppsych.2025.152592","DOIUrl":"10.1016/j.comppsych.2025.152592","url":null,"abstract":"<div><h3>Background</h3><div>Individuals with higher resilient coping may manage war-related trauma better than individuals with lower resilient coping. If so, resilient coping may weaken the relationship between war trauma and posttraumatic stress disorders.</div></div><div><h3>Objective</h3><div>This study aimed to investigate the role of resilient coping in moderating the associations between cumulative war trauma exposure and ICD-11 posttraumatic stress disorders during war.</div></div><div><h3>Methods</h3><div>This cross-sectional study included <em>N</em> = 851 Ukrainian students living in the Ukraine between December 2022 and January 2023 during the Russian-Ukrainian war. We tested a model in which resilient coping was specified as a moderator of the effect of war-related cumulative trauma exposure (Harvard Trauma Questionnaire-R) on ICD-11 posttraumatic stress disorder (PTSD), and disturbances in self-organization (DSO) symptom levels (International Trauma Questionnaire-R), respectively. We used Structural Equation Modeling and controlled our analysis for previous trauma exposure, gender, years of study, and level of income.</div></div><div><h3>Results</h3><div>In contrast to our hypothesis, the level of resilient coping did not moderate the effect of cumulative war trauma exposure on PTSD and DSO symptom levels. Instead, we found a strong direct effect of the level of resilient coping on PTSD and DSO symptom levels.</div></div><div><h3>Conclusions</h3><div>Resilient coping may directly affect the level of PTSD and DSO symptoms but may not weaken the association between trauma exposure and posttraumatic stress disorders during war.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"140 ","pages":"Article 152592"},"PeriodicalIF":4.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143815603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Comprehensive psychiatryPub Date : 2025-07-01Epub Date: 2025-04-15DOI: 10.1016/j.comppsych.2025.152598
Maria Bălăeţ , Ana Zadel , Anne Lingford-Hughes , Louise M. Paterson , Samuel R. Chamberlain , William Trender , Peter J. Hellyer , Adam Hampshire
{"title":"Changes in recreational drug use, reasons for those changes and their consequence during and after the COVID-19 pandemic in the UK","authors":"Maria Bălăeţ , Ana Zadel , Anne Lingford-Hughes , Louise M. Paterson , Samuel R. Chamberlain , William Trender , Peter J. Hellyer , Adam Hampshire","doi":"10.1016/j.comppsych.2025.152598","DOIUrl":"10.1016/j.comppsych.2025.152598","url":null,"abstract":"<div><div>Changes in drug use in the general population during the COVID-19 pandemic and their long-term consequences are not well understood. We employed natural language processing and machine learning to analyse a large dataset of self-reported rates of and reasons for drug use during the pandemic, along with their associations with anxiety, depression and substance use problems post-pandemic. Our findings revealed a transient decrease in drug use at the pandemic's peak, primarily attributed to reduced social opportunities. Conversely, some participants reported increased drug use for self-medication, boredom, and lifestyle disruptions. While users of psychedelics and MDMA had anxiety and depression rates similar to non-users, users of opioid agonists and depressants—representing one in ten active drug users—reported greater mental health challenges post-pandemic. These results suggest that a subset of active drug users with distinct profiles faces elevated risks, particularly for anxiety and depression, and may benefit from targeted support.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"140 ","pages":"Article 152598"},"PeriodicalIF":4.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Comprehensive psychiatryPub Date : 2025-05-01Epub Date: 2025-04-30DOI: 10.1016/j.comppsych.2024.152554
Juliette S. Mojgani , Anna M. Rzepka , Yejin Kang , Hashim Al-Bya , Beth Patterson , Michael Van Ameringen
{"title":"Obsessive-compulsive spectrum disorders and the menstrual cycle: A scoping review","authors":"Juliette S. Mojgani , Anna M. Rzepka , Yejin Kang , Hashim Al-Bya , Beth Patterson , Michael Van Ameringen","doi":"10.1016/j.comppsych.2024.152554","DOIUrl":"10.1016/j.comppsych.2024.152554","url":null,"abstract":"","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"139 ","pages":"Article 152554"},"PeriodicalIF":4.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}