Comprehensive psychiatry最新文献

{"title":"Beyond criticism, hostility, and emotional overinvolvement: Development and psychometric validation of the Comprehensive Expressed Emotion Scale (CEES) in schizophrenia.","authors":"Yingzhe He, Siu-Man Ng, Mao-Sheng Ran, Cong Wang, Yi-Yue Yang, Lie Zhou, Jia Cai","doi":"10.1016/j.comppsych.2025.152638","DOIUrl":"https://doi.org/10.1016/j.comppsych.2025.152638","url":null,"abstract":"<p><strong>Background: </strong>Expressed Emotion (EE) is a well-established predictor of schizophrenia relapse, but concerns remain regarding the content validity of its traditional components-criticism, hostility, and emotional overinvolvement (EOI). Recent research suggests a covert EE dimension (disassociation, apathy) unmeasured by current scales. This study developed and validated a self-report EE scale, the Comprehensive Expressed Emotion Scale (CEES), to reconceptualize EE.</p><p><strong>Methods: </strong>319 adults with schizophrenia in Mainland China completed CEES, relevant Family Environment Scale-Chinese Version (FES-CV) subscales, and SF-12. Ten patient-family dyads also underwent the Camberwell Family Interview (CFI). Exploratory and confirmatory factor analyses determined factor structure; reliability and validity were evaluated using established indices and correlations.</p><p><strong>Results: </strong>EFA supported a three-factor model-overt (criticism, hostility), covert (disassociation, apathy), and EOI-explaining 64 % of variance. CFA confirmed strong loadings for overt and covert items (0.70-0.91 and 0.72-0.90; all p < 0.001), but weaker, mostly non-significant loadings for EOI items. The three-factor model showed good fit (χ²(402) = 657.17, CFI = 0.971, TLI = 0.968, RMSEA = 0.061, SRMR = 0.079). The total scale and overt and covert subscales showed high internal consistency and strong construct and concurrent validity; EOI subscale reliability was moderate.</p><p><strong>Conclusions: </strong>CEES operationalizes covert EE in Chinese families, broadening EE assessment to include implicit conflict. It demonstrates strong psychometric properties and potential for targeted interventions, though EOI subscale reliability and generalizability remain limitations.</p>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"143 ","pages":"152638"},"PeriodicalIF":4.2,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The power of youth: Long-term differential effects of developmental functioning trajectory on social functioning, quality of life and personal recovery across the schizophrenia spectrum.","authors":"Jiasi Hao, Richard Bruggeman, Wim Veling, Behrooz Z Alizadeh","doi":"10.1016/j.comppsych.2025.152637","DOIUrl":"https://doi.org/10.1016/j.comppsych.2025.152637","url":null,"abstract":"<p><strong>Background: </strong>Compromised developmental functioning is frequently observed in patients with schizophrenia spectrum disorder (SSD) and is associated with poor outcomes, which remains understudied in individuals at varying risk of SSD. This study aimed to investigate the course of developmental functioning and its relationship with long-term outcomes within a population across the vulnerability spectrum of SSD. We hypothesized that developmental functioning negatively correlated with SSD vulnerability, and was positively associated with worse outcomes, regardless of disease status.</p><p><strong>Methods: </strong>We used data of 1119 patients, 1059 siblings, and 586 controls from the Dutch Genetic Risk and Outcome in Psychosis (GROUP) cohort. Group-based trajectory modelling and linear mixed models were employed to investigate the course of developmental functioning (measured by the Premorbid Adjustment Scale) and its associations with the outcomes, including social functioning (SF), personal recovery (PR), and quality of life (QoL).</p><p><strong>Results: </strong>In the combined sample, six developmental trajectories were identified: normal-stable (12.4 %), normal-slow decrease (12.3 %), mild-stable (46.9 %), all dominated by controls and siblings; and mild-rapid decrease (5.1 %), moderate-stable (16.5 %), and severe-slow decrease (6.8 %) more prevalent in patients. Compared to normal-stable, all other trajectories in developmental functioning were correlated with decreased SF; mild-rapid decrease and severe-slow decrease were linked to lower QoL. No association with PR was observed.</p><p><strong>Conclusion: </strong>Impaired developmental functioning variably lowers prolonged SF and QoL but not PR. Potentially influenced by factors encompassing environment, cognition, resilience and disease status, this finding demands screening for developmental deviance among youths and early preventive interventions to achieve normal functioning through a public health salutogenic approach.</p>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"143 ","pages":"152637"},"PeriodicalIF":4.2,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gaming disorder among Swedish adolescents: Measurement, risk factors, and classification","authors":"Amir Pakpour ,&nbsp;Marit Eriksson ,&nbsp;Daniel Kwasi Ahorsu ,&nbsp;Gunilla Björling ,&nbsp;Anders Broström ,&nbsp;Staffan Bengtsson ,&nbsp;Malin Jakobsson ,&nbsp;Karina Huus","doi":"10.1016/j.comppsych.2025.152635","DOIUrl":"10.1016/j.comppsych.2025.152635","url":null,"abstract":"<div><h3>Objectives</h3><div>This study examined the 1) psychometric properties of an independently translated Swedish version of the gaming disorder test (GDT) among Swedish adolescents based on two psychometric theories, 2) measurement invariance across age (i.e., 15 vs 16–17), gender (i.e., males vs females), and gaming time (i.e., &lt; 2 h vs ≥ 2 h), and 3) factors that predict gaming disorder. The findings will help researchers understand and ascertain the use of the GDT among Swedish adolescents.</div></div><div><h3>Methods</h3><div>A total of 5320 Swedish adolescents were recruited and responded to measures including gaming disorder, gaming duration, sleep duration, physical activity, mental well-being, and self-esteem. Statistical analyses were conducted using confirmatory factor analysis, regression analysis, latent class analysis, classical test theory, and Rasch analysis.</div></div><div><h3>Results</h3><div>Satisfactory and unidimensional psychometric properties for the independently translated Swedish version of the GDT were found. Specifically, the factor structure, internal consistencies, separation reliability and separation index were supported, but not the person separation reliability and index. Also, the GDT was invariant across ages but only partially so across gender and gaming time. The GDT can classify adolescents as having a high or low risk of gaming disorder. Lastly, factors that predicted gaming disorder were poorer mental well-being and longer gaming time among males and low physical activity and longer gaming time among females.</div></div><div><h3>Conclusion</h3><div>Due to its conciseness, researchers may use the independently translated Swedish version of the GDT for screening people for gaming issues even in busy settings like schools. Moreover, attention must be paid to males, those with poorer mental well-being, those who are physically inactive, and those with a longer gaming time to help curb gaming disorder. Future research may focus on examining the test-retest reliability and clinical validity of the GDT among adolescents.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"143 ","pages":"Article 152635"},"PeriodicalIF":4.2,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An extended model of gambling motives: The first results with the long and short versions of the gambling motives questionnaire-revised","authors":"Anna Magi ,&nbsp;Zsolt Horváth ,&nbsp;Cristina Villalba-García ,&nbsp;Borbála Paksi ,&nbsp;Andrea Eisinger ,&nbsp;Katalin Felvinczi ,&nbsp;Sherry H Stewart ,&nbsp;Beáta Bőthe ,&nbsp;Gyöngyi Kökönyei ,&nbsp;Zsolt Demetrovics ,&nbsp;Andrea Czakó","doi":"10.1016/j.comppsych.2025.152633","DOIUrl":"10.1016/j.comppsych.2025.152633","url":null,"abstract":"<div><h3>Background</h3><div>Motives underlying addictions have been widely studied, using validated tools such as the Gambling Motives Questionnaire (GMQ) (Stewart and Zack, 2008). Nevertheless, subsequent studies have suggested the need to extend this model. The present paper aimed to identify potential additional factors, such as escapism, omnipotence, pleasure and financial motives, in addition to the social, enhancement and coping aspects already included.</div></div><div><h3>Methods</h3><div>A total of 40 motivational items (adding 25 additional items to the original GMQ items) were analysed within two datasets. Sample 1 was a player panel from a gambling service provider (<em>N</em> = 1829; mean age: 42.4 [SD = 13.3]; Females: 30 % [<em>n</em> = 548]), while Sample 2 consisted of a nationally representative sample of the Hungarian population (<em>N</em> = 437; mean age: 42.9 [SD = 13.55]; Females: 49.2 % [<em>N</em> = 215]).</div></div><div><h3>Results</h3><div>Exploratory Factor Analysis on Sample 1 identified four factors (including a total of 27 items): coping/escapism, social motives, enhancement/pleasure, and financial motives. The four-factor structure was confirmed on Sample 2 with confirmatory factor analysis showing adequate model fit (CFI = 0.987; TLI = 0.986; RMSEA[CI] = 0.047 [0.041–0.052]); however, high inter-factor correlations were evident in the general population sample. A shorter, 14-item version of the scale was also suggested.</div></div><div><h3>Conclusions</h3><div>Although the newly identified motives overlap with the original ones, the content of the factors enables the inclusion of certain aspects, like escapism within the coping factor, that proved to be the most important in relation to other potentially addictive behaviours. This suggests that examining the role of motives in gambling may be crucial in differentiating between problem gambling and recreational gambling.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"143 ","pages":"Article 152633"},"PeriodicalIF":4.2,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145148063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric properties of the 4-week version of the Borderline Personality Disorder Severity Index-5","authors":"Shanna van Trigt ,&nbsp;Mariana Mendoza-Alvarez ,&nbsp;Tanja van der Zweerde ,&nbsp;Livia De Picker ,&nbsp;Annemieke van Straten ,&nbsp;Arnoud Arntz ,&nbsp;Hein J.F. van Marle","doi":"10.1016/j.comppsych.2025.152634","DOIUrl":"10.1016/j.comppsych.2025.152634","url":null,"abstract":"<div><div>This study evaluated the psychometric properties of a new version of the Borderline Personality Disorder Severity Index-5 that assesses BPD symptom severity over the course of 4 weeks instead of the standard 3 months: the BPDSI-5-4wk. Reliability and validity were evaluated in a mixed sample of patients with BPD (<em>n</em> = 92), patients with avoidant personality disorder (APD) as clinical control group (<em>n</em> = 16), and a non-patient control group (<em>n</em> = 20). The study demonstrated very high interrater agreement and test-retest reliability and acceptable to excellent internal consistencies of the BPDSI-5-4wk. Confirmatory factor analysis supported its assumed nine-factor structure. The BPDSI-5-4wk also showed very good construct (i.e. known-group) validity, as well as criterion-related (i.e. concurrent) validity when correlating the BPDSI-5-4wk with the BPDSI-5 (3-month version), the structured clinical interview for DSM personality disorders (SCID-5-P), and several other BPD- and other mental health-related self-report questionnaires. We additionally derived cut-off scores with high sensitivity and specificity for distinguishing BPD from clinical controls (21.02, 85 % sensitivity, 94 % specificity), from non-patient controls (10.50, 98 % sensitivity, 100 % specificity), and from both control groups combined (17.26, 93 % sensitivity, 92 % specificity). A reliable change criterion of 5.88 was established. Preliminary trial data additionally showed the BPDSI-5-4wk's sensitivity to change. The strong reliability and validity of the BPDSI-5-4wk support its value for detailed, dimensional assessment of BPD symptom severity over shorter time frames. This will facilitate frequent treatment response evaluations, rapid indication of follow-up treatment, and better alignment with shorter intervention and follow-up periods in clinical trials.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"143 ","pages":"Article 152634"},"PeriodicalIF":4.2,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145045662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative effects of pharmacological treatment for weight gain in patients treated with antipsychotics. A systematic review and network meta-analysis","authors":"Zuzanna Goetz-Kundera ,&nbsp;Bogusława Przekopińska ,&nbsp;Patryk Walichniewicz ,&nbsp;Maciej Niewada ,&nbsp;Michał Lew-Starowicz","doi":"10.1016/j.comppsych.2025.152632","DOIUrl":"10.1016/j.comppsych.2025.152632","url":null,"abstract":"<div><h3>Background</h3><div>Weight gain induced by antipsychotic treatment is a significant cardiometabolic risk factor associated with increased mortality.</div></div><div><h3>Methods</h3><div>Following PRISMA criteria Medline, Cochrane Central Register of Clinical Trials and Science Direct were systematically searched. Only randomised placebo-controlled trials evaluating pharmacological interventions to reduce antipsychotic drug-induced weight gain in adults were included.</div><div>Data on mean change in weight from baseline were extracted, together with parameters defining variability or dispersion. A fixed effects model and random effects mode were used. Treatments were ranked using SUCRA.</div></div><div><h3>Outcomes</h3><div>27 studies including 17 medications were included. The studies were divided into two groups with a time horizon of less or more than 12 weeks. A comparison of the short-term interventions showed significant advantages of nizatidine (MD -6,82; CI -13,36 to −0,55) and metformin (MD -4,17; CI -8,02 to −0,64) over placebo. For longer-term interventions, significant benefits were shown for liraglutide (MD -5,3; Cl −6,93 to −3,75), exenatide (MD -4,17; Cl −7,4 to −1,14), metformin (MD -2,08; Cl −2,86 to −1,35) and samidorphan (MD -1,91; CL −3,31 to −0,51) as compared to placebo. Liraglutide was superior to other drugs according to the SUCRA analysis.</div></div><div><h3>Interpretation</h3><div>Our network meta-analysis presents a comparison of pharmacological interventions to address weight gain associated with antipsychotic treatment. Metformin and liraglutide appear to have the strongest evidence for treating weight gain in the target group.</div></div><div><h3>Funding</h3><div>This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sector.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"143 ","pages":"Article 152632"},"PeriodicalIF":4.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145026460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aberrant anterior insula underlies interoceptive deficits in alexithymia among schizophrenia patients","authors":"Haoran Shen ,&nbsp;Yaping He ,&nbsp;Renjie Zeng ,&nbsp;Likun Ge ,&nbsp;Jingang Dai ,&nbsp;Juanhua Li ,&nbsp;Zezhi Li ,&nbsp;Gao-Xia Wei","doi":"10.1016/j.comppsych.2025.152630","DOIUrl":"10.1016/j.comppsych.2025.152630","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to investigate the unique neural mechanisms underpinning abnormal interoception in schizophrenia patients with comorbid alexithymia. The focus is on identifying aberrant activation patterns and functional connectivities of the insula cortex with regions involved in emotional processing.</div></div><div><h3>Methods</h3><div>Fifty schizophrenia patients were assessed using the Toronto Alexithymia Scale (TAS) and the Multidimensional Assessment of Interoceptive Awareness (MAIA). Task-based fMRI scans were conducted to observe brain activation patterns during interoceptive conditions.</div></div><div><h3>Results</h3><div>Alexithymic patients showed higher alexithymia and lower interoception compared to non-alexithymic patients. During the interoceptive task, alexithymic patients exhibited reduced activation in the anterior insula (AI), while no difference was observed in the posterior insula (PI). Functional connectivity analysis revealed reduced connectivity between the AI and the anterior cingulate cortex (ACC) as well as the superior frontal gyrus (SFG) in alexithymic patients. Moreover, the connection between the AI and the ACC mediated the relationship between interoception and alexithymia.</div></div><div><h3>Conclusion</h3><div>These results suggested that alexithymic schizophrenia patients struggle to integrate interoceptive afferents with emotional salience, and highlighted AI's role in the interplay between interoceptive awareness and emotional articulation in alexithymic schizophrenia, suggesting a potential neurobiological pathway for targeted interventions.</div><div><strong>Trial registration:</strong> The research is registered with the China Clinical Trials Registry (CCTR), under the registration number ChiCTR2400080313 on January 15, 2024.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"143 ","pages":"Article 152630"},"PeriodicalIF":4.2,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An exploratory analysis of obsessive-compulsive personality traits, pathologic anger and quality of life among trauma-exposed veterans","authors":"Meghan J. Kulak ,&nbsp;Meghan A. Gonsalves ,&nbsp;Timothy Y. Mariano ,&nbsp;Anthony Pinto ,&nbsp;Benjamin D. Greenberg ,&nbsp;Jennifer Barredo ,&nbsp;Zachary Kunicki ,&nbsp;M. Tracie Shea","doi":"10.1016/j.comppsych.2025.152628","DOIUrl":"10.1016/j.comppsych.2025.152628","url":null,"abstract":"<div><h3>Introduction</h3><div>Trauma exposure and post-traumatic stress disorder (PTSD) are associated with high rates of co-occurring personality pathology, including Obsessive Compulsive Personality Disorder (OCPD). OCPD is characterized by rigidity and perfectionism, leading to internalized distress, interpersonal difficulties, and lower quality of life (QOL). Individuals with OCPD often report high levels of anger, which may exacerbate distress and interpersonal issues. However, the relationship between OCPD, anger, and QOL in trauma-exposed Veterans remains understudied.</div></div><div><h3>Materials and methods</h3><div>92 Veterans with warzone trauma, hyperarousal symptoms, and moderate to severe problems with anger were recruited from a VA Medical Center for a study on cognitive-behavioral therapy for anger. Assessments included standardized interviews on demographics and trauma history, as well as self-reports on OCPD and borderline personality disorder (BPD) traits, anger, and QOL.</div></div><div><h3>Results</h3><div>OCPD scores were significantly correlated with higher state anger (<em>r</em> = 0.276, <em>p</em> = 0.013), trait anger (<em>r</em> = 0.275, <em>p</em> = 0.016), and lower social QOL (<em>r</em> = −0.344, <em>p</em> = 0.002). BPD scores were similarly associated with higher state (<em>r</em> = 0.242, <em>p</em> = 0.031) and trait anger (<em>r</em> = 0.291, <em>p</em> = 0.011), but had lower QOL in all domains.</div></div><div><h3>Conclusion</h3><div>In this exploratory analysis, OCPD traits in trauma-exposed Veterans were linked to higher anger and lower social QOL, with effect sizes comparable to BPD traits. This highlights the importance of screening for OCPD traits to inform treatment strategies and improve outcomes, especially given that OCPD traits receive less clinical attention than BPD traits.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"143 ","pages":"Article 152628"},"PeriodicalIF":4.2,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144892077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood-based DNA methylation profiles in major depressive disorder, bipolar disorder, and schizophrenia spectrum disorders","authors":"Friederike S. David ,&nbsp;Josef Frank ,&nbsp;Frederike Stein ,&nbsp;Susanne Meinert ,&nbsp;Lea Zillich ,&nbsp;Lea Sirignano ,&nbsp;Fabian Streit ,&nbsp;Eva C. Beins ,&nbsp;Lisa Sindermann ,&nbsp;Paula Usemann ,&nbsp;Janik Goltermann ,&nbsp;Elisabeth J. Leehr ,&nbsp;Sugirthan Sivalingam ,&nbsp;Stefan Herms ,&nbsp;Per Hoffmann ,&nbsp;Tim Hahn ,&nbsp;Stephanie H. Witt ,&nbsp;Nina Alexander ,&nbsp;Tilo Kircher ,&nbsp;Udo Dannlowski ,&nbsp;Andreas J. Forstner","doi":"10.1016/j.comppsych.2025.152629","DOIUrl":"10.1016/j.comppsych.2025.152629","url":null,"abstract":"<div><div>Alterations in DNA methylation (DNAm) profiles have been implicated in affective and psychotic disorders. However, no comprehensive understanding of peripheral DNAm profiles associated with diagnostic groups, course of illness, and other clinical variables has emerged yet. In particular, studies exploring commonalities and differences across diagnoses are lacking. Here we conducted a systematic epigenetic characterization of the transdiagnostic German FOR2107 cohort, including individuals with major depressive disorder (MDD, <em>n</em> = 342), bipolar disorder (BD, <em>n</em> = 99), or a schizophrenia spectrum disorder (SSD, <em>n</em> = 101) and healthy controls (HC, <em>n</em> = 339). For 183 MDD cases and 178 HC, we assessed additional DNAm data from the two-year follow-up study visit. To explore DNAm differences between and across diagnostic groups, case-control and case-case methylome-wide association studies were performed. Our sample was further characterized using methylation risk scores (MRS) for MDD and SSD. Finally, epigenetic age acceleration was examined and compared to a measure of brain age acceleration. We identified few methylome-wide significant associations with diagnostic groups. MRS for MDD did not differ between diagnostic groups, and an increase in MRS for SSD in SSD compared to HC did not remain significant when adjusting for smoking behavior and BMI. An increase in epigenetic age acceleration was most evident for SSD compared to HC, which did not remain significant when adjusting for covariates. No correlation between epigenetic and brain age acceleration was observed. Our findings emphasize the relevance of potential confounding factors in epigenetics research in psychiatry and contribute to a growing body of studies on DNAm profiles across affective and psychotic disorders.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"143 ","pages":"Article 152629"},"PeriodicalIF":4.2,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144895277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating attentional bias in low-dependence smokers with steady-state visual evoked potentials (SSVEPs): Linking wanting, liking, and neural responses","authors":"Domonkos File ,&nbsp;Bela Petro ,&nbsp;Lili Kővári ,&nbsp;Petia Kojouharova ,&nbsp;Zsófia Anna Gaál ,&nbsp;Zsolt Demetrovics ,&nbsp;István Czigler","doi":"10.1016/j.comppsych.2025.152627","DOIUrl":"10.1016/j.comppsych.2025.152627","url":null,"abstract":"<div><div>While traditional electrophysiological measures such as ERPs have been successfully used to study individual differences, their signal-to-noise ratio often limits the precision of single-subject analyses. To address this, the present study had two primary aims: (1) to explore the utility of steady-state visual evoked potential (SSVEP) method for investigating addiction-specific cognitive processes and (2) to examine the relationship between the imbalance of self-reported wanting and liking, and the neural correlates of tobacco smoking-related attentional bias. A total of 39 participants, including smokers (<em>N</em> = 22) and non-smokers (<em>N</em> = 17), were exposed to a passive visual oddball paradigm comprising rapidly flickering stimuli under two conditions: neutral (e.g., office tools) and smoking-related (e.g., cigarettes). Neural activity was recorded using EEG, and frequency-specific SSVEP responses were analyzed to assess attentional bias toward smoking-related stimuli. The results demonstrated that SSVEPs effectively captured the well-documented attentional bias effect between smokers and non-smokers. Furthermore, beyond group-level comparisons, SSVEPs proved suitable for examining attentional bias at the individual level, allowing for the investigation of correlations between neural responses to smoking cues and the difference between self-reported wanting and liking (WmL) imagined before, during and after smoking. A moderate to strong positive correlation was observed specifically for WmL-after and attentional-bias, supporting two conclusions: (1) SSVEPs represent a promising tool for assessing addiction-specific cognitive processes, and (2) self-reported assessments of incentive sensitization theory (IST) may be associated with attentional bias characteristic of addictive behaviors. These findings highlight the potential value of self-report measures in human IST research and underscore the need for further investigation.</div></div>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"142 ","pages":"Article 152627"},"PeriodicalIF":4.2,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144861311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}