Jiasi Hao, Richard Bruggeman, Wim Veling, Behrooz Z Alizadeh
{"title":"青年的力量：精神分裂症谱系中发育功能轨迹对社会功能、生活质量和个人康复的长期差异影响。","authors":"Jiasi Hao, Richard Bruggeman, Wim Veling, Behrooz Z Alizadeh","doi":"10.1016/j.comppsych.2025.152637","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Compromised developmental functioning is frequently observed in patients with schizophrenia spectrum disorder (SSD) and is associated with poor outcomes, which remains understudied in individuals at varying risk of SSD. This study aimed to investigate the course of developmental functioning and its relationship with long-term outcomes within a population across the vulnerability spectrum of SSD. We hypothesized that developmental functioning negatively correlated with SSD vulnerability, and was positively associated with worse outcomes, regardless of disease status.</p><p><strong>Methods: </strong>We used data of 1119 patients, 1059 siblings, and 586 controls from the Dutch Genetic Risk and Outcome in Psychosis (GROUP) cohort. Group-based trajectory modelling and linear mixed models were employed to investigate the course of developmental functioning (measured by the Premorbid Adjustment Scale) and its associations with the outcomes, including social functioning (SF), personal recovery (PR), and quality of life (QoL).</p><p><strong>Results: </strong>In the combined sample, six developmental trajectories were identified: normal-stable (12.4 %), normal-slow decrease (12.3 %), mild-stable (46.9 %), all dominated by controls and siblings; and mild-rapid decrease (5.1 %), moderate-stable (16.5 %), and severe-slow decrease (6.8 %) more prevalent in patients. Compared to normal-stable, all other trajectories in developmental functioning were correlated with decreased SF; mild-rapid decrease and severe-slow decrease were linked to lower QoL. No association with PR was observed.</p><p><strong>Conclusion: </strong>Impaired developmental functioning variably lowers prolonged SF and QoL but not PR. Potentially influenced by factors encompassing environment, cognition, resilience and disease status, this finding demands screening for developmental deviance among youths and early preventive interventions to achieve normal functioning through a public health salutogenic approach.</p>","PeriodicalId":10554,"journal":{"name":"Comprehensive psychiatry","volume":"143 ","pages":"152637"},"PeriodicalIF":4.2000,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The power of youth: Long-term differential effects of developmental functioning trajectory on social functioning, quality of life and personal recovery across the schizophrenia spectrum.\",\"authors\":\"Jiasi Hao, Richard Bruggeman, Wim Veling, Behrooz Z Alizadeh\",\"doi\":\"10.1016/j.comppsych.2025.152637\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Compromised developmental functioning is frequently observed in patients with schizophrenia spectrum disorder (SSD) and is associated with poor outcomes, which remains understudied in individuals at varying risk of SSD. This study aimed to investigate the course of developmental functioning and its relationship with long-term outcomes within a population across the vulnerability spectrum of SSD. We hypothesized that developmental functioning negatively correlated with SSD vulnerability, and was positively associated with worse outcomes, regardless of disease status.</p><p><strong>Methods: </strong>We used data of 1119 patients, 1059 siblings, and 586 controls from the Dutch Genetic Risk and Outcome in Psychosis (GROUP) cohort. Group-based trajectory modelling and linear mixed models were employed to investigate the course of developmental functioning (measured by the Premorbid Adjustment Scale) and its associations with the outcomes, including social functioning (SF), personal recovery (PR), and quality of life (QoL).</p><p><strong>Results: </strong>In the combined sample, six developmental trajectories were identified: normal-stable (12.4 %), normal-slow decrease (12.3 %), mild-stable (46.9 %), all dominated by controls and siblings; and mild-rapid decrease (5.1 %), moderate-stable (16.5 %), and severe-slow decrease (6.8 %) more prevalent in patients. Compared to normal-stable, all other trajectories in developmental functioning were correlated with decreased SF; mild-rapid decrease and severe-slow decrease were linked to lower QoL. No association with PR was observed.</p><p><strong>Conclusion: </strong>Impaired developmental functioning variably lowers prolonged SF and QoL but not PR. Potentially influenced by factors encompassing environment, cognition, resilience and disease status, this finding demands screening for developmental deviance among youths and early preventive interventions to achieve normal functioning through a public health salutogenic approach.</p>\",\"PeriodicalId\":10554,\"journal\":{\"name\":\"Comprehensive psychiatry\",\"volume\":\"143 \",\"pages\":\"152637\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2025-09-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Comprehensive psychiatry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.comppsych.2025.152637\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comprehensive psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.comppsych.2025.152637","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
The power of youth: Long-term differential effects of developmental functioning trajectory on social functioning, quality of life and personal recovery across the schizophrenia spectrum.
Background: Compromised developmental functioning is frequently observed in patients with schizophrenia spectrum disorder (SSD) and is associated with poor outcomes, which remains understudied in individuals at varying risk of SSD. This study aimed to investigate the course of developmental functioning and its relationship with long-term outcomes within a population across the vulnerability spectrum of SSD. We hypothesized that developmental functioning negatively correlated with SSD vulnerability, and was positively associated with worse outcomes, regardless of disease status.
Methods: We used data of 1119 patients, 1059 siblings, and 586 controls from the Dutch Genetic Risk and Outcome in Psychosis (GROUP) cohort. Group-based trajectory modelling and linear mixed models were employed to investigate the course of developmental functioning (measured by the Premorbid Adjustment Scale) and its associations with the outcomes, including social functioning (SF), personal recovery (PR), and quality of life (QoL).
Results: In the combined sample, six developmental trajectories were identified: normal-stable (12.4 %), normal-slow decrease (12.3 %), mild-stable (46.9 %), all dominated by controls and siblings; and mild-rapid decrease (5.1 %), moderate-stable (16.5 %), and severe-slow decrease (6.8 %) more prevalent in patients. Compared to normal-stable, all other trajectories in developmental functioning were correlated with decreased SF; mild-rapid decrease and severe-slow decrease were linked to lower QoL. No association with PR was observed.
Conclusion: Impaired developmental functioning variably lowers prolonged SF and QoL but not PR. Potentially influenced by factors encompassing environment, cognition, resilience and disease status, this finding demands screening for developmental deviance among youths and early preventive interventions to achieve normal functioning through a public health salutogenic approach.
期刊介绍：
"Comprehensive Psychiatry" is an open access, peer-reviewed journal dedicated to the field of psychiatry and mental health. Its primary mission is to share the latest advancements in knowledge to enhance patient care and deepen the understanding of mental illnesses. The journal is supported by a diverse team of international editors and peer reviewers, ensuring the publication of high-quality research with a strong focus on clinical relevance and the implications for psychopathology.
"Comprehensive Psychiatry" encourages authors to present their research in an accessible manner, facilitating engagement with clinicians, policymakers, and the broader public. By embracing an open access policy, the journal aims to maximize the global impact of its content, making it readily available to a wide audience and fostering scientific collaboration and public awareness beyond the traditional academic community. This approach is designed to promote a more inclusive and informed dialogue on mental health, contributing to the overall progress in the field.
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