Communications Biology最新文献_第7页

Author Correction: Generating synthetic task-based brain fingerprints for population neuroscience using deep learning. 作者更正：使用深度学习为人口神经科学生成基于任务的合成脑指纹。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-09-12 DOI: 10.1038/s42003-026-10937-y

Emin Serin, Kerstin Ritter, Gunter Schumann, Tobias Banaschewski, Andre Marquand, Henrik Walter

引用次数: 0

The vicious cycle of SASP and inflammaging promotes aging and age-related diseases. SASP和炎症的恶性循环促进衰老和与年龄有关的疾病。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-09-10 DOI: 10.1038/s42003-026-10826-4

Qian Liu, Yulin Zheng, Chongkui Sun

引用次数: 0

Cell-body curvature reduces stall frequency to enhance Vibrio cholerae swimming and chemotaxis through hydrogels. 胞体曲率降低失速频率，增强霍乱弧菌通过水凝胶的游动和趋化性。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-09-08 DOI: 10.1038/s42003-026-10883-9

Marwan Malik, Ziyang Chen, Andrew G T Pyo, Zemer Gitai, Ned S Wingreen, Marianne Grognot

{"title":"Cell-body curvature reduces stall frequency to enhance Vibrio cholerae swimming and chemotaxis through hydrogels.","authors":"Marwan Malik, Ziyang Chen, Andrew G T Pyo, Zemer Gitai, Ned S Wingreen, Marianne Grognot","doi":"10.1038/s42003-026-10883-9","DOIUrl":"10.1038/s42003-026-10883-9","url":null,"abstract":"The swimming motility of the bacterial pathogen Vibrio cholerae is a virulence factor that aids in breaching the mucus layer. V. cholerae has a curved cell shape, and previous work demonstrated that loss of curvature decreases infectivity. Here, we investigate the mechanism by which curvature affects single-cell motility. We compared the chemotactic performance of wild-type curved cells and straight mutants. The two exhibit similar swimming properties in liquid and viscous solutions but differ significantly in mucus-mimicking hydrogels, where curved cells demonstrate an 86% increase in chemotactic drift. Trajectory analysis indicates comparable swimming speeds, but straight mutants experience more frequent stalls, reducing total swimming time. Stalls further reduce chemotactic performance by imposing an average reorientation down the chemical gradient, regardless of cell shape. Coarse-grained molecular dynamics simulations corroborate these results across intestinal mucus hydrogel stiffnesses and identify an optimal curvature for movement through hydrogel-like meshes, close to the pathogen's median curvature. These findings highlight cell shape's role in pathogenicity and the need to study bacterial behaviors under conditions more closely mimicking the host environment.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13554207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: A nucleolar stress gene signature enables quantitative scoring across multi-omics contexts. 作者更正：核仁应激基因签名可以在多组学背景下进行定量评分。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-09-03 DOI: 10.1038/s42003-026-10858-w

Jianxiong Chen, Shuai Xiao, Zhe Hao, Huimeng Xu, Xuemei Xu, Jun Zhou

引用次数: 0

A who's who of cell types in skeletal muscle. 骨骼肌细胞类型的名人录。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-09-03 DOI: 10.1038/s42003-026-10803-x

Shubhangi Das Barman, Zofija Frimand, M Pilar J Stella, Anne-Sofie Clausen, Sierra L W Olsen, Antoine de Morree

引用次数: 0

On variability in local field potentials. 局部场电位的变异性。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-09-02 DOI: 10.1038/s42003-026-10881-x

Mohsen Parto-Dezfouli, Elizabeth L Johnson, Eleni Psarou, Conrado Arturo Bosman, B Suresh Krishna, Pascal Fries

{"title":"On variability in local field potentials.","authors":"Mohsen Parto-Dezfouli, Elizabeth L Johnson, Eleni Psarou, Conrado Arturo Bosman, B Suresh Krishna, Pascal Fries","doi":"10.1038/s42003-026-10881-x","DOIUrl":"10.1038/s42003-026-10881-x","url":null,"abstract":"Neuronal variability is a fundamental feature of neuronal coding. In spiking activity, across-trial variance (ATV) normalized by mean spike count (i.e., the Fano factor) shows stimulus-induced quenching. ATV has also been studied in electro/magneto-encephalography (E/MEG) without normalization, revealing effects of stimulation and cognition. Here we show that outside of event-related potentials (ERPs), ATV for both EEG and local field potential (LFP) is nearly identical to intra-trial variance (ITV), which equals signal power. ATV-ITV correlation decreases during ERPs, proportional to how much the ERP explains total power. While EEG ATV shows post-stimulus quenching, LFP ATV does not, particularly in the gamma band, where power increases after stimulus onset. To provide an independent variability measure, we introduce CV(power), the coefficient of variation of signal power, as a mean-normalized metric. CV(power) is the inverse of the signal-to-noise ratio of power and thus related to decodability, offering a variability measure applicable to E/MEG and LFP.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13538653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148879393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Single-organoid Workflow for quantitative Imaging classiFication and Tracking (SWIFT). 一种用于定量成像分类和跟踪（SWIFT）的单器官工作流。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-09-01 DOI: 10.1038/s42003-026-10768-x

Lucie Bracq, Romain Guiet, Sandra Offner, Béatrice Kunz, Gisou van der Goot, Nathalie Brandenberg

引用次数: 0

RhoA in postnatal spinal motoneuron is essential for peripheral myelination. 出生后脊髓运动神经元中的RhoA对外周髓鞘形成至关重要。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-09-01 DOI: 10.1038/s42003-026-10779-8

Ye He, Shuyi Xu, Ying Zou, Mengyao Zhao, Mi Li, Jiale Cai, Xinrui Ma, Anbo Zhang, Xianghai Wang, Jiasong Guo

引用次数: 0

SARS-CoV-2 Delta variant-specific ORF3a mutations destabilize lysosomal homeostasis to trigger lysosomal damage-mediated cell death. SARS-CoV-2 δ变异特异性ORF3a突变破坏溶酶体稳态稳定，引发溶酶体损伤介导的细胞死亡。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-08-31 DOI: 10.1038/s42003-026-10801-z

Ayushi Amin Dey, Sanchita Mishra, Vigneshwar Reddy Ashireddygari, Bharadwaj Vemparala, Anantika Chandra, Disha Jain, Narendra M Dixit, Prasad Tammineni, Sannula Kesavardhana

{"title":"SARS-CoV-2 Delta variant-specific ORF3a mutations destabilize lysosomal homeostasis to trigger lysosomal damage-mediated cell death.","authors":"Ayushi Amin Dey, Sanchita Mishra, Vigneshwar Reddy Ashireddygari, Bharadwaj Vemparala, Anantika Chandra, Disha Jain, Narendra M Dixit, Prasad Tammineni, Sannula Kesavardhana","doi":"10.1038/s42003-026-10801-z","DOIUrl":"10.1038/s42003-026-10801-z","url":null,"abstract":"The variants of concern (VOCs) of SARS-CoV-2 emerged independently and became dominant globally at different times. Despite the emergence of multiple VOCs, the Delta variant of SARS-CoV-2 showed heightened pathogenicity and unprecedented mortality. However, the Delta variant specific mechanisms underlying its increased pathogenicity are unclear. Here, we show that variations in SARS-CoV-2 ORF3a correlate with the pathogenic potential of VOCs and drive Delta variant-specific lysosomal damage that activates inflammatory cell death. ORF3a from the Delta variant shows unique mutational patterns distinct from other SARS-CoV-2 VOCs. ORF3a-specific phylogenetic analysis reveals noticeable differences in the evolutionary trajectories of VOCs, likely reflective of their pathogenic relatedness. Unlike the Omicron variant and the ancestral Wuhan strain, Delta-specific ORF3a mutations promotes robust lysosomal damage, peripheral distribution, and membrane localization with no apparent effect on viral titers. Furthermore, Delta ORF3a mutations-induced lysosomal damage promotes both apoptosis and necroptosis activation in human cells. Structurally, these Delta variant-specific mutations appear to stabilize the ORF3a oligomers through helical packing and formation of a non-native disulfide bond, possibly facilitating their lysosomal association and damage. Overall, our observations indicate that ORF3a disrupts lysosomal homeostasis and triggers cell death, suggesting Delta-variant-specific regulation of cell fate and inflammation-associated pathogenesis.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13530248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-supervised learning yields representational signatures of category-selective cortex. 自我监督学习产生类别选择皮层的表征特征。

IF 5.8 1区生物学

Communications Biology Pub Date : 2026-08-29 DOI: 10.1038/s42003-026-10843-3

Daniel Janini, Radoslaw Cichy

{"title":"Self-supervised learning yields representational signatures of category-selective cortex.","authors":"Daniel Janini, Radoslaw Cichy","doi":"10.1038/s42003-026-10843-3","DOIUrl":"10.1038/s42003-026-10843-3","url":null,"abstract":"The ventral visual stream contains category-selective regions with distinct feature tuning, most prominently the fusiform face area (FFA) and parahippocampal place area (PPA). Why do these brain regions exhibit distinct tuning properties? Recent work suggests that brain-like category-selective features emerge from a general visual learning mechanism without domain-specific biases. Here, we test this proposal by applying a functional localizer approach to both humans and self-supervised neural networks, identifying face- and scene-selective units in the brain and in models. We then compared fMRI and model responses across a broad stimulus set probing classic representational signatures of the FFA and PPA, including preferences relating to curvature, animacy, real-world size, mid-level features, face shapes, and spatial layout information. Category-selective model units largely recapitulate the distinct representational signatures of category-selective brain regions, capturing most of the effects in our test battery. Our findings demonstrate that domain-general learning objectives are sufficient to create humanlike category-selectivity, suggesting that the distinct representational signatures of category-selective cortex may emerge from a unified computational goal akin to self-supervised learning.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"9 1","pages":""},"PeriodicalIF":5.8,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148856996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0