Communications Biology最新文献_第6页

SpaCross deciphers spatial structures and corrects batch effects in multi-slice spatially resolved transcriptomics. SpaCross破译空间结构和纠正多层空间分解转录组的批效应。

IF 5.1 1区生物学

Communications Biology Pub Date : 2025-09-30 DOI: 10.1038/s42003-025-08810-5

Donghai Fang, Wenwen Min

{"title":"SpaCross deciphers spatial structures and corrects batch effects in multi-slice spatially resolved transcriptomics.","authors":"Donghai Fang, Wenwen Min","doi":"10.1038/s42003-025-08810-5","DOIUrl":"10.1038/s42003-025-08810-5","url":null,"abstract":"Spatially Resolved Transcriptomics (SRT) has revolutionized tissue architecture analysis by integrating gene expression with spatial coordinates. However, existing spatial domain identification methods struggle with unsupervised learning constraints, lack of implicit supervision in latent space, and challenges in balancing local spatial continuity with global semantic consistency, particularly in multi-slice integration. To address these issues, we propose SpaCross, a comprehensive deep learning framework for SRT that enhances spatial pattern recognition and cross-slice consistency. SpaCross employs a cross-masked graph autoencoder to reconstruct gene expression features while preserving spatial relationships and mitigating identity mapping issues. A cross-masked latent consistency module reinforces implicit constraints on latent representations, improving feature robustness. More importantly, an adaptive spatial-semantic graph structure dynamically integrates local and global contextual information, enabling effective multi-slice integration. Extensive evaluations demonstrate that SpaCross outperforms thirteen state-of-the-art methods on single-slice datasets and achieves robust batch effect correction while preserving biologically meaningful spatial architectures in multi-slice integration. Notably, SpaCross integrates embryonic mouse tissues across developmental stages, identifying conserved regions and uncovering stage-specific structures such as the dorsal root ganglion. In the heart domain, it reconstructs developmental trajectories capturing key transcriptional transitions and gene programs associated with cardiac maturation.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"8 1","pages":"1393"},"PeriodicalIF":5.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Galleria mellonella possesses the essential nutritional needs to host the fastidious Huanglongbing bacterial pathogen 'Candidatus Liberibacter asiaticus'. mellonella具有必需的营养需求，以宿主挑剔的黄龙冰细菌病原体“亚洲自由候选菌”。

IF 5.1 1区生物学

Communications Biology Pub Date : 2025-09-30 DOI: 10.1038/s42003-025-08802-5

Nabil Killiny, Yasser Nehela, Faraj Hijaz, Mahnaz Rashidi, Shelley E Jones

{"title":"Galleria mellonella possesses the essential nutritional needs to host the fastidious Huanglongbing bacterial pathogen 'Candidatus Liberibacter asiaticus'.","authors":"Nabil Killiny, Yasser Nehela, Faraj Hijaz, Mahnaz Rashidi, Shelley E Jones","doi":"10.1038/s42003-025-08802-5","DOIUrl":"10.1038/s42003-025-08802-5","url":null,"abstract":"Citrus greening disease, caused by 'Candidatus Liberibacter asiaticus', severely impacts citrus production worldwide. The development of sustainable control strategies for this disease is restricted by the unavailability of the bacterium in pure culture. Herein, the metabolic profile of the waxworm larvae, Galleria mellonella, was compared to that of Diaphorina citri, the vector of 'Ca. L. asiaticus'. Our findings showed that G. mellonella larvae possess the nutritional needs to host 'Ca. L. asiaticus', supporting its short-term persistence, and responds to infection with a visible immune reaction by producing melanin upon bacterial invasion. The inoculated larvae exhibit detectable bacterial titers for up to four days when inoculated with infected citrus phloem sap or D. citri haemolymph, after which bacterial titers decline, and infected larvae show reduced survival compared to mock-treated and 'Ca. L. asiaticus'-free controls. Metabolic profiling of G. mellonella, D. citri, and honeybees (Apis mellifera) reveals distinct chemical compositions in their haemolymph. G. mellonella contains higher levels of amino acids, organic acids, nucleotides, and sugar-nucleotides, providing essential nutrients for 'Ca. L. asiaticus', while D. citri is enriched in monosaccharides and sugar-alcohols. Citric acid was detected exclusively in the haemolymph of G. mellonella. These findings suggest G. mellonella as a convenient model that can transiently host 'Ca. L. asiaticus' for short-term use, which would facilitate high-throughput screening of antimicrobial compounds against 'Ca. L. asiaticus', as well as exploring host-pathogen interactions. This model could accelerate the development of effective treatments against citrus greening and inform broader strategies for managing vector-borne plant diseases.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"8 1","pages":"1398"},"PeriodicalIF":5.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential modulation of positive and negative prediction errors by stimulus variability in the mouse posterior parietal cortex. 小鼠后顶叶皮层刺激变异性对正、负预测误差的差异调节。

IF 5.1 1区生物学

Communications Biology Pub Date : 2025-09-30 DOI: 10.1038/s42003-025-08797-z

Benjamin Leonardon, Sergej Kasavica, Constanze Raltschev, Walter Senn, Katharina A Wilmes, Shankar Sachidhanandam

{"title":"Differential modulation of positive and negative prediction errors by stimulus variability in the mouse posterior parietal cortex.","authors":"Benjamin Leonardon, Sergej Kasavica, Constanze Raltschev, Walter Senn, Katharina A Wilmes, Shankar Sachidhanandam","doi":"10.1038/s42003-025-08797-z","DOIUrl":"10.1038/s42003-025-08797-z","url":null,"abstract":"To function in uncertain environments, we need to constantly update our internal model of the world. Sensory prediction errors are thought to drive these updates. EEG studies indicate that uncertainty affects neural correlates of prediction errors. It is unclear how uncertainty of the environment modulates prediction error responses in individual neurons. Here, we exposed awake head-restrained mice to sounds followed by tactile stimuli that were either fixed or variable in intensity, making them more or less predictable. Using tactile stimuli that were stronger or weaker than expected, we identified positive and negative prediction error neurons in layer 2/3 of the posterior parietal cortex with 2-photon calcium imaging. We show that positive prediction errors are upregulated while negative prediction errors are downregulated by variability. Finally, through modelling we show that variability-dependent modulation of inhibitory neurons best fits the data, suggesting a previously unrecognized role for inhibition in encoding uncertainty prediction errors.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"8 1","pages":"1397"},"PeriodicalIF":5.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distance-AF improves predicted protein structure models by AlphaFold2 with user-specified distance constraints. distance - af通过用户指定的距离约束改进了AlphaFold2预测的蛋白质结构模型。

IF 5.1 1区生物学

Communications Biology Pub Date : 2025-09-30 DOI: 10.1038/s42003-025-08783-5

Yuanyuan Zhang, Zicong Zhang, Yuki Kagaya, Genki Terashi, Bowen Zhao, Yi Xiong, Daisuke Kihara

{"title":"Distance-AF improves predicted protein structure models by AlphaFold2 with user-specified distance constraints.","authors":"Yuanyuan Zhang, Zicong Zhang, Yuki Kagaya, Genki Terashi, Bowen Zhao, Yi Xiong, Daisuke Kihara","doi":"10.1038/s42003-025-08783-5","DOIUrl":"10.1038/s42003-025-08783-5","url":null,"abstract":"The three-dimensional structure provides essential information for understanding biological functions of proteins. To aid structure determination, computational prediction has been extensively studied. Despite significant progress, challenges remain on difficult targets, such as those with multiple domains and proteins that fold into several conformations. Here we present Distance-AF, which aims to improve the performance of AlphaFold2 by incorporating distance constraints. Distance-AF reduced the root mean square deviation (RMSD) of structure models to native on average by 11.75 Å when compared to the models by AlphaFold2 on a test set of 25 targets. Distance-AF outperformed Rosetta and AlphaLink, which consider distance constraints. The average RMSD values for Distance-AF, Rosetta, and AlphaLink were 4.22 Å, 6.40 Å, and 14.29 Å, respectively. We further demonstrate its applications in various scenarios, including fitting structures into cryo-electron microscopy density maps, modeling active and inactive conformations, and generating conformational ensembles that satisfy Nuclear Magnetic Resonance data. Distance-AF has the potential to accelerate structural biology research, facilitate drug discovery, and provide a foundation for integrating experimental and computational approaches to study protein dynamics and interactions in complex biological systems.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"8 1","pages":"1392"},"PeriodicalIF":5.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The xIV-LDDMM toolkit of image-varifold based technologies for mapping 3D images and spatial-omics across scales. xIV-LDDMM基于图像可变技术的工具包，用于跨尺度映射3D图像和空间组学。

IF 5.1 1区生物学

Communications Biology Pub Date : 2025-09-30 DOI: 10.1038/s42003-025-08800-7

Kaitlin M Stouffer, Xiaoyin Chen, Hongkui Zeng, Benjamin Charlier, Laurent Younes, Alain Trouvé, Michael I Miller

{"title":"The xIV-LDDMM toolkit of image-varifold based technologies for mapping 3D images and spatial-omics across scales.","authors":"Kaitlin M Stouffer, Xiaoyin Chen, Hongkui Zeng, Benjamin Charlier, Laurent Younes, Alain Trouvé, Michael I Miller","doi":"10.1038/s42003-025-08800-7","DOIUrl":"10.1038/s42003-025-08800-7","url":null,"abstract":"Advancements in imaging and molecular techniques enable the collection of subcellular-scale data. Diversity in measured features, resolution, and physical scope of capture across technologies and experimental protocols pose numerous challenges to integrating data with reference coordinate systems and across scales. This paper describes a collection of technologies that we have developed for mapping data across scales and modalities, such as genes to tissues, specifically in a 3D setting. Our collection of technologies include (i) an explicit censored data representation for the partial matching problem mapping whole brains to subsampled subvolumes, (ii) a multi, scale-space optimization technology for generating resampling grids optimized to represent spatial geometry at fixed complexities, and (iii) mutual-information based functional feature selection. We integrate these technologies with our cross-modality mapping algorithm through the use of image-varifold measure norms to represent universally data across scales and imaging modalities. Collectively, these methods afford efficient representations of peta-scale imagery providing the algorithms for mapping from the nano to millimeter scales, which we term cross-modality image-varifold LDDMM (xIV-LDDMM).","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"8 1","pages":"1401"},"PeriodicalIF":5.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alzheimer's disease signatures in the brain transcriptome of Estuarine Dolphins. 河口海豚脑转录组中的阿尔茨海默病特征。

IF 5.1 1区生物学

Communications Biology Pub Date : 2025-09-30 DOI: 10.1038/s42003-025-08796-0

Wendy Noke Durden, Megan K Stolen, Susanna P Garamszegi, Sandra Anne Banack, Daniel J Brzostowicki, Regina T Vontell, Larry E Brand, Paul Alan Cox, David A Davis

{"title":"Alzheimer's disease signatures in the brain transcriptome of Estuarine Dolphins.","authors":"Wendy Noke Durden, Megan K Stolen, Susanna P Garamszegi, Sandra Anne Banack, Daniel J Brzostowicki, Regina T Vontell, Larry E Brand, Paul Alan Cox, David A Davis","doi":"10.1038/s42003-025-08796-0","DOIUrl":"10.1038/s42003-025-08796-0","url":null,"abstract":"Climate warming is one factor increasing the severity of harmful algal blooms (HABs). Innovative exposure models are needed to understand how HABs affect brain health. Here, we examined HAB exposure on the brain transcriptome of dolphins found stranded in Florida's Indian River Lagoon. We report the neurotoxin 2,4-diaminobutyric acid (2,4-DAB) is 2900 times more concentrated in dolphin brains during bloom seasons compared to non-bloom seasons. The same dolphins show 536 differentially expressed genes whose enrichment reveal impairment in GABAergic synapses, basement membrane alteration, and Alzheimer's disease (AD) risk factors that increase with each subsequent season. Dolphins also display concurrent AD-like neuropathological changes and elevated AD gene expression with 2,4-DAB exposure. Our study demonstrates disproportionate seasonal exposure to 2,4-DAB increases AD signatures in the brain transcriptome. As our climate warms, HABs will continue to intensify. Understanding the impact of HAB exposures will help to identify populations at risk for neurological illnesses.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"8 1","pages":"1400"},"PeriodicalIF":5.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal dedifferentiation of neural states with age during naturalistic viewing. 自然观赏时神经状态随年龄的去分化。

IF 5.1 1区生物学

Communications Biology Pub Date : 2025-09-30 DOI: 10.1038/s42003-025-08792-4

Selma Lugtmeijer, Djamari Oetringer, Linda Geerligs, Karen L Campbell

引用次数: 0

Social memory engram formation impairment in neuroligin-3 R451C knock-in mice is caused by disrupted prefrontal NMDA receptor-dependent potentiation. 神经素-3 R451C敲入小鼠的社会记忆印痕形成损伤是由前额叶NMDA受体依赖性增强破坏引起的。

IF 5.1 1区生物学

Communications Biology Pub Date : 2025-09-30 DOI: 10.1038/s42003-025-08806-1

Zhiyuan Li, Qun Yang, Huiyi Li, Jiali Ge, Hangtian Yan, Jiahui Li, Yuzhen Fu, Kexian Yan, Sien Li, Jialin Chen, Wenjie Dou, Junyu Xu, Jianhong Luo, Baoming Li, Wei Cao

{"title":"Social memory engram formation impairment in neuroligin-3 R451C knock-in mice is caused by disrupted prefrontal NMDA receptor-dependent potentiation.","authors":"Zhiyuan Li, Qun Yang, Huiyi Li, Jiali Ge, Hangtian Yan, Jiahui Li, Yuzhen Fu, Kexian Yan, Sien Li, Jialin Chen, Wenjie Dou, Junyu Xu, Jianhong Luo, Baoming Li, Wei Cao","doi":"10.1038/s42003-025-08806-1","DOIUrl":"10.1038/s42003-025-08806-1","url":null,"abstract":"Autism spectrum disorders (ASDs) are characterized by profound social cognitive deficits, including impairments in social memory-the ability to recognize and remember familiar conspecifics. However, the mechanisms underlying these deficits remain poorly understood. Here, we identify a distinct population of medial prefrontal cortical neurons that encode individual conspecifics and form social memory engram cells (SMECs) through N-methyl-D-aspartate receptor (NMDAR)-dependent long-term potentiation (LTP). Using the Neuroligin 3 R451C knock-in mouse model of autism, we demonstrate that disrupted NMDAR-dependent LTP impairs the formation of SMECs, leading to social memory deficits. Notably, these deficits are rescued by a well-tolerated, once-weekly \"pulsed\" administration of D-cycloserine, a partial NMDAR agonist. Our findings underscore the pivotal role of NMDAR-dependent synaptic plasticity in social memory encoding and position NMDAR-targeted therapies as a compelling avenue for addressing social cognitive deficits in ASDs.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"8 1","pages":"1404"},"PeriodicalIF":5.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seasonally and niche-differentiated diversity of active, dormant and dead microbes in coastal waters and surface sediments. 沿海水域和表层沉积物中活跃、休眠和死亡微生物的季节和生态位分化多样性。

IF 5.1 1区生物学

Communications Biology Pub Date : 2025-09-30 DOI: 10.1038/s42003-025-08789-z

Yunjun Yu, Guanzhe Li, Haoyuan Zhang, Zeyu Hu, Dirui Yu, Jun Gong

{"title":"Seasonally and niche-differentiated diversity of active, dormant and dead microbes in coastal waters and surface sediments.","authors":"Yunjun Yu, Guanzhe Li, Haoyuan Zhang, Zeyu Hu, Dirui Yu, Jun Gong","doi":"10.1038/s42003-025-08789-z","DOIUrl":"10.1038/s42003-025-08789-z","url":null,"abstract":"Metabarcoding surveys have rarely discriminated metabolically active, dormant, and dead microbes in environmental samples. This study employed a triple metabarcoding approach targeting environmental 16S and 18S rRNA genes and their transcripts to investigate the diversity of these physiologically distinct assemblages in the water column and surface sediments of a tropical coastal region. We found that dead bacteria, archaea, and microeukaryotes (relic DNA) accounted for ≤5% of the planktonic DNA pools but significantly contributed to ASV richness (53%, 50%, and 32%, respectively), while dominating in sediments (44% of sequence, 80% of richness). In viable assemblages, dormant microbes were rarer but enriched richness, particularly in the water (20%, 62%, and 28%, respectively). Collectively, the proportions of microbes in different physiological states exhibited niche-specific and seasonal patterns, primarily driven by pH and temperature. Significant differences in richness and assemblage composition were observed between water, sediment, and seasons for all physiological fractions. Active microbial communities responded to distinct environmental drivers compared to DNA-characterized assemblages, suggesting that DNA-based methods may misidentify factors driving functional diversity in biogeochemical cycles. Dormant taxa exhibited a broader taxonomic distribution than previously recognized, underscoring the need for further research on microbial ecophysiology, function, and biogeography across temporal and spatial scales.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"8 1","pages":"1388"},"PeriodicalIF":5.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreatic β-cell FFA2 deficiency suppresses multiple low dose streptozotocin induced diabetes in male mice. 胰腺β细胞FFA2缺乏抑制多种低剂量链脲佐菌素诱导的雄性小鼠糖尿病。

IF 5.1 1区生物学

Communications Biology Pub Date : 2025-09-30 DOI: 10.1038/s42003-025-08787-1

Kai Xu, Prabhakaran Kumar, Sophia R Chang Stauffer, Husena M Electricwala, Bellur S Prabhakar, Irene Corona-Avila, Nupur Pandya, Brian T Layden, Medha Priyadarshini

{"title":"Pancreatic β-cell FFA2 deficiency suppresses multiple low dose streptozotocin induced diabetes in male mice.","authors":"Kai Xu, Prabhakaran Kumar, Sophia R Chang Stauffer, Husena M Electricwala, Bellur S Prabhakar, Irene Corona-Avila, Nupur Pandya, Brian T Layden, Medha Priyadarshini","doi":"10.1038/s42003-025-08787-1","DOIUrl":"10.1038/s42003-025-08787-1","url":null,"abstract":"Reduced enrichment of short-chain fatty acid (SCFA)-producing pathways in the gut microbiome (GM) and SCFA levels are associated with increased risk of type 1 diabetes (T1D). Free fatty acid receptor 2 (FFA2), an SCFA receptor on pancreatic β-cells, mediates GM and β-cell crosstalk. Here, we examine its T1D-specific role in male mice, using a novel tamoxifen-inducible adult-onset β-cell FFA2 knockout (FFA2 βKO) mouse model and its controls (cre and flox), treated with multiple low-dose streptozotocin (MLDS). FFA2 βKO mice show significantly lower diabetes incidence compared to control mice (57% vs 100%). Early in the MLDS insult (7th day), FFA2 βKO mice show significantly lower β-cell apoptosis and higher β-cell mass, persisting up to 43 days. Mechanistically, we observed higher SOCS1/3 expression and reduced T1-IFN signaling in FFA2 βKO islets. Our data suggest that β-cell FFA2 modulates early islet apoptosis, likely via the T1-IFN-SOCS1/3 pathway and may be a pharmacological target for slowing T1D progression.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"8 1","pages":"1389"},"PeriodicalIF":5.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0