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Personal Use and Attitude toward Integrative Medicine and Nursing among Employees at a German University Hospital: Results of a Cross-Sectional Study. 德国一所大学医院员工对综合医学和护理的个人使用和态度——一项横断面研究的结果。
IF 1 4区 医学
Complementary Medicine Research Pub Date : 2025-01-01 Epub Date: 2025-11-12 DOI: 10.1159/000548783
Lena Mohr, Lea Raiber, Johanna Thiele, Klaus Kramer
{"title":"Personal Use and Attitude toward Integrative Medicine and Nursing among Employees at a German University Hospital: Results of a Cross-Sectional Study.","authors":"Lena Mohr, Lea Raiber, Johanna Thiele, Klaus Kramer","doi":"10.1159/000548783","DOIUrl":"10.1159/000548783","url":null,"abstract":"<p><p><p>Introduction: Previous studies have shown that integrative medicine (IM) is of considerable relevance from the patients' perspective. The acceptance of healthcare professionals is essential to meet patient needs and integrate IM into routine clinical practice. The aim of this study was to assess personal use and attitudes toward IM, as well as the implementation of integrative nursing (IN), among employees at a German university hospital.</p><p><strong>Methods: </strong>A cross-sectional online study was conducted among employees at University Hospital Ulm in 2022. Univariate analysis of frequencies and cross-tabulations with chi-square tests were performed.</p><p><strong>Results: </strong>A total of 244 employees participated in the survey, 80.7% of whom were female and 49.3% were nurses. The mean age was 38.3 ± 12.3 years. Most respondents were familiar with IM (87.3%; n = 179). Overall, 63.2% (n = 129) rated its benefit as high. A total of 26.1% (n = 54) indicated that IN had been implemented in their own work settings, while the majority (91.4%; n = 171) supported broader implementation. Interest in training and education on IN was expressed by 52.4% (n = 98). Subgroup analyses revealed statistically significant associations between age and familiarity with IM (p = 0.039), personal use of IM (p = 0.019), and the rating of its benefits (p = 0.009), as well as between work-related patient contact and interest in further IN training (p < 0.001). No significant associations were observed for sex and profession.</p><p><strong>Conclusion: </strong>The findings indicate a high level of personal use and favorable attitudes toward IM, along with notable interest in IN among hospital employees, highlighting potential for further implementation of IM within clinical practice. </p>.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"474-484"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12700579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145502576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Difference Has Been Made... 与众不同....
IF 1.1 4区 医学
Complementary Medicine Research Pub Date : 2025-01-01 Epub Date: 2024-11-12 DOI: 10.1159/000542512
Frauke Musial
{"title":"A Difference Has Been Made...","authors":"Frauke Musial","doi":"10.1159/000542512","DOIUrl":"10.1159/000542512","url":null,"abstract":"","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"1-2"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acupuncture as an Adjunctive Therapy for Acute Cerebral Infarction: A Modified Delphi Consensus Study. 针刺作为急性脑梗死的辅助治疗:一项修正德尔菲共识研究。
IF 0.8 4区 医学
Complementary Medicine Research Pub Date : 2025-01-01 Epub Date: 2025-07-05 DOI: 10.1159/000547286
Fang Xie, Yi He, Lu-Qiang Sun, Hui Zheng, Jia-Xin Xie, Xiao-Shuang Feng, Yu-Fei Wang, Yuan-Hui Gan, Xin-Ru Pan, Yao-Dan Zhang, Peng-Fei Wang, Ying Li, Xiao-Yi Xiong
{"title":"Acupuncture as an Adjunctive Therapy for Acute Cerebral Infarction: A Modified Delphi Consensus Study.","authors":"Fang Xie, Yi He, Lu-Qiang Sun, Hui Zheng, Jia-Xin Xie, Xiao-Shuang Feng, Yu-Fei Wang, Yuan-Hui Gan, Xin-Ru Pan, Yao-Dan Zhang, Peng-Fei Wang, Ying Li, Xiao-Yi Xiong","doi":"10.1159/000547286","DOIUrl":"10.1159/000547286","url":null,"abstract":"<p><strong>Background: </strong>Acupuncture is an effective adjunctive therapy for stroke and has been suggested for the treatment for acute cerebral infarction (ACI). However, there is a lack of high-quality data from randomized clinical trials. Thus, this study aims to reach a consensus to guide the clinical research and practice.</p><p><strong>Methods: </strong>The initial project list was based on a systematic review of research evidence and a clinical problem survey conducted by a multidisciplinary team. After discussion with experts and a two-round Delphi consensus survey, the final list was optimized. Then, Likert scale of 9 points was used to measure the degree of expert consensus (1 = strongly disagree, 9 = strongly agree) and 80% of scores between 7 and 9 were defined as \"agreement.\"</p><p><strong>Results: </strong>A total of 30 professionals (response rate: 100%) confirmed their participation in the voting group. After two rounds of Delphi voting, a consensus was achieved including 34 items that can be broadly categorized into six aspects. According to expert consensus, acupuncture should be initiated within 6 h and the main acupoints are Shuigou (GV26), Neiguan (PC6), Hegu (LI4), and Taichong (LR3), while the auxiliary acupoints include Quchi (LI11), Waiguan (SJ5), Huantiao (GB30), Weizhong (BL40), etc. Furthermore, the adverse events of acupuncture are generally considered to be few, only subcutaneous hematoma is commonly reported.</p><p><strong>Conclusion: </strong>This expert consensus provides recommendations for clinical research and practice in treating ACI with acupuncture. However, due to the limited clinical evidence, further exploration is needed through rigorous clinical trials.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"301-313"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of a Yoga and Naturopathy-Based Lifestyle Intervention with 9-Month Follow-Up on Lipid Profile in Patients with Hypertension: A Two-Arm Parallel Group Randomized Controlled Trial. 以瑜伽和自然疗法为基础的生活方式干预对高血压患者血脂水平的影响:一项双臂平行组随机对照试验。
IF 1.1 4区 医学
Complementary Medicine Research Pub Date : 2025-01-01 Epub Date: 2024-12-19 DOI: 10.1159/000543024
Prashanth Shetty, Sujatha Kannarpady Janardhana, Mooventhan Aruchunan, Nandeesh Nanjangud Subbanna, Jyotsna Kamalet Jayasingh, Ashwin Vontikoppal Prakash
{"title":"Effect of a Yoga and Naturopathy-Based Lifestyle Intervention with 9-Month Follow-Up on Lipid Profile in Patients with Hypertension: A Two-Arm Parallel Group Randomized Controlled Trial.","authors":"Prashanth Shetty, Sujatha Kannarpady Janardhana, Mooventhan Aruchunan, Nandeesh Nanjangud Subbanna, Jyotsna Kamalet Jayasingh, Ashwin Vontikoppal Prakash","doi":"10.1159/000543024","DOIUrl":"10.1159/000543024","url":null,"abstract":"<p><strong>Introduction: </strong>Hypertension is recognized as a modifiable risk factor for cardiovascular diseases, alongside dyslipidemia. Studies have revealed that between 15 and 31% of individuals have both hypertension and dyslipidemia. However, emerging evidence suggests that natural therapies and yoga can help manage mild increases in blood pressure. This study aimed to evaluate the impact of yogic and naturopathy treatments on lipid profiles in hypertensive patients, thereby contributing to the existing literature.</p><p><strong>Materials and methods: </strong>A randomized controlled experiment was conducted, involving 262 hypertensive patients randomly assigned to either the study group (SG) or control group (CG). The SG, consisting of 131 individuals, received yoga and naturopathic treatments for 10 days, while the CG (n = 131) did not. The lipid profile was measured at the beginning and end of the 10 days, and they were followed up and reassessed after 9 months.</p><p><strong>Results: </strong>The study involved a total of 262 individuals, with 111 in the SG and 125 in the CG. After the 10-day intervention period, the SG showed significant reductions in total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, very low-density lipoprotein, apolipoprotein-A (Apo-A), apolipoprotein-B (Apo-B), and lipoprotein-A (Lp-A) (p < 0.001) compared to the CG. Also, the change was observed after 9 months in Apo-A, Apo-B, and Lp-A significantly (p < 0.001).</p><p><strong>Conclusion: </strong>These findings underscore the potential of naturopathic and yogic interventions in improving lipid profiles in hypertensive patients, thereby contributing to the current literature. In conjunction with conventional management, these specific interventions could be considered as a safer form of complementary therapy in the treatment of dyslipidemia among hypertensive patients. Thus, these findings hold promise for the integration of naturopathic and yogic therapies in the standard care of hypertensive patients.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"37-44"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integration of Complementary Medicine in Geriatric Nursing Homes: A Prospective Comparative Observational Study. 老年疗养院的补充医学整合:一项前瞻性比较观察研究。
IF 1.1 4区 医学
Complementary Medicine Research Pub Date : 2025-01-01 Epub Date: 2025-02-13 DOI: 10.1159/000544712
Miriam Ortiz, Katharina Schnabel, Sylvia Binting, Susanne Lezius, Karl Wegscheider, Michael Teut, Ralf Suhr, Benno Brinkhaus
{"title":"Integration of Complementary Medicine in Geriatric Nursing Homes: A Prospective Comparative Observational Study.","authors":"Miriam Ortiz, Katharina Schnabel, Sylvia Binting, Susanne Lezius, Karl Wegscheider, Michael Teut, Ralf Suhr, Benno Brinkhaus","doi":"10.1159/000544712","DOIUrl":"10.1159/000544712","url":null,"abstract":"<p><strong>Introduction: </strong>A healthy lifestyle is considered to be an important factor for healthy aging. Kneipp therapy (KT) includes a combination of hydrotherapy, herbal medicine, mind-body medicine, physical activities, and healthy nutrition. In this study, we investigated the effectiveness of KT care on activities of daily living, health, and quality of life in residents of nursing homes.</p><p><strong>Methods: </strong>We conducted a prospective, two-armed comparative observational study to compare matched nursing homes with KT (Kneipp group) versus nursing homes with common preventive interventions (control group) over a 12-month period. Outcome measures included activities of daily living (Barthel Index), cognition (Mini-Mental State Examination [MMSE]), and quality of life (QUALIDEM; Short-Form 12 [SF-12]).</p><p><strong>Results: </strong>We included 7 nursing homes (n = 105 residents) for the Kneipp group and 6 nursing homes (n = 69) as control. Except for Barthel Index, there were no time point-dependent differences between the groups. The Barthel Index showed a smaller difference from baseline in the control group (mean difference 0.94, 95% CI [-1.94; 3.82]) compared to the Kneipp group (-4.08, 95% CI [-6.46; -1.69]; p = 0.009) after 6 months; mean difference between groups Kneipp versus control: 5.01, 95% CI [1.25; 8.77]; p = 0.009. Pooled over the time points, the SF-12 mental health sum scale exhibited a smaller difference from baseline in the Kneipp group (-1.3, 95% CI [-3.6; 0.9]) compared to the control group (-3.8, 95% CI [-6.3; -1.4]; p = 0.027). Furthermore, the MMSE sum score decreased less in the Kneipp group compared to control (-1.1, 95% CI [-2.2, -0.1]; p = 0.033) after 12 months. A post hoc comparison of residents from both groups who received at least 30 preventive interventions monthly exhibited better values for QUALIDEM items \"social relations,\" \"social isolation,\" and \"feeling at home.\"</p><p><strong>Conclusion: </strong>This comparative observational study showed only small differences in outcome measures between the groups. The frequency of treatments may positively influence social components of behavior and well-being in residents. High-quality pragmatic randomized trials are needed for further investigations.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"122-137"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11991749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurological Complications of Cupping Therapy: A Comprehensive Review. 火罐治疗的神经系统并发症:综合综述。
IF 1.1 4区 医学
Complementary Medicine Research Pub Date : 2025-01-01 Epub Date: 2025-01-21 DOI: 10.1159/000543511
Babak Daneshfard, Sajjad Sadeghi, Dennis Cordato
{"title":"Neurological Complications of Cupping Therapy: A Comprehensive Review.","authors":"Babak Daneshfard, Sajjad Sadeghi, Dennis Cordato","doi":"10.1159/000543511","DOIUrl":"10.1159/000543511","url":null,"abstract":"<p><strong>Background: </strong>Cupping therapy, a traditional treatment method, has been shown to be effective in various studies. However, there have been reports of significant neurological complications following cupping therapy. This comprehensive review aimed to investigate the important and potentially severe neurological complications documented in the literature.</p><p><strong>Summary: </strong>The review analyzed case reports and case studies published in three major databases (PubMed, Google Scholar, and Cochrane) up to June 2024. The search strategy involved a three-step process, where two traditional medicine experts independently searched for case reports and published case series, and then a 3-person committee consisting of two traditional medicine experts and a neurologist reviewed the selected articles. Out of 280 case reports and case series, 12 studies were included in the review, reporting 14 patients with neurological complications. The majority of cases (7/14) involved interventions combining cupping with other traditional medicine manual therapies. Complications reported included vascular and infectious complications, with subdural hemorrhage being the most common (4/14). Most patients (11/14) were free of underlying diseases, and all but 3 patients recovered from their complications with surgical and medical treatments.</p><p><strong>Key messages: </strong>The study concludes that although rare, neurological complications of cupping therapy can be severe and potentially life-threatening. Therefore, it is essential for traditional medicine practitioners to be aware of these risks and take necessary precautions to prevent them. Adopting proper techniques and adhering to health guidelines can help mitigate the likelihood of complications. The creation of an international system to record and report the side effects of cupping therapy is also recommended.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"151-159"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
St John's Wort (Hypericum perforatum) Fresh Plant Tincture for Patients with Mild to Moderate Depression: A Prospective Observational Study. 圣约翰草(贯叶连翘)新鲜植物酊剂用于轻度至中度抑郁症患者-一项前瞻性观察研究。
IF 1 4区 医学
Complementary Medicine Research Pub Date : 2025-01-01 Epub Date: 2025-09-04 DOI: 10.1159/000547920
Natalie Kalbermatten, Reinhard Saller
{"title":"St John's Wort (<i>Hypericum perforatum</i>) Fresh Plant Tincture for Patients with Mild to Moderate Depression: A Prospective Observational Study.","authors":"Natalie Kalbermatten, Reinhard Saller","doi":"10.1159/000547920","DOIUrl":"10.1159/000547920","url":null,"abstract":"<p><strong>Introduction: </strong>High-dose dry extract preparations of St John's wort (Hypericum perforatum) (hd-SJW) are equally effective as synthetic antidepressants (SAD) for mild to moderate depression as shown by various randomized controlled trials (RCTs). Other available preparations of SJW such as fresh plant tinctures are dosed lower and no clinical study about their effect has been published so far. The aim of this study was to evaluate the effect of a SJW fresh plant tincture (C-SJW-ft) on depressive symptoms and its tolerability in patients comparable to patients reported in hd-SJW RCTs applying the same outcome, the Hamilton Depression Scale 17 (HAM-D 17).</p><p><strong>Methods: </strong>Prospective observational study of outpatients with mild to moderate depressive episodes (ICD-10/DSM-IV) treated with C-SJW-ft. Outcomes were HAM-D 17 change from inclusion to 6 weeks (42 days ± 7 days), percentage of responders (>50% decline), and frequency and type of adverse events. Descriptive analysis was performed. From a systematic literature review of RCTs of hd-SJW applying HAM-D 17 as efficacy outcome at 6 weeks, the characteristics of the included patient population and the outcomes were extracted for comparison (rRCTs [\"reference RCTs\"]).</p><p><strong>Results: </strong>Fifty-two evaluable patients were included, 1 patient dropped out (switch to SADs). Of the 51 (per protocol [PP] \"expanded\") patients, 42 completed the second HAM-D 17 within 42 ± 7 days (PP \"strict\"). The included patient population was comparable to the 10 identified rRCTs with hd-SJW for age (51/50.6 years [mean, pp strict/pp expanded], 40.2-51.4 years [mean, rRCTs] and gender (76%/75% female [pp strict/pp expanded], 54-86% [rRCTs]). The baseline HAM-D 17 was slightly lower (PP strict: 16.4 [mean, range 9-28]; PP expanded 16.9 [9-28) compared to rRCTs (19.7-22.8). The decline of HAM-D 17 in patients treated with C-SJW-ft (baseline/end of observation period) was 49% (PP strict) and 52% (PP expanded) comparable to the decline of 45-59% in the rRCTs of hd-SJW; likewise, responders were 50% and 57% compared to 42-70%. Adverse events were lower (4%) compared to 20-39% in the rRCTs.</p><p><strong>Conclusion: </strong>In an observational prospective patient cohort with mild to moderate depressive episodes corresponding to patients included in RCTs of hd-SJW, applying the same efficacy outcome and timeframe, C-SJW-ft showed comparable effects and good tolerability. Further clinical trials seem justified.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"363-375"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12622987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Safety of GutGard® in Managing Gastroesophageal Reflux-Related Symptoms: A Phase III, Single-Centre, Double-Blind, Randomized Placebo-Controlled Trial. GutGard®治疗胃食管反流相关症状的有效性和安全性:一项III期、单中心、双盲、随机安慰剂对照试验
IF 1.1 4区 医学
Complementary Medicine Research Pub Date : 2025-01-01 Epub Date: 2025-02-10 DOI: 10.1159/000543367
Jeffrey Pradeep Raj, Unnati Saxena, Mahesh Namdeo Belhekar, Ambika Mamde, Harish Darak, Shwetal Pawar
{"title":"Efficacy and Safety of GutGard® in Managing Gastroesophageal Reflux-Related Symptoms: A Phase III, Single-Centre, Double-Blind, Randomized Placebo-Controlled Trial.","authors":"Jeffrey Pradeep Raj, Unnati Saxena, Mahesh Namdeo Belhekar, Ambika Mamde, Harish Darak, Shwetal Pawar","doi":"10.1159/000543367","DOIUrl":"10.1159/000543367","url":null,"abstract":"<p><strong>Introduction: </strong>Liquorice (Glycyrrhiza glabra) is a traditional herbal remedy with various pharmacological activities mainly used for digestive and respiratory ailments. GutGard® is a flavonoid-rich, deglycyrrhizinated liquorice root extract and is standardized to glabridin (≥3.5% w/w), and others viz., glabrol, eicosanyl caffeate, docosyl caffeate, and total flavonoids (≥10% w/w) with glycyrrhizin (≤3.0% w/w)  as glycyrrhizin causes electrolyte imbalance, hypertension, and water retention. Hence, the objective of the current study was to assess the efficacy, safety, and tolerability of GutGard® in managing gastroesophageal reflux (GER)-related symptoms when compared to placebo.</p><p><strong>Methods: </strong>It was a double-blind, parallel group, randomized, placebo-controlled trial with participants randomized in a 1:1 ratio to either the placebo group or GutGard® group. The duration of the interventions/treatment was for 28 days and the follow-up visits were done at day 7, day 14, day 28, and day 35. A telephonic follow-up was also done on day 21. The primary outcome measures studied was the change in the Gastroesophageal Reflux Disease-Health-Related Quality of Life and the Gastroesophageal Reflux Disease Symptom Assessment Scale.</p><p><strong>Results: </strong>We screened a total of n = 296 participants and enrolled n = 200 participants and obtained written, informed consent from them. Participants in the GutGard® group reported a significantly better quality of life at the end of the intervention period (p = 0.014). They also reported earlier resolution of symptoms of GER as against the placebo group, especially the symptoms of heartburn (p = 0.017 on day 14 and p = 0.005 on day 28) and regurgitation (p = 0.025 on day 7, p = 0.029 on day 14, and p = 0.022 on day 28).</p><p><strong>Conclusions: </strong>The GutGard® group showed better and earlier resolution (within 2 weeks) of symptoms of GER as against the placebo group, especially heartburn and regurgitation.</p><p><strong>Introduction: </strong>Liquorice (Glycyrrhiza glabra) is a traditional herbal remedy with various pharmacological activities mainly used for digestive and respiratory ailments. GutGard® is a flavonoid-rich, deglycyrrhizinated liquorice root extract and is standardized to glabridin (≥3.5% w/w), and others viz., glabrol, eicosanyl caffeate, docosyl caffeate, and total flavonoids (≥10% w/w) with glycyrrhizin (≤3.0% w/w)  as glycyrrhizin causes electrolyte imbalance, hypertension, and water retention. Hence, the objective of the current study was to assess the efficacy, safety, and tolerability of GutGard® in managing gastroesophageal reflux (GER)-related symptoms when compared to placebo.</p><p><strong>Methods: </strong>It was a double-blind, parallel group, randomized, placebo-controlled trial with participants randomized in a 1:1 ratio to either the placebo group or GutGard® group. The duration of the interventions/treatment was for 28 days and the fo","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"26-36"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Long COVID, Post-COVID-Syndrom: Langzeitfolgen von SARS-CoV-2-Infektionen und Nutzen von standardisierten Ginkgo-biloba Extrakten]. [COVID- 19长期,COVID- 19后综合征:SARS-CoV-2感染的长期影响和银杏叶的好处]。
IF 0.8 4区 医学
Complementary Medicine Research Pub Date : 2025-01-01 Epub Date: 2025-08-19 DOI: 10.1159/000548075
Andreas Schapowal
{"title":"[Long COVID, Post-COVID-Syndrom: Langzeitfolgen von SARS-CoV-2-Infektionen und Nutzen von standardisierten Ginkgo-biloba Extrakten].","authors":"Andreas Schapowal","doi":"10.1159/000548075","DOIUrl":"10.1159/000548075","url":null,"abstract":"<p><p>Hintergrund: Long COVID und das Post-COVID-Syndrom sind langfristige Folgen einer SARS-CoV-2-Infektion, die eine Vielzahl physischer, kognitiver und psychischer Symptome hervorrufen können. Dazu gehören Erschöpfung, Atemnot, Gedächtnisstörungen und Schlafprobleme. Die zugrunde liegenden Mechanismen sind noch nicht vollständig geklärt, umfassen jedoch persistierende Viruspartikel, mikrovaskuläre Dysfunktionen, Autoimmunreaktionen und eine Dysregulation des autonomen Nervensystems. Fragestellung: Welchen Nutzen könnten standardisierte Ginkgo-biloba-Extrakte aufgrund ihrer pharmakologischen Wirkungen und ihrer klinischen Wirksamkeit bei Long COVID und Post-COVID-Syndrom bringen? Zusammenfassung: Die Diagnose von Long COVID bleibt aufgrund fehlender standardisierter Tests eine Herausforderung. Therapeutisch wird ein multimodaler Ansatz empfohlen, der symptomatische Medikation, Physiotherapie, Psychotherapie sowie Ernährungs- und Bewegungstherapie umfasst. Ein vielversprechender ergänzender Therapieansatz ist die Verwendung von standardisierten Ginkgo-biloba-Extrakten. Dank ihrer antioxidativen, entzündungshemmenden und neuroprotektiven Eigenschaften könnten sie zur Verbesserung kognitiver Beeinträchtigungen, Fatigue und kardiovaskulärer Symptome beitragen. Erste Studien und Fallberichte deuten auf positive Effekte hin, jedoch sind weitere klinische Untersuchungen erforderlich, um die Wirksamkeit zu bestätigen. Kernaussagen: Long COVID und das Post-COVID-Syndrom betreffen zahlreiche Organsysteme und beeinträchtigen die Lebensqualität erheblich. Die Diagnose bleibt schwierig, da es keine spezifischen Tests gibt. Eine multimodale Therapie ist derzeit der vielversprechendste Behandlungsansatz. Standardisierte Ginkgo-biloba-Extrakte zeigen in ersten Studien positive Effekte auf neurokognitive und kardiovaskuläre Symptome.</p>","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"432-437"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to the Letter: "Constructive Evaluation of CATHIS". 对信的回应:“对cathis的建设性评价”。
IF 0.8 4区 医学
Complementary Medicine Research Pub Date : 2025-01-01 Epub Date: 2025-08-20 DOI: 10.1159/000547571
Katharina Gaertner, Robert G Hahn, Radmila Razlog, Frauke Musial, Stephan Baumgartner, Martin Loef, Harald Walach
{"title":"Response to the Letter: \"Constructive Evaluation of CATHIS\".","authors":"Katharina Gaertner, Robert G Hahn, Radmila Razlog, Frauke Musial, Stephan Baumgartner, Martin Loef, Harald Walach","doi":"10.1159/000547571","DOIUrl":"10.1159/000547571","url":null,"abstract":"","PeriodicalId":10541,"journal":{"name":"Complementary Medicine Research","volume":" ","pages":"357-359"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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