Angelika Buczyńska , Iwona Sidorkiewicz , Maria Kościuszko , Katarzyna Wincenciuk , Marcin Adamski , Katarzyna Siewko , Anna Popławska-Kita , Adam Jacek Krętowski , Agnieszka Adamska
{"title":"Parallel investigation of oxidative stress and nutritional profile in women with Hashimoto's thyroiditis","authors":"Angelika Buczyńska , Iwona Sidorkiewicz , Maria Kościuszko , Katarzyna Wincenciuk , Marcin Adamski , Katarzyna Siewko , Anna Popławska-Kita , Adam Jacek Krętowski , Agnieszka Adamska","doi":"10.1016/j.clnu.2025.08.017","DOIUrl":"10.1016/j.clnu.2025.08.017","url":null,"abstract":"<div><div>Genetic predisposition, inflammation, and oxidative stress are known contributors to the development of Hashimoto's thyroiditis (HT). While genetic factors are non-modifiable, lifestyle, nutritional factors and oxidative stress may represent areas for intervention. This study aimed to assess biochemical markers of oxidative stress and evaluate dietary intake in women with newly diagnosed HT, identified through population-based screening. A cross-sectional analysis was conducted on 600 women aged 18–45 years, where 92 were diagnosed with euthyroid HT. Nutrients, based on a seven-day food diary, and biochemical evaluation, including thyroid autoantibodies (anti-thyroid peroxidase (ATPO) and anti-thyroglobulin (ATG)), metabolic parameters, and oxidative stress markers (total oxidative capacity (TOC), total antioxidant capacity (TAC), TOC/TAC ratio), were performed. Results revealed elevated TOC and TOC/TAC ratios in the HT group, suggesting oxidative stress despite preserved TAC. Dietary analysis showed significantly lower intake of cholesterol (p = 0.017) and retinol (p = 0.014) in the HT group. Additionally, negative correlations were observed between ATPO levels and dietary intake of vitamin E (r = −0.33; p < 0.01), vitamin C (r = −0.22; p = 0.05), and retinol (r = −0.23; p = 0.04). While ATG levels correlated negatively with HDL (r = −0.30; p = 0.01) and retinol (r = −0.23; p = 0.04). Additionally, TOC levels showed positive correlations with fasting insulin (r = 0.30; p = 0.01), triglycerides (r = 0.25; p = 0.04), and free triiodothyronine (FT3) (r = 0.28; p = 0.01) concentrations, suggesting potential links between oxidative stress, metabolic activity, and thyroid function. In conclusion, maintaining an adequate intake of antioxidant nutrients with limiting potentially pro-oxidative dietary factors, may represent a reasonable adjunctive approach in the dietary management of HT. Further research is needed to clarify the role of diet in modulating oxidative stress and immune activity in HT and to explore its potential as a supportive strategy in disease management.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"53 ","pages":"Pages 177-187"},"PeriodicalIF":7.4,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hyobin Lee , Woo-Kyoung Shin , Katherine De la Torre , Sukhong Min , Sung Hyun You , Wonshik Han , Jung Eun Lee , Daehee Kang
{"title":"Meat intake and breast cancer risk from the Health Examinees study","authors":"Hyobin Lee , Woo-Kyoung Shin , Katherine De la Torre , Sukhong Min , Sung Hyun You , Wonshik Han , Jung Eun Lee , Daehee Kang","doi":"10.1016/j.clnu.2025.08.025","DOIUrl":"10.1016/j.clnu.2025.08.025","url":null,"abstract":"<div><h3>Background & aims</h3><div>The association between meat intake and breast cancer risk remains unclear. This study examined the relationship between specific types of meat intake and breast cancer risk in a prospective cohort study.</div></div><div><h3>Methods</h3><div>This study included 71,264 women aged 40–69 years from the Health Examinees-Gem (HEXA-G) study (2004–2013). Cancer diagnosis was identified via the Korea Central Cancer Registry and death certificate-linked data were provided by the Korea National Statistical Office until 31 December 2018. Cox proportional hazards models were used to estimated multivariate hazard ratios (HRs) and 95 % confidence intervals (CIs) for breast cancer risk by meat intake.</div></div><div><h3>Results</h3><div>During 655,566.9 person-years of follow-up, 713 breast cancer cases were identified. Women who consumed one or more servings of processed meat per week had a 57 % increased risk of breast cancer (HR = 1.57, 95 % CI: 1.09–2.27, p for trend = 0.003), compared to those who did not consume processed meat. Stronger associations were observed among women under 50 years of age (p for trend = 0.021), with no family history of breast cancer (p for trend = 0.001), no regular exercise (p for trend = 0.028), no alcohol consumption (p for trend = 0.002) and a body mass index (BMI) below 25 kg/m<sup>2</sup> (p for trend = 0.005). Beef intake was associated with a potential reduction in breast cancer risk (HR = 0.82, 95 % CI: 0.67–1.01, p trend = 0.051, for 2 or more servings per month vs. none). Also, reduction of breast cancer risk was observed in women who consumed alcohol (p for trend = 0.036). More pronounced associations were found in women without family history of breast cancer (p for trend = 0.049), and in women who did not engage in regular exercise (p for trend = 0.015).</div></div><div><h3>Conclusions</h3><div>Our results suggest that processed meat intake is linked to a higher risk of breast cancer, whereas beef consumption may reduce the risk of breast cancer.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"53 ","pages":"Pages 109-118"},"PeriodicalIF":7.4,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wanting Su , Zhigang Cui , Jinhe Sun , He Miao , Qianhui Chen , Yuzhong Zhang , Shubo Zhang , Zhihua Yin , Renyu Ding
{"title":"Identification and validation of chronic critical illness subphenotypes using urea–creatinine ratio trajectories","authors":"Wanting Su , Zhigang Cui , Jinhe Sun , He Miao , Qianhui Chen , Yuzhong Zhang , Shubo Zhang , Zhihua Yin , Renyu Ding","doi":"10.1016/j.clnu.2025.08.023","DOIUrl":"10.1016/j.clnu.2025.08.023","url":null,"abstract":"<div><h3>Background & aims</h3><div>Chronic critical illness (CCI) is common in intensive care units (ICUs) and is highly heterogeneous. We utilized urea–creatinine ratio (UCR) trajectories to develop and validate subphenotypes and reveal the heterogeneous treatment effects of medical nutrition therapy.</div></div><div><h3>Methods</h3><div>This retrospective study included all CCI patients from three public critical care databases. Group-based trajectory modeling (GBTM) was applied to the UCR for subphenotype development and validation. A multivariate Cox regression model was used to assess the independent associations of these subphenotypes with mortality. Generalized estimation equations were used to reveal the potential heterogeneity in medical nutrition therapy between survivors and nonsurvivors in different subphenotypes.</div></div><div><h3>Results</h3><div>A total of 4047 CCI patients were divided into three subphenotypes on the basis of their UCR trajectories. Stable low subphenotype had a low UCR with a slight upwards trend, the youngest age, and the fewest comorbidities. Intermediate subphenotype was characterized by a medium UCR. Stable high subphenotype had a high UCR with a rapid increase and the highest ICU mortality (14.72 %), hospital mortality (36.20 %) and 28-day mortality (39.26 %) (p < 0.05). In the multivariate Cox regression with Stable low subphenotype as control, Stable high subphenotype had increased risks of hospitalization mortality (HR: 2.74; 95 % CI: 2.01–3.72; P < 0.001), 28-day mortality (HR: 3.20; 95 % CI: 2.36–4.34; P < 0.001) and ICU mortality (HR: 2.78; 95 % CI: 1.71–4.52; P < 0.001). In CCI patients, the dose of nutritional intake within 5 days after CCI diagnosis were greater in the survival group (P < 0.05), especially survivors in Intermediate and Stable high subphenotypes.</div></div><div><h3>Conclusion</h3><div>We demonstrated that longitudinal UCR trajectories during the first 10 days of ICU admission serve as robust biomarkers for predicting CCI into three distinct subphenotypes to understand patient heterogeneity. For CCI patients, higher doses of enteral nutrition and protein intake after CCI diagnosis may improve prognosis, especially for patients in the subphenotypes with the higher baseline UCR values showing an upward trend and poorer prognosis. A prospective study is needed to validate these findings, inform practice and guide future research on personalized care.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"53 ","pages":"Pages 76-87"},"PeriodicalIF":7.4,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144922136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retraction notice to ‘The effects of vitamin D and probiotic co-supplementation on glucose homeostasis, inflammation, oxidative stress and pregnancy outcomes in gestational diabetes: A randomized, double-blind, placebo-controlled trial’ [Clinical Nutrition 38 (2019) 2098–2105]","authors":"Mehri Jamilian , Elaheh Amirani , Zatollah Asemi","doi":"10.1016/j.clnu.2025.08.008","DOIUrl":"10.1016/j.clnu.2025.08.008","url":null,"abstract":"<div><div>This article has been retracted: please see Elsevier policy on Article Correction, Retraction and Removal (<span><span>https://www.elsevier.com/about/policies-and-standards/article-withdrawal</span><svg><path></path></svg></span>).</div><div>This article has been retracted at the request of the journal editorial team.</div><div>Significant concerns were raised by a third party about the integrity of the data and the reported findings in the article.</div><div>When approached for an explanation, the authors have been cooperative in providing some responses and documents. To verify the reported findings, the article and the documents provided by the authors were further evaluated by the Ethics Editor and the journal editorial team.</div><div>The journal editorial team and the Ethics Editor were unable to confirm the integrity of the data presented in tables and their main outcome was that the article's results and conclusions are unreliable. Therefore, as the editorial team no longer have confidence in the reported conclusions the decision has been made to retract the article.</div><div>The authors listed in the publication have been informed. The authors do not agree with the retraction.</div><div>We have been informed in our decision-making by our editorial policies and the COPE guidelines.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"53 ","pages":"Page 278"},"PeriodicalIF":7.4,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Flavia Prodam , Roberta Ricotti , Alice Caramaschi , Valentina Mancioppi , Valentina Antoniotti , Marina Caputo , Francesca Archero , Nicoletta Filigheddu , Sabrina Tini , Stefano Celano , Marcello Manfredi , Nadia Massa , Simonetta Bellone , Elisa Bona
{"title":"The ecology of the microbiota in children with obesity is associated with the intake of carbohydrates and insulin resistance","authors":"Flavia Prodam , Roberta Ricotti , Alice Caramaschi , Valentina Mancioppi , Valentina Antoniotti , Marina Caputo , Francesca Archero , Nicoletta Filigheddu , Sabrina Tini , Stefano Celano , Marcello Manfredi , Nadia Massa , Simonetta Bellone , Elisa Bona","doi":"10.1016/j.clnu.2025.08.018","DOIUrl":"10.1016/j.clnu.2025.08.018","url":null,"abstract":"<div><h3>Background & aims</h3><div>Among diet, microbiota, and obesity exists a close correlation that remains insufficiently explored, particularly within the pediatric age. We aimed to deeply investigate the relationship between dietary composition and microbiota in pediatric subjects with obesity before an educational training in a Mediterranean-style diet.</div></div><div><h3>Methods</h3><div>55 subjects (10–18 years) with overweight or obesity and visceral adiposity, diet naïve, or failure to a previous weight loss program were phenotypically described through clinical and metabolic parameters, including circulating LPS levels. 16S DNA sequencing was used to profile the microbiota. Lifestyle habits (KIDMED score, 24-h recall, International Physical Activity Questionnaire for Adolescents) and diet composition were assessed.</div></div><div><h3>Results</h3><div>Five different main enterotypes were found. Females at the end of puberty were well separated from the other subjects in the principal component analysis. Microbiota composition changed with the progression of puberty, and LPS levels negatively correlated with Tanner stages. Gut microbiota composition, considering all the clinical parameters, was significantly modulated mostly by the percentage of carbohydrate intake and insulin resistance. Carbohydrate intake ranging from 45 to 55 % determined a high number of species, but with a reduction of biodiversity (Shannon and Simpson indexes). <em>Bacteroides dorei, Turicibacter sanguinis,</em> and <em>B. vulgatus</em> were among the main species involved in signatures of carbohydrate intake, whereas an enrichment in <em>Bacteroides stercoris</em> was found in subjects with a low fiber intake. Adherence to the Mediterranean diet was associated with a great presence of dietary fiber metabolizers, including <em>Faecalibacterium prausnitzii</em> and <em>Lachnospira</em> sp. <em>Alistipes finegoldii</em> and <em>Akkermansia muciniphila</em> were more represented in low insulin resistance, while <em>Bifidobacterium pseudocatenulatum</em> and <em>Clostridium clostridioforme</em> were enriched in patients with high insulin resistance.</div></div><div><h3>Conclusion</h3><div>Carbohydrate content of the diet, insulin resistance, and microbiota are strictly related in children with obesity. A certain degree of dysbiosis could link obesity to a severe phenotype. Since gender and puberty status impact the microbiota signature, clustering pediatric patients for diet intervention is a challenge.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"53 ","pages":"Pages 119-132"},"PeriodicalIF":7.4,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144989314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Benedicte Beichmann , Eli P. Sollerud , Nicole Sonja Warmbrodt , Inger Ottestad , Mari Mohn Paulsen , Christine Henriksen , Ingvild Paur
{"title":"Measured and predicted energy expenditure among patients with distal bowel cancer: Results from the GAIN-project","authors":"Benedicte Beichmann , Eli P. Sollerud , Nicole Sonja Warmbrodt , Inger Ottestad , Mari Mohn Paulsen , Christine Henriksen , Ingvild Paur","doi":"10.1016/j.clnu.2025.08.022","DOIUrl":"10.1016/j.clnu.2025.08.022","url":null,"abstract":"<div><h3>Rationale</h3><div>The purpose of this study was to compare the agreement between measured and predicted energy expenditure in patients newly diagnosed with colon, rectal, or anal cancer.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, resting energy expenditure (REE) was measured with indirect calorimetry in canopy mask mode using a COSMED Q-NRG device. Measurements were compared with predicted REE from five different equations, validated for healthy individuals. Total energy expenditure (TEE), calculated as measured REE multiplied by an estimated physical activity level (PAL) of 1.4 (referred to as Q-NRG-based TEE), was compared to the ESPEN recommendation of 25–30 kcal/kg/day. Agreements between the measured and predicted values were assessed.</div></div><div><h3>Results</h3><div>Forty adults newly diagnosed with colon (n = 7), rectal (n = 23), or anal (n = 10) cancer were included (52 % males, body mass index (BMI) 27 ± 5 kg/m<sup>2</sup>, age: 60 ± 8 years, measured REE: 1788 ± 383 kcal/day). All prediction equations underestimated REE compared to the measured REE. Wide limits of agreement were observed. The WHO/FAO/UNU equation had the narrowest limits of agreement (−587, 295 kcal/day). The mean predicted TEE, based on 30 kcal/kg/day, did not differ from the mean Q-NRG-based TEE. Further, this prediction showed a better agreement with Q-NRG-based TEE, as compared to 25 kcal/kg/day, although the limits of agreement were wide.</div></div><div><h3>Conclusion</h3><div>The prediction equations underestimated measured REE on a group level in patients newly diagnosed with distal bowel cancer. The results suggest that 30 kcal/kg/day could be used as an initial goal for TEE, but caution and close monitoring are needed to avoid a negative energy balance as the individual variations are large.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"53 ","pages":"Pages 88-98"},"PeriodicalIF":7.4,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Catrin Herpich , Donna Li , Daniela Weber , Bastian Kochlik , Ursula Müller-Werdan , Tilman Grune , Kristina Norman
{"title":"Postprandial amino acid profiles in older and younger adults following high and normal protein ingestion","authors":"Catrin Herpich , Donna Li , Daniela Weber , Bastian Kochlik , Ursula Müller-Werdan , Tilman Grune , Kristina Norman","doi":"10.1016/j.clnu.2025.08.019","DOIUrl":"10.1016/j.clnu.2025.08.019","url":null,"abstract":"<div><h3>Background & aims</h3><div>Disruptions in protein metabolism can impact health outcomes in older age, with amino acid metabolism playing a central role. Aging is associated with impaired muscle protein synthesis, insulin resistance, and inflammation, all of which may alter postprandial amino acid responses.</div></div><div><h3>Methods</h3><div>This study analyzed amino acid profiles in older (n = 40, female n = 32) and younger (n = 30, female n = 21) adults after consuming test meals with standard protein [NP; 16 energy percent (E%) protein, 68 E% carbohydrates] or high protein [HP; 77 E% protein, 17 E% carbohydrates; 450 kcal each]. Postprandial plasma amino acids were quantified at 0, 30, 60, 120, and 240 min using liquid chromatography coupled with tandem mass spectrometry, with plasma amino acids responses evaluated as the incremental area under the curve (iAUC).</div></div><div><h3>Results</h3><div>Fasting amino acid concentrations were similar between age groups, but significant postprandial changes (p < 0.05) were observed after both meals. Older adults exhibited altered branched-chain amino acids, proline, and tyrosine dynamics (all p < 0.05) after HP ingestion. Postprandial amino acid dynamics were comparable age between groups after NP ingestion, except for higher glutamine in older adults, but markedly higher postprandial amino acid concentrations occurred in older adults after HP. Regression analysis revealed insulin resistance, insulin response, and interleukin-6 as key determinants of amino acid iAUCs after NP, while skeletal muscle mass index, habitual protein intake and liver enzymes were significant factors after HP.</div></div><div><h3>Conclusions</h3><div>These findings suggest that amino acid dynamics in older adults are shaped by habitual protein intake, muscle mass, insulin resistance, and inflammation rather than age alone. A more pronounced postprandial amino acid response to a high-protein meal in older adults may reflect reduced amino acid uptake due to lower muscle mass.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"53 ","pages":"Pages 69-75"},"PeriodicalIF":7.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144919831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retraction notice to “The effects of probiotic and selenium co-supplementation on mental health parameters and metabolic profiles in type 2 diabetic patients with coronary heart disease: A randomized, double-blind, placebo-controlled trial” [Clin Nutr 38 (2019) 1594–1598].","authors":"Fariba Raygan , Vahidreza Ostadmohammadi , Zatollah Asemi","doi":"10.1016/j.clnu.2025.08.015","DOIUrl":"10.1016/j.clnu.2025.08.015","url":null,"abstract":"","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"53 ","pages":"Page 283"},"PeriodicalIF":7.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}