Clinical nutrition最新文献

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Intravenous lipid emulsions designed to meet preterm infant requirements increase plasma and tissue levels of docosahexaenoic acid and arachidonic acid in mice 为满足早产儿需求而设计的静脉注射脂质乳剂可提高小鼠血浆和组织中二十二碳六烯酸和花生四烯酸的水平
IF 6.6 2区 医学
Clinical nutrition Pub Date : 2024-08-23 DOI: 10.1016/j.clnu.2024.08.019
{"title":"Intravenous lipid emulsions designed to meet preterm infant requirements increase plasma and tissue levels of docosahexaenoic acid and arachidonic acid in mice","authors":"","doi":"10.1016/j.clnu.2024.08.019","DOIUrl":"10.1016/j.clnu.2024.08.019","url":null,"abstract":"<div><h3>Background &amp; aims</h3><p>Intravenous lipid emulsions used in preterm infants contain insufficient docosahexaenoic acid (DHA) and arachidonic acid (ARA) to support normal development, resulting in deficiencies that contribute to complications of prematurity and cognitive delay. We sought to investigate the effects of new intravenous lipid emulsions designed to contain sufficient DHA and ARA to meet preterm needs, while avoiding liver toxicity.</p></div><div><h3>Methods</h3><p>Three new lipid emulsions (NLE A-C) were laboratory-generated using high pressure homogenization. First, a long-term experiment evaluated the impact on plasma, liver, and frontal cortex fatty acid composition compared to commercially available lipid emulsions. Lipid emulsions were administered via daily orogastric gavage to four-week-old C57Bl/6 J mice. Next, liver toxicity was evaluated in a murine model of parenteral nutrition-induced hepatosteatosis. Mice were provided an <em>ad lib</em> fat-free high carbohydrate diet, with intravenous lipid emulsion administration every other day for 19 days.</p></div><div><h3>Results</h3><p>Administration of commercially available lipid emulsions (soybean oil, mixed oil, or fish oil) resulted in decreased plasma and tissue levels of DHA and/or ARA compared to a chow control. The new lipid emulsions demonstrated a dose-response effect in plasma and tissue concentration of DHA and ARA. NLE C (with an approximately even DHA:ARA ratio), compared to chow, maintained similar DHA (19.2 ± 0.3 vs. 19.3 ± 0.3%, <em>P</em> = 1.00) and ARA (10.4 ± 0.2 vs. 9.9 ± 0.2% ARA, <em>P</em> = 0.75) content in frontal cortex tissue. All three new lipid emulsions prevented biochemical liver injury and pathologist-assessed hepatosteatosis; soybean oil lipid emulsion and mixed oil lipid emulsion treatment resulted in hepatosteatosis in both experiments.</p></div><div><h3>Conclusion</h3><p>Long-term treatment with the new lipid emulsions in juvenile mice resulted in increased plasma and tissue DHA and/or ARA content compared to currently available lipid emulsions. The new lipid emulsions also prevented hepatosteatosis and biochemical liver injury with enteral and parenteral administration.</p></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142089352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply - Letter to the editor - YCLNU-D-24-02083 答复--致编辑的信--YCLNU-D-24-02083
IF 6.6 2区 医学
Clinical nutrition Pub Date : 2024-08-23 DOI: 10.1016/j.clnu.2024.08.025
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引用次数: 0
Promoting body composition changes as promising non-invasive prognostic biomarkers 促进身体成分变化成为有前途的非侵入性预后生物标志物
IF 6.6 2区 医学
Clinical nutrition Pub Date : 2024-08-22 DOI: 10.1016/j.clnu.2024.08.013
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引用次数: 0
Response to Letter to the Editor: Comment on “risk factors for low muscle mass, malnutrition, and (probable-) sarcopenia in adults with or without a history of cancer in the UK Biobank” 回复致编辑的信:关于 "英国生物库中有或无癌症病史的成年人肌肉质量低、营养不良和(可能)肌肉疏松症的风险因素 "的评论
IF 6.6 2区 医学
Clinical nutrition Pub Date : 2024-08-22 DOI: 10.1016/j.clnu.2024.08.022
{"title":"Response to Letter to the Editor: Comment on “risk factors for low muscle mass, malnutrition, and (probable-) sarcopenia in adults with or without a history of cancer in the UK Biobank”","authors":"","doi":"10.1016/j.clnu.2024.08.022","DOIUrl":"10.1016/j.clnu.2024.08.022","url":null,"abstract":"","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply - Letter to the Editor: Further understanding of the association between higher dietary live microbe intake and a lower risk of sarcopenia 回复--致编辑的信:进一步了解更多膳食活微生物摄入量与降低患肌肉疏松症风险之间的关系
IF 6.6 2区 医学
Clinical nutrition Pub Date : 2024-08-22 DOI: 10.1016/j.clnu.2024.08.020
{"title":"Reply - Letter to the Editor: Further understanding of the association between higher dietary live microbe intake and a lower risk of sarcopenia","authors":"","doi":"10.1016/j.clnu.2024.08.020","DOIUrl":"10.1016/j.clnu.2024.08.020","url":null,"abstract":"","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142089353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and survival implications of malnutrition and sarcopenia in metastatic breast cancer: A longitudinal analysis 转移性乳腺癌患者营养不良和肌肉疏松症的患病率和对生存的影响:纵向分析。
IF 6.6 2区 医学
Clinical nutrition Pub Date : 2024-08-22 DOI: 10.1016/j.clnu.2024.08.009
{"title":"Prevalence and survival implications of malnutrition and sarcopenia in metastatic breast cancer: A longitudinal analysis","authors":"","doi":"10.1016/j.clnu.2024.08.009","DOIUrl":"10.1016/j.clnu.2024.08.009","url":null,"abstract":"","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Geriatric nutritional risk index as a predictor for fragility fracture risk in elderly with type 2 diabetes mellitus 预测 2 型糖尿病老人脆性骨折风险的老年营养风险指数
IF 6.6 2区 医学
Clinical nutrition Pub Date : 2024-08-22 DOI: 10.1016/j.clnu.2024.08.024
{"title":"Geriatric nutritional risk index as a predictor for fragility fracture risk in elderly with type 2 diabetes mellitus","authors":"","doi":"10.1016/j.clnu.2024.08.024","DOIUrl":"10.1016/j.clnu.2024.08.024","url":null,"abstract":"","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply - Letter to the editor 答复 - 致编辑的信
IF 6.6 2区 医学
Clinical nutrition Pub Date : 2024-08-22 DOI: 10.1016/j.clnu.2024.08.021
{"title":"Reply - Letter to the editor","authors":"","doi":"10.1016/j.clnu.2024.08.021","DOIUrl":"10.1016/j.clnu.2024.08.021","url":null,"abstract":"","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142084448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on “feasibility, safety, and efficacy of dietary or lifestyle interventions for hypothalamic obesity: A systematic review” 评论 "下丘脑肥胖症饮食或生活方式干预的可行性、安全性和有效性:系统综述 "发表评论。
IF 6.6 2区 医学
Clinical nutrition Pub Date : 2024-08-22 DOI: 10.1016/j.clnu.2024.08.023
{"title":"Comment on “feasibility, safety, and efficacy of dietary or lifestyle interventions for hypothalamic obesity: A systematic review”","authors":"","doi":"10.1016/j.clnu.2024.08.023","DOIUrl":"10.1016/j.clnu.2024.08.023","url":null,"abstract":"","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the editor: “The effects of exposure to and timing of a choline-deficient diet during pregnancy and early postnatal life on the skeletal muscle transcriptome of the offspring” 致编辑的信:"孕期和产后早期摄入胆碱缺乏饮食以及摄入胆碱缺乏饮食的时间对后代骨骼肌转录组的影响"
IF 6.6 2区 医学
Clinical nutrition Pub Date : 2024-08-22 DOI: 10.1016/j.clnu.2024.08.018
{"title":"Letter to the editor: “The effects of exposure to and timing of a choline-deficient diet during pregnancy and early postnatal life on the skeletal muscle transcriptome of the offspring”","authors":"","doi":"10.1016/j.clnu.2024.08.018","DOIUrl":"10.1016/j.clnu.2024.08.018","url":null,"abstract":"","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":null,"pages":null},"PeriodicalIF":6.6,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142129731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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