Clinical nutrition最新文献

{"title":"Association between ultra-processed food and drink consumption and lipoprotein subclass profiles among middle-to older-aged population: A cross-sectional study","authors":"Kai Zhang, Ye Wang, Xuan Xuan Chen, Bo Li","doi":"10.1016/j.clnu.2024.09.005","DOIUrl":"10.1016/j.clnu.2024.09.005","url":null,"abstract":"","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"43 10","pages":"Pages 2344-2345"},"PeriodicalIF":6.6,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply – Letter to the editor: Ultra-processed food and drink consumption and lipoprotein subclass profiles: A cross-sectional study of a middle-to older-aged population","authors":"Seán R. Millar, Janas M. Harrington, Ivan J. Perry, Catherine M. Phillips","doi":"10.1016/j.clnu.2024.09.006","DOIUrl":"10.1016/j.clnu.2024.09.006","url":null,"abstract":"","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"43 10","pages":"Pages 2348-2349"},"PeriodicalIF":6.6,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low muscle mass is associated with efficacy of biologics in Crohn's disease","authors":"Ye Fang ,&nbsp;Luyan Fang ,&nbsp;Mengqian Ye ,&nbsp;Hanyue Jiang ,&nbsp;Xinyu Long ,&nbsp;Haoxuan Zhang ,&nbsp;Qianqian Zhang ,&nbsp;Daopo Lin ,&nbsp;Xiaoxiao Shao","doi":"10.1016/j.clnu.2024.09.003","DOIUrl":"10.1016/j.clnu.2024.09.003","url":null,"abstract":"<div><h3>Background</h3><p>Low muscle mass (LMM) can be a frequent complication in Crohn's disease (CD). We attempted to explore the effect of LMM on the efficacy of biologics in patients with CD.</p></div><div><h3>Methods</h3><p>The retrospective cohort study included moderate-to-severe CD patients treated with infliximab or ustekinumab, and appendicitis patients as control. The skeletal muscle area (SMA) of L3 was assessed to evaluate the patients’ muscle mass. After propensity score matching, the impact of LMM on drug efficacy was assessed in CD patients.</p></div><div><h3>Results</h3><p>A total of 269 patients with CD and 172 appendicitis patients were included. The CD group had lower skeletal muscle density and BMI, and a higher risk of developing LMM than the control group. BMI (<em>OR</em> = 0.48, <em>p</em> &lt; 0.001) and previous use of biologics (<em>OR</em> = 2.94, <em>p</em> = 0.019) were found to be independently associated with LMM. LMM was found to be associated with a decrease in clinical response (at weeks 8–14), clinical remission (at weeks 8–14, 24–30 and 52) and biochemical remission (at week 52). At weeks 24–30 and 52, LMM was independently associated with loss of response (LOR). We found LMM could be a predictor of lower clinical remission at week 30, lower clinical remission at week 52 and a higher LOR rate at week 30 in infliximab. While in ustekinumab, LMM was associated with lower endoscopic remission at week 24, biochemical remission at week 52 and a higher LOR rate at weeks 24 and 52.</p></div><div><h3>Conclusions</h3><p>The prevalence of LMM was higher in the CD group compared to the control group. For CD patients with LMM, the efficacy of infliximab and ustekinumab was relatively poor in both the short-term and long-term.</p></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"43 10","pages":"Pages 2354-2363"},"PeriodicalIF":6.6,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Maternal non-compliance with recommended folic acid supplement use alters global DNA methylation levels in cord blood of newborns: A cohort study","authors":"Anoosha Khan,&nbsp;Satesh Kumar,&nbsp;Mahima Khatri","doi":"10.1016/j.clnu.2024.09.007","DOIUrl":"10.1016/j.clnu.2024.09.007","url":null,"abstract":"","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"43 10","pages":"Page 2427"},"PeriodicalIF":6.6,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of whey protein supplementation on muscle strength and physical performance of older adults: A systematic review and meta-analysis of randomized clinical trials","authors":"Alaa H. Al-Rawhani ,&nbsp;Siti Nur’Asyura Adznam ,&nbsp;Zalina Abu Zaid ,&nbsp;Nor Baizura Md. Yusop ,&nbsp;Hakimah M. Sallehuddin ,&nbsp;Mohammed A. Alshawsh","doi":"10.1016/j.clnu.2024.08.033","DOIUrl":"10.1016/j.clnu.2024.08.033","url":null,"abstract":"<div><h3>Background</h3><p>The efficacy of whey protein supplement (WPS) in improving muscle strength, physical performance, and body composition in older adults has been widely promoted. However, the results of randomized clinical trials in this regard have been inconsistent. We aimed to determine the impact of WPS, compared to a placebo, during or without training on muscle strength, physical function, and body composition in older adults.</p></div><div><h3>Methods</h3><p>Randomized controlled trials were thoroughly searched using PubMed, EMBASE, the Cochrane Library Database, and Scopus databases up to June 2024. The analysis focused on key parameters such as handgrip strength (HS), leg press, knee extension, gait speed (GS), 6-min walking test (6MWT), Timed-up and go test (TUG), lean body mass (LBM), fat mass (FM), and appendicular skeletal muscle mass (ASM). A pooled effect size was calculated using a random-effects model based on standardized mean differences (SMD).</p></div><div><h3>Results</h3><p>Thirty studies involving 2105 participants aged 60 and older met the inclusion criteria. The meta-analysis of 26 RCTs showed no significant positive effect of WPS on HS (n = 11, SMD: 0.18; 95% CI: −0.13, 0.49; <em>I</em>^<em>2</em> = 69%), 6MWT (n = 5, SMD: −0.08; 95%CI: −0.31, 0.16; <em>I</em>^<em>2</em> = 0%), GS test (n = 4, SMD: −0.08; 95%CI: −0.43, 0.28; <em>I</em>^<em>2</em> = 36%), TUG test (n = 9, SMD: 0.0, 95% CI -0.15, 0.14; <em>I</em>^<em>2</em> = 0%), LBM (n = 11, SMD: 0.02; 95%CI: −0.13, 0.17; <em>I</em>^<em>2</em> = 0%), FM (n = 15, SMD: −0.04; 95%CI: −0.18, 0.10; <em>I</em>^<em>2</em> = 0%). However, ASM significantly improved after WPS consumption but with high heterogeneity (n = 2, SMD: 0.39; 95%CI: 0.28, 0.51; <em>I</em>^<em>2</em> = 69%). In interventions incorporating RE, statistically significant positive effects of WPS on lower body strength were observed (n = 11, SMD: 0.25; 95%CI: 0.05, 0.45; <em>I</em>^<em>2</em> = 0%).</p></div><div><h3>Conclusion</h3><p>The present meta-analysis indicates that WPS, when combined with resistance training (RT), can enhance lower body strength but does not seem to have a significant beneficial effect on handgrip strength, physical performance, or body composition. Further large-scale studies are necessary to confirm these findings and elucidate the potential benefits of WPS in this population.</p></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"43 10","pages":"Pages 2412-2426"},"PeriodicalIF":6.6,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142243738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avoiding the use of long-term parenteral support in patients without intestinal failure: A position paper from the European Society of Clinical Nutrition & Metabolism, the European Society of Neurogastroenterology and Motility and the Rome Foundation for Disorders of Gut–Brain Interaction","authors":"","doi":"10.1016/j.clnu.2024.05.027","DOIUrl":"10.1016/j.clnu.2024.05.027","url":null,"abstract":"<div><p>The role of long-term parenteral support in patients with underlying benign conditions who do not have intestinal failure (IF) is contentious, not least since there are clear benefits in utilising the oral or enteral route for nutritional support. Furthermore, the risks of long-term home parenteral nutrition (HPN) are significant, with significant impacts on morbidity and mortality. There has, however, been a recent upsurge of the use of HPN in patients with conditions such as gastro-intestinal neuromuscular disorders, opioid bowel dysfunction, disorders of gut–brain interaction and possibly eating disorders, who do not have IF. As a result, the European Society of Clinical Nutrition and Metabolism (ESPEN), the European Society of Neuro-gastroenterology and Motility (ESNM) and the Rome Foundation for Disorders of Gut Brain Interaction felt that a position statement is required to clarify - and hopefully reduce the potential for harm associated with – the use of long-term parenteral support in patients without IF.</p><p>Consensus opinion is that HPN should not be prescribed for patients without IF, where the oral and/or enteral route can be utilised. On the rare occasions that PN commencement is required to treat life-threatening malnutrition in conditions such as those listed above, it should only be prescribed for a time-limited period to achieve nutritional safety, while the wider multi-disciplinary team focus on more appropriate biopsychosocial holistic and rehabilitative approaches to manage the patient's primary underlying condition.</p></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"43 9","pages":"Pages 2279-2282"},"PeriodicalIF":6.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0261561424001730/pdfft?md5=ded2f54853b11189992ec8d7af2aec08&pid=1-s2.0-S0261561424001730-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141031326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply-letter to the editor","authors":"Weijia Huang ,&nbsp;Congjun Wang ,&nbsp;Junqiang Chen","doi":"10.1016/j.clnu.2024.07.046","DOIUrl":"10.1016/j.clnu.2024.07.046","url":null,"abstract":"","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"43 9","pages":"Pages 2283-2284"},"PeriodicalIF":6.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of time-restricted eating and low-carbohydrate diet on psychosocial health and appetite in individuals with metabolic syndrome: A secondary analysis of a randomized controlled trial","authors":"Yixuan Zheng ,&nbsp;Xin Wang ,&nbsp;Jingya Wang ,&nbsp;Jing Yang ,&nbsp;Ting Wang ,&nbsp;Qian Li ,&nbsp;Wenzhi Zhu ,&nbsp;Yue Wang ,&nbsp;Jing Sui ,&nbsp;Wei Qiang ,&nbsp;Hui Guo ,&nbsp;Yanan Wang ,&nbsp;Bingyin Shi ,&nbsp;Mingqian He","doi":"10.1016/j.clnu.2024.08.029","DOIUrl":"10.1016/j.clnu.2024.08.029","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background &amp; aims&lt;/h3&gt;&lt;p&gt;Time-restricted eating (TRE) and low-carbohydrate diet (LCD) can improve multiple cardiometabolic parameters in patients with metabolic syndrome (MetS), but their effects on psychosocial health and satiety are unclear. In this study, we aimed to evaluate the effects of TRE, LCD, and their combination (TRE + LCD) on quality of life (QoL), sleep, mood, appetite, and metabolic hormones in patients with MetS.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;This is a secondary analysis of a single-center, 3-month, open-label, randomized clinical trial investigating the effects of TRE, LCD, and TRE + LCD on weight and cardiometabolic parameters in individuals with MetS. This secondary analysis examined QoL, sleep, mood, and appetite using the Rand 36-Item Short Form (SF-36); Pittsburgh Sleep Quality Index (PSQI); Depression, Anxiety, and Stress Scale; and Eating Behavior Rating Scale, respectively, as well as measured levels of metabolic hormones including leptin, amylin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1 (GLP-1), pancreatic polypeptide (PP), and peptide YY. Between-group comparisons were conducted via one-way ANOVAs and post hoc LSD tests for normally distributed variables or Kruskal‒Wallis H tests and the Nemenyi test for abnormally distributed variables. P &lt; 0.017 was considered significant in multiple comparisons following Bonferroni adjustment.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;A total of 162 participants (mean [SD] age, 41.2 [9.9] years; mean [SD] body mass index, 29.3 [3.4] kg/m&lt;sup&gt;2&lt;/sup&gt;; 102 [63%] men) who started the intervention were analyzed. After 3 months, only the TRE group decreased GLP-1 levels (−0.9 [IQR, −1.9 to −0.3] pg/mL; P = 0.002), increased PP levels (8.9 [IQR, −7.6 to 71.8] pg/mL; P = 0.011), physical functioning in the SF-36 (5.2 [95% CI, 1.9 to 8.5]; P = 0.001), social functioning in the SF-36 (9.1 [95% CI, 2.5 to 15.6]; P = 0.005), role-physical in the SF-36 (24.1 [95% CI, 11.8 to 36.4]; P &lt; 0.001), role-emotional in the SF-36 (22.4 [95% CI, 12.6 to 32.2]; P &lt; 0.001), and sleep efficiency in the PSQI (0.29 [95% CI, 0.03 to 0.55]; P = 0.021). Compared with changes in LCD, TRE further increased general health in the SF-36 (9.7 [95% CI, 3.3 to 16.0]; P = 0.006). Relative to the changes of TRE + LCD, TRE significantly increased role-emotional in the SF-36 (19.9 [95% CI 4.9 to 34.8]; P = 0.006). Changes in sleep quality, mood status, appetite, and metabolic hormones did not differ among three groups. Greater weight loss was associated with decreased leptin levels (r = 0.538), decreased amylin levels (r = 0.294), reduced total appetite scores (r = 0.220), and improved general health (r = −0.253) (all P ≤ 0.01).&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;p&gt;TRE, LCD, and TRE + LCD all could improve psychosocial health and reduce appetite. Notably, TRE yielded greater benefits in QoL compared with LCD or TRE + LCD in individuals with MetS.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Trial registrat","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"43 10","pages":"Pages 2316-2324"},"PeriodicalIF":6.6,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0261561424003078/pdfft?md5=efb7766a18c7ad98f52ca179a42b4872&pid=1-s2.0-S0261561424003078-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health economic evaluation of an artificial intelligence (AI)-based rapid nutritional diagnostic system for hospitalised patients: A multicentre, randomised controlled trial","authors":"Ming-Yao Sun ,&nbsp;Yu Wang ,&nbsp;Tian Zheng ,&nbsp;Xue Wang ,&nbsp;Fan Lin ,&nbsp;Lu-Yan Zheng ,&nbsp;Mao-Yue Wang ,&nbsp;Pian-Hong Zhang ,&nbsp;Lu-Ying Chen ,&nbsp;Ying Yao ,&nbsp;Jie Sun ,&nbsp;Zeng-Ning Li ,&nbsp;Huan-Yu Hu ,&nbsp;Hua Jiang ,&nbsp;Han-Yang Yue ,&nbsp;Qian Zhao ,&nbsp;Hai-Yan Wang ,&nbsp;Lei Han ,&nbsp;Xuan Ma ,&nbsp;Meng-Ting Ji ,&nbsp;Wei Chen","doi":"10.1016/j.clnu.2024.08.030","DOIUrl":"10.1016/j.clnu.2024.08.030","url":null,"abstract":"<div><h3>Background &amp; aims</h3><p>Malnutrition is prevalent among hospitalised patients, and increases the morbidity, mortality, and medical costs; yet nutritional assessments on admission are not routine. This study assessed the clinical and economic benefits of using an artificial intelligence (AI)-based rapid nutritional diagnostic system for routine nutritional screening of hospitalised patients.</p></div><div><h3>Methods</h3><p>A nationwide multicentre randomised controlled trial was conducted at 11 centres in 10 provinces. Hospitalised patients were randomised to either receive an assessment using an AI-based rapid nutritional diagnostic system as part of routine care (experimental group), or not (control group). The overall medical resource costs were calculated for each participant and a decision-tree was generated based on an intention-to-treat analysis to analyse the cost-effectiveness of various treatment modalities. Subgroup analyses were performed according to clinical characteristics and a probabilistic sensitivity analysis was performed to evaluate the influence of parameter variations on the incremental cost-effectiveness ratio (ICER).</p></div><div><h3>Results</h3><p>In total, 5763 patients participated in the study, 2830 in the experimental arm and 2933 in the control arm. The experimental arm had a significantly higher cure rate than the control arm (23.24% versus 20.18%; p = 0.005). The experimental arm incurred an incremental cost of 276.52 CNY, leading to an additional 3.06 cures, yielding an ICER of 90.37 CNY. Sensitivity analysis revealed that the decision-tree model was relatively stable.</p></div><div><h3>Conclusion</h3><p>The integration of the AI-based rapid nutritional diagnostic system into routine inpatient care substantially enhanced the cure rate among hospitalised patients and was cost-effective.</p></div><div><h3>Registration</h3><p>NCT04776070 (<span><span>https://clinicaltrials.gov/study/NCT04776070</span><svg><path></path></svg></span>).</p></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"43 10","pages":"Pages 2327-2335"},"PeriodicalIF":6.6,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142129729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of ultra-processed foods consumption throughout childhood and trajectories of growth and adiposity","authors":"Vânia Magalhães ,&nbsp;Milton Severo ,&nbsp;Sofia Vilela ,&nbsp;Duarte Torres ,&nbsp;Carla Lopes","doi":"10.1016/j.clnu.2024.08.032","DOIUrl":"10.1016/j.clnu.2024.08.032","url":null,"abstract":"<div><h3>Background &amp; aims</h3><p>Ultra-processed foods (UPF) consumption has been associated with unhealthy outcomes. However, the literature lacks robust longitudinal studies considering its cumulative effect, particularly in young populations. This study aimed to evaluate the relationship between UPF consumption patterns throughout childhood with growth and adiposity trajectories.</p></div><div><h3>Methods</h3><p>Generation XXI population-based birth cohort (Porto, Portugal) participants were included. Food frequency questionnaire items at 4, 7 and 10 years were classified according to the processing degree using NOVA. UPF consumption patterns based on total quantity were identified using a probabilistic Gaussian mixture model using participants with complete data and predicting for the total sample (n = 8647). To assess whether the outcome trajectories from 4 to 13 years [body weight (kg), height (cm), body mass index (BMI) z-score, waist circumference (WC) (cm) and fat mass (FM) (%)] depend on UPF patterns, a mixed-effects model with linear and quadratic terms for age adjusted for confounders was used. Participants with at least 2 measurements at 4, 7, 10 or 13 years were included in this study (n range: 5885–6272).</p></div><div><h3>Results</h3><p>Four UPF consumption patterns were identified: <em>constantly lower consumption</em> (15.4%), <em>constantly intermediate consumption</em> (56.4%), <em>transition from low to high consumption</em> (11.2%), and <em>constantly higher consumption</em> (17.1%). Compared to the <em>constantly lower UPF consumption</em>, the <em>constantly higher consumption</em> pattern was associated with greater acceleration in body weight (β: 0.119; 95%CI: 0.027; 0.212), BMI z-score (β: 0.014; 95%CI: 0.004; 0.023), WC (β: 0.232; 95%CI: 0.144; 0.319) and FM% (β: 0.200; 95%CI: 0.092; 0.308) and with lower acceleration in height (β: −0.063; 95%CI: −0.111;-0.015). The <em>constantly intermediate UPF consumption</em> pattern was associated with greater acceleration in body weight (β: 0.123; 95%CI: 0.043; 0.203), WC (β: 0.120; 95%CI: 0.045; 0.195) and FM% (β: 0.146; 95%CI: 0.054; 0.238).</p></div><div><h3>Conclusion</h3><p>C<em>onstantly higher</em> and <em>constantly intermediate UPF consumption</em> throughout childhood were associated with worse growth and adiposity trajectories until adolescence.</p></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"43 10","pages":"Pages 2364-2371"},"PeriodicalIF":6.6,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0261561424003108/pdfft?md5=1ed4c09c58ddfec15dce18587f777b32&pid=1-s2.0-S0261561424003108-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}