Clinical nutrition最新文献

{"title":"Reply to Letter to the Editor: Determinants of journal impact factors in Nutrition and Dietetics","authors":"Dileep N. Lobo, Keith R. Neal","doi":"10.1016/j.clnu.2025.04.012","DOIUrl":"10.1016/j.clnu.2025.04.012","url":null,"abstract":"","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"49 ","pages":"Pages 211-212"},"PeriodicalIF":6.6,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding unintentional weight loss: How the right questions make a difference","authors":"Jos W. Borkent ,&nbsp;Barbara S. van der Meij ,&nbsp;Marian A.E. de van der Schueren","doi":"10.1016/j.clnu.2025.04.009","DOIUrl":"10.1016/j.clnu.2025.04.009","url":null,"abstract":"<div><h3>Background/aims</h3><div>Malnutrition screening tools often include questions about unintentional weight loss (UWL). It is unclear whether individuals who intentionally desire to lose weight or perceive themselves as overweight interpret questions regarding UWL accurately. We assessed potential misclassification of UWL-related questions in these groups.</div></div><div><h3>Method</h3><div>Data from the Lifelines cohort was used (ñ125.000, age &gt;18 years). Prevalence ratios (PRs) were calculated with a simple question regarding UWL as the dependent variable and the desire to lose weight and perception of one's body weight (too heavy vs. just right/too light) as separate independent variables. Associations were stratified by body mass index (BMI) group (normal weight vs. overweight/obesity) and adjusted for various comorbidities, demographics, and quality of life.</div></div><div><h3>Results</h3><div>Of participants with normal weight, 30.3 % desired to lose weight, 37.9 % perceived their body weight as too heavy and 5.1 % reported UWL; this was 80.1 %, 92.7 % and 2.7 % for those with overweight/obesity. In both BMI groups, the prevalence of UWL was ∼60 % lower in participants who desired to lose weight or perceived themselves as too heavy (prevalence ratios 0.40–0.43, p-value &lt;0.05).</div></div><div><h3>Conclusion</h3><div>Since there is no logical basis for the desire to lose weight or one's perception of body weight to prevent UWL, lower reported prevalence rates on UWL-related questions are likely the result of misinterpretation. Malnutrition screening tools that include questions regarding UWL might underestimate the prevalence rates of malnutrition in higher BMIs, as individuals in these groups often aspire to lose weight or perceive themselves as too heavy.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"49 ","pages":"Pages 98-101"},"PeriodicalIF":6.6,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synbiotics protected radiation-induced tissue damage in rectal cancer patients: A controlled trial","authors":"Christina Stene ,&nbsp;Jie Xu ,&nbsp;Sérgio Fallone de Andrade ,&nbsp;Ingrid Palmquist ,&nbsp;Göran Molin ,&nbsp;Siv Ahrné ,&nbsp;Henrik Thorlacius ,&nbsp;Louis B. Johnson ,&nbsp;Bengt Jeppsson","doi":"10.1016/j.clnu.2025.03.025","DOIUrl":"10.1016/j.clnu.2025.03.025","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Colorectal cancer (CRC), particularly rectal cancer, often requires neoadjuvant radiotherapy (RT) as part of its treatment plan. Although effective, RT can cause significant gastrointestinal side effects. Because the onset of RT-induced tissue injury can be anticipated, there is an opportunity to apply preventive measures before the damage occurs. This study aimed to assess whether prebiotic and synbiotic interventions could mitigate RT-induced gut injury by modulating the mucosa-associated microbiota, reducing inflammation, and enhancing gut barrier function in patients undergoing RT for rectal cancer.</div></div><div><h3>Methods</h3><div>Thirty patients with rectal adenocarcinoma scheduled for preoperative short-term RT (5 × 5 Gy) were divided into three groups: a control group (Ctrl), a prebiotic group (Fiber) receiving oat bran, and a synbiotic group (Synbiotics) receiving oat bran with <em>L. plantarum</em> HEAL19 and blueberry husks. The study products were administered daily for two weeks, starting one week before RT. Blood, faecal, and biopsy samples were collected before and after RT to evaluate inflammatory markers, intestinal permeability, histopathological changes, and mucosa-associated microbiota.</div></div><div><h3>Results</h3><div>The Fiber and Synbiotics groups exhibited a significant reduction in white blood cell counts following RT (p = 0.01 for both), whereas the Ctrl group did not demonstrate a significant change. However, there was no significant difference in the magnitude of change in white blood cell counts among the three groups (p = 0.12). Histopathological analysis revealed that the Synbiotics group had reduced inflammation and fibrosis compared to the Fiber and Ctrl groups. Although RT reduced bacterial diversity overall, the Synbiotics group preserved a greater proportion of bacterial species, experiencing only a 25.1 % reduction compared to a 55.4 % reduction in the Fiber group.</div></div><div><h3>Conclusion</h3><div>Synbiotic interventions may protect rectal mucosa by reducing inflammation and modulating mucosa-associated microbiota. The effects were primarily localized to the tissue, reflecting the short-term duration of treatment. While immediate benefits were observed, longer-term interventions should be explored to reduce systemic inflammation.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"49 ","pages":"Pages 33-41"},"PeriodicalIF":6.6,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143839155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fish and sea products consumption and allergic rhinitis: A multicenter case–control study","authors":"Carlos Regueira ,&nbsp;Narmeen Mallah ,&nbsp;Jurgita Saulyte ,&nbsp;Francisco-Javier González-Barcala ,&nbsp;Bahi Takkouche","doi":"10.1016/j.clnu.2025.04.005","DOIUrl":"10.1016/j.clnu.2025.04.005","url":null,"abstract":"<div><h3>Background</h3><div>The association of allergic diseases with the intake of fish-derived proteins and fatty acids remains unclear, with studies showing divergent results. We aimed to examine the association of those nutrients with the occurrence of allergic rhinitis (AR).</div></div><div><h3>Methods</h3><div>A multicenter case–control study was conducted with 411 AR cases and 477 controls. Adjusted odds ratios (OR) of AR and their 95 % confidence intervals (CI) were estimated using multivariate logistic regression models. Stratified analyses by fish type and macronutrient were undertaken.</div></div><div><h3>Results</h3><div>Blue fish consumption, except tuna, is associated with an important decrease in the odds of AR (1 serving/week: OR = 0.46; 95%CI: 0.27–0.80; 2 servings/week: OR = 0.30; 95%CI: 0.17–0.54; 3–4 servings/week: OR = 0.38; 95%CI: 0.20–0.68). Conversely, compared to no intake, white fish consumption is associated with higher odds of AR (3 servings/week: OR = 5.49; 95%CI: 3.27–9.24).</div><div>A high n-6/n-3 polyunsaturated fatty acids (PUFAs) ratio is associated with higher odds of AR (OR = 1.79; 95%CI: 1.03–3.13 for the highest intake level compared to the lowest). High intake of n-3 PUFAs is associated with substantially lower odds of AR ranging between 46 % and 58 % (stearidonic acid OR = 0.42; 95%CI: 0.24–0.74; eicosapentaenoic acid OR = 0.45; 95%CI: 0.25–0.80; and docosapentaenoic acid OR = 0.54; 95%CI: 0.31–0.96).</div></div><div><h3>Conclusions</h3><div>A high intake of blue fish, except tuna, is associated with lower odds of AR while that of white fish has an opposite association with the disease occurrence.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"49 ","pages":"Pages 42-49"},"PeriodicalIF":6.6,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between triglyceride-glucose related indices and severe infection requiring hospital admission or resulting in mortality among individuals with metabolic dysfunction-associated steatotic liver disease","authors":"Ming Zhao ,&nbsp;Chenyu Liang ,&nbsp;Jiayi Huang ,&nbsp;Luojia Dai ,&nbsp;Haili Wang ,&nbsp;Xin Zhang ,&nbsp;Shuzhen Zhao ,&nbsp;Chengnan Guo ,&nbsp;Zhenqiu Liu ,&nbsp;Tiejun Zhang","doi":"10.1016/j.clnu.2025.04.006","DOIUrl":"10.1016/j.clnu.2025.04.006","url":null,"abstract":"<div><h3>Background and aims</h3><div>Despite increasing evidence linking triglyceride-glucose (TyG) related indices with metabolic and cardiovascular outcomes, the associations with severe infection in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) remain unclear.</div></div><div><h3>Methods</h3><div>We analyzed data from a large population-based cohort, which included participants who were diagnosed with MASLD and enrolled in 2016 and 2017, with follow-up until December 2022. Severe infections were defined as those requiring hospital admission or resulting in mortality. Multivariate Cox and restricted cubic spline (RCS) regression models were used to evaluate the associations between TyG-related indices and severe infection among participants with MASLD. Additionally, we examined these associations within subgroups defined by age, sex, hypertension, diabetes, obesity, and hyperlipidemia.</div></div><div><h3>Results</h3><div>Among the 11,782 eligible participants with MASLD (mean age 57.02 years; 34.36 % male), a total of 898 (7.62 %) severe infections occurred during the median follow-up of 5.71 years. The multivariate Cox regression analyses revealed that high levels of TyG (HR = 1.175, 95%CI = 1.049–1.315), TyG-BMI (HR = 1.004, 95%CI = 1.001–1.006), and TyG-WC (HR = 1.002, 95%CI = 1.001–1.003) indices were significantly associated with the severe infection in patients with MASLD. The RCS curves showed positive linear correlations between three TyG-related indices with severe infection in MASLD. Subgroup analyses showed these associations were more pronounced among MASLD patients without obesity. Additionally, incorporating TyG-related indices into the basic model considerably improved the predictive ability for severe infection.</div></div><div><h3>Conclusions</h3><div>Our study indicated that a high TyG-related indices are associated with an increased risk of severe infection in MASLD patients. TyG-related indices would be the surrogate biomarkers for the follow-up of the MASLD population.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"49 ","pages":"Pages 1-10"},"PeriodicalIF":6.6,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omega-3 and conjugated fatty acids impact on human microbiota modulation using an in vitro fecal fermentation model","authors":"Ana Sofia Salsinha ,&nbsp;Helena Araújo-Rodrigues ,&nbsp;Cindy Dias ,&nbsp;André Cima ,&nbsp;Luís Miguel Rodríguez-Alcalá ,&nbsp;João B. Relvas ,&nbsp;Manuela Pintado","doi":"10.1016/j.clnu.2025.04.007","DOIUrl":"10.1016/j.clnu.2025.04.007","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Gut microbiota has been gaining increasing attention and its important role in the maintenance of a general good health condition is already established. The potential of gut microbiota modulation through diet is an important research focus to be considered. Lipids, as omega-3 fatty acids, are well known for their beneficial role on organs and corresponding diseases. However, their impact on gut microbiota is still poorly defined, and studies on the role of other polyunsaturated fatty acids, such as conjugated linoleic and linolenic acids, are even scarcer.</div></div><div><h3>Methods</h3><div>By using an <em>in vitro</em> human fermentation model, we assessed the effect of omega-3, CLA isomers, and punicic acid on microbiota modulation.</div></div><div><h3>Results</h3><div>Fish oil, Omega-3, and CLA samples positively impact <em>Akkermansia</em> spp. and <em>Bifidobacterium</em> spp. growth. Moreover, all the samples supported <em>Roseburia</em> spp. growth after 24 h of fermentation and, importantly, they were able to maintain the Firmicutes: Bacteroidetes ratio near 1. All the bioactive fatty acid samples, except Pomegranate oil, were able to significantly increase butyrate levels compared to those found in the positive control (FOS) sample. Moreover, Fish oil and Omega-3 samples were able to increase the concentration of GABA, alanine, tyrosine, phenylalanine, isoleucine, and leucine between 12 and 24 h of fermentation.</div></div><div><h3>Conclusions</h3><div>The impact of the assessed polyunsaturated fatty acids in gut microbiota has been observed in its impact on key bacteria (<em>Akkermansia</em>, <em>Bifidobacterium,</em> and <em>Roseburia</em>) as well as their metabolic byproducts, including butyrate and amino acids, which could potentially play a role in modulating the gut-brain axis.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"49 ","pages":"Pages 102-117"},"PeriodicalIF":6.6,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct gut microbiota signatures in older people with sarcopenic obesity and sarcopenia without obesity","authors":"Ling Wang ,&nbsp;Xiangfeng He ,&nbsp;Zhen Zhang ,&nbsp;Nan Chen","doi":"10.1016/j.clnu.2025.04.004","DOIUrl":"10.1016/j.clnu.2025.04.004","url":null,"abstract":"<div><h3>Background</h3><div>Previous evidence suggests that gut dysbiosis plays an important role in the development and progression of sarcopenia and sarcopenic obesity (SO), but evidence supporting this association is lacking. Thus, this study aimed to investigate the characteristics of gut microbiota in older people with sarcopenia and SO.</div></div><div><h3>Methods</h3><div>A total of 1558 older adults (age ≥65 years) from a community-based cohort in Shanghai, China, underwent sarcopenia screening using the SARC-F questionnaire, with 351 participants completing further assessment. On the basis of the Asian Working Group for Sarcopenia 2019 and the World Health Organization obesity criteria, 60 participants were categorized into three groups: SO (n = 20), sarcopenia without obesity (Sar, n = 18), and controls (Con, n = 22). Gut microbiota composition was analyzed using 16S rRNA sequencing (V3–V4 regions).</div></div><div><h3>Results</h3><div>Significant differences in the diversity and composition of the gut microbiota were observed in the Sar and SO groups. A reduction in alpha diversity (Chao1 and ACE indices) was found in the SO group. Beta diversity based on unweighted Unifrac PCoA was significantly different among the three groups. LEfSe analysis identified 39 taxa with significant differential abundances across groups. The Sar group exhibited enrichment of <em>Christensenellaceae</em><em>_R-7_group</em>, <em>Alistipes</em>, <em>Ruminococcus</em>, <em>Odoribacter</em>, <em>Prevotellaceae</em><em>_UCG-001</em>, <em>Hungatella</em>, <em>Family_XIII_AD3011_group</em>, <em>Anaerotruncus</em>, <em>Ruminiclostridium</em>, and <em>Oxalobacter</em>, along with their high taxonomic classifications. Meanwhile, <em>Enterobacteriaceae</em>, <em>Allisonella</em>, and <em>Peptoclostridium</em> were enriched in the SO group. Feature selection via Boruta algorithm identified five and four discriminatory taxa to construct random forest models, effectively distinguishing individuals with Sar and SO from Con. Key predictors for Sar included reduced <em>Enterococcus</em>, <em>Enterobacter</em>, and <em>Hungatella</em> and increased <em>Odoribacter</em> and <em>Christensenellaceae</em><em>_R-7_group</em>. Conversely, SO was characterized by decreased <em>Enterobacter</em>, <em>Alloprevotella</em>, and <em>Enterococcus</em> and increased <em>Allisonella</em>. Five-fold cross-validation confirmed robust diagnostic efficacy, achieving AUCs of 0.860 (95 % CI: 0.786–0.996) for Sar and 0.826 (95 % CI: 0.735–0.970) for SO.</div></div><div><h3>Conclusion</h3><div>This study demonstrated that the gut microbiota of SO and Sar have distinct diversity and composition profiles. The results provide new insights into the role of gut microbiota in SO, highlighting its potential as a therapeutic target in this condition.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"49 ","pages":"Pages 77-89"},"PeriodicalIF":6.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolonged disturbances in citrulline metabolism following resistance exercise in COPD","authors":"Tarun Sontam ,&nbsp;Nicolaas E.P. Deutz ,&nbsp;Clayton L. Cruthirds ,&nbsp;Robert Mbilinyi ,&nbsp;Laura E. Ruebush ,&nbsp;Gabriella AM. Ten Have ,&nbsp;John J. Thaden ,&nbsp;Mariёlle P.K.J. Engelen","doi":"10.1016/j.clnu.2025.03.021","DOIUrl":"10.1016/j.clnu.2025.03.021","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Disturbances in arginine (ARG) and protein metabolism, as well as in gut function have been observed in response to an endurance exercise session in patients with Chronic Obstructive Pulmonary Disease (COPD). We studied whether resistance exercise also affects the acute response in arginine (role in nitric oxide synthesis), citrulline (CIT, marker of gut health), and (muscle) protein metabolism differently in COPD as compared to healthy older adults.</div></div><div><h3>Methods</h3><div>Patients with stable moderate to severe COPD (n = 24) and healthy controls (n = 25) completed a high-intensity resistance exercise session in the postabsorptive state. We administered a pulse of multiple stable isotopes of amino acids before, and 1 h and 24 h post-resistance exercise to assess the whole body production (WBP) and intracellular productions by compartmental analysis of ARG and CIT, and of tau-methylhistidine (TauMETHIS), phenylalanine (PHE), tyrosine (TYR), and PHE &gt; TYR conversion as markers of muscle (myofibrillar) protein breakdown and whole body (net) protein breakdown, respectively. Muscle fatigue was determined by assessing the decay in peak leg extension torque post-resistance exercise.</div></div><div><h3>Results</h3><div>COPD patients overall exhibited lower WBP ARG (p &lt; 0.0001), CIT (p &lt; 0.0001), PHE (p = 0.0001), TYR (p &lt; 0.0001), and tau-METHIS (p = 0.0004) compared to controls. Resistance exercise did not change WBP of PHE, tau-METHIS, or PHE &gt; TYR conversion, despite prolonged muscle fatigue in COPD. WBP CIT was increased at 1- and 24-h post-exercise in both groups (p &lt; 0.003). Plasma CIT concentrations were reduced in both groups (p &lt; 0.006) and remained lower at 24 h post-exercise in COPD only (p &lt; 0.05) despite a third less work performed.</div></div><div><h3>Conclusions</h3><div>Both COPD and healthy participants exhibited upregulated whole-body citrulline production following resistance exercise. However, in COPD, this increase was insufficient to counteract the sustained reduction in plasma citrulline concentration, despite performing significantly less work during the exercise session. This prolonged disturbance in citrulline metabolism in COPD points to a potential exercise-induced enterocyte dysfunction, highlighting a novel area for understanding the impact of resistance exercise on gut health in this population.</div></div><div><h3>Clinical trial registry</h3><div>Trial registration ClinicalTrials.gov: <span><span>NCT02780219</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"49 ","pages":"Pages 21-32"},"PeriodicalIF":6.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early time-restricted eating with energy restriction has a better effect on body fat mass, diastolic blood pressure, metabolic age and fasting glucose compared to late time-restricted eating with energy restriction and/or energy restriction alone: A 3-month randomized clinical trial","authors":"Tanja Črešnovar,&nbsp;Bernarda Habe,&nbsp;Nina Mohorko,&nbsp;Saša Kenig,&nbsp;Zala Jenko Pražnikar,&nbsp;Ana Petelin","doi":"10.1016/j.clnu.2025.04.001","DOIUrl":"10.1016/j.clnu.2025.04.001","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Time-restricted eating (TRE) has attracted increasing attention from researchers and the public. Recent studies suggest that the combination of TRE with energy restriction (ER) may have more favourable effects on both physical and biochemical aspects compared to ER alone. The aim of the present 3-month intervention study was to determine the effects of an 8-h early time-restricted eating and an 8-h late time-restricted eating with ER (eTRE + ER and lTRE + ER) compared to 12-h ER alone on body mass and other anthropometric and cardiometabolic risk factors in participants with overweight and obesity.</div></div><div><h3>Methods</h3><div>Participants (n = 108) were allocated to three different groups according to their personal chronotype: eTRE + ER (37 participants), lTRE + ER (37 participants) and ER (34 participants). Ninety-three participants completed the entire 3-month intervention (34 in eTRE + ER, 28 in lTRE + ER and 31 in ER). Anthropometric and cardiometabolic risk factors were measured at baseline and after 1, 2 and 3 months of the intervention. Sleep quality and quality of life were assessed at baseline and after 3 months of the intervention. ER was determined based on the individual's resting metabolic rate. Effects were analyzed using the <em>per-protocol</em> approach.</div></div><div><h3>Results</h3><div>Results showed a significant time main effect (p &lt; 0.001), suggesting a decrease in body mass at the end of the 3-month intervention with a mean loss of −5.0 kg (95 % CI, −5.7, −4.3) for the eTRE + ER group, −4.4 kg (95 % CI, −5.2, −3.6) for the lTRE + ER group and −4.3 kg (95 % CI, −5.0, −3.6) for the ER group, with no significant difference between the groups (p = 0.319). eTRE + ER had greater improvements in fat mass (−1.2 % (95 % CI, −2.1, −0.2), p = 0.013) and fasting glucose (−0.35 mmol/L (95 % CI, −0.63, −0.06), p = 0.012) than participants in the lTRE + ER group and greater improvements in fat mass (−1.1 % (95 % CI, −2.0, −0.1), p = 0.022), metabolic age (−3 years (95 % CI, −5, −0), p = 0.028) and diastolic blood pressure (−4 mmHg (95 % CI, −8, −0), p = 0.033) than the participants in the ER group. No significant changes were found between the groups for the other parameters measured.</div></div><div><h3>Conclusions</h3><div>There was no difference in body mass between the eTRE + ER, lTRE + ER and ER groups after 3 months of intervention. However, eTRE + ER showed a greater benefit for fasting blood glucose, certain anthropometric parameters and diastolic blood pressure compared to lTRE + ER and/or ER alone. Other anthropometric, biochemical and health-related parameters were not affected by eating window.</div></div><div><h3>Trial Registration</h3><div><span><span>https://clinicaltrials.gov/study/NCT05730231</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"49 ","pages":"Pages 57-68"},"PeriodicalIF":6.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143839158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long term impact of formula choice in children with cow milk protein allergy: 6-year follow-up of the Atopic March Cohort Study","authors":"Rita Nocerino ,&nbsp;Giorgio Bedogni ,&nbsp;Laura Carucci ,&nbsp;Greta Aquilone ,&nbsp;Franca Oglio ,&nbsp;Serena Coppola ,&nbsp;Antonio Masino ,&nbsp;Roberto Berni Canani","doi":"10.1016/j.clnu.2025.03.026","DOIUrl":"10.1016/j.clnu.2025.03.026","url":null,"abstract":"<div><h3>Background and aims</h3><div>Cow's milk protein allergy (CMPA) is a significant health issue in the pediatric age, carrying lifelong health implications. To compare the impact of different formulas on the occurrence of other atopic manifestations (AMs), autoimmune disorders (ADs) and the time of immune tolerance acquisition in a population of children with immunoglobulin E (IgE)-mediated cow CMPA.</div></div><div><h3>Methods</h3><div>In a 72-month prospective cohort study the occurrence of other AMs (i.e., eczema, urticaria, asthma, and rhinoconjunctivitis), ADs (i.e., celiac disease, thyroiditis, type 1 diabetes, inflammatory bowel diseases, idiopathic juvenile arthritis) and the time of immune tolerance acquisition were comparatively evaluated in IgE-mediated CMPA children treated with different formulas: extensively hydrolyzed casein formula containing the probiotic <em>L. rhamnosus</em> G (EHCF + LGG), rice hydrolyzed formula (RHF), soy formula (SF), extensively hydrolyzed whey formula (EHWF), or amino-acid based formula (AAF).</div></div><div><h3>Results</h3><div>313 subjects were evaluated: EHCF + LGG (n = 64), RHF(n = 62), SF(n = 63), EHWF(n = 60) and AAF (n = 64). The incidence of AMs was: 0.30(Bonferroni-corrected 95%CI 0.15 to 0.44) for EHCF + LGG cohort, 0.68 (0.52–0.83) for RHF cohort, 0.73 (0.59–0.87) for SF cohort, 0.70 (0.55–0.85) for EHWF cohort and 0.83 (0.71–0.95) for AAF cohort. The corresponding risk ratios are 2.28 (1.51–3.45) for RHF vs. EHCF + LGG (p &lt; 0.001), 2.46 (1.64–3.69) for SF vs. EHCF + LGG (p &lt; 0.001), 2.36 (1.56–3.56) for EHWF vs. EHCF + LGG (p &lt; 0.001), and 2.79 (1.88–4.13) for AAF vs. EHCF + LGG (p &lt; 0.001). The 72-month immune tolerance acquisition rate was higher in the EHCF + LGG cohort. The incidence of celiac disease was 2/313 (0.006, binomial exact 95%CI 0.0007 to 0.023). No cases of other ADs were reported.</div></div><div><h3>Conclusion</h3><div>The dietary treatment with EHCF + LGG is associated with lower incidence of AMs and higher rate of immune tolerance acquisition in children with CMPA.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"48 ","pages":"Pages 134-143"},"PeriodicalIF":6.6,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143807416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}