The anti-tumour role of ketogenic diet based on energy metabolism

IF 6.6 2区医学 Q1 NUTRITION & DIETETICS

Clinical nutrition Pub Date : 2025-06-13 DOI:10.1016/j.clnu.2025.06.006

Jiasheng Wu , Xinyu Sun , Hanmou Luo , Xiaoqi Luo , Suxia Sun

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引用次数: 0

Abstract

Background

Unlike the energy metabolism of normal cells, tumour cells favor aerobic glycolysis to meet their unique energy demands, while disrupting normal mitochondrial metabolism. This specialized energy metabolic pathway promotes tumour growth, proliferation, and metastasis. The ketogenic diet (KD) is a high-fat diet inducing ketone bodies (KBs) for energy metabolism by restricting carbohydrate intake and promoting fatty acid breakdown. Due to the unique energy metabolism of tumours, KD has the potential to counteract tumour energy metabolism.

Methods

The current literature was reviewed for potential anti-tumour mechanisms of KD based on energy metabolism and the clinical evidence suggested for KD roles in tumours.

Results

KD exerts anti-tumour effects by inhibiting tumour aerobic glycolysis, inducing KBs, activating AMP-activated protein kinase (AMPK), and regulating reactive oxygen species (ROS) levels.

Conclusion

This review groundbreakingly concludes that KD manifests the potential of anti-tumour effects based on energy metabolism. Furthermore, this study establishes a theoretical foundation for exploring the anti-cancer properties of KD and its potential as a adjunctive therapy for cancer.

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基于能量代谢的生酮饮食的抗肿瘤作用

与正常细胞的能量代谢不同，肿瘤细胞倾向于有氧糖酵解来满足其独特的能量需求，同时破坏正常的线粒体代谢。这种特殊的能量代谢途径促进肿瘤生长、增殖和转移。生酮饮食（KD）是一种通过限制碳水化合物摄入和促进脂肪酸分解来诱导酮体（KBs）进行能量代谢的高脂肪饮食。由于肿瘤独特的能量代谢，KD具有中和肿瘤能量代谢的潜力。方法综述了KD在能量代谢方面的潜在抗肿瘤机制，以及KD在肿瘤中的临床作用。结果skd通过抑制肿瘤有氧糖酵解、诱导KBs、激活amp活化蛋白激酶（AMPK）、调节活性氧（ROS）水平发挥抗肿瘤作用。结论具有开创性的结论，KD具有基于能量代谢的抗肿瘤作用潜力。此外，本研究为探索KD的抗癌特性及其作为癌症辅助治疗的潜力奠定了理论基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical nutrition 医学-营养学

CiteScore

14.10

自引率

6.30%

发文量

356

审稿时长

28 days

期刊介绍： Clinical Nutrition, the official journal of ESPEN, The European Society for Clinical Nutrition and Metabolism, is an international journal providing essential scientific information on nutritional and metabolic care and the relationship between nutrition and disease both in the setting of basic science and clinical practice. Published bi-monthly, each issue combines original articles and reviews providing an invaluable reference for any specialist concerned with these fields.