Clinical nutrition最新文献

{"title":"Identification of Pappalysin-2 (PAPP-A2), a modulator of Insulin-like Growth Factor-1 pathway, as a potential marker of teduglutide efficacy in patients with short bowel syndrome","authors":"Brune de Dreuille ,&nbsp;Rémy Nicolle ,&nbsp;Jérôme Cros ,&nbsp;Dominique Cazals-Hatem ,&nbsp;Anaïs Chassac ,&nbsp;Nicolas Poté ,&nbsp;Johanne Le Beyec-Le Bihan ,&nbsp;André Bado ,&nbsp;Maude Le Gall ,&nbsp;Francisca Joly","doi":"10.1016/j.clnu.2025.05.006","DOIUrl":"10.1016/j.clnu.2025.05.006","url":null,"abstract":"<div><h3>Background</h3><div>Teduglutide, a glucagon-like peptide-2 (GLP-2) analog, is indicated to treat short bowel syndrome (SBS) since 2015. It has been shown to reduce parenteral support (PS) in SBS patients, although patients’ response is quite heterogeneous. The exact mechanisms of action of GLP-2 on intestinal cells are still poorly understood. The aim of this study was to explore the intestinal action of teduglutide to identify molecular mechanisms underlying response heterogeneity.</div></div><div><h3>Methods</h3><div>A retrospective study was conducted in 39 SBS patients treated with teduglutide for at least 6 months. Intestinal biopsy specimens collected before and after treatment initiation were selected and analyzed by RNA sequencing to identify genes differentially expressed and pathways regulated following teduglutide treatment.</div></div><div><h3>Results</h3><div>Of the 39 patients included in the study, 29 (74%) had a colon in continuity. The overall response to teduglutide was a reduction by 75% (interquartile range: 42–100) in PS volume. Among the genes differentially expressed in the small bowel during teduglutide treatment, the most significantly upregulated gene was <em>PAPPA2</em> (q-value &lt; 0.0001), encoding the metalloproteinase Pappalysin-2 (PAPPA-2) involved in Insulin-like Growth Factor (IGF) bioavailability. The best responders to teduglutide showed a lower <em>PAPPA2</em> expression at baseline (p &lt; 0.01). <em>PAPPA2</em> expression at baseline also correlated positively with the percentage of remnant colon (p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>We identified a new stakeholder, PAPPA-2, known to modulate IGF bioavailability, as playing a possible role in GLP-2 mechanism of action in human with SBS. We showed by association the existence of a greater spontaneous intestinal adaptation in SBS patients with a colon in continuity that could reduce sensitivity to teduglutide. Additionally, we suggest that initial <em>PAPPA2</em> expression could serve as a predictive biomarker for teduglutide efficacy.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"50 ","pages":"Pages 128-136"},"PeriodicalIF":6.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144125221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CiR-EIS alleviates metabolic dysfunction-associated steatohepatitis by modulating macrophage polarization involving the miR-548m/IGF1 axis","authors":"Xiaoman Chen ,&nbsp;Zhiping Wan ,&nbsp;Lili Wu ,&nbsp;Xiang Cai ,&nbsp;Hang Si ,&nbsp;Xiaoquan Liu ,&nbsp;Qiyi Zhao ,&nbsp;Fen Xu ,&nbsp;Hong Deng","doi":"10.1016/j.clnu.2025.05.009","DOIUrl":"10.1016/j.clnu.2025.05.009","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Metabolic dysfunction-associated steatohepatitis (MASH) is a significant public health concern, with macrophage phenotypes implicated in its progression. Although extensive inflammation-suppressing circular RNA (ciR-EIS, formerly named as hsa_circ_0008882) has been implicated in inflammation regulation, its role in macrophage polarization within the context of MASH remains unexplored. This study aimed to clarify the effect of ciR-EIS on macrophage polarization in MASH.</div></div><div><h3>Methods</h3><div>Immunofluorescence-fluorescence in situ hybridization was used to evaluate the localization of ciR-EIS in human liver sections. THP-1-derived macrophages (TDMs) were utilized to study ciR-EIS functions in vitro<em>.</em> Flow cytometry and RT-qPCR were employed to evaluate macrophage polarization after transfection. Bodipy assay was used to measure lipid buildup in HepG2 cells. Immunohistochemistry was used to confirm liver insulin-like growth factor 1 (IGF1) expression. Retrospective clinical records were analyzed to examine the association between cir-EIS, IGF1, and MASH.</div></div><div><h3>Results</h3><div>CiR-EIS was downregulated in patients with MASH and colocalized with the macrophage marker CD68. CiR-EIS and mitochondrially encoded NADH dehydrogenase 5 (MT-ND5) were downregulated in M1 macrophages and upregulated in M2 macrophages. TDM-derived supernatants overexpressed ciR-EIS, significantly reducing HepG2 lipid deposition and inhibiting LX2 proliferation. Overexpression of ciR-EIS in TDMs significantly inhibited M1 macrophage markers CD86, interleukin-1 beta, and tumor necrosis factor-alpha while enhancing M2 macrophage markers CD163 and CD206. CiR-EIS regulated macrophage polarization in a manner involving the miR-548m/IGF1 axis. Serum IGF1 levels were positively correlated with ciR-EIS, and both of them were notably reduced in patients with MASH and inversely correlated with APRI and FIB-4 scores.</div></div><div><h3>Conclusions</h3><div>CiR-EIS regulates macrophage polarization in a manner involving the miR-548/IGF1 axis, thereby reducing hepatocyte lipid accumulation and stellate cell proliferation in MASH. It demonstrates potential as a diagnostic marker and therapeutic target for MASH.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"50 ","pages":"Pages 104-116"},"PeriodicalIF":6.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “ESPEN practical short micronutrient guideline” [Clin Nutr 43 (2024) 825–857]","authors":"Mette M. Berger ,&nbsp;Alan Shenkin ,&nbsp;Oguzhan Sıtkı Dizdar ,&nbsp;Karin Amrein ,&nbsp;Marc Augsburger ,&nbsp;Hans-Konrad Biesalski ,&nbsp;Stephan C. Bischoff ,&nbsp;Michael P. Casaer ,&nbsp;Kursat Gundogan ,&nbsp;Hanna-Liis Lepp ,&nbsp;Angelique M.E. de Man ,&nbsp;Giovanna Muscogiuri ,&nbsp;Magdalena Pietka ,&nbsp;Loris Pironi ,&nbsp;Serge Rezzi ,&nbsp;Anna Schweinlin ,&nbsp;Cristina Cuerda","doi":"10.1016/j.clnu.2025.04.020","DOIUrl":"10.1016/j.clnu.2025.04.020","url":null,"abstract":"","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"50 ","pages":"Page 75"},"PeriodicalIF":6.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bifidobacterium animalis subsp. lactis BL-11 promotes height growth in 3- to 7-year-Old children with below-average height: A self-controlled clinical trial","authors":"Qian Wang ,&nbsp;Yanan Yang ,&nbsp;Yin Xiao ,&nbsp;Ziyi Liu ,&nbsp;Mingxi Li ,&nbsp;Yue Yu ,&nbsp;Nannan Wang ,&nbsp;Junyan Li ,&nbsp;Xiaohui Li ,&nbsp;Chuanhui Xu ,&nbsp;Deyun Liu ,&nbsp;Chongming Wu","doi":"10.1016/j.clnu.2025.05.001","DOIUrl":"10.1016/j.clnu.2025.05.001","url":null,"abstract":"<div><h3>Background</h3><div>Short stature of children has captured extensive attention since it reflects the health status of children and affects physical and psychological health throughout children's life. Compelling evidences have revealed that gut microbiota plays a critical role in growth regulation through nutrient metabolism, inflammation modulation, and endocrine signaling. <em>Bifidobacterium animalis</em> subsp. lactis BL-11 (BL-11) is a probiotic strain with potential benefits for gut health and metabolic function, but its effect on growth promotion in children with mild growth delay has not been fully explored.</div></div><div><h3>Objectives</h3><div>This study aimed to evaluate the effect of BL-11 supplementation on height velocity (HV) and annual growth rate (AGR) in 3- to 7-year-old children with below-average height using a self-controlled clinical trial design over a 3-month intervention period.</div></div><div><h3>Methods</h3><div>A total of 124 children aged 3–7 years with height in the 3rd to 25th percentiles (P3–P25) range and an AGR of &lt;5 cm/year were enrolled. Each child received a daily dose of BL-11 for 3 months. Baseline height was measured before the intervention, and post-intervention height was recorded at the end of the 3-month period. The primary outcome was the change in HV and AGR and secondary outcomes included changes in height percentile.</div></div><div><h3>Results</h3><div>After 3 months of BL-11 supplementation, the children showed a significant increase in HV, with a mean improvement of 2.23 cm/3-month (8.92 cm/year) compared to the pre-intervention rate of &lt;5 cm/year (<em>P</em> value = 0.004). The height percentiles were also improved and about 55.88 % (19/34) children with height in P3–P10 shifted to P10–P25. No serious adverse events were reported.</div></div><div><h3>Conclusions</h3><div>Supplementation with <em>Bifidobacterium animalis</em> subsp<em>. lactis</em> BL-11 for 3 months significantly improved height velocity in 3- to 7-year-old children with below-average height. The findings suggest that BL-11 may be a safe and effective probiotic intervention for promoting growth in children with mild growth delay. Further long-term studies are warranted to confirm the durability and consistency of these effects.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"50 ","pages":"Pages 57-65"},"PeriodicalIF":6.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of a traditional Mediterranean Diet with ultra-processed food consumption in relation to all-cause and cause-specific mortality: Prospective findings from the Moli-sani Study","authors":"Marialaura Bonaccio ,&nbsp;Augusto Di Castelnuovo ,&nbsp;Simona Costanzo ,&nbsp;Emilia Ruggiero ,&nbsp;Simona Esposito ,&nbsp;Chiara Cerletti ,&nbsp;Maria Benedetta Donati ,&nbsp;Giovanni de Gaetano ,&nbsp;Licia Iacoviello","doi":"10.1016/j.clnu.2025.04.024","DOIUrl":"10.1016/j.clnu.2025.04.024","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Ultra-processed foods (UPFs) are increasingly displacing traditional diets with threatening health impacts. We therefore aimed to examine the association between different combinations of adherence to a traditional Mediterranean Diet (MD) and ultra-processed food (UPF) consumption with all-cause and cause-specific mortality amongst adult Italians.</div></div><div><h3>Methods</h3><div>We prospectively analysed data from 22,939 men and women (mean age 55 ± 12 years) followed for 15.0 years (median). Food intake was assessed by a 188-item FFQ. UPF was defined following the Nova classification and calculated as a weight ratio. The Mediterranean Diet Score (MDS; range 0–9) was used to assess adherence to MD. Low/High MD adherence (<em>i.e.</em> MDS &lt;6 or ≥6, respectively) was combined with low/high UPF consumption (<em>i.e.</em> &lt;9.4 or ≥9.4, i.e. population median intake) to obtain a 4-level dietary variable resulting in the following dietary combinations: 1) low MD/high UPF; 2) High MD/high UPF; 3) Low MD/low UPF; and 4) High MD/low UPF.</div></div><div><h3>Results</h3><div>When compared to the low MD/high UPF category, a high adherence to a traditional MD combined with low UPF consumption emerged as the optimal dietary pattern for reducing the risk of all-cause mortality (HR = 0.76; 95%CI 0.68–0.85), as well as cardiovascular (HR = 0.80; 95%CI 0.67–0.96) and non-cardiovascular/non-cancer mortality (HR = 0.57; 95%CI 0.47–0.70). An interaction between these two dietary factors was observed for ischemic heart disease (IHD)/cerebrovascular and non-cardiovascular/non-cancer mortality outcomes (p values for multiplicative interaction = 0.050 and 0.0011, respectively), indicating that these two dietary factors work synergistically. No association was found with cancer-related mortality.</div></div><div><h3>Conclusions</h3><div>In a large cohort of adult Italians, a high adherence to a traditional MD combined with low consumption of UPFs was the optimal dietary combination for improved survival rates and lower non-cancer-related mortality. Dietary guidelines should emphasize the importance of reducing UPF consumption alongside following an MD to fully maximize its health benefits.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"50 ","pages":"Pages 83-91"},"PeriodicalIF":6.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-year lifestyle changes, genetic risk, and risk of frailty among older adults: A national community-based cohort study","authors":"Wen-Fang Zhong ,&nbsp;Xiao-Meng Wang ,&nbsp;Wei-Qi Song ,&nbsp;Huan Chen ,&nbsp;Jia-Hao Xie ,&nbsp;Hao Yan ,&nbsp;Jun-Jie Wang ,&nbsp;Yue-Bin Lv ,&nbsp;Zhi-Hao Li ,&nbsp;Xiao-Ming Shi ,&nbsp;Chen Mao","doi":"10.1016/j.clnu.2025.04.033","DOIUrl":"10.1016/j.clnu.2025.04.033","url":null,"abstract":"<div><h3>Background</h3><div>The association between change in lifestyle in late-life and frailty mediated by genetic risk is yet to be elucidated. This study aimed to investigate the associations of change in lifestyle in late-life and genetic risk with frailty among older adults.</div></div><div><h3>Methods</h3><div>6945 participants aged 65 or older were included from the Chinese Longitudinal Healthy Longevity Survey. Three-year lifestyle changes were assessed by comparing the first survey (2002, 2005, 2008, 2011) with the second survey (2005, 2008, 2011, 2014), evaluating changes in overall lifestyle scores, lifestyle combinations, and four factors (smoking, alcohol use, physical activity, and diet). A weighted polygenic risk score was constructed using 25 frailty-associated Single Nucleotide Polymorphism in a subsample of 4346 participants. Frailty was defined as a frailty index ≥0.25. Cox proportional hazards regression models, with age as the time scale and stratified by 5-year age groups, were used to estimate the interaction between genetic and lifestyle factors on frailty risk.</div></div><div><h3>Results</h3><div>During a median follow-up time of 5.7 years [interquartile range (IQR): 3.1–8.9), 2525 participants developed frailty. Compared to consistently unhealthy lifestyles, the hazard ratios (<em>HR</em>s) for frailty were 0.64 [95 % confidence interval (<em>CI</em>): 0.54–0.75] for healthy-to-healthy, 0.80 (95 % <em>CI</em>: 0.68–0.93) for moderate-to-moderate, and 0.83 (95 % <em>CI</em>: 0.70–0.99) for moderate-to-healthy changes. Participants with a high genetic risk group suffered from 87 % (95%<em>CI</em>: 1.68–2.08) higher risk of frailty. Notably, the highest frailty risk was observed in individuals with high genetic risk who changed from a healthy to an unhealthy lifestyle (<em>HR</em>: 2.86, 95%<em>CI</em>: 1.89–4.34).</div></div><div><h3>Conclusion</h3><div>Improving or maintaining a healthy lifestyle over three years, even in late life, was associated with a lower risk of frailty. This underscores the importance of a healthy lifestyle in preventing frailty, particularly for individuals with a high genetic risk.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"50 ","pages":"Pages 29-37"},"PeriodicalIF":6.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food consumption by degree of processing and perceived mental and physical health: A cross-sectional analysis in the Moli-sani Study cohort","authors":"Francesca Bracone ,&nbsp;Augusto Di Castelnuovo ,&nbsp;Anwal Ghulam ,&nbsp;Simona Costanzo ,&nbsp;Giuseppe Grosso ,&nbsp;Giuseppe Di Costanzo ,&nbsp;Chiara Cerletti ,&nbsp;Maria Benedetta Donati ,&nbsp;Giovanni de Gaetano ,&nbsp;Licia Iacoviello ,&nbsp;Marialaura Bonaccio ,&nbsp;Moli-sani Study Investigators","doi":"10.1016/j.clnu.2025.04.031","DOIUrl":"10.1016/j.clnu.2025.04.031","url":null,"abstract":"<div><h3>Background and aims</h3><div>Diet quality has been linked to perceived mental and physical health, but the potential relationship with degree of food processing remains unexplored. We examined cross–sectional associations between food consumption categorized according to the Nova classification with perceived mental and physical health in a large cohort of adults.</div></div><div><h3>Methods</h3><div>Cross-sectional analyses were run using data from 18,243 participants recruited in the Moli-sani Study (mean age 54 ± 11 years) in 2005–2010. The mental and physical component scores of the Short Form 36-item were calculated. Food intake was categorized through the Nova classification into four groups: 1) unprocessed/minimally processed foods; 2) processed culinary ingredients; 3) processed foods; 4) ultra-processed foods (UPFs). The Mediterranean Diet Score (MDS) was used to assess overall diet quality.</div></div><div><h3>Results</h3><div>In multivariable-adjusted linear regression analyses, a larger dietary share of unprocessed/minimally processed food was linked to both higher mental (β = 1.39; 95%CI 0.98 to 1.79 for Q4 vs. Q1) and physical components scores (β = 0.33; 95%CI 0.06 to 0.60 for Q4 vs. Q1). Conversely, highest consumption of processed foods and UPFs was associated with lower values of the mental component scores (β = −1.36 points; 95%CI -1.79 to −0.92; and β = −0.57; 95%CI -0.94 to −0.21, respectively, for Q4 vs. Q1).</div></div><div><h3>Conclusions</h3><div>Larger consumption of either processed foods or UPFs was associated with poorer mental health, whereas higher intake of unprocessed/minimally processed foods was linked to better perceived mental and physical health. These associations were independent of diet quality, suggesting that non-nutrient components may influence mental health outcomes. Future studies should more accurately reflect current patterns of processed food consumption in relation to perceived mental health.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"50 ","pages":"Pages 38-47"},"PeriodicalIF":6.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional frailty and the incidence of depression and anxiety among middle-aged and older adults: A prospective cohort study","authors":"Yan Liu ,&nbsp;Jiani Tong ,&nbsp;Liangkai Chen ,&nbsp;Wei Chen ,&nbsp;Yang Yang","doi":"10.1016/j.clnu.2025.04.032","DOIUrl":"10.1016/j.clnu.2025.04.032","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Frailty has been linked to an increased risk of mental disorders. However, little is known about the impact of nutritional frailty, a crucial phenotype of frailty, on depression and anxiety. We aimed to examine the prospective associations between nutritional frailty and the incidence and progression of depression and anxiety among middle-aged and older adults.</div></div><div><h3>Methods</h3><div>Data were obtained from a large prospective cohort study with over 500,000 participants. Nutritional frailty was defined as the copresence of physical frailty (assessed by weight loss, exhaustion, low physical activity level, slowness, and weakness) and nutritional imbalance (assessed by body mass index, skeletal muscle index, and sodium, potassium, and iron intake). Depression, anxiety, and their comorbidity were identified via the International Statistical Classification of Diseases and Related Health Problems, Ninth Revision and Tenth Revision, on the basis of the primary or secondary diagnosis. We performed Cox proportional hazards models to investigate the associations between nutritional frailty and incident depression, anxiety, and their comorbidity. Multistate models were used to examine how nutritional frailty influences transitions from a baseline state to single mental disorders, their comorbidity, and mortality.</div></div><div><h3>Results</h3><div>We included 176,987 participants with a mean age of 56.1 years (SD 8.0), of whom 2648 (1.5%) had nutritional frailty at baseline. During a median follow-up of 12.2 years, 4794 (2.7%) developed depression, 6081 (3.4%) developed anxiety, and 1610 (0.9%) developed both conditions. Individuals with nutritional frailty had a significantly greater risk of developing depression, anxiety, and their comorbidity than robust individuals and those with physical frailty and nutritional imbalance (depression: nutritional frailty HR 3.21 [95% CI 2.77<strong>–</strong>3.73]; physical frailty 3.11 [2.70–3.58]; nutritional imbalance 1.19 [1.11–1.28]; anxiety: 2.25 [1.93<strong>–</strong>2.63], 2.17 [1.87–2.51], 1.20 [1.13–1.28]; comorbidity: 3.69 [2.92<strong>–</strong>4.66], 3.43 [2.74–4.28], 1.31 [1.15–1.50]), even after multivariable adjustment. Baseline nutritional frailty adversely impacts transitions from a baseline state to single mental disorders (depression: 2.89 [2.49–3.36], anxiety: 1.82 [1.54–2.16]) and death (1.95 [1.71–2.22]), from single mental disorders to their comorbidity (depression: 1.96 [1.32–2.89]; anxiety 1.78 [1.17–2.71]), and from comorbidity to death (2.04 [1.07–3.91]).</div></div><div><h3>Conclusions</h3><div>Nutritional frailty is an independent risk factor for incident depression, anxiety, and their comorbidity and adversely influences the progression of these conditions among middle-aged and older adults.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"50 ","pages":"Pages 10-19"},"PeriodicalIF":6.6,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-restricted eating improves appetite regulation and sleep characteristics in adults with poor sleep quality","authors":"Annette Beaumont ,&nbsp;Rut Farías ,&nbsp;Wladimir Fernandez ,&nbsp;Catalina Lizama ,&nbsp;Joselyn González ,&nbsp;Alejandro Villar ,&nbsp;Krista A. Varady ,&nbsp;Patricio Peirano ,&nbsp;Rodrigo Chamorro","doi":"10.1016/j.clnu.2025.04.028","DOIUrl":"10.1016/j.clnu.2025.04.028","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Time-restricted eating (TRE), a type of intermittent fasting (IF), appears to improve metabolic health in adults but shows inconsistent effects on appetite and sleep regulation, with less data on adults with poor sleep. Our study evaluated the impact of TRE on appetite and nighttime sleep in individuals with normal-weight and inadequate sleep.</div></div><div><h3>Methods</h3><div>A randomized controlled trial involved 30 young (age: 25.7 ± 5.6 years; 21F), normal-weight (body mass index (BMI): 23.0 ± 1.8 kg/m²) adults with poor sleep (&lt;7 h/night or poor quality). Participants were randomized to two groups for 8 weeks: i) control group (CON), maintaining usual eating habits (CON, n = 16) or ii) time-restricted eating group (TRE), following a self-selected 10-h eating window (mandatory fasting from 23:00 to 06:00) for 8 weeks with no dietary changes (TRE, n = 14). Appetite, satiety, and craving for food were assessed using Visual Analog Scales (VAS) and the Food Craving Inventory-SP (FCI-SP), respectively. Sleep duration and quality were evaluated by using the Pittsburgh Sleep Quality Index (PSQI) and 7-day actigraphic recordings.</div></div><div><h3>Results</h3><div>The TRE group reported higher satiety and fullness feeling together with a lower capacity to eat compared to CON (p &lt; 0.038), while overall craving scores showed no between-group differences (p = 0.381). Sleep duration did not differ between groups, whereas several sleep characteristics improved. After TRE intervention, actigraphic assessments revealed an earlier sleep onset and later wake-up time (both p &lt; 0.001) and fewer movements during sleep (p &lt; 0.025).</div></div><div><h3>Conclusion</h3><div>An 8-week, 10-h TRE protocol positively affects appetite regulation and sleep characteristics in normal-weight young adults with insufficient or poor sleep. TRE appears promising for addressing appetite regulation and sleep disturbances in this group.</div></div><div><h3>Trial registration</h3><div><span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> (NCT06485037).</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"50 ","pages":"Pages 66-74"},"PeriodicalIF":6.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional associations of zinc supplement intake with biological ageing interacted by metabolic equivalent of task: A large-scale population-based Biobank study","authors":"Yang Zhou ,&nbsp;Jiayan Zhou ,&nbsp;Zhao Li ,&nbsp;Jingyi Wang ,&nbsp;Hongzheng Li ,&nbsp;Xiangjun Yin ,&nbsp;Jialiang Gao ,&nbsp;Ying Wu ,&nbsp;Jinlin Li ,&nbsp;Ya Xuan Sun ,&nbsp;Yige Li ,&nbsp;Weiguang Wang ,&nbsp;Pinar O. Eser ,&nbsp;Themistocles L. Assimes ,&nbsp;Jie He ,&nbsp;Guang Chen","doi":"10.1016/j.clnu.2025.04.029","DOIUrl":"10.1016/j.clnu.2025.04.029","url":null,"abstract":"<div><h3>Background</h3><div>The association of zinc intake with biological ageing and whether physical exercise modifies this association remain uncertain. We aimed to explore the correlations between zinc intake and biological ageing and to evaluate the modifying effect of physical exercise.</div></div><div><h3>Methods</h3><div>Data were extracted from 68,947 participants in the Biobank. Daily zinc intake and biological age were calculated using standard equations, and physical exercise was measured by the metabolic equivalent of task (MET) per week. Generalized linear regression models, adjusted for confounding factors, were employed to explore the associations between zinc intake and biological ageing. Pre-specified subgroup and sensitivity analyses were performed to identify effect modification of MET and to validate the robustness of findings, respectively.</div></div><div><h3>Results</h3><div>The regression models revealed that zinc intake with recommended dose was associated with 0.13-year delayed biological age [95 % Confidence Interval (CI) = −0.21 to −0.05], while an excessive intake of zinc (&gt;40 mg per day) was associated with 3.23-year biological age acceleration (95 % CI = 0.18 to 6.28). Participants adhering to the recommended zinc intake combined with sufficient physical exercise (&gt;600 MET per week) demonstrated a 31 % lower likelihood of experiencing accelerated biological ageing compared to those with inadequate zinc intake and insufficient physical exercise (Odds Ratio = 0.69, 95 % CI = 0.66 to 0.74, p &lt; 0.001). Subgroup analyses indicated that the association between zinc intake and delayed biological ageing was more pronounced in the low-income population with an annual household income before tax of less than £30,999 (P-interaction &lt;0.001). Sensitivity analyses confirmed the robustness of these results.</div></div><div><h3>Conclusion</h3><div>A recommended dose of zinc intake is associated with delayed biological ageing, with physical exercise exceeding 600 MET per week enhancing this association. Conversely, excessive zinc intake is linked to accelerated biological ageing. We suggest that people take daily zinc supplements with caution.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"50 ","pages":"Pages 1-9"},"PeriodicalIF":6.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}