Colorectal Disease最新文献

{"title":"Addressing survivorship challenges in locally recurrent rectal cancer: Methodological considerations and future directions","authors":"Manhong Xu, Huiting Fu","doi":"10.1111/codi.70116","DOIUrl":"https://doi.org/10.1111/codi.70116","url":null,"abstract":"","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic en bloc supralevator posterior exenteration—A video vignette","authors":"Sujata Sai, Syed Althaf, Ravi Arjunan, Srinivas Chunduri, Pavan Sugoor","doi":"10.1111/codi.70115","DOIUrl":"https://doi.org/10.1111/codi.70115","url":null,"abstract":"","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143938941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of sacrocolporectopexy on pelvic anatomy assessed in an upright position using MRI","authors":"Mart C. P. Kortman,&nbsp;Jan W. P. Vanstiphout,&nbsp;Akeel Alhafidh,&nbsp;Frank F. J. Simonis,&nbsp;Anique T. M. Grob","doi":"10.1111/codi.70114","DOIUrl":"https://doi.org/10.1111/codi.70114","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Rectopexy with concomitant sacrocolpopexy (sacrocolporectopexy) is the favoured technique for treating combined pelvic organ prolapse and internal or external rectal prolapse, despite limited functional improvement. Previous studies have assessed anatomical change after standalone rectopexy or sacrocolpopexy, based on supine MRI defaecography. Since a supine position can underestimate the extent of pelvic organ prolapse, it might also incorrectly assess the anatomical effect of sacrocolporectopexy. The aim of this study was to assess the effect of sacrocolporectopexy on the pelvic anatomy in an upright position.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>Twenty one female patients undergoing sacrocolporectopexy from December 2022 to June 2024 were included. All patients underwent physical examination and MRI defaecography preoperatively and postoperatively. The descent of the bladder, vaginal vault and anorectal junction and the size of the rectocele and enterocele were assessed on the MRI defaecography images during maximum straining. Significance was tested using a paired <i>t</i>-test and an improvement of ≥10 mm was considered clinically relevant. The results were compared with previous studies, which used supine assessment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Postoperative improvement was found for the bladder, vaginal vault, anorectal junction, rectocele and enterocele with 14, 44, 5, 16 and 54 mm respectively. The bladder, vaginal vault, rectocele and enterocele showed clinically relevant improvement. Compared with supine results, upright assessments revealed a larger organ lift for the vaginal vault as well as a higher, overall, position of the anorectal junction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Upright assessment of sacrocolporectopexy differs from supine assessment, with statistical and clinically relevant lift for the pelvic organs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/codi.70114","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143914607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biofeedback training versus botox injection for the treatment of dyssynergic defaecation: A randomized controlled trial","authors":"Noha Emad,&nbsp;Hosam Ghazy Elbanna,&nbsp;Ahmed AbdelMawla,&nbsp;Mohamed Balata","doi":"10.1111/codi.70109","DOIUrl":"https://doi.org/10.1111/codi.70109","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Dyssynergic defaecation (DD) is a condition characterized by impaired relaxation or paradoxical contraction of the puborectalis muscle and external anal sphincter during defaecation. This dysfunction leads to chronic constipation and obstructed defaecation, significantly impacting quality of life. The aim of this work was to compare biofeedback (BFB) training and botulinum toxin type-A (BTX-A) injection in the management of DD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>This a randomized, controlled, intervention including 78 patients complaining of DD. The patients were classified into two categories each comprising 39 participants: Group I (BFB training group) underwent six sessions of BFB over one and half months of retraining and Group II (BTX-A injection group) underwent three-dimensional endoluminal ultrasound-guided BTX-A injection at the Colorectal Surgery Unit, Mansoura University Hospitals, Mansoura, Egypt from August 2023 to August 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A statistically significant difference was observed between before and after BTX-A injection regarding the presence of anal fissure. There was a significant relation between history of vaginal delivery and change in maximum resting pressure (<i>p</i> = 0.02) and in maximum tolerable volume (<i>p</i> = 0.03). In contrast, no relation was observed with the changes in maximum squeeze pressure, rectal sensation and desire to defaecate. There was no statistically significant difference between the two groups with regard to the preintervention Wexner Constipation Score (WCS). On the other hand, there were significant differences at 2 weeks (<i>p</i> = 0.006), 1 month (<i>p</i> = 0.009) and 3 months (<i>p</i> = 0.01) postintervention in favour of the BFB group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Both groups were effective in managing DD; however, BFB demonstrated greater short-term improvement in WCS while BTX-A significantly improved anorectal physiology, as evidenced by anorectal manometry.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143914045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low anterior resection syndrome in patients undergoing bowel segmental resection for rectosigmoid endometriosis: A retrospective long-term follow-up study","authors":"Sandra Coll,&nbsp;Yannick Hurni,&nbsp;Nuria Barbany-Freixa,&nbsp;Francesco La Torre,&nbsp;Carlota Vilarrubí-Jordà,&nbsp;Maria Montaño-Serrano,&nbsp;Laura Lázaro-García,&nbsp;Silvia Cabrera,&nbsp;Francesc Tresserra,&nbsp;Pere N. Barri-Soldevila,&nbsp;Maria Antonia Lequerica-Cabello","doi":"10.1111/codi.70113","DOIUrl":"https://doi.org/10.1111/codi.70113","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The aim of this work was to evaluate the prevalence of low anterior resection syndrome (LARS) and its long-term evolution following colorectal segmental resection for deep infiltrating endometriosis (DIE) and identify any associated risk factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>A retrospective observational study was conducted on 124 patients who underwent bowel segmental resection for DIE between 2008 and 2023 at a single tertiary centre. Postoperative rectal function was assessed using the LARS score, and logistic regression analysis was performed to identify independent risk factors for minor/major LARS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>LARS was observed in 5.6% of patients, with 1.6% presenting minor LARS and 4.0% major LARS. Logistic regression identified parametrial resection (odds ratio = 6.2, <i>p</i> = 0.04) as an independent risk factor for minor/major LARS. LARS severity remained stable in all cases over a mean follow-up of 6.9 ± 3.7 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>As for previously reported studies, our data highlight a relatively low prevalence of LARS following bowel DIE surgery with stable severity over time. Identifying parametrial resection as an independent risk factor underlines the critical need to recognize this specific aspect of endometriosis surgery, ensuring that it is thoroughly addressed during surgical planning and integrated into patient counselling for proper outcomes and expectations. Prospective studies are needed to confirm these findings, explore additional risk factors and better understand the factors influencing long-term outcomes in this patient population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143914008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reassessing adjuvant chemotherapy in rectal cancer: Implications of early mortality exclusion and methodological rigour","authors":"Yingying Li,&nbsp;Qingming Wang","doi":"10.1111/codi.70108","DOIUrl":"https://doi.org/10.1111/codi.70108","url":null,"abstract":"","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143900878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple robotic stapler firings to transect the rectum are not associated with anastomotic leakage","authors":"Stefano Cardelli,&nbsp;Luca Stocchi,&nbsp;Amit Merchea,&nbsp;Dorin T. Colibaseanu,&nbsp;Michelle F. DeLeon,&nbsp;Nitin Mishra,&nbsp;Kevin J. Hancock,&nbsp;David W. Larson","doi":"10.1111/codi.70094","DOIUrl":"https://doi.org/10.1111/codi.70094","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The relationship between the number of stapler firings (SFs) during robotic rectal transection and the risk of colorectal/coloanal anastomotic leakage (AL) is controversial. This study investigates whether the number of robotic SFs is associated with an increased risk of AL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>Retrospective review of adult patients who underwent robotic total mesorectal excision (TME) and partial mesorectal excision (PME) with double-stapled colorectal or coloanal anastomosis for both benign and malignant colorectal diseases between 2015 and 2023 across three enterprise-wide hospitals. Primary outcome: the effect of multiple SFs on postoperative AL rate among patients who underwent one, two, or three or more SFs. Secondary outcome: the effects of other potential risk factors on postoperative AL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 503 patients who underwent robotic colorectal resection with a double-stapled anastomosis, 56 (11%) developed a postoperative AL. The number of SFs was not associated with the AL rate (<i>p</i> = 0.51): the univariable and multivariate analyses found no correlation between the AL rate and the increasing number of SFs required, compared with one SF as the reference (adjusted two SFs, OR = 1.1, 95% CI: 0.6–2.2, <i>p</i> = 0.77 vs. adjusted three or more SFs, OR = 0.98, 95% CI: 0.4–2.3, <i>p</i> = 0.96). On multivariate analysis, AL was strongly associated with male gender (OR = 2.5, 95% CI: 1.3–4.9, <i>p</i> = 0.005) and with TME versus PME (OR = 2.8, 95% CI: 1.5–5.5, <i>p</i> = 0.002).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The number of robotic SFs for rectal transection is not correlated with postoperative AL.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143900983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic peritonectomy of quadrants 5, 6 and 7 because of peritoneal carcinomatosis of colorectal origin—A video vignette","authors":"María del Pilar Gutiérrez-Delgado,&nbsp;Alberto Titos-García,&nbsp;Joaquin Carrasco-Campos,&nbsp;Ivan González-Poveda,&nbsp;Santiago Mera-Velasco","doi":"10.1111/codi.70101","DOIUrl":"https://doi.org/10.1111/codi.70101","url":null,"abstract":"","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143900879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pilot study of gut mucosal and faecal microbiota in rectal cancer: associations with histological response and adverse events following preoperative chemoradiotherapy","authors":"Shigenobu Emoto,&nbsp;Ryo Inoue,&nbsp;Shin Murai,&nbsp;Yuriko Inagaki,&nbsp;Hiroaki Nozawa,&nbsp;Kazuhito Sasaki,&nbsp;Koji Murono,&nbsp;Kensuke Kaneko,&nbsp;Yuichiro Yokoyama,&nbsp;Shinya Abe,&nbsp;Yuzo Nagai,&nbsp;Takahide Shinagawa,&nbsp;Yuichi Tachikawa,&nbsp;Satoshi Okada,&nbsp;Takamitsu Tsukahara,&nbsp;Kai Ohashi,&nbsp;Masashi Ohno,&nbsp;Akira Andoh,&nbsp;Soichiro Ishihara","doi":"10.1111/codi.70106","DOIUrl":"https://doi.org/10.1111/codi.70106","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Preoperative chemoradiotherapy (CRT) is administered for locally advanced rectal cancer (LARC); however, its efficacy and toxicity vary among patients. This study aimed to elucidate the relationship between the gut microbiota and the effectiveness and adverse events of CRT.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective study included 21 patients with LARC with no history of antibiotic or probiotic administration for 6 months. Tumour mucosa, non-tumour mucosa and faecal samples were collected before and after CRT, and bacterial DNA was extracted. Metataxonomic analysis targeting the V3 and V4 regions of the 16S rRNA gene was conducted to determine the diversity and composition of the microbiota. Linear discriminant analysis effect size (LEfSe) was used to explore potential bacterial taxa predicting pathological complete response (pCR) and treatment-associated diarrhoea, which are major adverse events of CRT.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 21 patients, five achieved pCR and seven experienced severe treatment-associated diarrhoea. There were no significant differences in α-diversity and β-diversity of the microbiota between the groups at any sampling sites before or after CRT. Exploratory analysis using LEfSe identified <i>Peptostreptococcus</i>, <i>Coprococcus</i> and <i>Phoceaicola</i> in the tumour mucosa before CRT as significant indicators for achieving pCR. Additionally, <i>Collinsella</i>, <i>Haemophilus</i> and <i>Desulfovibrionaceae</i> are associated with treatment-associated diarrhoea. Microbiome composition changed before and after CRT, with a notable decrease in the genus <i>Fusobacterium_C</i> and other taxa. β-diversity in the tumour area also changed significantly (<i>P</i> = 0.03).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study suggests an association between the gut microbiota, the therapeutic effectiveness of CRT and the occurrence of treatment-associated diarrhoea in rectal cancer. These results indicate the potential for predicting treatment efficacy and adverse events based on the microbiota composition.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/codi.70106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143896793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Splenic flexure takedown: A step-by-step robotic versus laparoscopic comparison—A video vignette","authors":"Antonio Jesús Garcia-Moriana,&nbsp;Miriam Alvarez-Aguilera,&nbsp;Maria L. Reyes-Diaz,&nbsp;Irene Ramallo-Solis,&nbsp;Fernando De la Portilla,&nbsp;Rosa M. Jimenez-Rodriguez","doi":"10.1111/codi.70107","DOIUrl":"https://doi.org/10.1111/codi.70107","url":null,"abstract":"","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143896812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}