Colorectal Disease最新文献

{"title":"The ILEOSTIM trial: A multicentre randomised controlled trial evaluating the impact of efferent loop stimulation prior to ileostomy reversal on postoperative ileus.","authors":"Jorge Arredondo, Adriana Uriz, Irene Oliva, José I Martín, Christian N Iglesias, Ekta Choolani, Ainhoa Valle, Javier Rivera, Sebastián Jerí-McFarlane, Juan M Romero, Carolina González, Alicia Alvarellos, Marta Tasende, Lourdes Gómez, Laura Lázaro, Blanca Montcusí, Patricia Tejedor, Jeancarlos Trujillo-Díaz, Alicia Ruiz de la Hermosa, Jorge Baixauli, Jorge M Núñez-Córdoba, Daniel Aliseda","doi":"10.1111/codi.70448","DOIUrl":"10.1111/codi.70448","url":null,"abstract":"<p><strong>Background: </strong>Strategies to optimise bowel function before stoma reversal surgery (SRS) are needed to improve postoperative outcomes. Efferent bowel stimulation (EBS) prior to stoma closure has been proposed as a potential strategy to reduce postoperative ileus (POI) incidence and improve the patient's postoperative course.</p><p><strong>Methods: </strong>A multicentre randomised controlled trial was designed to evaluate the effectiveness of pre-SRS EBS in reducing POI incidence. Patients scheduled for elective SRS were randomised 1:1 to either an intervention group, receiving daily EBS with saline and a nutritional thickener for 2 weeks preoperatively, or a control group, undergoing SRS without stimulation. The primary endpoint was POI incidence. Secondary outcomes included the time to oral diet tolerance, passage of first flatus/stool, surgery-related comorbidities, length of hospital stay and incidence of Low Anterior Resection Syndrome (LARS) (NCT05302557-31/03/2022).</p><p><strong>Results: </strong>From June 2021 to April 2023, 175 patients were enrolled from 18 hospitals in Spain, 78 (44.5%) and 97 (55.4%) of whom were allocated to the intervention and control groups, respectively. We found that EBS was not significantly associated with a decrease in POI incidence (7.6% vs. 16.4%, p = 0.088). No significant differences in the median hospital stay (p = 0.545) or LARS at discharge (p = 0.087) were observed between the two groups. The EBS group showed fewer but more severe complications (p = 0.015).</p><p><strong>Conclusion: </strong>Preoperative EBS is a feasible and reproducible intervention that may represent a potential strategy to reduce POI following SRS.</p>","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"28 5","pages":"e70448"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Faecal calprotectin in perianal fistula: Can a negative test miss isolated Crohn's disease?","authors":"Semra Demirli Atici","doi":"10.1111/codi.70477","DOIUrl":"https://doi.org/10.1111/codi.70477","url":null,"abstract":"","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"28 5","pages":"e70477"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harmonizing pouch fistula outcomes: From PAVFCOS to a core measurement set.","authors":"Zubing Mei, Ye Han, De Zheng","doi":"10.1111/codi.70474","DOIUrl":"https://doi.org/10.1111/codi.70474","url":null,"abstract":"","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"28 5","pages":"e70474"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NMES for neurogenic bowel: Prioritizing time based outcomes and clarifying mechanism.","authors":"Baodong Wang, Jiayuan Huang, Zhiyun Chen","doi":"10.1111/codi.70480","DOIUrl":"https://doi.org/10.1111/codi.70480","url":null,"abstract":"","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"28 5","pages":"e70480"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic surgery for colorectal cancer: A proof-of-concept in single surgeon laparoscopic right hemicolectomy-A video vignette.","authors":"Christophe Riquoir, Cristián Jarry, Eugenio Grasset","doi":"10.1111/codi.70479","DOIUrl":"https://doi.org/10.1111/codi.70479","url":null,"abstract":"","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"28 5","pages":"e70479"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-related quality of life and functional outcomes of colon cancer patients in the Netherlands: A population-based study.","authors":"A J Pennings, G R Vink, S van Kuijk, M Koopman, J Melenhorst, G L Beets, A M May, S O Breukink","doi":"10.1111/codi.70461","DOIUrl":"https://doi.org/10.1111/codi.70461","url":null,"abstract":"<p><strong>Background: </strong>Colon cancer treatment has evolved significantly through earlier detection, less invasive surgery, optimised perioperative care and shortening chemotherapy duration from 6 to 3 months in 2017. These multidisciplinary improvements may contribute to better health-related quality of life (HRQoL), yet population-based data on their real-world impact on HRQoL and functional outcomes remain limited.</p><p><strong>Methods: </strong>This cross-sectional study used data from the Dutch Prospective PLCRC cohort, including patients with stage I-III colon cancer who completed patient-reported outcome measures (PROMs) at 12 or 24 months post-diagnosis. HRQoL was assessed using EORTC QLQ-C30, QLQ-CR29 and the LARS score. Patients diagnosed in 2014-2016 (Group A) were compared with those from 2017 to 2019 (Group B). Propensity score matching (1:4) was applied for age, sex and tumour stage. Multivariable analyses were adjusted accordingly, minimally important differences (MIDs) guided clinical relevance and the values were compared with Dutch population values.</p><p><strong>Results: </strong>A total of 1,749 patients were included in the analysis. Following propensity score matching, no clinically meaningful differences in the EORTC QLQ-C30 functional or symptom scales were observed at 12 months post-diagnosis between patients diagnosed in 2014-2016 (Group A) and those diagnosed in 2017-2019 (Group B). At 24 months, Group B demonstrated a modestly better QLQ-C30 summary score (mean difference + 1.3; 95% CI: 0.6-1.9), as well as statistically significant but clinically negligible improvements in role and cognitive functioning, and lower reported levels of fatigue, appetite loss and financial difficulties. Functional outcomes assessed via QLQ-CR29 and LARS score were comparable between groups, with a non-significant trend towards fewer major LARS cases in Group B at 24 months (14.6% vs. 19.9%; p = 0.068).</p><p><strong>Conclusion: </strong>Dutch colon cancer patients reported good HRQoL and functional outcomes up to 2 years post-diagnosis, with no clinically relevant differences between 2014-2016 and 2017-2019. These findings suggest a consistently high standard of care nationwide. Ongoing monitoring remains essential to address individual symptom burden and evaluate the impact of evolving treatment strategies.</p>","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"28 5","pages":"e70461"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13107233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The patient perspective on colorectal anastomotic leaks: A qualitative study.","authors":"Danique J I Heuvelings, Anke H C Gielen, Matthijs H Bosveld, Merel L Kimman, Olivia Monton, Julio F Fiore, Stephanie O Breukink, Abe Fingerhut, Marylise Boutros, Nader Francis, Nicole D Bouvy, Patricia Sylla","doi":"10.1111/codi.70471","DOIUrl":"10.1111/codi.70471","url":null,"abstract":"<p><strong>Aim: </strong>Anastomotic leakage is a well-known complication following colorectal surgery, however, there is limited knowledge about patients' experiences with leaks across the care pathway, from initial diagnosis and treatment to long-term recovery. To explore patients' experiences of anastomotic leakage following colorectal resection and identify patient-reported priorities relevant to standardized reporting.</p><p><strong>Methods: </strong>Qualitative descriptive study reported using the COnsolidated criteria for REporting Qualitative research. Online semi-structured interviews were conducted with patients from five countries (Australia, Canada, Netherlands, United Kingdom, and United States). Ten participants (six males, median age 53 [range 39-65 years]) who experienced an anastomotic leak following a colorectal resection. Themes and subthemes emerging from thematic analysis until saturation were reached.</p><p><strong>Results: </strong>Four main themes were identified: (1) physical impact, (2) emotional impact, (3) coping mechanisms, and (4) anastomotic leak care. Within these themes, participants detailed their lived experience during the different phases of the care pathway: diagnosis, treatment, early and late recovery. Additionally, participants indicated the elements of anastomotic leak care that they deemed most important, including preoperative education, communication, support from medical staff and peers, sharing of information, aftercare, shared decision-making, and case management.</p><p><strong>Conclusions: </strong>Patients having experienced a colorectal anastomotic leak reported a physical and emotional impact, applied different coping strategies, and emphasized the importance of clear communication, comprehensive care, and sustained attention beyond the early postoperative and treatment phase.</p>","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"28 5","pages":"e70471"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13136405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of home biofeedback in dyssynergic defaecation: A prospective pilot study.","authors":"Ahmet Omak, Alisina Bulut, Wafi Attaallah","doi":"10.1111/codi.70475","DOIUrl":"10.1111/codi.70475","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the effectiveness of home biofeedback therapy in patients with dyssynergic defaecation.</p><p><strong>Method: </strong>This single-centre prospective cohort study was conducted in a tertiary general surgery outpatient clinic. Adult patients with dyssynergic defaecation confirmed according to Rome IV criteria and physiological testing were prospectively enrolled after ethical approval. Participants received training on the use of a home-based anal biofeedback device and performed biofeedback exercises at home for 30 min daily over a 12-week period. Changes in Obstructed Defaecation Syndrome Score (ODS-S) and Patient Assessment of Constipation Quality of Life (PAC-QoL) score were evaluated.</p><p><strong>Results: </strong>Twenty-four patients were included in the study. The median ODS-S significantly improved from 17.5 (range, 13-20) at baseline to 3 (range, 0-12) after treatment (P < 0.001). The median PAC-QoL score also showed a significant improvement, decreasing from 104 (range, 65-126) to 49 (range, 32-81) (P < 0.001). Clinical improvement, defined as an ODS-S < 9, was achieved in 75% of patients.</p><p><strong>Conclusion: </strong>Home-based biofeedback therapy is an effective and accessible treatment option for dyssynergic defaecation. Its low cost, ease of use and ability to preserve patient privacy suggest that this modality may serve as a practical first-line therapy.</p>","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"28 5","pages":"e70475"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13144429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients' experiences of participating in a nurse-led clinic for bowel dysfunction following rectal cancer: A qualitative interview study.","authors":"Birgitte Schantz Laursen, Gitte Kjær Sørensen, Margit Majgaard, Karen Irene Jacobsen, Helle Vindfeldt Rasmussen, Mathilde Grosell, Therese Juul, Peter Christensen, Marianne Krogsgaard","doi":"10.1111/codi.70460","DOIUrl":"https://doi.org/10.1111/codi.70460","url":null,"abstract":"<p><strong>Background: </strong>An increasing number of patients survive rectal cancer, leading to a rise in the number of patients with late sequelae following surgical and oncological treatments. Consequently, the demand for information, treatment and counselling among these patients is on the rise. Nurse-led clinics, staffed by nurses with specialised expertise in Low Anterior Resection Syndrome and following structured treatment programs, are being established as part of specialised hospital departments in Denmark and other countries in an attempt to increase patient survivorship.</p><p><strong>Aim: </strong>This study aimed to gain insights into the perspective of rectal cancer patients who received surgical treatment on participating in such treatment programs, which may help identify the most significant aspects from their viewpoint and assist healthcare professionals in determining follow-up programs.</p><p><strong>Methods: </strong>The study employed a qualitative design, utilising semi-structured interviews to collect data, which was then analysed through thematic analysis. A total of 24 rectal cancer patients treated for low anterior resection syndrome (LARS) at a nurse-led late sequelae clinic were included in the study.</p><p><strong>Results: </strong>The analysis revealed three key themes: (1) The significance of being seen as a whole person, (2) Tailored solutions within a structured framework and (3) The importance of managing everyday life.</p><p><strong>Conclusion: </strong>This study's findings complement existing knowledge by illustrating how nurse-led clinics can deliver personalised care that addresses both physical symptoms and social and emotional needs. The use of structured treatment algorithms offers a professional and coherent approach to symptom management, which patients find reassuring and supportive.</p><p><strong>Originality statement: </strong>This study supports already known knowledge and adds new insight by highlighting how rectal cancer survivors value holistic, personalised support within structured nurse-led clinics. It demonstrates that combining tailored interventions with professional treatment algorithms enhances patients' sense of recognition, safety and ability to manage everyday life, an understudied perspective in current survivorship care literature.</p>","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"28 5","pages":"e70460"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13107234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic posterior pelvic exenteration with perineal reconstruction with a fasciocutaneous flap - A video vignette.","authors":"Irene Maya, Barbara Noiret, Benjamin Merlot, Quentin Denost","doi":"10.1111/codi.70470","DOIUrl":"https://doi.org/10.1111/codi.70470","url":null,"abstract":"","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"28 5","pages":"e70470"},"PeriodicalIF":2.7,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}