Colorectal Disease最新文献

{"title":"One step beyond right hemicolectomy with D3 lymphadenectomy: Central ligation of middle colic vessels—A video vignette","authors":"Jorge Sancho-Muriel, Hanna Cholewa, Francisco Giner, Carmen Gutierrez, Blas Flor, Matteo Frasson","doi":"10.1111/codi.70017","DOIUrl":"10.1111/codi.70017","url":null,"abstract":"","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic multiquadrant surgery for synchronous neoplasms: The value of a multidisciplinary approach—A video vignette","authors":"María Sánchez-Rodríguez, Gabriel Ogaya, Adnan Alsourani, Renan Carlo Colombari, Silvia Kayser, Patricia Tejedor","doi":"10.1111/codi.17291","DOIUrl":"10.1111/codi.17291","url":null,"abstract":"","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SELective defunctioning Stoma Approach in low anterior resection for rectal cancer (SELSA): Protocol for a prospective study with a nested randomized clinical trial investigating stoma-free survival without major LARS following total mesorectal excision","authors":"Martin Rutegård,&nbsp;Marcus Lindsköld,&nbsp;Fredrik Jörgren,&nbsp;Kalle Landerholm,&nbsp;Peter Matthiessen,&nbsp;Håvard Mjørud Forsmo,&nbsp;Jennifer Park,&nbsp;Jacob Rosenberg,&nbsp;Johannes Schultz,&nbsp;Lars T. Seeberg,&nbsp;Josefin Segelman,&nbsp;Pamela Buchwald","doi":"10.1111/codi.70009","DOIUrl":"10.1111/codi.70009","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Accumulated data suggest that routine use of defunctioning stoma in low anterior resection for rectal cancer may cause kidney injury, bowel dysfunction and a higher risk of permanent stomas. We aim to study whether avoidance of a diverting stoma in selected patients is safe and reduces adverse consequences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>SELSA is a multicentre international prospective observational study nesting an open-label randomized clinical trial. All patients with primary rectal cancer planned for low anterior resection are eligible. Patients operated with curative intent, aged &lt;80 years, with an American Society of Anaesthesiologists' fitness grade I or II, and a low predicted risk of anastomotic leakage are eligible to 1:1 randomization between no defunctioning stoma (experimental arm) or a defunctioning stoma (control arm). The primary outcome is the composite measure of 2-year stoma-free survival without major low anterior resection syndrome (LARS). Secondary outcomes include anastomotic leakage, postoperative mortality, reinterventions, stoma-related complications, quality of life measures, LARS score, and permanent stoma rate. To be able to state superiority of any study arm regarding the main outcome, with 90% statistical power and assuming 25% attrition, we aim to enrol 212 patients. Patient inclusion will commence in the autumn of 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The SELSA study is investigating a tailored approach to defunctioning stoma use in low anterior resection for rectal cancer in relation to the risk of anastomotic leakage. Our hypothesis is that long-term effects will favour the selective approach, enabling some patients to avoid a defunctioning stoma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial registration</h3>\u0000 \u0000 <p>Swedish Ethical Review Authority approval (2023–04347-01, 2024–02418-02 and 2024–03622-02), Regional Ethics Committee Denmark (H-24014463), and ClinicalTrials.gov (NCT06214988).</p>\u0000 </section>\u0000 </div>","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11780343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of ileal conduit length on long-term kidney function decline after total pelvic exenteration for colorectal cancer","authors":"Yusuke Yatabe,&nbsp;Hiroyasu Kagawa,&nbsp;Ryo Yamashita,&nbsp;Akio Shiomi,&nbsp;Shoichi Manabe,&nbsp;Yusuke Yamaoka,&nbsp;Yusuke Tanaka,&nbsp;Shunsuke Kasai,&nbsp;Takahiro Igaki,&nbsp;Akifumi Notsu,&nbsp;Yusuke Kinugasa","doi":"10.1111/codi.70011","DOIUrl":"10.1111/codi.70011","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Understanding of kidney function decline (KFD) after pelvic exenteration (PE) for colorectal cancer remains limited, and the effects of a long ileal conduit (IC) on kidney disorders are unclear. The aim of this study was to investigate long-term kidney function following PE in colorectal cancer and to evaluate the effects of IC length on KFD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>This was a retrospective, single-centre cohort study. KFD was defined as a decline in estimated glomerular filtration rate (eGFR) of ≥30% compared with preoperative data. IC length was measured from a postoperative computed tomography scan. The primary endpoint was the number of patients with KFD 5 years after surgery. The rate of decline of eGFR, cumulative KFD incidence and correlation between IC length and rate of decline of eGFR were also analysed. The patients were divided into two groups (short IC and long IC) based on an IC length of 20 cm.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Forty-three patients were included in the analysis. Fourteen (33%) and 29 (67%) patients were included in the short- and long-IC groups, respectively. The long-IC group was significantly more likely to be diagnosed with KFD within 5 years than the short-IC group (51% vs. 14%, <i>p</i> = 0.023). Multivariate analyses revealed that a longer IC was identified as an independent risk factor for KFD (hazard ratio 4.140, 95% CI 1.035–16.560, <i>p</i> = 0.045). Pearson's correlation and linear regression analyses demonstrated a significant association between IC length and rate of decline of eGFR (<i>r</i> = 0.466, <i>p</i> = 0.002).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>A significant number of patients with colorectal cancer have decreased kidney function after PE. A longer conduit may impair kidney function.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic pain after colorectal cancer treatment: A population-based cross-sectional study","authors":"Hossam Elfeki,&nbsp;Reem A. Alharbi,&nbsp;Therese Juul,&nbsp;Asbjørn M. Drewes,&nbsp;Peter Christensen,&nbsp;Søren Laurberg,&nbsp;Katrine J. Emmertsen","doi":"10.1111/codi.17296","DOIUrl":"10.1111/codi.17296","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>With the recently validated tool for estimating chronic pain after colorectal cancer surgery, the aims of this study were to calculate the prevalence and to identify predictive risk factors for chronic pain after colorectal cancer treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>Clinical data from colorectal cancer patients treated between 2001 and 2014 were obtained from the Danish Colorectal Cancer Group database. In 2016, all survivors were invited to participate in a national cross-sectional questionnaire study on long-term functional outcomes, including the chronic pain questionnaire. The prevalence of chronic pain was analysed in groups based on demographic data and treatment-related factors. Multivariate logistic regression analysis was performed to determine significant predictors of chronic pain, displayed as odds ratios (OR) and 95% confidence intervals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The response rate was 63.8%, representing 11 600 patients (7127 colon and 4473 rectal cancer patients). The overall prevalence of pain was 41.5%, with 15.4% having major pain. Major pain was more prevalent in rectal cancer patients than colon cancer patients (16.7% vs. 14.5%, <i>p</i> &lt; 0.001). Predictors for major pain were: young age &lt;60 years [OR 1.7 (95% CI 1.51–1.91)]; female sex [OR 1.63 (95% CI 1.46–1.82)]; an open surgical approach [OR 1.18 (95% CI 1.05–1.33)]; chemotherapy [OR 1.32 (95% CI 1.18–1.49)]; radiotherapy [OR 1.39 (95% CI 1.17–1.65)]; permanent stoma [1.56 (95% CI 1.31–1.86)]; comorbidity [OR 1.69 (95% CI 1.5–1.9)]; anastomotic leakage [OR 1.31 (95% CI 1.05–1.64)].</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Chronic pain is prevalent after colorectal cancer surgery. All patients should be informed about the risks before cancer treatment, particularly those who are at an increased risk of developing major pain.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative application of the Versius Surgical System® in subtotal colectomy for refractory slow-transit constipation: A video vignette","authors":"Alice Pecorino,&nbsp;Andrea Grego,&nbsp;Ugo Grossi,&nbsp;Enzo Mammano,&nbsp;Nicola Passuello,&nbsp;Giacomo Sarzo","doi":"10.1111/codi.70014","DOIUrl":"10.1111/codi.70014","url":null,"abstract":"","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender-specific outcomes in pilonidal sinus disease: Female outcomes after cleft lift surgery in a large prospective Danish cohort","authors":"I. K. Faurschou,&nbsp;J. L. Ankersen,&nbsp;N. Pedersen,&nbsp;M. J. Sørensen,&nbsp;M. L. Friis,&nbsp;A. G. Pedersen,&nbsp;D. Doll,&nbsp;S. Haas","doi":"10.1111/codi.70003","DOIUrl":"10.1111/codi.70003","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Pilonidal sinus disease (PSD) is a common condition particularly affecting young men. Females affected by the condition account for about 20% of patients and are rarely mentioned, much less studied specifically. In this study we evaluate the surgical outcomes in a female population following Bascom's cleft lift (BCL) surgery in primary extensive disease, non-healing wounds after previous surgery and recurrent disease in a large Danish cohort from a high-volume centre.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>The study is based on a prospective database established at Randers Regional Hospital in 2016. All patients undergoing BCL surgery from June 2016 until October 2022 were included in this study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In all, 560 patients underwent BCL surgery at our centre during this period. Eighty-eight (15.7%) were women. Only 10 (11.3%) were operated due to primary extensive manifestations. The rest presented with either non-healing wounds after previous surgery (47.7%) or recurrent PSD (41%). Risk of recurrence in female patients was 30% higher than in male patients (risk ratio 1.30, 95% CI 0.79–2.09) and the risk of prolonged healing after BCL surgery was 46% higher in women compared to men (risk ratio 1.46, 95% CI 1.02–2.14).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Female PSD patients may represent a subcategory of patients at higher risk of treatment failure and should be dealt with as such. Initially, few present with the need for extensive surgery. However, given the common occurrence of prolonged healing and recurrence, we recommend a minimal invasive approach when possible.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11772908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic right hemicolectomy with CME and omentectomy, HIPEC and right parietal peritonectomy – A video vignette","authors":"Jonathan Tiong,&nbsp;Amrish K. S. Rajkomar,&nbsp;Thomas Barnes,&nbsp;Amy J. Thomas,&nbsp;Satish K. Warrier","doi":"10.1111/codi.70006","DOIUrl":"10.1111/codi.70006","url":null,"abstract":"","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term survival outcomes in young-onset colorectal cancer: A population-based cohort study","authors":"Amy M. Y. Cao,&nbsp;Michael L. R. Lonne,&nbsp;David A. Clark","doi":"10.1111/codi.70007","DOIUrl":"https://doi.org/10.1111/codi.70007","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Long-term survival outcomes in young-onset colorectal cancer patients are contradictory and inconsistent. Some studies report overall survival to be significantly superior compared with older adults, while others report worse survival. Worldwide, the incidence of young-onset colorectal cancer has, alarmingly, nearly doubled since the 1990s, in stark contrast to that in those over 50 years of age. Long-term survival in young-onset colorectal cancer has not been explored in the Australian population. The aim of this study was to investigate cancer-specific and overall survival up to 10 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>This was a retrospective population-based cohort study. All colorectal cancer diagnoses between 2001 and 2020 in the state of Queensland, Australia were reviewed. Young-onset colorectal cancer (20–49 years) was compared with late-onset colorectal cancer (50 years+).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There were 52 697 adults diagnosed with colorectal cancer in Queensland. Young-onset colorectal cancer accounted for 7.7% of these. Young-onset colorectal cancer had a greater proportion of Stage III and IV disease than the late-onset group (66% vs. 59%, <i>p</i> &lt; 0.001). Despite this, young-onset colorectal cancer had statistically significant improved overall survival at all time points to 10 years (<i>p</i> &lt; 0.001). Stage-for-stage cancer-specific survival to 10 years was superior in all stages in young-onset colorectal cancer (<i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Both stage-for-stage cancer-specific and overall survival were superior in young-onset colorectal cancer compared with those aged 50 years and above, up to 10 years.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/codi.70007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143119591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colorectal cAncer and CrohN's DIsease study (CANDID): An international multicentre retrospective audit","authors":"Zoe Garoufalia,&nbsp;Sameh Hany Emile,&nbsp;Justin Dourado,&nbsp;Marylise Boutros,&nbsp;Richard Brady,&nbsp;Valerio Celentano,&nbsp;Justin Davies,&nbsp;Phillip R. Fleshner,&nbsp;Rachel Gefen,&nbsp;Stefan D. Holubar,&nbsp;Nir Horesh,&nbsp;Alaa El-Hussuna,&nbsp;Deborah Keller,&nbsp;Amy Lightner,&nbsp;Gianluca Pellino,&nbsp;Sherief Shawki,&nbsp;Spyros Siakavellas,&nbsp;Antonino Spinelli,&nbsp;Janindra Warusavitarne,&nbsp;Steven D. Wexner","doi":"10.1111/codi.70005","DOIUrl":"https://doi.org/10.1111/codi.70005","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Inflammatory bowel disease (IBD) affects more than 10 million people worldwide. Men and women are equally affected by Crohn's disease (CD). It has been shown that patients with CD are at an increased risk of a colorectal cancer (CRC) diagnosis and CRC-related mortality. During the last two decades, biological therapies have revolutionized the treatment of CD. There are no current studies investigating the prevalence of CRC in patients with CD in the era of biological therapy and the possible features of patients with CD who are at high risk of developing CRC.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Aim&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We aim to assess the prevalence of CRC, risk factors and profile of CRC in patients with CD receiving biological treatment compared with those who are not under biological therapy and the impact of CD-associated colorectal strictures on CRC development. The study hypothesis is that the use of biological therapy in the control of CD activity may decrease the risk of developing CRC.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Study design and setting&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;An international, retrospective, snapshot of the prevalence of CRC in patients with CD, reported according to the SPIRIT guidelines. The study will involve centres that hold regular IBD multidisciplinary team meetings and have both IBD colorectal surgeons and gastroenterologists. Each participating centre will provide a local consultant lead and a local trainee lead. Data will be collected within a 2-year recruitment period (January 2017–January 2019).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Study population&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Adult patients who presented with CD during the study period. Patients with an incidental diagnosis of CD during evaluation for CRC will be excluded.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Statistical plan&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Baseline patient characteristics will be summarized using the appropriate descriptive statistics. Univariable, multivariable and Cox regression models will be used to identify factors significantly associated with CRC. For noncontinuous variables a comparison between the subgroups will be carried out using the chi-square test corrected by Fisher's exact test if appropriate. A &lt;i&gt;p&lt;/i&gt;-value of &lt;0.05 will be considered statistically significant.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Data storage&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Data will be stored on a secured server, pin-code protected according to th","PeriodicalId":10512,"journal":{"name":"Colorectal Disease","volume":"27 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/codi.70005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143119604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}