CNS Spectrums最新文献_第4页

Cognition in trichotillomania: a meta-analysis. 毛手毛脚症的认知：一项荟萃分析。

IF 3.3 3区医学

CNS Spectrums Pub Date : 2024-06-01 Epub Date: 2024-03-13 DOI: 10.1017/S1092852924000129

Aliza Ali, Konstantinos Ioannidis, Jon E Grant, Samuel R Chamberlain

{"title":"Cognition in trichotillomania: a meta-analysis.","authors":"Aliza Ali, Konstantinos Ioannidis, Jon E Grant, Samuel R Chamberlain","doi":"10.1017/S1092852924000129","DOIUrl":"10.1017/S1092852924000129","url":null,"abstract":"Objective: Trichotillomania (TTM) is a mental health disorder characterized by repetitive urges to pull out one's hair. Cognitive deficits have been reported in people with TTM compared to controls; however, the current literature is sparse and inconclusive about affected domains. We aimed to synthesize research on cognitive functioning in TTM and investigate which cognitive domains are impaired.Methods: After preregistration on the International Prospective Register of Systematic Reviews (PROSPERO), we conducted a comprehensive literature search for papers examining cognition in people with TTM versus controls using validated tests. A total of 793 papers were screened using preestablished inclusion/exclusion criteria, yielding 15 eligible studies. Random-effects meta-analysis was conducted for 12 cognitive domains.Results: Meta-analysis demonstrated significant deficits in motor inhibition and extradimensional (ED) shifting in people with TTM versus controls as measured by the stop-signal task (SST) (Hedge's g = 0.45, [CI: 0.14, 0.75], p = .004) and ED set-shift task (g = 0.38, [CI: 0.13, 0.62], p = .003), respectively. There were no significant between-group differences in the other cognitive domains tested: verbal learning, intradimensional (ID) shifting, road map spatial ability, pattern recognition, nonverbal memory, executive planning, spatial span length, Stroop inhibition, Wisconsin card sorting, and visuospatial functioning. Findings were not significantly moderated by study quality scores.Conclusions: Motor inhibition and ED set-shifting appear impaired in TTM. However, a cautious interpretation of results is necessary as samples were relatively small and frequently included comorbidities. Treatment interventions seeking to improve inhibitory control and cognitive flexibility merit exploration for TTM.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140109560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A double-blind, randomized, placebo-controlled plus open trial of adjunctive suvorexant for treatment-resistant insomnia in patients with bipolar disorder. 双盲、随机、安慰剂对照加开放性试验：针对双相情感障碍患者的难治性失眠症，辅助使用苏伐沙坦。

IF 3.4 3区医学

CNS Spectrums Pub Date : 2024-05-24 DOI: 10.1017/S1092852924000336

Rita Cafaro, Monica Macellaro, Trisha Suppes, Bernardo Dell'Osso, Terence Ketter, Michael Ostacher, Shefali Miller, Lauren Chang, Jihun Lyu, Po W Wang

{"title":"A double-blind, randomized, placebo-controlled plus open trial of adjunctive suvorexant for treatment-resistant insomnia in patients with bipolar disorder.","authors":"Rita Cafaro, Monica Macellaro, Trisha Suppes, Bernardo Dell'Osso, Terence Ketter, Michael Ostacher, Shefali Miller, Lauren Chang, Jihun Lyu, Po W Wang","doi":"10.1017/S1092852924000336","DOIUrl":"10.1017/S1092852924000336","url":null,"abstract":"Background: Sleep pattern alteration is a core feature of bipolar disorder (BD), often challenging to treat and affecting clinical outcomes. Suvorexant, a hypnotic agent that decreases wakefulness, has shown promising results in treating primary insomnia. To date, data on its use in BD are lacking. This study evaluated the efficacy and tolerability of adjunctive suvorexant for treatment-resistant insomnia in BD patients.Methods: Thirty-six BD outpatients (19 BDI, 69.4% female, 48.9 [±15.2] years) were randomized for 1 week to double-blind suvorexant (10-20 mg/day) versus placebo. Then, all subjects who completed the randomized phase were offered open suvorexant for 3 months. Subjective total sleep time (sTST) and objective total sleep time (oTST) were assessed.Results: During the randomized control trial (RCT) phase, an overall increase in the oTST emerged, which was statistically significant for the Cole-Kripke algorithm (p = 0.035). The comparison between the suvorexant and placebo groups was limited by significant differences between measurements at baseline. During the open phase, no significant improvement was detected relative to either sTST and oTST. No adverse events nor major intolerances were reported.Discussion: Efficacy results are inconsistent. During the RCT phase, only a small increase in the objective oTST emerged, while during the open phase, no significant improvement was detected. While this is the first ever study of suvorexant in BD-related insomnia, the limitation of the small sample and the high rate of dropouts limits the generalizability of these findings. Larger studies are needed to assess suvorexant in treating BD-related insomnia.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141086958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CNS volume 29 issue 3 Cover and Front matter CNS 第 29 卷第 3 期封面和封底

IF 3.3 3区医学

CNS Spectrums Pub Date : 2024-05-23 DOI: 10.1017/s1092852924000312

引用次数: 0

Serotonin reuptake inhibitors augmentation with cariprazine in patients with treatment-resistant obsessive-compulsive disorder: a retrospective observational study. SRIs 与 Cariprazine 在治疗难治性强迫症患者中的增强作用：回顾性观察研究

IF 3.4 3区医学

CNS Spectrums Pub Date : 2024-05-22 DOI: 10.1017/S1092852924000348

Vassilis Martiadis, Enrico Pessina, Azzurra Martini, Fabiola Raffone, Carlo I Cattaneo, Domenico De Berardis, Ilenia Pampaloni

引用次数: 0

Expert consensus statement for telepsychiatry and attention-deficit hyperactivity disorder. 远程精神病学与注意缺陷多动障碍专家共识声明。

IF 3.4 3区医学

CNS Spectrums Pub Date : 2024-05-20 DOI: 10.1017/S1092852924000208

Jennifer Hong, Gregory W Mattingly, Julie A Carbray, Takesha V Cooper, Robert L Findling, Martin Gignac, Paul E Glaser, Frank A Lopez, Vladamir Maletic, Roger S McIntyre, Adelaide S Robb, Manpreet K Singh, Mark A Stein, Stephen M Stahl

{"title":"Expert consensus statement for telepsychiatry and attention-deficit hyperactivity disorder.","authors":"Jennifer Hong, Gregory W Mattingly, Julie A Carbray, Takesha V Cooper, Robert L Findling, Martin Gignac, Paul E Glaser, Frank A Lopez, Vladamir Maletic, Roger S McIntyre, Adelaide S Robb, Manpreet K Singh, Mark A Stein, Stephen M Stahl","doi":"10.1017/S1092852924000208","DOIUrl":"10.1017/S1092852924000208","url":null,"abstract":"Changing practice patterns caused by the pandemic have created an urgent need for guidance in prescribing stimulants using telepsychiatry for attention-deficit hyperactivity disorder (ADHD). A notable spike in the prescribing of stimulants accompanied the suspension of the Ryan Haight Act, allowing the prescribing of stimulants without a face-to-face meeting. Competing forces both for and against prescribing ADHD stimulants by telepsychiatry have emerged, requiring guidelines to balance these factors. On the one hand, factors weighing in favor of increasing the availability of treatment for ADHD via telepsychiatry include enhanced access to care, reduction in the large number of untreated cases, and prevention of the known adverse outcomes of untreated ADHD. On the other hand, factors in favor of limiting telepsychiatry for ADHD include mitigating the possibility of exploiting telepsychiatry for profit or for misuse, abuse, and diversion of stimulants. This Expert Consensus Group has developed numerous specific guidelines and advocates for some flexibility in allowing telepsychiatry evaluations and treatment without an in-person evaluation to continue. These guidelines also recognize the need to give greater scrutiny to certain subpopulations, such as young adults without a prior diagnosis or treatment of ADHD who request immediate-release stimulants, which should increase the suspicion of possible medication diversion, misuse, or abuse. In such cases, nonstimulants, controlled-release stimulants, or psychosocial interventions should be prioritized. We encourage the use of outside informants to support the history, the use of rating scales, and having access to a hybrid model of both in-person and remote treatment.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Panic-agoraphobic symptoms in adults with ASD: the role of ruminative thinking and inflexibility. 患有自闭症的成年人的恐慌-惧高症状：反刍思维和缺乏灵活性的作用。

IF 3.4 3区医学

CNS Spectrums Pub Date : 2024-05-09 DOI: 10.1017/S1092852924000282

Liliana Dell'Osso, Giulia Amatori, Chiara Bonelli, Benedetta Nardi, Enrico Massimetti, Ivan Mirko Cremone, Barbara Carpita

{"title":"Panic-agoraphobic symptoms in adults with ASD: the role of ruminative thinking and inflexibility.","authors":"Liliana Dell'Osso, Giulia Amatori, Chiara Bonelli, Benedetta Nardi, Enrico Massimetti, Ivan Mirko Cremone, Barbara Carpita","doi":"10.1017/S1092852924000282","DOIUrl":"10.1017/S1092852924000282","url":null,"abstract":"Background: Scientific literature has highlighted the link between autism spectrum disorder (ASD) and anxiety disorders, but few studies have delved into the relationship between ASD and panic-agoraphobic disorders. The aim of this study is to investigate the relationship between autism spectrum and panic-agoraphobic symptoms, examining whether and which autistic domains are predictive of the presence of specific panic-agoraphobic symptoms.Materials and methods: Forty-five adult subjects with ASD and 50 healthy controls (HCs) were evaluated through the Structured Clinical Interview for DSM-5, Research Version and assessed with the Adult Autism Subthreshold Spectrum (AdAS Spectrum) and the Panic-Agoraphobic - Short Version (PAS-SV) questionnaires. Statistical analyses included Mann-Whitney U test, chi-square test, and a set of linear and logistic regression analyses.Results: The PAS-SV total and domain scores were significantly higher in the ASD group than in the HC group. A higher AdAS total score appeared to be predictive of a higher PAS-SV total score. The AdAS domain Restricted Interests and Rumination would increase the risk of obtaining higher PAS-SV total and domain scores. Conversely, the AdAS Spectrum domain Inflexibility and Adherence to Routine would predict lower total PAS-SV score.Conclusion: This study revealed a greater representation of panic-agoraphobic symptoms in adults with ASD, as well as an increased risk of showing such symptoms in the presence of significant autistic traits. Restricted interests and ruminative thinking emerged as predominant risk factors for panic-agoraphobic manifestations.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140891606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abnormal neural activation during negative emotion processing in anxiety disorders: a coordinate-based meta-analysis. 焦虑症患者负面情绪处理过程中的异常神经激活：基于坐标的荟萃分析。

IF 3.3 3区医学

CNS Spectrums Pub Date : 2024-05-06 DOI: 10.1017/S1092852924000166

Rui Wang, Lu Lu, Yingxue Gao, Hui Qiu, Haoran Xu, Juliana Huang, John A Sweeney, Qiyong Gong, Jeffrey R Strawn

引用次数: 0

Unmasking disparities: the challenge of diversity, equity, and inclusion in Press Ganey surveys. 揭开差距：Press Ganey 调查中的多样性、公平性和包容性挑战。

IF 3.3 3区医学

CNS Spectrums Pub Date : 2024-04-01 Epub Date: 2023-08-22 DOI: 10.1017/S1092852923002390

Jagannadha Avasarala, Phenu Zachariah

引用次数: 0

Rumination and altered reactivity to sensory input as vulnerability factors for developing post-traumatic stress symptoms among adults with autistic traits. 反刍和对感官输入反应的改变是自闭症成人出现创伤后应激症状的易感因素。

IF 3.3 3区医学

CNS Spectrums Pub Date : 2024-04-01 Epub Date: 2024-01-15 DOI: 10.1017/S1092852924000014

Liliana Dell'Osso, Giulia Amatori, Federico Giovannoni, Enrico Massimetti, Ivan Mirko Cremone, Barbara Carpita

{"title":"Rumination and altered reactivity to sensory input as vulnerability factors for developing post-traumatic stress symptoms among adults with autistic traits.","authors":"Liliana Dell'Osso, Giulia Amatori, Federico Giovannoni, Enrico Massimetti, Ivan Mirko Cremone, Barbara Carpita","doi":"10.1017/S1092852924000014","DOIUrl":"10.1017/S1092852924000014","url":null,"abstract":"Objective: Recent literature has suggested that individuals with autism spectrum disorder (ASD) or autistic traits (ATs) would be more likely to encounter traumatic events in their lifetime and to develop post-traumatic stress disorder (PTSD). However, the nature of this relationship has not yet been fully elucidated. The aims of this study were to evaluate the relationship between AT and PTSD and to investigate which specific autistic dimension was more associated with trauma and stress-related symptoms.Methods: A total of 68 subjects with ASD and 64 healthy controls (HCs) were assessed with the Adult Autism Subthreshold Spectrum (AdAS Spectrum) and the Trauma and Loss Spectrum (TALS) questionnaires. Statistical analyses included Mann-Whitney U test, chi-square test, calculation of Spearman's coefficients, and logistic regression analysis.Results: Patients with significant AT reported a 30% rate of PTSD and higher TALS total and domain scores than HCs, among whom no PTSD was found instead. Significant positive correlations were reported between AdAS Spectrum and TALS-SR scores in the whole sample. AdAS Spectrum total scores were statistically predictive of the presence of PTSD. High scores at AdAS Spectrum Inflexibility and adherence to routine and Restrictive interest and rumination domains were identified as positive predictors of a probable PTSD.Conclusion: Compared to HCs, subjects with significant AT are more likely to present symptoms of PTSD. In particular, AT related to ruminative thinking, narrow interests, and sensorial reactivity would seem to predict the presence of post-traumatic stress symptomatology.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139466154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insomnia and parasomnia induced by validated smoking cessation pharmacotherapies and electronic cigarettes: a network meta-analysis. 有效戒烟药物疗法和电子香烟诱发的失眠和副失眠：一项网络荟萃分析。

IF 3.4 3区医学

CNS Spectrums Pub Date : 2024-04-01 Epub Date: 2024-03-04 DOI: 10.1017/S1092852924000087

Paul Vanderkam, Charlotte Pomes, Palina Dzeraviashka, Philippe Castera, Nematollah Jaafari, Claire Lafay-Chebassier

{"title":"Insomnia and parasomnia induced by validated smoking cessation pharmacotherapies and electronic cigarettes: a network meta-analysis.","authors":"Paul Vanderkam, Charlotte Pomes, Palina Dzeraviashka, Philippe Castera, Nematollah Jaafari, Claire Lafay-Chebassier","doi":"10.1017/S1092852924000087","DOIUrl":"10.1017/S1092852924000087","url":null,"abstract":"We aim to assess the relationship between validated smoking cessation pharmacotherapies and electronic cigarettes (e-cigarettes) and insomnia and parasomnia using a systematic review and a network meta-analysis. A systematic search was performed until August 2022 in the following databases: PUBMED, COCHRANE, CLINICALTRIAL. Randomized controlled studies against placebo or validated therapeutic smoking cessation methods and e-cigarettes in adult smokers without unstable or psychiatric comorbidity were included. The primary outcome was the presence of \"insomnia\" and \"parasomnia.\" A total of 1261 studies were selected. Thirty-seven studies were included in the quantitative analysis (34 for insomnia and 23 for parasomnia). The reported interventions were varenicline (23 studies), nicotine replacement therapy (NRT, 10 studies), bupropion (15 studies). No studies on e-cigarettes were included. Bayesian analyses found that insomnia and parasomnia are more frequent with smoking cessation therapies than placebo except for bupropion. Insomnia was less frequent with nicotine substitutes but more frequent with bupropion than the over pharmacotherapies. Parasomnia are less frequent with bupropion but more frequent with varenicline than the over pharmacotherapies. Validated smoking cessation pharmacotherapies can induce sleep disturbances with different degrees of frequency. Our network meta-analysis shows a more favorable profile of nicotine substitutes for insomnia and bupropion for parasomnia. It seems essential to systematize the assessment of sleep disturbances in the initiation of smoking cessation treatment. This could help professionals to personalize the choice of treatment according to sleep parameters of each patient. Considering co-addictions, broadening the populations studied and standardizing the measurement are additional avenues for future research.","PeriodicalId":10505,"journal":{"name":"CNS Spectrums","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140021088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0