Neuromodulation of the right inferior frontal gyrus in bipolar disorder to target response inhibition: a proof-of-concept study.

IF 4.1 3区医学 Q2 CLINICAL NEUROLOGY

CNS Spectrums Pub Date : 2025-06-27 DOI:10.1017/S1092852925100308

Karling Luciani, Laura Schmid, Bazyl Carroll, Alexandra Sebastian, Fidel Vila-Rodriguez, Christian G Schütz

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引用次数: 0

Abstract

Objective: Bipolar disorder (BD) affects over 1% of the population and is characterized by deficits in response inhibition. Response inhibition, a crucial component of executive functions, involves the ability to suppress or withhold a planned or ongoing response that is no longer required or appropriate in a given context. Response inhibition may be dissociated into three subcomponents: interference inhibition, action withholding, and action cancellation. These subcomponents are assessed using the hybrid response inhibition (HRI) task. Previous research has shown that inhibitory control is strongly lateralized to the right hemisphere. Specifically, the right inferior frontal gyrus (rIFG) is a key node underpinning response inhibition and might be amenable to neuromodulation using repetitive transcranial magnetic stimulation (rTMS). This proof-of-concept study aimed to investigate the effects of rTMS targeting the rIFG on response inhibition in individuals with BD and controls.

Methods: We investigated HRI performance scores in individuals with BD (n = 12) and sex-/age-matched controls (n = 12) immediately before and after intermittent theta-burst stimulation (iTBS) and continuous TBS to modulate cortical excitability of the rIFG.

Results: The response inhibition subcomponent "action withholding" was significantly improved in the HRI task following iTBS in the BD group. No other significant effects were observed in the results.

Conclusions: Our study is the first to show that iTBS to the rIFG neuromodulated a specific subcomponent of response inhibition in BD. Further research investigating the potential therapeutic effect of neuromodulation of the rIFG in BD is warranted.

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双相情感障碍右额下回的神经调节以靶反应抑制：一项概念验证研究。

目的：双相情感障碍（BD）影响超过1%的人群，其特征是反应抑制缺陷。反应抑制是执行功能的一个重要组成部分，涉及抑制或保留在给定环境中不再需要或不合适的计划或正在进行的反应的能力。反应抑制可分解为干扰抑制、动作保留和动作取消三个组成部分。使用混合反应抑制（HRI）任务评估这些子成分。先前的研究表明，抑制控制强烈偏向右半球。具体来说，右额下回（rIFG）是支持反应抑制的关键节点，可能适合使用重复经颅磁刺激（rTMS）进行神经调节。这项概念验证性研究旨在探讨rTMS靶向rIFG对双相障碍患者和对照组反应抑制的影响。方法：我们研究了12名双相障碍患者和12名性别/年龄匹配的对照组，分别在间歇性脑波爆发刺激（iTBS）和连续脑波爆发刺激（TBS）前后的HRI表现评分，以调节皮质兴奋性。结果：BD组在iTBS后HRI任务中的反应抑制子成分“动作抑制”显著改善。结果中没有观察到其他显著的影响。结论：我们的研究首次表明，iTBS对rIFG神经调节了双相障碍反应抑制的一个特定子成分。进一步的研究表明，神经调节rIFG对双相障碍的潜在治疗作用是有必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CNS Spectrums 医学-精神病学

CiteScore

6.20

自引率

6.10%

发文量

239

审稿时长

>12 weeks

期刊介绍： CNS Spectrums covers all aspects of the clinical neurosciences, neurotherapeutics, and neuropsychopharmacology, particularly those pertinent to the clinician and clinical investigator. The journal features focused, in-depth reviews, perspectives, and original research articles. New therapeutics of all types in psychiatry, mental health, and neurology are emphasized, especially first in man studies, proof of concept studies, and translational basic neuroscience studies. Subject coverage spans the full spectrum of neuropsychiatry, focusing on those crossing traditional boundaries between neurology and psychiatry.